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Raloxifene as Treatment for Various Types of Brain Injuries and Neurodegenerative Diseases: A Good Start.

Recent studies have shown that the selective estrogen receptor modulator (SERM) raloxifene had pronounced protective effects against progres … odels, raloxifene showed curative effects. Furthermore, raloxifene showed healing effects regarding multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) in cell culture. The adverse biological signals typical of these conditions relate to neuronal activity, neurotransmitters and their receptors, plasticity, inflammation, oxidative stress, nitric oxide, ca …

Statins, neuromuscular degenerative disease and an amyotrophic lateral sclerosis-like syndrome: an analysis of individual case safety reports from vigibase.

BACKGROUND: The WHO Foundation Collaborating Centre for International Drug Monitoring (Uppsala Monitoring Centre [UMC]) has received many in … was not seen for statins and Parkinson's disease, Alzheimer's disease, extrapyramidal disorders, or multiple sclerosis-like syndromes. DISCUSSION: Because the cases were sometimes atypical we propose the use of the term 'ALS-like syndrome' and speculate whether this is part of a spectrum of rare neuromuscular damage. The diagnosis of ALS is often problematic, and t …

Fixing the jugular flow reduces ventricle volume and improves brain perfusion.

OBJECTIVE: Increased ventricle volume and brain hypoperfusion are linked to neurodegeneration. We hypothesized that in patients with restric … by age and gender (8 male, 6 female; mean age, 44 ± 11 years) who were not treated. Comorbidity was multiple sclerosis without significant differences in relapsing remitting (RR) and secondary progressive (SP) clinical course among groups. In the control group, neither ECD nor SPECT-CT showed any significant changes at follow-up. On the contrary, in the group operat …

Влияние телереабилитационных платформ на качество жизни людей с множественной склерозом: систематический обзор рандомизированных клинических испытаний.

ВВЕДЕНИЕ: Многофакторная демиелинизация (МД) — это хроническое нейродегенеративное заболевание, которое сопровождается высокими затратами, прогрессирующей дисфункцией и снижением качества жизни (КЖ). Телереабилитация (ТР), поддерживаемая новыми технологиями, появляется как альтернатива или дополнение к индивидуальной реабилитации, потенциально снижая социально-экономическое воздействие и улучшая КЖ. ЦЕЛЬ: Цель данного исследования заключалась в оценке влияния ТР на КЖ людей с МД по сравнению с индивидуальной реабилитацией или отсутствием вмешательства. МЕТОДЫ И МАТЕРИАЛЫ: Проведена системати

Совпадение в аннотации оригинала
INTRODUCTION: Multiple sclerosis (MS) is a chronic neurodegenerative disease that entails high costs, progressive disability, and reduced quality of life (QoL). Telerehabilitation (TR), supported by new technologies, is emerging as an alternative or complement to in-person rehabilitation, potentially lowering socioeconomic impact and improving QoL. AIM: The…

Platelet-rich plasma for the treatment of scleroderma-associated ulcers: a single-center experience and literature review.

Systemic sclerosis (SS) is a complex connective tissue disease characterized by vasculopathy and progressive fibrosis, primarily considered an autoimmune disorder. SS can affect multiple organs and tissues, including the skin, respiratory, gastrointestinal, genitourinary, cardiovascular, and musculoskeletal systems. Skin involvement is common, and SS-related ulcers, especially digital ulcers, occur in roughly 50% of patients. These ulcers not only cause pain but also significantly impact patients' quality of life, and in severe cases, they can lead to infection, gangrene, and amputation. The s

Animal models.

Epilepsy accounts for a significant portion of the dis-ease burden worldwide. Research in this field is fundamental and mandatory. Animal models have played, and still play, a substantial role in understanding the patho-physiology and treatment of human epilepsies. A large number and variety of approaches are available, and they have been applied to many animals. In this chapter the in vitro and in vivo animal models are discussed,with major emphasis on the in vivo studies. Models have used phylogenetically different animals - from worms to monkeys. Our attention has been dedicated mainly to r

Purine nucleoside analogs as immunosuppressive and antineoplastic agents: mechanism of action and clinical activity.

The purine nucleoside analogs (PNA) form an important group of cytotoxic drugs active in the treatment of neoplastic and autoimmune diseases … on-Hodgkin's lymphoma and chronic lymphocytic leukemia. 2-CdA exhibits some activity in progressive multiple sclerosis and other autoimmune disorders. This review will summarize current knowledge concerning the mechanism of action, pharmacological properties, clinical activity and toxicity of PNA accepted for use in clinical practice as well as new agents available …

Effectiveness and Safety of Rituximab in Filipino Patients With Relapsing-Remitting Multiple Sclerosis: A Real-World Retrospective Cohort Study in a Resource-Limited Setting.

BACKGROUND: Multiple sclerosis (MS) is a chronic autoimmune disorder requiring prompt initiation of disease-modifying therapies to mitigate long-term disability. In resource-limited settings like the Philippines, the high cost of approved therapies makes evaluating accessible, off-label high-efficacy treatments like rituximab a clinical priority. OBJECTIVE: To evaluate the real-world efficacy and safety of off-label rituximab in patients with relapsing-remitting MS (RRMS) in a tertiary center in the Philippines. METHODS: This single-center retrospective cohort study involved 32 patients with…

The Association Between the Occurrence of Sensory Integration Disorders, Depression, and Chronic Fatigue in Patients with Relapsing-Remitting Multiple Sclerosis.

Background/Objectives: Multiple sclerosis (MS) is a chronic neurological disease associated not only with motor dysfunction but also with non-motor symptoms such as depression and MS-related fatigue (MSRF). Sensory integration disorders (SID) in MS remain poorly characterized. This study aimed to evaluate the association between SID and depression, MSRF, disability level, disease duration, and disease activity in patients with relapsing-remitting MS (RRMS). Methods: A total of 205 patients with RRMS were assessed using the Daniel Travis sensory integration questionnaire, Beck Depression Invent…

Функциональное и когнитивное расстройство у пациентов с повторным множественным склерозом: когнитивные тесты и уровни плясной нейрофильной цепи.

Фон и цели: Множественный склероз (MS) представляет собой хроническое воспалительное, аутоиммунное и нейродегенеративное заболевание центральной нервной системы. Болезнь может проявляться и развиваться с физическими и когнитивными симптомами, влияющими на повседневную деятельность пациента. Цель нашего исследования состояла в том, чтобы изучить корреляцию между функциональным статусом, когнитивными функциями и уровнями световых цепочек нейрофильтрации в плазме у пациентов с MS. Материалы и методы: В ходе перекрестного исследования были включены пациенты, имеющие курс релапсирования (согласно к

Совпадение в аннотации оригинала
Background and Objectives: Multiple sclerosis (MS) is a chronic inflammatory, autoimmune, and neurodegenerative disease of the central nervous system. The disease can manifest and progress with both physical and cognitive symptoms, affecting the patient's daily activities. The aim of our study was to investigate the correlation between functional status, cog…

The association between cognition and gait disturbance in central nervous system demyelinating disorder with mild disability.

INTRODUCTION: Gait disturbance in central nervous system (CNS) demyelinating disorders, including multiple sclerosis (MS) and neuromyelitis optica (NMO) is one of the most troublesome problems that has a direct impact on the quality of life. However, the associations between gait disturbance and other clinical variables of these two diseases have not been fully elucidated. OBJECTIVE: This study aimed to evaluate gait disturbance using a computerized gait analysis system and its association with various clinical variables in patients with MS and NMO. METHODS: A total of 33 patients (14 with M…

Social Media Surveillance of Multiple Sclerosis Medications Used During Pregnancy and Breastfeeding: Content Analysis.

BACKGROUND: Multiple sclerosis (MS) is a chronic neurological disease occurring mostly in women of childbearing age. Pregnant women with MS are usually excluded from clinical trials; as users of the internet, however, they are actively engaged in threads and forums on social media. Social media provides the potential to explore real-world patient experiences and concerns about the use of medicinal products during pregnancy and breastfeeding. OBJECTIVE: This study aimed to analyze the content of posts concerning pregnancy and use of medicines in online forums; thus, the study aimed to gain a t…

A Review of Possible Herbal Treatment in Multiple Sclerosis in Traditional Persian Medicine.

BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system (CNS) and is the most common cause of neurologic disability in young adults (20-40 years old). About 2.5 million patients all over the world are suffering from MS. Common symptoms of the disease include sensory disorders, optic neuritis, and limb weakness. Following disease progression, other symptoms like fatigue, bladder disorders, and cognitive impairment also occur. Traditional Persian medicine (TPM) is an ancient medical system from 6000 years ago in Persia, where Iran was its most important st…

Adenosine receptors and neurological disease: neuroprotection and neurodegeneration.

Adenosine receptors modulate neuronal and synaptic function in a range of ways that may make them relevant to the occurrence, development an … rations of their roles in Lesch-Nyhan syndrome, Creutzfeldt-Jakob disease, Huntington's disease and multiple sclerosis, as well as the brain damage associated with stroke. In addition to the potential pathological relevance of adenosine receptors, there are earnest attempts in progress to generate ligands that will target adenosine receptors as therapeutic agents to …

Involvement of SWAP-70 in proteolipid protein-induced experimental autoimmune encephalomyelitis.

BACKGROUND/AIM: Multiple sclerosis (MS) is a chronic demyelinating inflammatory disease of the central nervous system. Studies have shown that B cells may play an important role in the induction and progression of MS. Switch-associated protein 70 (SWAP-70) is a signal transduction molecule abundantly expressed in B cells and involved in B-cell polarization, directed migration, endothelial cell adhesion, and tissue homing. B-cell stimuli increase its expression. SWAP-70 has been implicated in the pathogenesis of autoimmune disorders, including MS. This study aims to investigate the effects of a…

Akkermansia muciniphila: Пробиотика следующего поколения, поддерживающая нейрорепэр и функциональное восстановление.

Ось мозга - это двунаправленная система трансдукции сигнала между желудочно-кишечным трактом и центральной нервной системой, соединяющей нейронные, эндокринные и иммунные функции. В последние годы все большее внимание уделяется роли кишечной флоры в регулировании нейронной функции и на развитии различных неврологических заболеваний. Akkermansia muciniphila — бактерий кишечной флоры, содержащийся в кишечном слизе, который может регулировать иммунитет хозяина, кишечный барьер и нейроиммунный гомеостаз. В последние годы растет количество литературы, согласно которой Akkermansia muciniphila может

Совпадение в аннотации оригинала
The brain-gut axis is a bidirectional signal transduction system between the gastrointestinal tract and the central nervous system that inte … results on the role of Akkermansia muciniphila in neurological diseases such as spinal cord injury, multiple sclerosis, Parkinson's disease, and Alzheimer's disease. The mechanisms by which Akkermansia muciniphila regulates inflammatory cytokines, neurotransmitters, and short-chain fatty acids are also highlighted. Various Akkermansia muciniphila -based intervention …

Gut dysbiosis in multiple sclerosis patients: a comparative analysis in fecal samples.

Multiple sclerosis (MS) is a chronic, inflammatory disease of the central nervous system characterized by neuroinflammation, demyelination, and axonal damage. Recent evidence suggests that gut microbiota may play a critical role in MS pathogenesis by modulating immune responses and contributing to systemic inflammation. Alterations in the abundance of specific bacterial species, such as Bacteroides fragilis, Faecalibacterium prausnitzii, and Bifidobacterium spp., have been linked to immune dysregulation in MS. However, the role of gut microbiota in treatment-naïve patients at the earliest stag…

Идентификация сигнатуры, связанной с микроглией, в экспериментальном аутоиммунном энцефаломиелите.

Множественный склероз (MS) — хроническое нервно-воспалительное расстройство, характеризующееся демиелинизацией и иммунной диагностикой, и микроглией играет центральную роль в прогрессии заболеваний. Несмотря на это, конкретные микроглиальные генные сигнатуры, способствующие НР, по-прежнему недостаточно характеризуются. МЕТОДЫ: Мы использовали экспериментальную аутоиммунную модель мышьяка-энцефаломиэлита (EAE) и провели последовательность RNA для выявления дифференциально выраженных RNA (DEmRNA), длинных некодирующих RNA (DElncRNA), циркулярных RNA (DEcirRNA) и микроRNA (DEmiRNA) в микроглии. П

Совпадение в аннотации оригинала
BACKGROUND: Multiple sclerosis (MS) is a chronic neuroinflammatory disorder characterized by demyelination and immune dysregulation, and microglia play a central role in disease progression. Despite this, the specific microglial gene signatures contributing to MS remain inadequately characterized. METHODS: We utilized an experimental autoimmune encephalomye…

A systematic review: Virtual-reality-based techniques for human exercises and health improvement.

Virtual Reality (VR) has emerged as a new safe and efficient tool for the rehabilitation of many childhood and adulthood illnesses. VR-based … esbyopia, and Age-related Macular Degeneration (AMD), and neurological disorders such as Alzheimer, Multiple Sclerosis (MS) Epilepsy and Autism spectrum disorder. This review highlights the fundamentals of VR technologies regarding their clinical research in healthcare. Moreover, these findings will raise community awareness of using VR training and help researchers …

Impact of rituximab in Mexican patients with Multiple Sclerosis-A single-center retrospective study.

BACKGROUND: Multiple Sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS). B cells have an essential role in the disease pathogenesis and therefore selective B-cell depletion are commonly used to treat the disease. Rituximab (RTX), a chimeric anti-CD20 monoclonal antibody had demonstrated reduced inflammatory activity and radiological activity in MS patients. Due to economic constrains and treatment access limitations, RTX is often used as a treatment alternative in these patients. Here, we described our center experience in RTX -treated MS patients. METHODS: A s…