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An updated h-index measures both the primary and total scientific output of a researcher.

The growing interest in scientometry stems from ethical concerns related to the proper evaluation of scientific contributions of an author working in a hard science. In the absence of a consensus, institutions may use arbitrary methods for evaluating scientists for employment and promotion. There are several indices in use that attempt to establish the most appropriate and suggestive position of any scientist in the field he/she works in. A scientist's Hirsch-index (h-index) quantifies their total effective published output, but h-index summarizes the total value of their published work withou

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… Moreover, a careful evaluation is critical for the career of scientists, as well as for employers in academia and science alike. Why do we need an updated h-index? The h-index, introduced by professor J.E. Hirsch in 2005, is now widely accepted and employed. …

Role of decentralized clinical trials in cancer drug development: Results from a survey of oncologists and patients.

As a result of the unprecedented challenges imposed by the COVID-19 pandemic on enrollment to cancer clinical trials, there has been an urgency to identify and incorporate new solutions to mitigate these difficulties. The concept of decentralized or hybrid clinical trials has rapidly gained currency, given that it aims to reduce patient burden, increase patient enrollment and retention, and preserve quality of life, while also increasing the efficiency of trial logistics. Therefore, the clinical trial environment is moving toward remote collection and assessment of data, transitioning from the

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… Participants The oncologists were all board-certified and affiliated with group practices, hospital systems, academia, government, or private practice. … Group practice | 56% (42) Hospital system | 23% (17) Academia | 17% (13) Government | 1% (1) Something else | 3% (2) How many years have you been a practicing Oncologist? …

ASENT 2022 Annual Meeting.

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… While Neuroscience-focused drug development efforts have been laden by a high-rate failure in clinical trials over the past ten years, a significant number of scientists in academia and industry are renewing their interest in the development of new therapies for the treatment of neurological and psychiatric … In this presentation, we outline to neuroscientists in academia and industry NINDS/DTR-BPN funding mechanism and resources to accelerate the translation of their experimental discoveries into new therapies and support their ongoing preclinical and translational activities in the field of neuroscience …

Quality of life in dysphagia and functional performance of cancer patients in palliative care.

PURPOSE: To correlate the functional performance and impact of dysphagia on the quality of life of cancer patients in palliative care. METHODS: This cross-sectional, quantitative study was conducted at the outpatient clinic and oncology ward of a university hospital. Inclusion criteria required patients to respond positively to the question: "Do you have difficulty or problems swallowing?". Patients were excluded if they had been diagnosed with head and neck cancer, were unable to answer questionnaires due to actively dying status, were in a state of drowsiness, experienced extreme pain and s

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… São Paulo: Academia Nacional de Cuidados Paliativos; 2012. O papel do fonoaudiólogo na equipe. pp. 358–360. 7. Moreira MJS, Guimarães MF, Lopes L, Moreti F. Contribuições da Fonoaudiologia nos cuidados paliativos e no fim da vida. … São Paulo: Academia Nacional de Cuidados Paliativos; 2012. O papel do nutricionista na equipe. 9. Kim DY, Park HS, Park SW, Kim JH. The impact of dysphagia on quality of life in stroke patients. Medicine. 2020;99(4):e21795. doi: 10.1097/MD.0000000000021795. 10. …

Opinion: more mouse models and more translation needed for ALS.

Amyotrophic lateral sclerosis is a complex disorder most of which is 'sporadic' of unknown origin but approximately 10% is familial, arising from single mutations in any of more than 30 genes. Thus, there are more than 30 familial ALS subtypes, with different, often unknown, molecular pathologies leading to a complex constellation of clinical phenotypes. We have mouse models for many genetic forms of the disorder, but these do not, on their own, necessarily show us the key pathological pathways at work in human patients. To date, we have no models for the 90% of ALS that is 'sporadic'. Potenti

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… As a result, for over a decade SOD1 overexpressing transgenic animals were the only available models of ALS and therefore, due to the need for treatments, were extensively used for therapeutics development by academia and industry. … • How do we resolve the tension between the biology/pathology of ALS models versus the constraints of time/financial realities in pharma/biotech/academia? …

Anticancer drug prices and clinical outcomes: a cross-sectional study in Italy.

ObjectiveTo investigate whether the prices of new anticancer drugs correlated with their relative benefit despite negotiation.DesignRetrospective cross-sectional study correlating new anticancer drugs prices with clinical outcomes.SettingWe did a retrospective cross-sectional study including all new anticancer drugs approved by the European Medicines Agency (EMA) (2010-2016) and reimbursed in Italy.Main outcomes and measuresInformation on clinical outcomes-in terms of median overall survival (OS), median progression-free survival (PFS) and objective response rate (ORR)-was extracted from pivot

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… The second approach that could attain lower prices would require an increased transparency on the costs of drug development process, including the relative contributions from academia and public sector to the development of a drug. 34–38 For instance, research conducted to evaluate efforts of drug development … N Engl J Med 2011 ; 364 : 535 – 41 . 10.1056/NEJMsa1008268 21306239 35 Kesselheim AS , Tan YT , Avorn J The roles of academia, rare diseases, and repurposing in the development of the most transformative drugs . …

Джанкарло Коми: наследие в неврологии и многочисленных склерозовых исследованиях.

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… Consistently active in academia, he served as President of the European Charcot Foundation, Executive Council Member of ECTRIMS from 2003 to 2007, becoming an honorary member in 2014. 4 He recently served as Honorary Professor at Vita-Salute University, Chairman of the Scientific Committee of the Human …

Editorial: Women in science-Regulatory science 2021.

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… EUPATI CH initiated a multi-stakeholder survey involving patient representatives, academia, pharmaceutical industry, healthcare professionals, and government agencies. A need for collaboration amongst stakeholders as well as funding, knowledge and human resources was identified. …

CAR-Based Cell and Gene Therapies: Global Clinical Landscape and Emerging Therapeutic Strategies from ClinicalTrials.gov.

Chimeric Antigen Receptor (CAR)-based cell and gene therapies have become transformative treatments, offering targeted and durable responses, especially in hematologic malignancies. This review analyzes 1,744 CAR clinical trials registered on Clinical-Trials.gov as of 2024, focusing on platform types, indications, target antigens, therapeutic strategies, and late-phase development. CAR-T therapies predominate, followed by CAR-NK, CAR-NKT, CAR-M and CAR-DC platforms. Approximately 92% of trials target tumors, with hematologic malignancies accounting for 65% of indications; CD19 and BCMA are pri

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… A similar pattern is observed in CAR-NK trials, with hospitals leading at (49%), followed by industry (32%) and academia (17%). … As a result, industry players began to recognize the therapeutic and commercial potential of CAR-based therapies, shifting the developmental focus from academia to the private sector. …

Algae-Derived Bioactive Compounds as Platforms for Translational Biotechnology and Health Applications.

Marine macroalgae, microalgae, and associated microorganisms are increasingly recognised as valuable sources of bioactive compounds with applications across biotechnology and health. The environmental and ecological conditions they inhabit shape their metabolite diversity, leading to the production of high-value compounds such as sulphated polysaccharides, lipids, pigments, phenolics, and peptides. These compounds exhibit conserved biological activities that underpin potent antioxidant, anti-inflammatory, cytotoxic, and pro-regenerative effects with strong potential for translation. Although e

Effect of mazindol on feeding behaviour and on noradrenergic function of various parts of the rat brain.

The effect of mazindol on feeding behaviour was investigated in rats fasted for 24 hours. They were then given mazindol i.p. and placed in a new environment. The effect of the drug on the disappearance of 3H-noradrenaline (3H-NA) from various parts of the brain after injection into the cerebral ventricles was also investigated. Mazindol was more potent in suppressing feeding behaviour than in reducing food intake, indicating that a number of aspects of feeding behaviour may be more sensitive indices of the anorectic effect of a drug than food intake per se. Mazindol, in a dose of 30 mg/kg, acc

Long-term results of vagotomy in the light of endoscopy.

In the period 1968 to 1973, 177 patients were vagotomized. Endoscopy had to be performed because of definite symptoms in 37 of these patients on 56 occasions between 1971 and 1979. Vagotomy had been selective in 22, truncal in 15 cases. The intervention, regardless of its type, had failed to give the expected benefit in 21% of the patients, a proportion not inferior to the postresection figures. On the other hand, in 12% it was a recurrence of the ulcer which accounted for the symptoms. This is greatly in excess of the recurrences recorded after gastric resection either of the Billroth I or th

Elevated opioid activity in sera of chronic schizophrenics.

The effect of native serum samples from schizophrenic and control patients on the electrically induced contractions of the isolated mouse vas deferens (MVD) preparations was investigated. It was demonstrated that only the samples of schizophrenic origin elicited a naloxone dependent inhibition on the contractions of the MVD preparations, while sera from healthy individuals and those from non schizophrenic but mentally ill patients proved to be ineffective in this respect. By using ultrafiltration and gel chromatographic techniques, four fractions disclosing MVD related biological activity coul

Clinical features and course of IgA glomerulonephritis.

A review of the clinical features, laboratory findings and course in 50 cases of IgA glomerulonephritis confirmed by biopsy is presented. The onset and clinical course of the process was oligosymptomatic in the majority of the cases with a predominance of microhematuria and persistent proteinuria. By the end of the observation period more than 50 per cent of the patients became hypertensive and in 16 cases serum creatinine levels attained 132 mumol/l (1.5 mg per 100 ml) or more. Proteinuria in excess of 1 g/24h, hypertension and an impaired concentration capacity at the onset heralded early pr

Sensitizing activity to egg protein of an A1PO4-adjuvant full-virus influenza vaccine.

The sensitizing activity to egg protein of an A1PO4-adjuvant purified and concentrated influenza-A vaccine was examined in animal experiments and in man. Intravenous injection of ovalbumin caused anaphylactic symptoms and/or fatal anaphylactic shock in prevaccinated guinea-pigs. Ovalbumin-specific antibodies detectable by the passive haemagglutination reaction (PHA) appeared in the blood serum of the vaccinated animals. Model experiments with purified ovalbumin suggested that 1 human dose of the vaccine contained egg protein in the range from 0.1 to 1 ng, and that the antigenic effect of the v

Isolation of aerobic bacteria from the placenta.

Cultures for aerobic bacteria were prepared from 353 placentas. Specimens were taken from the chorion after removing the amnion. The specimens were immersed into Stuart transport medium. Microscopic examination of the placenta and cultures from the throat and ear of newborns were also done. The rate of positive bacterial cultures was 16%. Chorioamnionitis was found in 15%. The proportion of chorioamnionitis caused by aerobic bacteria was 44%. The rate of positive bacterial cultures from the placenta in the group of newborns with clinical signs of intrauterine infection was 63%. Bacteria can be

Unusual chromosome aberrations in 3 children with Down syndrome.

In 3 children with Down syndrome extremely rare chromosome aberrations were found. In the first patient, the karyotype showed 46 chromosomes with a de novo duplication of the q22-qter segment. This finding supports that the 21q22-qter band was responsible for the characteristic mongoloid features. In the second case, trisomy 21 was present and out of 78 investigated cells, 60 contained a small, supernumerary marker chromosome in addition to trisomy 21. The parents were cytogenetically and clinically normal. In the third case trisomy 21 with inv(10) (p13q22) occurred. The inversion was inherite