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From the Field to the Emergency Room: A Systematic Case-Level Review of Exertional Rhabdomyolysis and Acute Kidney Injury in Athletes.

Exertional rhabdomyolysis is a potentially life-threatening syndrome caused by skeletal muscle breakdown with release of myoglobin and creatine kinase (CK) into the circulation. Clinical severity ranges from transient enzyme elevation to severe acute kidney injury (AKI) requiring renal replacement therapy (RRT). Although increasingly recognized, the published literature remains fragmented and largely descriptive. This review systematically aggregated case-level data to characterize biochemical severity and renal outcomes across different athlete populations and exertional contexts. PubMed, Emb…

The impact of pazopanib and extremity radiotherapy on transaminase elevations in soft tissue sarcoma.

BACKGROUND AND PURPOSE: Unexpected high rates of grade ≥ 3 transaminase elevations were observed in patients receiving pazopanib and extremi … erapy-only patients experienced grade ≥ 3 elevations. Post-irradiation ALT/AST, creatine kinase and myoglobin elevations were minimal. Grade ≥ 3 elevations occurred in 6% of patients receiving pazopanib and 36% of those receiving both radiotherapy and pazopanib. All elevations typically resolved after pazopanib discontinuation. Grade ≥ 3 elevations were sig …

A novel myopathy with autophagic vacuoles associated with biallelic variants in CLN8.

Autophagic vacuoles in muscle fibers are a characteristic finding in several muscle diseases and usually indicate perturbed lysosomal protei … oman presented with seizures followed by transient muscle weakness and myalgia. Creatine kinase and myoglobin levels were moderately elevated. Over time, she developed progressive muscle weakness and cognitive fatigue. Muscle biopsy showed an autophagic vacuolar myopathy with fat tissue replacement and increased interstitial connective tissue. There was a m …

Angiopoietin-2 adsorption attempt with the cytokine adsorber cytosorb in critically ill patients.

Angiopoietin 2 (Ang-2) is a growth factor in angiogenesis, causing pericyte migration and vascular regression, leading to increased vascular … Cytosorb (CS) (included in continuous kidney replacement therapy) for the removal of cytokines and myoglobin. Ang-2 was measured in the patient´s blood and pre- and post-CS at defined time points (ten minutes, one, three, six, and twelve hours after initiation). Ang-2 extracorporeal clearances (ml/min) were calculated with: [Formula: see text] U-Test was u …

Research on the spectrum of complications in robotic surgery for obese urologic patients: a 6-year retrospective study.

The prevalence of obesity has reached epidemic proportions globally, with obese patients facing significantly higher perioperative risks due … I. Serious complications including pulmonary embolism (0.3%), delayed bleeding (0.3%), and critical myoglobin value (0.3%) occurred rarely. BMI subgroup analysis revealed complication rates of 11.3% in mild obesity, 5.3% in moderate obesity, and 0% in severe obesity, suggesting higher BMI did not increase complication rates. Robot-assisted surgery demonstra …

Successful management with hemoperfusion and antidotal therapy of severe combined dichlorvos and rodenticide poisoning: a case report.

BACKGROUND: This case report presents a rare instance of combined dichlorvos (organophosphate) and brodifacoum (rodenticide) poisoning. By a … not observed in this case. Additionally, electrolyte disturbances and myocardial biomarkers such as myoglobin and troponin require close observation, as they may reflect ongoing systemic injury. While this case highlights several clinical considerations, further studies are needed to establish standardized protocols for managing multi-toxin exposures of thi …

Predictive Value of Cardiac Biomarkers Combined with Clinical, Radiological Factors for Venous Thromboembolism in Patients with Spontaneous Intracerebral Hemorrhage.

INTRODUCTION: Venous thromboembolism (VTE) is an important complication after spontaneous intracerebral hemorrhage (ICH). However, it remain … 1.012-1.056, p = 0.002), intraventricular hemorrhage (HR = 3.268, 95% CI: 1.635-6.530, p < 0.001), myoglobin (Myo; HR = 1.002, 95% CI: 1.000-1.003, p = 0.010), and B-type natriuretic peptide (BNP; HR = 1.003, 95% CI: 1.001-1.006, p = 0.007) as independent predictors. The combined model showed better predictive performance than the clinical-radiological mod …

Reduction in systemic muscle stress markers after exercise-induced muscle damage following concurrent training and supplementation with specific collagen peptides - a randomized controlled trial.

INTRODUCTION: Collagen peptide supplementation in conjunction with exercise has been shown to improve structural and functional adaptations … rformed. Blood samples were collected to measure creatine kinase (CK), lactate dehydrogenase (LDH), myoglobin (MYO) and high-sensitivity C-reactive protein (hsCRP) before, after, and at 2 h, 24 h and 48 h post exercise. RESULTS: A combination of concurrent training and SCP administration showed statistically significant interaction effects, implying a lowe …

Сравните клинические характеристики пневмонии у 35 пациентов и бактериальной пневмонии у 46 пациентов.

Мы поставили перед собой цель описать разницу между группой хламидии пситтачи и группой пневмонии, не связанной с К. пситтачи, в общине, приобретенной пневмонией, в ходе этого одноцентрального клинического исследования. МЕТОДЫ: Мы собрали данные о 35 пациентах, страдающих пневмонией К. пситтачи, и 46 пациентах, страдающих бактериальной пневмонией не К., у которых диагностировали метагеномию следующего поколения в период с февраля 2019 года по декабрь 2021 года в больнице &quot; Уайхуа - первый народ &quot; в Китае. РЕЗУЛЬТАТЫ: В группе Пситтачи с пневмонией 35 пациентов (100%) имели возможност

Совпадение в аннотации оригинала
BACKGROUND: We aimed to describe the difference between Chlamydia psittaci pneumonia group and non C. psittaci bacterial pneumonia group in … pneumonia. Percentage of neutrophils, C-reactive protein, procalcitonin, lactate dehydrogenase, and myoglobin levels are higher. Blood calcium and corrected calcium are lower. Chest CT showed pleural effusion, pericardial effusion, and mediastinal lymphadenopathy.

Prolonged Moderate-Intensity Exercise Does Not Increase Muscle Injury Markers in Symptomatic or Asymptomatic Statin Users.

BACKGROUND: Statin use may exacerbate exercise-induced skeletal muscle injury caused by reduced coenzyme Q10 (CoQ10) levels, which are postu … , or 50 km/d for 4 consecutive days. Muscle injury markers (lactate dehydrogenase, creatine kinase, myoglobin, cardiac troponin I, and N-terminal pro-brain natriuretic peptide), muscle performance, and reported muscle symptoms were assessed at baseline and after exercise. Leukocyte CoQ10 was measured at baseline. RESULTS: All muscle injury markers were com …

Pistachios as a recovery food following downhill running exercise in recreational team-sport individuals.

We aimed to investigate the impact of pistachio nut consumption on muscle soreness and function following exercise-induced muscle damage. Us … rtical jump), and blood markers of muscle damage/inflammation (creatine kinase, C-reactive protein, myoglobin, superoxide dismutase) were measured pre (baseline) and post (24, 48, and 72 h) exercise. No trial order effects were observed for any outcome measurement across trials. Mean quadriceps soreness (non-dominant leg) during exercise recovery was reduce …

Protective effect of tin chloride on rhabdomyolysis-induced acute kidney injury in rats.

The heme component of myoglobin plays a crucial role in the pathogenesis of rhabdomyolysis-associated acute kidney injury (RM-AKI). Heme oxiganenase-1 (HO-1) is the rate-limiting enzyme of heme catabolism, and its metabolites, iron, biliverdin, and carbon monoxide, have antioxidant properties. Tin chloride (SnCl2) is a kidney specific HO-1 inducer. In this study, we examined whether the induction of HO-1 in the kidney by SnCl₂ pretreatment ameliorates RM-AKI in rats and if the effect is due to the degradation of excess renal free heme. We developed an RM-AKI rat (male Sprague-Dawley rats) mode…

Biomarkers of heatstroke-induced organ injury and repair.

NEW FINDINGS: What is the topic of this review? The status and potential role of novel biological markers (biomarkers) that can help identif … otein 2), the brain (serum S100β and neuron-specific enolase) and skeletal muscle (creatine kinase, myoglobin). No specific biomarkers have been identified so far for liver or lung injury in heatstroke. Before translating the identified biomarkers into clinical practice, additional preclinical and clinical prospective studies are required to further underst …

Influence of Alpha-Actinin-3 R577X Polymorphism on Muscle Damage and the Inflammatory Response after an Acute Strength Training Session.

The objective of this study was to verify the influence of the ACTN3 R577X polymorphism on muscle damage and the inflammatory response after … chemokine ligand 2 (CCL2), interleukin-8 (IL-8), creatine kinase (CK), lactate dehydrogenase (LDH), myoglobin, testosterone, and cortisol were measured before the ST session and 30 min and 24 h postsession. The ACTN3 R577X polymorphism effect was observed, with increased concentrations of CCL2 (p < 0.01), IL-8 (p < 0.01), and LDH (p < 0.001) in XX individua …

[Risk factors associated with acute kidney injury caused by pesticide poisoning].

Objective: To analyze the clinical characteristics of pesticide poisoning patients and explore the risk factors of acute kidney injury (AKI) … neutrophil count, alanine aminotransferase, aspartate aminotransferase, high sensitive troponin T, myoglobin and creatine kinase isoenzyme were the risk factors of AKI in patients with pesticide poisoning (P<0.05) . Multivariate logistic regression analysis showed that the time from poisoning to treatment >6 h was an independent risk factor for AKI in pati …

Severe Chlamydia psittaci pneumonia: clinical characteristics and risk factors.

BACKGROUND: Psittacosis ranges from a mild illness to fulminant severe pneumonia with multi-organ failure. It's crucial to understand the cl … alcitonin, urea nitrogen, lactate dehydrogenase, creatine kinase (CK), B natriuretic peptide (BNP), myoglobin, IL-6, and IL-10, as well as lower lymphocyte and CD8+ T cell counts, and PaO2/FiO2 ratio. Among patients with severe infection, CT showed that 46.7% had multi-lobar (more than two lobes) pneumonia, whereas its incidence was 0% in non-severe patient …

Reducing Fatty Acid Oxidation Improves Cancer-free Survival in a Mouse Model of Li-Fraumeni Syndrome.

Germline mutations of TP53, which cause the cancer predisposition disorder Li-Fraumeni syndrome (LFS), can increase mitochondrial activity as well as fatty acid β-oxidation (FAO) in mice. Increased fatty acid metabolism can promote cancer malignancy, but its specific contribution to tumorigenesis in LFS remains unclear. To investigate this, we crossed LFS mice carrying the p53 R172H knock-in mutation (p53172H/H , homolog of the human TP53 R175H LFS mutation) with myoglobin-knockout (MB-/- ) mice known to have decreased FAO. MB-/- p53172H/H double-mutant mice also showed mildly reduced FAO in t…

[Effects of angiotensin converting enzyme inhibitor/angiotensin receptor blocker on clinical characteristics of coronavirus disease 2019 patients with hypertension].

Objective: To analyze the effects of angiotensin converting enzyme inhibitor/angiotensin receptor blocker (ACEI/ARB) on coronavirus disease … ons: ACEI/ARB drugs have no significant effects on baseline clinical parameters (serum creatine and myoglobin excluded) , outcome, and prognosis of COVID-19 patients with hypertension. Antihypertensive drugs are not suggested to adjust in those patients, but the potential impairment of renal function as elevation of serum creatinine should be paid attention …

Peroxiredoxin 6 overexpression regulates adriamycin-induced myocardial injury, oxidative stress and immune response in rats.

BACKGROUND: Adriamycin is an anthracycline drug used to treat a variety of tumors. Adriamycin has a much stronger affinity for myocardial ti … X6 and PRDX6 mRNA than those of the Adriamycin + LV group. Serum creatine kinase isoenzyme (CK-MB), myoglobin (Mb), cardiac troponin I (cTnI), myocardial injury, positive rate of caspase-3, B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X protein (Bax) levels, malondialdehyde (MDA), lactate dehydrogenase (LDH), IL-1β, IL-6, inducible nitric oxide synthase (iNOS …

The Effect of L-Carnitine Supplementation on Exercise-Induced Muscle Damage: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Accumulating evidence of previous experimental studies indicated that L-Carnitine positively ameliorates muscle damage. However, findings fr … o placebo. Also, pooled data indicated that L-Carnitine significantly reduced creatine kinase (CK), myoglobin (Mb), and lactate dehydrogenase (LDH) levels at one follow-up period (24 h). However, no effects have been observed beyond this period. Our outcomes indicate that L-Carnitine supplementation improves delayed-onset muscle soreness (DOMS) and markers …