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Role of ion channels in immune regulation of psoriasis.

Psoriasis is a chronic inflammatory skin disease marked by abnormal keratinocyte growth, immune dysfunction, and a weakened skin barrier. Affecting 2-3% of the global population, it lowers quality of life and is linked to systemic conditions. Though treatments have improved, many patients still lack effective options. Recent research emphasizes the critical role of ion channels, especially cation channels, in psoriasis. These channels influence keratinocyte proliferation, differentiation, immune responses, and apoptosis. Dysregulation of calcium, potassium, sodium, and chloride channels contri…

The 'inflammazone' in chronic inflammatory diseases: psoriasis and sarcoidosis.

Chronic inflammatory diseases show significant heterogeneity in their phenotypes, with diverse immune cells and mediators interacting in response to various stimuli. This review proposes the concept of the 'inflammazone' framework - which maps the distribution of immune components driving disease pathogenesis - using sarcoidosis and psoriasis as examples. Sarcoidosis features granulomatous inflammation with macrophages and CD4+ T cells, which can spread to lymph nodes and other organs. Psoriasis, affecting primarily the skin, involves Th1, Th17, and Th22 pathways with CD8+ T cells and dendriti…

Psoriasis treatments in Europe during the 19th century.

Psoriasis is a dermatological disorder whose clinical manifestations have attracted the interest of physicians since ancient times. Hippocrates of Kos in the 5th century B.C. and later Galen in the 1st century A.D. were the first to refer to skin lesions characterized by scales and itching. In the 19th century, dermatology progressed, gaining scientific autonomy and leading to improvements both in the clinical study of psoriasis and in the search for new treatment methodologies. The dermatological schools established in this century, located in London, Paris, and Vienna, dedicated themselves t…

Pyzchiva (ustekinumab-ttwe): A New Biosimilar for Psoriasis.

OBJECTIVE: The objective of the study is to analyze the pharmacology, efficacy, and safety of ustekinumab-ttwe in the treatment of moderate-to-severe plaque psoriasis. DATA SOURCES: PubMed, Embase, and ClinicalTrials.gov were searched using the following search terms: ustekinumab, biosimilar, ustekinumab-ttwe, Pyzchiva, SB17, and psoriasis. STUDY SELECTION AND DATA EXTRACTION: Articles published in English between January 9, 2015, and June 21, 2025, related to the pharmacology, pharmacokinetics, efficacy, safety, immunogenicity, and clinical trials were reviewed. DATA SYNTHESIS: Search resu…

Implication of epigenetic factors in development and recurrence of psoriasis.

Psoriasis is a chronic autoimmune skin disease characterized by abnormal proliferation and differentiation of keratinocytes, with a complex pathogenesis often linked to environmental and genetic factors. Although many treatments are available, the disease still exhibits a high recurrence rate. Epigenetic regulation appears to bridge external stimuli and genetic abnormalities in the development of psoriasis. Skin-resident cells may contribute to disease recurrence through an 'inflammatory memory' formed through epigenetic modifications. This review focuses on skin-resident cells in psoriasis, e…

Oral Icotrokinra for Plaque Psoriasis in Adults and Adolescents.

BACKGROUND: Icotrokinra, a targeted oral peptide that selectively binds the interleukin-23 receptor, is under investigation for the treatment of plaque psoriasis. METHODS: We conducted a phase 3, double-blind, randomized, placebo-controlled trial involving adults and adolescents (≥12 years of age) with moderate-to-severe plaque psoriasis, as defined by all the following: a total body-surface area of psoriasis involvement of at least 10%, a Psoriasis Area and Severity Index (PASI) score of at least 12 (range, 0 to 72, with higher scores indicating a greater extent or severity of psoriasis), an…

Label-Free Multiphoton Microscopy for Diagnosis of Psoriasis.

Psoriasis is a global problem that significantly affects patients both physically and mentally. Accurate and rapid detection of psoriasis is crucial for diagnosis and treatment. Herein, we utilized multiphoton microscopy (MPM) to rapidly image psoriasis in imiquimod-induced mouse and human psoriatic samples. Our results showed that MPM accurately monitored the thickening of stratum corneum and epidermis in psoriatic tissues, similar to traditional H&E staining. Notably, we observed an increased alignment and number of collagen fibers in both mouse models and human psoriatic samples. Furthermor…

Synergistic effects of LCN2 and TWEAK on the progression of psoriasis.

Lipocalin 2 (LCN2) and the TWEAK/Fn14 signaling pathways are pivotal in psoriasis, influencing epidermal development, inflammatory cell chemotaxis, and inflammatory factor release. Despite their significant roles, the intricate relationship between LCN2 and TWEAK/Fn14 pathways remains unclear. Our study revealed the correlation between the expression of TWEAK, LCN2, and Fn14 in psoriatic lesions. We found that TWEAK is expressed by keratinocytes and macrophages, while LCN2 is expressed by keratinocytes and neutrophils. Surface plasmon resonance experiments demonstrated binding between LCN2 and…

TMAO promotes disorders of lipid metabolism in psoriasis.

OBJECTIVES: Psoriasis is associated with lipid metabolism disorders, but the underlying mechanisms remain unclear. This study aims to investigate the role of trimethylamine N-oxide (TMAO) in lipid metabolism dysregulation in psoriasis. METHODS: An imiquimod (IMQ)-induced psoriasis-like mouse model was used to assess lipid metabolism parameters, TMAO levels, and liver flavin monooxygenase 3 (FMO3) mRNA expression. Blood samples from healthy individuals and psoriatic patients were collected to measure serum TMAO levels and lipid profiles. To clarify the role of TMAO in the lipid metabolism diso…

Neuroimmune Crosstalk in Psoriasis: Mechanisms and Therapeutic Implications.

Psoriasis is a chronic, immune-mediated inflammatory skin disorder characterized by keratinocyte hyperproliferation, dermal vascular remodeling, and dense immune cell infiltration. While the conventional immunopathological model emphasizes the IL-23/Th17 axis and aberrant T-cell responses, growing evidence highlights the central role of neuroimmune crosstalk in the initiation, amplification, and persistence of disease. This review systematically dissects the cellular and molecular mechanisms underpinning neuroimmune interactions in psoriasis, focusing on the dynamic interplay between periphera…

Successful Treatment with Secukinumab in a Psoriasis Patient on Hemodialysis.

Moderate to severe psoriasis has been reported as an independent risk factor for IgA nephropathy (IgAN). IgAN is characterized by episodic microscopic hematuria, which can progress to end-stage renal disease (ESRD). Managing therapeutic interventions for psoriasis patients requiring dialysis due to ESRD presents significant challenges. We present a case of severe plaque psoriasis in a patient concurrently diagnosed with IgAN who is dependent on hemodialysis. Over the past two months, his condition has worsened without any identifiable triggers. Physical examination revealed generalized scaly p…

Proinflammatory cytokines and neuropeptides in psoriasis, depression, and anxiety.

Psoriasis vulgaris has established associations with psychiatric conditions such as depression, anxiety, and chronic stress. This review aims to evaluate current theories and evidence regarding the role of proinflammatory cytokines and neuropeptides in connecting systemic inflammation, psychological stress, and inflammatory skin diseases, namely psoriasis. A literature review was conducted to analyze studies that explore the connections between psoriasis, psychiatric conditions, and biological mediators, including inflammatory cytokines [interferon (IFN)-γ, interleukin (IL)-1, IL-2, IL-6, IL-1…

Spesolimab for treatment of generalized pustular psoriasis of pregnancy.

INTRODUCTION: Generalized pustular psoriasis (GPP) is a severe, desquamating skin disorder associated with pregnancy that presents as fever, fatigue, malaise and sterile pustules. It is associated with profound maternal morbidity, maternal mortality, placental insufficiency and stillbirth. Treatment often includes glucocorticoids that are continued until delivery. Monoclonal antibody spesolimab was approved for treatment of GPP in 2022 but there is a paucity of pregnancy data. CASE: A 39-year-old multiparous African American patient with chronic hypertension presented at 19 weeks gestational …

Psoriasis in the Context of Dermatologic Disorders: A Comprehensive Overview.

Psoriasis is a chronic, immune-mediated dermatosis that affects approximately 125 million people worldwide. Traditionally considered a dermatologic condition, it is now perceived as a systemic disease with numerous comorbidities. While its associations with psoriatic arthritis, metabolic syndrome, and psychiatric disorders are well established, less attention has been given to its coexistence with other dermatoses. This narrative review aims to explore and summarize the existing evidence on the relationships between psoriasis and other skin diseases, highlighting potential overlaps in clinical…

Частота псориаза у австралийских пациентов с множественным склерозом.

Множественный склероз (MS) — иммунопосредованная, обезображивающая болезнь центральной нервной системы. Хотя, как сообщается, псориаз и псориасиформный дерматит встречаются у пациентов с синдромом MS, распространенность этих заболеваний во всем мире остается неопределенной и неизученной в Австралии. Цель этого исследования состоит в том, чтобы определить частотность псориаза в больничной когорте австралийских пациентов с синдромом MS. С июля 2018 года по декабрь 2022 года в Северном Сиднее было проведено обследование 204 пациентов в возрасте 18 лет и старше, которые посещали третичную клинику

Совпадение в аннотации оригинала
BACKGROUND: Multiple Sclerosis (MS) is an immune-mediated, demyelinating disease of the central nervous system. Although psoriasis and psoriasiform dermatitis are reported in MS patients, the prevalence of the diseases is uncertain globally and unstudied in Australia. This study aims to determine the frequency of psoriasis in a clinic-based cohort of Austral…

Is Sortilin an Indicator of Subclinical Atherosclerosis in Patients with Psoriasis?

OBJECTIVE: Atherosclerosis and related cardiovascular events are quite common in patients with psoriasis. We aimed to evaluate the role of serum sortilin as a potential marker for subclinical atherosclerosis in psoriasis patients. MATERIALS AND METHODS: Serum levels of sortilin were measured by Enzyme-Linked Immunosorbent Assay (ELISA) in 33 psoriasis patients and 33 healthy controls. Waist circumference and body mass index were recorded for both groups; fasting plasma glucose (FPG), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), serum lipid levels, and sortilin levels were al…

Clinical Implications of Metabolic Syndrome in Psoriasis Management.

Psoriasis is an increasingly common chronic immune-mediated skin disease recognized for its systemic effects that extend beyond the skin and include various cardiovascular diseases, neurological diseases, type 2 diabetes, and metabolic syndrome. This study aimed to explore the complex relationship between psoriasis and metabolic syndrome by analyzing clinical, biochemical, and immunological parameters in patients with psoriasis alone and in patients combining psoriasis and metabolic syndrome. A total of 150 patients were enrolled, 76 with psoriasis only (PSO) and 74 with psoriasis and metaboli…