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Effectiveness of seasonal malaria chemoprevention at scale in west and central Africa: an observational study.

BACKGROUND: Seasonal malaria chemoprevention (SMC) aims to prevent malaria in children during the high malaria transmission season. The Achi … h year (2015 and 2016) to children younger than 5 years, in Burkina Faso, Chad, The Gambia, Guinea, Mali, Niger, and Nigeria. SMC was administered monthly by community health workers who visited door-to-door. Drug administration was monitored via tally sheets and via household cluster-sample coverage surveys. Pharmacovigilance was based on targeted spo …

Impact of population ageing on cancer-related disability-adjusted life years: A global decomposition analysis.

BACKGROUND: As the global population ages, the burden of cancer is increasing. We aimed to assess the impact of population ageing on cancer-related disability-adjusted life years (DALYs). METHODS: We used the decomposition method to estimate the impact of ageing, population growth, and epidemiological change on cancer-related DALYs from 1990 to 2019, stratified by 204 countries/territories and by their sociodemographic index (SDI). This approach separates the net effect of population ageing from population growth and change in age-specific DALY rates. RESULTS: Cancer-related DALYs among indi

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… | −0.17 196 | Chad | −0.13 | Guinea | −0.29 | Cameroon | −0.17 197 | Guinea | −0.13 | Uganda | −0.33 | Burkina Faso | −0.19 198 | Mali | −0.16 | Mali | −0.33 | Mozambique | −0.25 199 | Democratic Republic of the Congo | −0.17 | Democratic Republic of the Congo | −0.40 | Uganda | −0.33 200 | Mozambique … | −25.26 | Benin | −32.40 | Guinea | −20.92 199 | Mozambique | −27.31 | Sierra Leone | −37.61 | Sierra Leone | −22.84 200 | Sierra Leone | −29.23 | Burkina Faso | −39.05 | Mali | −23.59 201 | Chad | −33.52 | Mozambique | −43.59 | Liberia | −28.04 202 | Liberia | −43.84 | Liberia | −61.80 | Equatorial …

Targeting phosphatidylinositol-3-kinase pathway for the treatment of Philadelphia-negative myeloproliferative neoplasms.

Myeloproliferative neoplasms (MPN) are a diverse group of chronic hematological disorders that involve unregulated clonal proliferation of white blood cells. Sevearl of them are associated with mutations in receptor tyrosine kinases or cytokine receptor associated tyrosine kinases rendering them independent of cytokine-mediated regulation. Classically they have been broadly divided into BCR-ABL1 fusion + ve (Ph + ve) or -ve (Ph-ve) MPNs. Identification of BCR-ABL1 tyrosine kinase as a driver of chronic myeloid leukemia (CML) and successful application of small molecule inhibitors of the tyrosi

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… Ma P, Mali RS, Martin H, Ramdas B, Sims E, Kapur R. Role of intracellular tyrosines in activating KIT-induced myeloproliferative disease. Leukemia. 2012;26:1499–506. doi: 10.1038/leu.2012.22. 34. Mali RS, Ramdas B, Ma P, Shi J, Munugalavadla V, Sims E, et al. … Martin H, Mali RS, Ma P, Chatterjee A, Ramdas B, Sims E, et al. Pak and Rac GTPases promote oncogenic KIT-induced neoplasms. J Clin Invest. 2013;123:4449–63. doi: 10.1172/JCI67509. 41. Chatterjee A, Ghosh J, Ramdas B, Mali RS, Martin H, Kobayashi M, et al. …

Ageing, exposure to pollution, and interactions between climate change and local seasons as oxidant conditions predicting incident hematologic malignancy at KINSHASA University clinics, Democratic Republic of CONGO (DRC).

BACKGROUND: The global burden of hematologic malignancy (HM) is rapidly rising with aging, exposure to polluted environments, and global and local climate variability all being well-established conditions of oxidative stress. However, there is currently no information on the extent and predictors of HM at Kinshasa University Clinics (KUC), DR Congo (DRC). This study evaluated the impact of bio-clinical factors, exposure to polluted environments, and interactions between global climate changes (EL Nino and La Nina) and local climate (dry and rainy seasons) on the incidence of HM. METHODS: This…

Demographic, epidemiological, and health transitions: are they relevant to population health patterns in Africa?

BackgroundStudies of trends in population changes and epidemiological profiles in the developing world have overwhelmingly relied upon the concepts of demographic, epidemiological, and health transitions, even though their usefulness in describing and understanding population and health trends in developing countries has been repeatedly called into question. The issue is particularly relevant for the study of population health patterns in Africa and sub-Saharan Africa, as the history and experience there differs substantially from that of Western Europe and North America, for which these conce

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… 0.33 | 0.19 Guinea | 39.2; 47.4 | 12.7; 33.2 | 13.9; 29.4 | 5.4; 6.6 | 1990 | 33.08 | 54.47 | 0.37 | 0.26 Guinea-Bissau | 39.4; 54.5 | 13.5; 25.4 | 15.1; 32.9 | 5.3; 7.4 | 1955 | 40.58 | 52.99 | 0.19 | 0.19 Liberia | 38.6; 49.2 | 10.3; 30.5 | 16.5; 29.8 | 5.2; 7.0 | 1985 | 33.12 | 58.11 | 0.36 | 0.43 Mali …

Interventions for improving coverage of childhood immunisation in low- and middle-income countries.

BACKGROUND: Immunisation plays a major role in reducing childhood morbidity and mortality. Getting children immunised against potentially fa … nya, Nigeria, Nepal, Nicaragua, Pakistan, Zimbabwe), and three lower-income countries (Afghanistan, Mali, Rwanda). The interventions evaluated in the studies were health education (seven studies), patient reminders (13 studies), digital register (two studies), household incentives (three studies), regular immunisation outreach sessions (two studies), h …

Percutaneous vertebral augmentation-pearls and pitfalls.

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… Voormolen MH, Mali WP, Lohle PN, et al. Percutaneous vertebroplasty compared with optimal pain medication treatment: short-term clinical outcome of patients with subacute or chronic painful osteoporotic vertebral compression fractures. The VERTOS study. AJNR Am J Neuroradiol 2007;28:555-60. 12. …

Глобальное, региональное и национальное бремя множественной миеломы, 1990 в адрес 2021 и прогнозы 2035:: анализ исследования глобального бремени болезней; 2021.

Предыстория и объективная мультипликативная миелома (ММ) является вторым по распространенности гематологической злокачественности. Цель этого исследования состояла в том, чтобы оценить глобальное бремя множественной миеломы по всему миру. 204 странами и территориями 1990 в адрес 2021Данные для этого исследования были получены из Глобального центра по проблемам заболеваемости (ГБЗ) 2021 набор данных, содержащий всеобъемлющую информацию о глобальном и региональном бремени 369 - болезни, травмы и 88 факторов риска в различных областях 204 странами и территориями 1990 в адрес 2021. Мы проанализиро

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Background and objectiveMultiple myeloma (MM) is the second most common haematologic malignancy. This study aimed to assess the global burden of multiple myeloma across 204 countries and territories from 1990 to 2021.MethodsThe data for this study were obtained from the Global Burden of Disease (GBD) 2021 dataset, which provides comprehensive information on …

Strategies to overcome the main challenges of the use of CRISPR/Cas9 as a replacement for cancer therapy.

CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated protein 9) shows the opportunity to treat a diverse array of untreated various genetic and complicated disorders. Therapeutic genome editing processes that target disease-causing genes or mutant genes have been greatly accelerated in recent years as a consequence of improvements in sequence-specific nuclease technology. However, the therapeutic promise of genome editing has yet to be explored entirely, many challenges persist that increase the risk of further mutations. Here, we highlighted the main challenges fa

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… Subsequently, Cong and Mali teams made genome editing with the CRISPR/Cas9 system possible, who used two different type II Cas systems to make DNA cuts in cell cultures [ 24 , 25 ]. … Mali P, Esvelt KM, Church GM. Cas9 as a versatile tool for engineering biology. Nat Methods. 2013;10(10):957–63. doi: 10.1038/nmeth.2649. 99. Zhang X, Zhang D, Thompson JA, Chen SC, Huang Z, Jennings L, et al. …

Глобальные, региональные и национальные факторы метаболического риска, связанные с множественной миеломой, 1990-2021:: анализ на основе глобального исследования бремени болезней; 2021.

Цель настоящего исследования заключалась в изучении глобального бремени болезней, связанных с множественной миеломой (ММ), которая связана с метаболическими факторами. Использование данных GHDx тарирования 1990-2021, случаи MM были выявлены через ICD-10 коды (C90.0). Были проанализированы ключевые показатели, включая коэффициент смертности и коэффициент лет жизни с поправкой на инвалидность (DALY); стандартизированные по возрасту показатели (ASMR, ASDR) и расчетные годовые процентные изменения (EAPC) были рассчитаны с использованием R для сопоставления различий между регионами, полами и возрас

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… The lowest age-standardized mortality rates were found in Mali (2.17E-06 [95% UI: -5.10E-07~6.27E-06]/100,000), Niger (0.001852 [95% UI: -0.00043–0.006015]/100,000), and Burkina Faso (0.002055 [95% UI: -0.00043–0.006015]/100,000) ( Supplementary Table 1, pp14–23 ). … Countries like the Commonwealth of the Bahamas and Principality of Monaco exhibited high age-standardized mortality and DALYs rates, whereas Mali and Niger showed lower rates—correlating with economic status and population metabolic health. …

Low dose continuous lenalidomide in heavily pretreated patients with relapsed or refractory classical Hodgkin lymphoma: a retrospective case series.

Patients with relapsed or refractory (R/R) classical Hodgkin lymphoma (cHL) following autologous stem cell transplant (ASCT) remain a manage … e elevation, aspartate transaminase/alanine transaminase elevation, and treatment related secondary malignancy. In a heavily treated R/R cHL patient population, daily LDC lenalidomide was associated with a high disease control rate with a favorable toxicity profile.

Population and fertility by age and sex for 195 countries and territories, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017.

BACKGROUND: Population estimates underpin demographic and epidemiological research and are used to track progress on numerous international … 12 of 34 high-income countries, and less than 50% of the national population was of working age in Mali, Chad, and Niger. INTERPRETATION: Population trends create demographic dividends and headwinds (ie, economic benefits and detriments) that affect national economies and determine national planning needs. Although TFRs are decreasing, the global pop …

Stakeholder Perceptions of Key Aspects of High-Quality Cancer Care to Assess with Patient Reported Outcome Measures: A Systematic Review.

Performance measurement is the process of collecting, analyzing, and reporting standardized measures of clinical performance that can be compared across practices to evaluate how well care was provided. We conducted a systematic review to identify stakeholder perceptions of key symptoms and health domains to test as patient-reported performance measures in oncology. Stakeholders included cancer patients, caregivers, clinicians, and healthcare administrators. Standard review methodology was used, consistent with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). MEDLIN

Global, regional, and national multiple myeloma burden from 1990 to 2021: a systematic analysis for of the Global Burden of Disease Study 2021.

BackgroundMultiple myeloma (MM) is the second most common haematological malignancy worldwide. A comprehensive global analysis of MM based on diverse geographic locations and timeframes is lacking. This study aimed to provide the incidence, mortality rate, and disability-adjusted life years (DALYs) of MM, from 1990 to 2021, focusing on the age structure and temporal trends of the disease burden.MethodsThis study analysed the most recent MM data (1990 to 2021) from 204 countries and territories obtained from the Global Burden of Disease database. MM incidence, age-standardised mortality rate (A…

In vivo modulation of ubiquitin chains by N-methylated non-proteinogenic cyclic peptides.

Cancer and other disease states can change the landscape of proteins post-translationally tagged with ubiquitin (Ub) chains. Molecules capable of modulating Ub chains are potential therapeutic agents, but their discovery represents a significant challenge. Recently, it was shown that de novo cyclic peptides, selected from trillion-member random libraries, are capable of binding particular Ub chains. However, these peptides were overwhelmingly proteinogenic, so the prospect of in vivo activity was uncertain. Here, we report the discovery of small, non-proteinogenic cyclic peptides, rich in non-

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… Mali S. M. Vamisetti G. B. Sun H. Bercovich B. Huang Y. Ciechanover A. Fushman D. Suga H. Brik A. Nat. Chem. 2019 11 644 652 10.1038/s41557-019-0278-x 31182821 PMC7341950 Nguyen T. Ho M. Kim K. Yun S. I. Mizar P. Easton J. W. Lee S. S. Kim K. K. … Mali S. M. Singh S. K. Meledin R. Brik A. Kwon Y. T. Kravtsova-Ivantsiv Y. Bercovich B. Ciechanover A. Proc. Natl. Acad. Sci. U. S. A. 2019 116 7805 7812 10.1073/pnas.1822148116 30867293 PMC6475391 Goldberg A. L. J. Cell Biol. 2012 199 583 588 10.1083/jcb.201210077 23148232 PMC3494858 Mansour W. …

Mechanical and surgical interventions for treating primary postpartum haemorrhage.

BACKGROUND: Primary postpartum haemorrhage (PPH) is commonly defined as bleeding from the genital tract of 500 mL or more within 24 hours of … s (944 women) conducted in Pakistan, Turkey, Thailand, Egypt (four trials), Saudi Arabia, Benin and Mali. Overall, included trials were at an unclear risk of bias. Due to substantial differences between the studies, it was not possible to combine any trials in meta-analysis. Many of this review's important outcomes were not reported. GRADE assessments …

A single-center 7-year experience with end-stage renal disease care in Nigeria-a surrogate for the poor state of ESRD care in Nigeria and other sub-saharan african countries: advocacy for a global fund for ESRD care program in sub-saharan african countries.

Background. A single-center ESRD care experience in a Nigerian teaching hospital is presented as a surrogate case to demonstrate the prevailing ESRD care situation in Nigeria and most SSA countries. Methods. The data of 320 consecutive ESRD patients undergoing maintenance haemodialysis treatment during a seven-year period were retrospectively analyzed. Results. Over 80% of the subjects funded dialysis treatments from direct out of pocket payment. The mean duration on dialysis before dropout was 5.2 ± 7.6 weeks, with majority 314 (98.1%) of the patients unable to sustain dialysis above 12 weeks

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… The number of patients on dialysis in some SSA countries, shown in a 2003 report [ 8 ], indicates the following number of patients per country: Mauritania (50), Senegal (20–30), Mali (20), Burkina Faso (18), Ivory Coast (130), and Ghana (30), respectively. …

Глобальное, региональное и национальное бремя связанных с табаком неврологических расстройств 1990 в адрес 2021Тенденции и прогнозы на будущее.

ВВЕДЕНИЕ: Потребление табака является одной из основных проблем здравоохранения во всем мире, отрицательно сказывающейся на качестве жизни. Цель нашего исследования состоит в том, чтобы проанализировать тенденции изменения бремени связанных с табаком неврологических расстройств на глобальном, региональном и национальном уровнях. 1990 в адрес 2021, а также потенциальные будущие тенденции. МЕТОДЫ: Мы провели вторичный анализ наборов данных для оценки смертности и лет жизни с поправкой на инвалидность (DALYs) с использованием данных, полученных в рамках исследования глобального бремени болезней,

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… Between 1990 and 2021, Seychelles, Kyrgyzstan, and Mali exhibited the most rapid upward trends in tobacco-related ND, while Cape Verde, Ecuador, and South Africa showed the most significant decreases. …

Combination therapy with novel agents for acute myeloid leukaemia: Insights into treatment of a heterogenous disease.

The treatment landscape of acute myeloid leukaemia (AML) is evolving rapidly. Venetoclax in combination with intensive chemotherapy or doublets or triplets with targeted or immune therapies is the focus of numerous ongoing trials. The development of mutation-targeted therapies has greatly enhanced the treatment armamentarium, with FLT3 inhibitors and isocitrate dehydrogenase inhibitors improving outcomes in frontline and relapsed/refractory (RR) AML, and menin inhibitors showing efficacy in RR NPM1mut and KMT2A-rearranged AML. With so many new drugs approved, the number of potential combinator

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… Daver N , Perl AE , Maly J , Levis M , Ritchie E , Litzow M , Venetoclax plus gilteritinib for FLT3-mutated relapsed/refractory acute myeloid leukemia . J Clin Oncol . 2022 ; 40 : 4048 – 59 . 35849791 10.1200/JCO.22.00602 PMC9746764 34. … Singh Mali R , Zhang Q , DeFilippis RA , Cavazos A , Kuruvilla VM , Raman J , Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models . …

The Challenging Approach to Multiple Myeloma: From Disease Diagnosis and Monitoring to Complications Management.

The outcome of multiple myeloma (MM) has significantly improved in the last few decades due to several factors such as new biological discoveries allowing to better stratify disease risk, development of more effective therapies and better management of side effects related to them. However, handling all these aspects requires an interdisciplinary approach involving multiple knowledge and collaboration of different specialists. The hematologist, faced with a patient with MM, must not only choose a treatment according to patient and disease characteristics but must also know when therapy needs t