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Animal studies on the modulation of differential efficacy of polyethylene glycol loxenatide by intestinal flora.

BACKGROUND: Gut microbiota has demonstrated an increasingly important role in the onset and development of type 2 diabetes mellitus (T2DM), … ignificantly reduced in the ideal group. 16srDNA sequencing showed that the levels of Bacteroidota, Akkermansia, Parabacteroides, Bifidobacteria and other bacteria in the ideal efficacy group were significantly higher than those in the non-ideal efficacy group (P<0.05). The levels of Firmicutes, Romboutsia, Clostridium, Turicibacter and other bacteria in the …

Gut dysbiosis, low-grade inflammation, and renal impairment severity in elderly diabetic nephropathy.

BACKGROUND: The specific mechanism of diabetic nephropathy (DN) has not been fully elucidated, and more and more evidence shows that the dev … of the gut microbiota, as well as with the relative abundances of Bacteroides, Bifidobacterium, and Akkermansia, and was negatively correlated with the relative abundances of Clostridium, Klebsiella, and Enterococcus (P < 0.05). Logistic regression analysis indicated that lower Chao, Ace, and Shannon indices and higher Simpson index were associated with an in …

Polysaccharides in Medicinal and Food Homologous Plants regulate intestinal flora to improve type 2 diabetes: Systematic review.

BACKGROUND: Medicinal and food homologous plants (MFHPs) which can improve Type 2 Diabetes Mellitus (T2DM) draw significant attention among … the improvement of T2DM by MFHPPs is associated with the modulation of 12 key genera: Allobaculum, Akkermansia, Bifidobacterium, Lactobacillus, Helicobacter, Halomonas, Olsenella, Oscillospira, Shigella, Escherichia-Shigella, Romboutsia and Bacteroides. At the molecular level, MFHPPs primarily act by modulating the intestinal flora to increase short-chain fa …

Banxia Xiexin decoction modulates gut microbiota and gut microbiota metabolism to alleviate DSS-induced ulcerative colitis.

ETHNOPHARMACOLOGICAL RELEVANCE: Banxia Xiexin decoction (BXD) is a classic traditional Chinese medicine prescription for treating ulcerative … erota and Actinobacteriota increased; at the genus level, g__norank__f__Muribaculaceae, Dubosiella, Akkermansia, and Lactobacillus increased, whereas Faecalibaculum, Alloprevotella, Turicibacter, and g_Paraprevotella decreased. g__norank_f__Muribaculaceae was positively correlated with body weight and colon length and negatively with colon index scores, splen …

[Comparative analysis of the intestinal microbiota in patients with exocrine pancreatic insufficiency of various severity].

BACKGROUND: Exocrine pancreatic insufficiency (EPI) is a critical host factor in determining the composition of the gut microbiota. Diseases … varied: in patients with severe EPI and CP, compared with mild, statistically significant genera - Akkermansia, Ruminococcus gauvreauii group and Holdemanella; compared with CP without exocrine insufficiency, Prevotella, Ruminococcus gauvreauii group, Peptostreptococcus and Blautia dominated. The CP group with mild EPI was dominated by the following genera: …

Protein-Based Strategies and Mediterranean-Style Diets Show the Most Consistent Benefits for Sarcopenia in Older Adults.

BACKGROUND: Sarcopenia - age-related loss of skeletal muscle mass, strength and physical performance - affects 6-22% of adults aged ≥65 year … low-to-very-low-certainty evidence, via short-chain fatty acid (SCFA) production and enrichment of Akkermansia and Faecalibacterium. CONCLUSIONS: Evidence supports a hierarchical but certainty-graded model. Protein-anchored strategies (≥1.0-1.2 g/kg/day, leucine-enriched, paired with resistance training) and vitamin D repletion in deficient older adults are …

Effects of different protein sources on rumen fermentation-microbial characteristics, nutrient utilization, and fecal and urinary metabolites in periparturient breeding cows.

INTRODUCTION: As a core nutrient regulating ruminant metabolic networks, immune homeostasis, and rumen microbial community structure, the so … LT levels in the TG3 increased significantly at PP30 d; beneficial bacteria such as Fibrobacter and Akkermansia were significantly enriched in the TG2 and TG3 (p < 0.05). (2) In the TG3, Urea and triglycerides (TG) levels were significantly elevated at PP30 d, while blood ammonia levels were reduced; in the TG2, energy metabolism was active at 0 d and stabili …

Beetroot juice intake positively influenced gut microbiota and inflammation but failed to improve functional outcomes in adults with long COVID: A pilot randomized controlled trial.

BACKGROUND & AIMS: Long-term effects of coronavirus disease 2019 (long COVID) develop in a substantial number of people following an acute C … ed beetroot juice had a greater abundance of bacteria with well-known beneficial effects, including Akkermansia, Oscillospira, Prevotella, Roseburia, Ruminococcaceae, and Turicibacter, compared with placebo. Participants allocated to beetroot juice supplementation were also characterized by significantly higher levels of fecal nicotinate, trimethylamine, and …

Schizochytrium sp. and lactoferrin supplementation alleviates Escherichia coli K99-induced diarrhea in preweaning dairy calves.

Calf diarrhea, a common disease mainly induced by Escherichia coli infection, is one of the main reasons for nonpredator losses. Hence, an e … iota, Bifidobacterium and Actinobacteria were negatively associated with IL-10 and d-lactate, while Akkermansia was negatively associated with endothelin-1 and positively correlated with LPS, fecal scores, and d-lactate levels. Our results indicated that LF and SZ supplements could alleviate E. coli O101:K99-induced calf diarrhea individually or in combinatio …

Immune Cell-Mediated Causal Link Between Gut Microbiota Traits and Childhood Asthma: Evidence From Mendelian Randomization and Metagenomic Sequencing.

BACKGROUND: The gut microbiota may be involved in childhood asthma. However, the causal relationship between the gut microbiota and childhoo … he asthma group was characterized by enriched Bacteroides, whereas healthy controls had predominant Akkermansia and Lachnospiraceae, which was consistent with the MR findings. Alpha diversity analysis showed a trend of higher microbial species abundance in children with asthma without statistical significance. KEGG functional analysis indicated that different …

Lycium barbarum L. polyphenols improve HFD-induced NAFLD through liver and colon metabolism and intestinal microbiota:potential role of methionine cycle.

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a widespread metabolic liver disease. Colonic metabolic disorders and intestinal mi … ng the following microorganisms: Paramuribaculum, Muribaculaceae, Eisenbergiell, Lactobacillus, and Akkermansia. Correlation analysis further demonstrated close associations between microbial shifts, methyl donor metabolism, and host phenotypes, highlighting the coordinated regulation of the gut-liver axis by LBP. CONCLUSIONS: Multi-tissue metabolic analysis …

Chemotherapeutic Drugs Induce Different Gut Microbiota Disorder Pattern and NOD/RIP2/NF-κB Signaling Pathway Activation That Lead to Different Degrees of Intestinal Injury.

5-Fluorouracil (5-FU), irinotecan (CPT-11), oxaliplatin (L-OHP), and calcium folinate (CF) are widely used chemotherapeutic drugs to treat c … athway. Redundancy analysis/canonical correlation analysis (RDA/CCA) revealed that Bifidobacterium, Akkermansia, Allobaculum, Catenibacterium, Mucispirillum, Turicibacter, Helicobacter, Proteus, Escherichia Shigella, Alloprevotealla, Vagococcus, Streptococcus, and "Candidatus Saccharimonas" were highly correlated with the NOD/RIP2/NF-κB signaling pathway and …

New strain of Pediococcus pentosaceus alleviates ethanol-induced liver injury by modulating the gut microbiota and short-chain fatty acid metabolism.

BACKGROUND: Intestinal dysbiosis has been shown to be associated with the pathogenesis of alcoholic liver disease (ALD), which includes chan … versity, restored the relative abundance of Lactobacillus, Pediococcus, Prevotella, Clostridium and Akkermansia and increased propionic acid and butyric acid production by modifying SCFA-producing bacteria. Furthermore, the levels of the tight junction protein ZO-1, mucin proteins (mucin [MUC]-1, MUC-2 and MUC-4) and the antimicrobial peptide Reg3β were incre …

Antidiabetic action of the Chinese formula Shouhuitongbian and the underlying mechanism associated with alteration of gut microbiota.

BACKGROUND: The prevalence and incidence of type 2 diabetes mellitus (T2DM) have dramatically increased. The intestinal flora and its derive … ing found that SHTB reshaped the composition of intestinal flora, as indicated by the enrichment of Akkermansia and Parabacteroides in both HFD-fed and db/db mice. Moreover, SHTB enhanced the intestinal production of short-chain fatty acids (SCFAs) and branched short-chain fatty acids (BSCFAs), and reduced the levels of the fecal and circulating branched-chai …

[Effect of Liangxue Huoxue decoction on intestinal flora and NLRP3/caspase-1/GSDMD signaling pathway in mice model of sepsis-induced acute kidney injury].

OBJECTIVE: To investigate the effect of Liangxue Huoxue decoction on intestinal flora, intestinal barrier and NOD-like receptor protein 3 (N … us and Escherichia-Shigella, and significantly increase the relative abundance of Lactobacillus and Akkermansia. In addition, Liangxue Huoxue decoction can significantly reduce mRNA expressions of IL-1β and IL-18 in kidney tissue [IL-1β mRNA (2-ΔΔCt): 1.59±0.05 vs. 4.61±0.88, IL-18 mRNA (2-ΔΔCt): 1.69±0.17 vs. 2.86±0.63, both P < 0.05] and the protein express …

Analysis of fecal microbiota and related clinical indicators in ICU patients with sepsis.

BACKGROUND: To analyze the characteristics of fecal microbiota disturbance in the intensive care unit (ICU) patients with sepsis and the cor … bundance in the ND_S group were Escherichia-Shigella, Enterococcus, Bifidobacterium, Lactobacillus, Akkermansia, and Klebsiella. Compared with the Clinical Improvement group, the relative abundance of Escherichia-Shigella and Klebsiella in the Death or DAMA group showed an increasing trend with no significant significance, while the relative abundance of Ente …

Perturbed microbial ecology in neuromyelitis optica spectrum disorder: Evidence from the gut microbiome and fecal metabolome.

BACKGROUND: Neuromyelitis optica spectrum disorder (NMOSD) is a central nervous system inflammatory demyelinating immune-mediated ailment, w … s was characterized by Ruminococcaceae_unclassified, Campylobacter, Parabacteroides, Lactobacillus, Akkermansia, Streptococcus oralis, Clostridium leptum, Clostridium asparagiforme, Firmicutes bacterium CAG 238, and Lactobacillus fermentum. (3) The relative abundances of Coprobacter, Turicimonas, Gemmiger, Enterobacter, Roseburia sp.CAG 471, Veillonella tobet …

Сложные связи между человеком и бактериями: связи между множественным склерозом и микробиомом человека.

Множественный склероз (MS) — хроническое иммунопосредованное заболевание центральной нервной системы, патогенез которого связан со сложным взаимодействием между генетической предрасположенностью, экологическими факторами и дисрегуляцией иммунной реакции. Этот обзор критически обобщает имеющиеся данные исследований, демонстрирующих значительные изменения в составе микробиома человека у отдельных лиц с MS. В ходе этой работы обобщается нынешнее состояние знаний о составе, разнообразии и дисбиозе кишечного микробиома в MS, при этом подчеркивается неоднородность наблюдаемых микробных изменений в з

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… The interpretation of the role of Akkermansia muciniphila remains inconclusive. … A potentially informative parameter is the Bifidobacterium/Akkermansia ratio. A lower ratio of Bifidobacterium adolescentis to Akkermansia muciniphila (BA:AM) in patients with MS correlated with higher disability scores (EDSS). …

Gut microbiota shapes cancer immunotherapy responses.

The gut microbiota significantly influences cancer immunotherapy efficacy by modulating immune responses, remodeling the tumor microenvironment (TME), and producing key metabolites. Strategies such as FMT, probiotics, and dietary interventions show promise in enhancing responses to ICIs and ACTs while reducing immune-related adverse events (irAEs). This review summarizes clinical and preclinical findings and discusses microbiota-based interventions and future directions for precision immunotherapy.

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… In contrast, NSCLC, RCC, and HCC patients with greater abundance of Akkermansia muciniphila exhibit improved anti-PD-1 efficacy 25 , 102 . Interestingly, Akkermansia muciniphila has also been linked to resistance in antibiotic-treated patients, suggesting a dual role in ICI response 103 . … Advancements in NGS have identified Akkermansia as another probiotic that promotes immunotherapy 292 , 293 . …

Role of NLRP3 in the metabolism of bile acids and gut microbiota in CCl4-induced liver fibrosis.

NOD-like receptor protein 3 (NLRP3) is an important pro-fibrosis factor in the liver. Abnormal bile acid (BA) metabolism and gut dysbiosis a … t analysis (LDA) coupled with effect size (LEfSe) analysis showed that the abundances of Aeromonas, Akkermansia, and Dehalobacterium increased in the gut of CCl4 group and decreased in NLRP3-/- +CCl4 mice at the genus level. The abundances of Allobaculum, Odoribacter, and Ruminococcus decreased in the gut of CCl4 group and increased in NLRP3-/- +CCl4 mice. Th …