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VTD-melphalan is well tolerated and results in very high rates of stringent CR and MRD-negative status in multiple myeloma.

The addition of cytotoxic drugs to high-dose melphalan as a preparative regimen for autologous stem cell transplantation in multiple myeloma has not resulted in superior activity. Although novel agents have significantly improved outcome in multiple myeloma, their role in preparative regimens remains largely unknown. We have evaluated the toxicity and efficacy of combining bortezomib, thalidomide, and dexamethasone with high-dose melphalan. An institutional review board-approved retrospective analysis was performed on 100 consecutive patients receiving 153 transplants; 53 had tandem transplant

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… The metabolism/nutrition grade 3 toxicities and higher were hypophosphatemia, 40%; hypocalcemia, 29%; hypokalemia, 16%; anorexia requiring total parenteral nutrition, 12%; hyperglycemia, 10%; hyponatremia, 6%; hypoalbuminemia, 2.5%; hypomagnesemia, 2%; hyperkalemia, 2%; and hypernatremia, 0.7%. …

[Application effects of bundle nursing of citric acid extracorporeal anticoagulation on continuous renal replacement therapy of severe burn patients].

Objective: To explore the application effects of bundle nursing of citric acid extracorporeal anticoagulation on continuous renal replacemen … in bundle nursing group. During hospitalization, there were no treatment-related bleeding events or hypernatremia related to citric acid treatment of patients in the two groups. The ratio of total calcium to ionic calcium in one patient in bundle nursing group was >2.5, but there was no manifestation of citric acid accumulation poisoning; 1 patient had hypoioni …

45th International Symposium on Intensive Care & Emergency Medicine.

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CRLF1 and CLCF1 in Development, Health and Disease.

Cytokines and their receptors have a vital function in regulating various processes such as immune function, inflammation, haematopoiesis, cell growth and differentiation. The interaction between a cytokine and its specific receptor triggers intracellular signalling cascades that lead to altered gene expression in the target cell and consequent changes in its proliferation, differentiation, or activation. In this review, we highlight the role of the soluble type I cytokine receptor CRLF1 (cytokine receptor-like factor-1) and the Interleukin (IL)-6 cytokine CLCF1 (cardiotrophin-like cytokine fa

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… Kidney In one recent CS/CISS1 report, the patient presented with urinary system complications, including a small ectopic nonfunctioning right kidney and persistent mild hypernatremia, suggesting a possible role of CRLF1 in renal development [ 65 ]. …

Inpatient Medicine

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The Onco-Nephrology Field: The Role of Personalized Chemotherapy to Prevent Kidney Damage.

In recent years, the onco-nephrology field has acquired a relevant role in internal medicine due to the growing number of cases of renal dysfunction that have been observed in cancer patients. This clinical complication can be induced by the tumor itself (for example, due to obstructive phenomena affecting the excretory tract or by neoplastic dissemination) or by chemotherapy, as it is potentially nephrotoxic. Kidney damage can manifest as acute kidney injury or represent a worsening of pre-existing chronic kidney disease. In cancer patients, physicians should try to set preventive strategies

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… Hypernatremia seems to be caused by diabetes insipidus related to brain metastasis, anorexia, and, in the most severe cases, to cachexia and gastro-intestinal disorders [ 129 ]. Moreover, this electrolyte alteration is ascribable to chemotherapeutic drugs, inducing vomiting and diarrhea [ 130 ]. …

36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016.

P001 - Sepsis impairs the capillary response within hypoxic capillaries and decreases erythrocyte oxygen-dependent ATP efflux R. M. Bateman, … after heart surgery S. Reddy, M. Bailey, R. Beasley, R. Bellomo, D. Mackle, P. Young P178 - Extreme hypernatremia and sepsis in a patient with Huntington’s dementia: a conundrum in fluid management H. Venkatesh, S. Ramachandran, A. Basu, H. Nair P179 - Diagnosis and management of severe hypernatraemia in the critical care setting S. Egan, J. Bates P180 - Correl …

COVID-19 in Adult Patients with Hematological Malignancies-Lessons Learned after Three Years of Pandemic.

The COVID-19 pandemic is undoubtedly the most difficult health challenge of the 21st century with more than 600 million laboratory-confirmed SARS-CoV-2 infections and over 6.5 million deaths worldwide. The coronavirus pandemic contributed to rapid development of mRNA vaccines, which, along with new antiviral drugs, have been the subject of extensive research for many decades. Nevertheless, elderly, multi-morbid and immunocompromised patients continue to face a more severe clinical course and a higher risk of death from COVID-19, even now that the risk of COVID-19 in the general population is s

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… It has been proven that long-term glucocorticoids therapy might be associated with side effects, such as carbohydrate metabolism disorders, hypertension, cataracts, infections, fluid retention, increased risk of gastrointestinal bleeding or hypernatremia. …

How does academia respond to the burden of infectious and parasitic disease?

BackgroundAcademic research is one of the main avenues through which humans can fight the threat of infectious diseases. However, there have been concerns regarding whether the academic system has provided sufficient efforts to fight infectious diseases we potentially face. Answering these questions could contribute to evidence-based recommendations for setting research priorities and third-mission policies.MethodsWith a focus on one of the most common categories of communicable diseases, infectious and parasitic diseases (IPDs), we searched Web of Science for articles and reviews relevant to

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… Amyloidosis" OR "Thalassaemias" OR "Sickle cell disorder" OR "trait disorder" OR "haemoglobinopathies" OR "haemolytic anaemia" OR "Cystic fibrosis" OR "Dysmetabolic syndrome" OR "Hemochromatosis" OR "Hyperbilirubinemia" OR "Hypercalcemia" OR "hypercholesterolaemia" OR "Hyperkalemia" OR "hyperlipidaemia" OR "Hypernatremia …

Heart Failure in Older Patients: An Update.

Heart failure (HF) is a clinical syndrome with high incidence and prevalence and high morbidity and death rate, even in the short term, representing a serious public health issue, mainly in older people. It is a growing cause for hospital admission in this age group, being frequently associated with several comorbidities, further aggravating the disease's course. Moreover, older HF patients are usually affected by clinical conditions, like frailty, malnutrition, and cachexia, which significantly impact the overall management of HF and need to be properly identified and treated. Diagnosing and

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… In addition, laboratory exams may reveal peculiar findings in elderly HF patients, as routine tests often show reduced hemoglobin (Hb) levels and impaired serum sodium levels, both in term of hyponatremia, due to hemodilution by fluid retention-congestion or loop-diuretics therapy, and of hypernatremia …

The Continuum of Thyroid Disorders Related to Immune Checkpoint Inhibitors: Still Many Pending Queries.

BackgroundUntil more data are available to shed light on the thyroid disorders related to immune checkpoint inhibitors (ICPi) implemented for the treatment of hematological malignancies, the decision-making is guided by pertinent data derived mostly from solid tumors.MethodsThe present review provides a comprehensive and updated overview of the thyroid disorders related to ICPi, namely to inhibitors of cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed cell death (PD) 1 (PD-1), and the ligand of the latter (PD-L1).ResultsWith the increasing recognition of ir thyroid disorders, many outstand

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… Thus, the correction of ir hypothyroidism can trigger, respectively, an adrenal crisis and hypernatremia, with devastating consequences. …

Специальный выпуск: резюме 11th Конгресс Европейской академии неврологии, Хельсинки, Финляндия.

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PROCEEDINGS 32nd Symposium ESVN-ECVN WROCLAW, POLAND 12th-14th September 2019. Selected research communications of the 32nd Symposium of the ESVN-ECVN Wroclaw, Poland 12th to 14th September 2019.

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Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview.

Respiratory viruses represent a major public health concern, as they are highly mutated, resulting in new strains emerging with high pathogenicity. Currently, the world is suffering from the newly evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus is the cause of coronavirus disease 2019 (COVID-19), a mild-to-severe respiratory tract infection with frequent ability to give rise to fatal pneumonia in humans. The overwhelming outbreak of SARS-CoV-2 continues to unfold all over the world, urging scientists to put an end to this global pandemic through biological and

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… If corticosteroids are used, keep an eye on hyperglycemia, hypernatremia, and hypokalemia. Keep an eye out for the recurrence of inflammation and signs of adrenal insufficiency after stopping corticosteroids; these may need to be lowered. …

High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer.

Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer agent when administered intravenously and in high doses (high-dose IVC). Early phase clinical trials have confirmed safety and indicated efficacy of IVC in eradicating tumour cells of various cancer types. In recent years, the multi-targeting effects of vitamin C were unravelled, demonstrating a role as cancer-specific, pro-oxidative cytotoxic agent, anti-cancer epigenetic regulator and immune modulator, reversing epithelial-to-mesenchymal transition, inhibiting hypoxia and oncogenic kinase signalling and b

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… Grade 3 or higher adverse events possibly related to IVC treatment were reported in only 1–2 cases per study (with 17–24 patients included per study, see Table 2 ), the most common being hypokalemia [ 13 , 65 ], hypernatremia [ 13 ], hypertension and anemia [ 66 ]. …

ESICM LIVES 2016: part three : Milan, Italy. 1–5 October 2016

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Abstracts of the 36th Annual Meeting of the Society of General Internal Medicine. April 24-27, 2013. Denver, Colorado, USA.

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Diseases of the Nervous System

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Abstracts - IANCON 2025

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… However, ODS associated with hypernatremia, especially in the postpartum period, is exceedingly rare. Neuroimaging plays a pivotal role in diagnosis, with the ‘wine glass’ appearance on MRI being a notable radiologic hallmark. … Hypernatremia-induced ODS is infrequently reported and may present with characteristic neuroimaging findings. The postpartum state, with associated fluid shifts and possible dehydration, may predispose to such electrolyte imbalances. …

Proceedings of the RAMI Intern Section Meeting.

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