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Механические свойства мышечных мышц Лумбопелвича у женщин с множественным склерозом: перекрестное исследование под контролем.

Предыстория/цели: Сопоставление мышечных механических свойств (МПМ) у женщин с множественным склерозом (МС) и без него и изучение взаимосвязей между этими свойствами и социально-демографическими/клиническими характеристиками. Методы: Это межсекторальное исследование охватывало 22 женщины с НР и 22 женщины с матчными возрастами и БИ без НР. С помощью устройства MyotonPRO была произведена оценка ММП (частота, жесткость, обесцвечивание, релаксация и полость) тазового пола и поясничных мышц. Были также собраны социально-демографические и клинические данные, касающиеся здоровья тазового пола. Резул

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… Institutional Review Board Statement The study was conducted in accordance with the Declaration of Helsinki and approved by the Research Bioethics Committee of Cordoba, under protocol code SPEM21, version 1.0, dated: 10 July 2021 (reference 5199). …

Ассоциация гинекологов-преподавателей в области медицинского образования - обзор скопирования.

Экзамен по фону Pelvic является ядром, но в то же время вызывающим тревогу, клиническим навыком в высшем медицинском образовании. Традиционные подходы к преподаванию - зачастую оппортунистические или основанные на моделировании - подвергались критике за лишение технических навыков от реляционной и этической практики. В качестве альтернативной модели появились специально подготовленные педагоги, которые используют свои собственные тела для обучения и предоставления олицетворенной обратной связи. Цель этого аналитического обзора состояла в том, чтобы составить карту того, что известно о ПГС, чьи

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… Friesen P., “Educational Pelvic Exams on Anesthetized Women: Why Consent Matters,” Bioethics 32, no. 5 (2018): 298–307. 11. …

A qualitative study on blood and marrow transplant recipients' perceptions of health professional roles following BMT and preferences for ongoing care.

PurposeSurvivors of blood and marrow transplantation (BMT) require life-long follow-up involving both tertiary transplant and primary care services. This paper explores the attitudes and preferences of BMT survivors and their carers regarding the transition from BMT centre care to primary care.MethodsThis qualitative study involved semi-structured interviews with BMT survivors and carers from New South Wales, Australia. Interviews were audio-recorded, transcribed verbatim and thematically analysed.ResultsTwenty-two BMT survivors and six carers were interviewed. Two themes emerged: (1) 'Relatio

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… Bioethics. 2022;36(8):849–57. 29. …

The Impact of a 6-Week Nordic Walking Training Cycle and a 14-Hour Intermittent Fasting on Disease Activity Markers and Serum Levels of Wnt Pathway-Associated Proteins in Patients with Multiple Myeloma.

Background: Multiple myeloma (MM) accounts for about 10-15% of all diagnosed hematologic malignancies and about 1-2% of all cancer cases. Approximately 80-90% of MM patients develop bone disease and the changes rarely regress. It is only possible to stop or slow their progression. A major role in bone destruction in MM is attributed to the Wnt signaling pathway, and its action can be modified by various types of interventions including training and diet. Therefore, the aim of this project was to evaluate the effects of a Nordic Walking (NW) training cycle and intermittent fasting (IF) on the l

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… Approval from the bioethics committee (60/KBL/OIL/2022) was also obtained to undertake the study. 2.2. Study Protocol Patients in the training group (n = 21) were subjected to a cycle of Nordic walking exercise classes held 3 times a week for a period of 6 weeks. A single workout lasted 60 min. …

Early Impact of Mobilization Process on Cardiac Function and Size in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation.

Background: The hematopoietic stem cell transplantation (HSCT) process is known to cause cardiac toxicity of different grades. In this paper, we aimed to evaluate the impact of mobilization procedure of hematopoietic stem cells for autologous HSCT process for left and right ventricle sizes and functions. Material and Methods: The data of 47 patients undergoing autologous HSCT were analyzed. All patients underwent hematopoietic stem cell mobilization with chemotherapy and filgrastim at 10 µg/kg/d. Echocardiography was performed two times: before enrolling in the transplantation process and afte

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… Bioethics approvement for the prospective study was obtained (No. BE-2-96). All patients gave their informed consent to take part in the study. …

Depressive symptom trajectories among general population during the COVID-19 pandemic in Iceland: a prospective cohort study (2020-2023).

IntroductionWhile changes in the prevalence of depressive symptoms during the COVID-19 pandemic have been described across populations, few studies have incorporated multidimensional variables to characterise the varying effects of the pandemic on the population's mental health.MethodsThis cohort study included 6423 participants aged ≥18 years from the Icelandic COVID-19 National Resilience Cohort. Data on depressive symptoms and pandemic-related and non-pandemic-related factors were obtained during three pandemic assessment periods (baseline, follow-up wave 1 and follow-up wave 2; April 2020-

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… All participants provided electronic informed consent before answering the web-based questionnaire, and the study was approved by the National Bioethics Committee (NBC 2020-073) and the Data Protection Authority in Iceland. …

Longevity leap: mind the healthspan gap.

Life expectancy has increased by three decades since the mid-twentieth century. Parallel healthspan expansion has however not followed, largely impeded by the pandemic of chronic diseases afflicting a growing older population. The lag in quality of life is a recognized challenge that calls for prioritization of disease-free longevity. Contemporary communal, clinical and research trends aspiring to extend the health horizon are here outlined in the context of an evolving epidemiology. A shared action integrating public and societal endeavors with emerging interventions that target age-related m

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… A dedicated framework of regulatory science, quality control, and bioethics has been deployed for responsible translation of a versatile regenerative medicine toolbox into validated patient delivery 71 . The clinical readiness of regenerative therapies is maturing in age-related disease. …

The contribution of Cyprus to non-communicable diseases and biomedical research from 2002 to 2013: implications for evidence-based health policy.

BackgroundNon-communicable diseases (NCDs) are the leading causes of disease burden and mortality at the European level and in Cyprus. This research was conducted to map the research activities of Cypriot institutions in five NCDs, namely oncology, cardiovascular diseases, diabetes, mental health and respiratory conditions.MethodsFor the period 2002-2013, research in Cyprus was assessed on its biomedical outputs and compared to the rest of Europe relative to their GDP. The research output in the five NCDs was obtained and contrasted to their respective disease burdens. The results from each of

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… website [ 97 ], the following organisations were individually searched, and the lists of members were obtained either directly from the website or from contact with the organisation’s administration: Cyprus Anti-Drugs Council Cyprus Mental Health Commission Health Insurance Organisation National Bioethics … These are the Cyprus Anti-Drugs Council, the Cyprus Mental Health Commission and the National Bioethics Committee for Biomedical Research, with 26 committee members in total and 36 produced papers during 2002 and 2013. …

Catching Them Early: Framework Parameters and Progress for Prenatal and Childhood Application of Advanced Therapies.

Advanced therapy medicinal products (ATMPs) are medicines for human use based on genes, cells or tissue engineering. After clear successes in adults, the nascent technology now sees increasing pediatric application. For many still untreatable disorders with pre- or perinatal onset, timely intervention is simply indispensable; thus, prenatal and pediatric applications of ATMPs hold great promise for curative treatments. Moreover, for most inherited disorders, early ATMP application may substantially improve efficiency, economy and accessibility compared with application in adults. Vindicating t

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… The resulting tradeoff for therapy development is that the underlying bioethical guidelines protect the unborn or young life, while at the same time often hiding the true potential of ATMPs by application in adults, where early-onset diseases may already have caused irreparable direct or pleiotropic … These points may weigh on the mind of bioethics review boards or of the treating physician, but they will also determine attitudes of the affected couples, because for in utero treatment, the notion of parental protection and responsibility is even more acute than for pediatric application. …

Disproportionality analysis of sex-stratified adverse event signals in growth impairment: Insights from the FDA adverse event reporting system.

This study aimed to examine sex-disaggregated adverse event signals associated with growth impairment in pediatric patients, utilizing data from the FDA adverse event reporting system, with a particular focus on growth hormone and related therapeutic agents. A disproportionality analysis was performed on FDA adverse event reporting system data spanning 2004 Q1 to 2025 Q1. The analysis encompassed 3281 growth impairment-related reports, disaggregated by gender, employing Reporting Odds Ratios (ROR) and proportional reporting ratios for signal detection, with temporal patterns assessed via Weibu

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… A disability bioethics reading of the FDA and EMA evaluations on the marketing authorisation of growth hormone for idiopathic short stature children. Health Care Anal . 2020 ; 28 : 266 – 82 . 32056083 10.1007/s10728-020-00390-1 PMC7411515 [17] Lin X-N Zeng Y-J Cao S Jing X-B . …

The Effect of Self-Rehabilitation on Physical Fitness in Adults with Hematological Malignancies (HMs) Undergoing Hematopoietic Stem Cell Transplantation (HSCT).

Background: Hematologic malignancies (HMs) represent a growing global health burden, and HSCT remains a cornerstone of treatment for many HMs. Despite improvements in survival, transplantation-related physical deconditioning is a persistent clinical challenge, and evidence supporting structured inpatient exercise interventions is scarce. Objectives: To evaluate the effects of a self-directed aerobic exercise program on a cycle ergometer in inpatients under isolation precautions related to HSCT. Methods: In this single-center prospective, non-randomized controlled interventional study, 73 patie

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… The study protocol was approved by the Bioethics Committee of Wroclaw Medical University (No. KB-843/2021; 28 October 2021) and conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from all participants. 2.1. …

Haematological nurses' experiences about palliative care trajectories of patients with life-threatening haematological malignancies: A qualitative study.

AimsTo explore haematological nurses' experiences about the palliative care trajectories of patients with life-threatening haematological malignancies.DesignA qualitative study with a descriptive and explorative design.MethodsData were collected through 12 individual semi-structured interviews of nurses who work with patients with haematological malignancies from four hospitals in Norway. The data were analysed using systematic text condensation. The study was reported according to the Consolidated Criteria for Reporting Qualitative Research checklist.ResultsThree categories emerged from the d

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… Re‐defining moral distress: A systematic review and critical re‐appraisal of the argument‐based bioethics literature. Clinical Ethics, 14(4), 195–210. Sung, H. , Ferlay, J. , Siegel, R. L. , Laversanne, M. , Soerjomataram, I. , Jemal, A. , & Bray, F. (2021). …

Patients' perspectives on the derivation and use of organoids.

Organoid research is enhancing understanding of human development and diseases as well as aiding in medication development and selection, raising hopes for even more future therapeutic options. Nevertheless, this work raises important ethical issues and there is a paucity of data regarding patients' perspectives on them. We report on 60 interviews with adult patients or parents of pediatric patients from diverse disease populations who receive medical care at a major academic research institution in the United States. Interviewees expressed broad support for organoid development and use. Howev

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… Conflicts of interest Jeremy Sugarman is a member of Merck KGaA's Bioethics Advisory Panel and Stem Cell Research Oversight Committee, a member of IQVIA's Ethics Advisory Panel, a member of Aspen Neurosciences Scientific Advisory Board, a member of a Merck data monitoring committee, a consultant to …

Потребность в помощи и соответствующий вопросник для семей, обеспечивающих уход за пациентами с множественной миеломой: исследование по вопросам развития и перекрестной проверки.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: В течение всего периода болезни пациентов с множественной миеломой (ММ) те, кто ухаживает за членами семьи, играют важнейшую вспомогательную роль, и они сами имеют вспомогательные потребности в уходе (СХН), которые зачастую не удовлетворяются. Одной из неотложных проблем является быстрое и точное выявление удовлетворяемых и неудовлетворенных потребностей семей, обеспечивающих уход за членами семьи. ЦЕЛИ: Разработка вопросника для лиц, осуществляющих уход за пациентами с множественной миеломой, в целях удовлетворения потребностей в поддержке и снабжения, а также оценка ег

Крисдесалазин смягчает воспаление в экспериментальной аутоиммунной энцефаломиэлитовой модели склерозной мыши, регулируя иммунную систему.

Микроглиа/макропатии участвуют в разработке и восстановлении экспериментального аутоиммунного энцефаломиелита (EAE), а процесс перехода на макрофаж M1 (провоспалительное)/M2 (против воспаления) осуществляется на этапе развития заболеваний EAE. Мы провели оценку эффективности хрисдезалезина (нового микросомального простагландина E2 ингибитора синтазы-1) в модели EAE, включая его иммунную силу регулирования в липополисакхаридно-стимулированных макрофагах, и его нейрозащитное воздействие в макрофаге-еврокультуре. Крисдезалезин значительно смягчил клинические симптомы, интрузивную инфильтрацию кле

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… As per Article 33, Paragraph 1, Item 1–3 of the Enforcement Rules in the Bioethics and Safety Act, research using study materials (including pathogens, cell lines, etc.) that are separated and processed from human-derived materials, which are accessible to the general public without directly collecting …

The Real-World Evidence on the Fragility and Its Impact on the Choice of Treatment Regimen in Newly Diagnosed Patients with Multiple Myeloma over 75 Years of Age.

Fragility scales are intended to help in therapeutic decisions. Here, we asked if the fragility assessment in MM patients ≥ 75 years old qualified for treatment by the local physician correlates with the choice of treatment: a two- or three-drug regimens. Between 7/2018 and 12/2019, we prospectively enrolled 197 MM patients at the start of treatment from the 13 Polish Myeloma Group centers. The data to assess fragility were prospectively collected, but centrally assessed fragility was not disclosed to the local center. The activity of daily living (ADL) could be assessed in 192 (97.5%) and was

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… Institutional Review Board Statement The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Independent Bioethics Committee for Scientific Research in Gdansk (Poland) (NKBBN/647/2018–2020, 11 December 2020). …

Restoration of Peripheral Intermediate and Classical Monocytes Expressing HLA-DR in Patients With Lung Adenocarcinoma After Platinum-Based Chemotherapy.

Lung adenocarcinoma represents one of the lung cancer subtypes with major prevalence. Accumulating evidence indicates that the immune system plays an important role in the evolution of the neoplastic process; additionally, several reports suggest that chemotherapy has an immunomodulatory effect. In order to identify the peripheral subpopulations of leukocytes that may change after chemotherapy, we evaluated several peripheral immune subpopulations of monocytes and lymphocytes by multicolor flow cytometry. In addition, we also measured cytokines and growth factors on plasma in order to evaluate

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… Methods Ethics Statement This study was approved by the Scientific and Bioethics Committee of the National Institute of Respiratory Diseases “Ismael Cosío Villegas.” All participants provided written informed consent. …

Effect of the specific proteasome inhibitor bortezomib on cancer-related muscle wasting.

BACKGROUND: Muscle wasting, a prominent feature of cancer cachexia, is mainly caused by sustained protein hypercatabolism. The enhanced muscle protein degradation rates rely on the activity of different proteolytic systems, although the Adenosine triphosphate (ATP)-ubiquitin-proteasome-dependent pathway and autophagy have been shown to play a pivotal role. Bortezomib is a potent reversible and selective proteasome and NF-κB inhibitor approved for the clinical use, which has been shown to be effective in preventing muscle wasting in different catabolic conditions. The aim of the present study h

A decision exercise to engage cancer patients and families in deliberation about Medicare coverage for advanced cancer care.

BackgroundConcerns about unsustainable costs in the US Medicare program loom as the number of retirees increase and experiences serious and costly illnesses like cancer. Engagement of stakeholders, particularly cancer patients and their families, in prioritizing insured services offers a valuable strategy for informing Medicare coverage policy. We designed and evaluated a decision exercise that allowed cancer patients and family members to choose Medicare benefits for advanced cancer patients.MethodsThe decision tool, Choosing Health plans All Together (CHAT) was modified to select services fo

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… was supported in part by grants RO1 HS018360 (Agency for Health Care Research and Quality), 1UC4NR012584 (National Institute of Nursing Research), by a grant from the Health Care Financing and Organization initiative (HCFO), a Program of the Robert Wood Johnson Foundation, and by the Department of Bioethics …

ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016.

The European Society for Medical Oncology (ESMO) and the American Society of Clinical Oncology (ASCO) are publishing a new edition of the ESMO/ASCO Global Curriculum (GC) thanks to contribution of 64 ESMO-appointed and 32 ASCO-appointed authors. First published in 2004 and updated in 2010, the GC edition 2016 answers to the need for updated recommendations for the training of physicians in medical oncology by defining the standard to be fulfilled to qualify as medical oncologists. At times of internationalisation of healthcare and increased mobility of patients and physicians, the GC aims to p