Результаты поиска

Examination of the evidence for off-label use of gabapentin.

OBJECTIVES: (1) Describe the relevance of off-label use of gabapentin to managed care pharmacy; (2) summarize recent FDA warnings and media … pheral neuropathy, diabetic neuropathy, complex regional pain syndrome, attention deficit disorder, restless legs syndrome, trigeminal neuralgia, periodic limb movement disorder of sleep, migraine headaches, and alcohol withdrawal syndrome. A common theme in the medical literature for gabapentin is the prevalence of open-label studies and a lack of randomized controlled …

Mice lacking Ptprd exhibit deficits in goal-directed behavior and female-specific impairments in sensorimotor gating.

Protein Tyrosine Phosphatase receptor type D (PTPRD) is a member of the protein tyrosine phosphatase family that mediates cell adhesion and synaptic specification. Genetic studies have linked Ptprd to several neuropsychiatric phenotypes, including Restless Leg Syndrome (RLS), opioid abuse disorder, and antipsychotic-induced weight gain. Genome-wide association studies (GWAS) of either pediatric obsessive-compulsive traits, or Obsessive-Compulsive Disorder (OCD), have identified loci near PTPRD as genome-wide significant, or strongly suggestive for this trait. We assessed Ptprd wild-type (WT),

Perceived quality of sleep across the menopausal transition: A retrospective cohort study.

BACKGROUND AND AIMS: To compare sleep quality among naturally and surgically post-menopausal women, and to identify lifestyle factors that predict sleep quality in pre, peri, and postmenopausal women. METHODS: This is a retrospective cohort study of data collected from 429 women who participated in Fels Longitudinal Study data. Sleep quality, based on the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale, demographics, medical history, depression, quality of life, and physical activity levels were included in the analysis. RESULTS: The four study groups did not differ on overal

Effects of total parathyroidectomy treatment on parathyroid hormone levels, recurrent laryngeal nerve function, and the rate of infection complications of secondary hyperparathyroidism patients under image information health monitoring by magnetic resonance imaging.

In order to explore the application of computer information health monitoring technology in the evaluation of the treatment effect after total parathyroidectomy (T-PTX) for patients with Secondary Hyperparathyroidism (SHPT), preoperative magnetic resonance imaging (MRI) computer health monitoring technology was used to locate and diagnose the parathyroid glands. Autotransplantation were performed. The changes of total intact parathyroid hormone (iPTH) before and after surgery, serum Calcium (Ca), serum phosphorus (P), and alkaline phosphatase (ALP) were observed and recorded. The postoperative

Pramipexole enhances disadvantageous decision-making: Lack of relation to changes in phasic dopamine release.

Pramipexole (PPX) is a high-affinity D2-like dopamine receptor agonist, used in the treatment of Parkinson's disease (PD) and restless leg syndrome. Recent evidence indicates that PPX increases the risk of problem gambling and impulse-control disorders in vulnerable patients. Although the molecular bases of these complications remain unclear, several authors have theorized that PPX may increase risk propensity by activating presynaptic dopamine receptors in the mesolimbic system, resulting in the reduction of dopamine release in the nucleus accumbens (NAcc). To test this possibility, we subjec

Prevalence of residual excessive sleepiness in CPAP-treated sleep apnoea patients: the French multicentre study.

The percentage of compliant continuous positive airway pressure (CPAP)-treated apnoeic patients that continue to experience residual excessive sleepiness (RES) is unknown. RES was defined by an Epworth Sleepiness Scale (ESS) score of >or=11. In total, 502 patients from 37 French sleep centres using CPAP >3 h night(-1) attending their 1-yr follow-up visit were eligible. ESS and polysomnographic data as well as symptoms, quality of life, depression scores and objective CPAP compliance at 1 yr were collected. Overall, 60 patients remained sleepy on CPAP (ESS 14.3+/-2.5) leading to a prevalence ra

Diagnosis and management of insomnia.

The symptom of insomnia concerns not only psychiatrists, but other physicians as well. Most cases of insomnia resolve with the passage of time or when the underlying medical or psychiatric condition is treated. For situational insomnias or psychophysiologic insomnias, consider nonpharmacologic interventions before prescribing a sedative-hypnotic. When a sedative-hypnotic is indicated, the BZs are the drugs of choice because of their better margin of safety and lower potential for abuse. In most cases, limit the use of a sedative-hypnotic to several days to a few weeks.

Sleep-Wake Disturbances in Patients With Chronic Pain-Associations With Physical Activity Levels.

BACKGROUND: Sleep-wake disturbances are frequently reported by patients with chronic pain. Physical activity, recommended as a first-line tr … ity Index (ISI), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), symptoms of restless legs syndrome (RLS), STOP-Bang score, pain intensity assessed by Numeric Rating Scale (NRS), Hospital Anxiety and Depression Scale (HADS), and self-reported level of physical activity. RESULTS: Overall, nearly all participants experienced sleep-wake disturbances …

Sleep Health and Female Lower Urinary Tract Symptoms: A Systematic Review.

PURPOSE: Emerging evidence suggests a close relationship between sleep health and female lower urinary tract symptoms (LUTS). However, avail … UI generally exhibited poorer sleep quality. Limited evidence also suggested associations involving restless legs syndrome and healthy sleep patterns. Potential mechanisms include autonomic dysregulation, systemic inflammation, circadian rhythm disruption, hormonal alterations, and psychological distress, supporting a bidirectional relationship between sleep disorders a …

Sleep and circadian health in the UK Biobank: report on the 2023 sleep questionnaire enhancement.

STUDY OBJECTIVES: Our study introduced the 2023 UK Biobank sleep questionnaire and described variation in sleep health dimensions and the pr … p disorder, with insomnia being the most common (14.4%) followed by obstructive sleep apnea (8.0%), restless legs syndrome (4.1%), and frequent nightmares (3.7%). Sleep disorders were associated with higher levels of anxiety, depression, fatigue, and cognitive complaints. CONCLUSIONS: Poor sleep quality and operationally defined sleep disorders are common in the UK Bio …

Insomnia in ambulatory care: A clinical review.

PURPOSE: One-third to one-half of ambulatory care patients report insomnia. The objective of this clinical review is to detail the many causes and evidence-based treatment options for insomnia in outpatients and to recommend screening and summarize evidence for the place in therapy of prescription and nonprescription treatments. SUMMARY: This work provides an overview of the literature on insomnia regarding causes, patient assessment, and nonpharmacological and pharmacological treatments. Patients who present with insomnia should be assessed for sleep apnea, restless legs syndrome, narcolepsy…

Creating a Japanese version of the attitudes toward dreams scale: Attitude toward dreams may predict sleep disorders.

Previous studies have identified two factors that influence people's attitudes toward dreams: positive and negative. However, cultural differences may influence these attitudes. This study aimed to develop a Japanese version of a scale to assess attitudes toward dreams and to examine factors related to Japanese participants' attitudes toward dreams. These factors included dream attitudes, dream-recall frequency, and various sleep-related variables (Pittsburgh Sleep Quality Index, sleep apnea, restless legs syndrome, insomnia, and rapid eye movement sleep behavior disorder), personality traits,…

Sleep disorders in renal patients: a comparative analysis of dialysis and post-renal transplant outcomes.

Sleep disorders are common among individuals with end-stage renal disease (ESRD) on dialysis and can persist after renal transplantation. Th … STOP-BANG questionnaire, Pittsburgh Sleep Quality Index (PSQI), and questionnaires for insomnia and Restless legs syndrome (RLS). The study analyzed a total of 386 participants, comprising 227 (58.8%) patients with ESRD on dialysis and 159 (41.2%) who had undergone renal transplants. The results from the unmatched analysis revealed that renal transplantation patients ha …

Safety profile of ramelteon from the perspective of physicians and pharmacists: a 20-year real-world pharmacovigilance analysis based on the FAERS database.

BACKGROUND: Ramelteon is the first selective melatonin receptor agonist approved by the FDA, demonstrating significant clinical value in imp … s (e.g., visual hallucinations), and rare but clinically significant reactions (e.g., glossoptosis, restless legs syndrome, and photopsia). These findings expand the current understanding of ramelteon's safety and underscore the importance of closely monitoring patients' responses during treatment. Emphasis should be placed on individualized treatment strategies and str …

Доставка пациентов пероральными Железными добавками: практическое руководство.

Железо является важным элементом, имеющим важное значение для развития, структуры и функционирования мозга. Железо как положительно, так и неблагоприятно причастно к нейропсихиатрическим расстройствам. Например, было высказано мнение о том, что железосодержание в период беременности и в раннем детстве позволяет снизить риск нервных расстройств и шизофрении, однако железные механизмы были связаны с нейродегенеративными расстройствами, множественным склерозом и инсультом. Можно отметить, что дополнительное железо лечит синдром беспокойных ног, акатисию и пика, но чаще оно лечит железодефицит, св

Совпадение в аннотации оригинала
Iron is an essential trace element that is important for the development, structure, and functioning of the brain. Iron has been both favora … degenerative disorders, multiple sclerosis, and stroke. Supplemental iron may be indicated to treat restless legs syndrome, akathisia, and pica, but more commonly to treat iron deficiency associated with poor nutrition in major mental illness. Supplemental iron is commonly orally administered but is poorly absorbed by this route. It is therefore necessary to know what i …

Association between sleep disorders and preeclampsia: a systematic review and meta-analysis.

BACKGROUND: Sleep disorders are prevalent during pregnancy and are associated with unfavorable outcomes. The meta-analysis evaluated the ass … disorders investigated included insomnia, poor sleep quality, breathing problems, sleep apnea, and restless legs syndrome. Two authors independently reviewed and assessed the quality of the studies using the Newcastle-Ottawa Scale. Heterogeneity was evaluated using the I2 statistic. Data were analyzed using RevMan 5, presenting results as random effects odds ratios (OR …

Prevalence and associations of multiple hypnotic prescriptions in a clinical sample.

STUDY OBJECTIVES: We examined the prevalence of multiple hypnotic prescriptions and its association with clinical and demographic characteri … le hypnotic prescriptions had higher rates of mood disorders, anxiety disorders, suicidal ideation, restless legs syndrome, and chronic pain (all P < 1 e-10). CONCLUSIONS: Receiving multiple hypnotic prescriptions is common and associated with a greater prevalence of psychiatric, chronic pain, and sleep-related movement disorders. Future studies should examine potentia …

NonREM Disorders of Arousal and Related Parasomnias: an Updated Review.

Parasomnias are abnormal behaviors and/or experiences emanating from or associated with sleep typically manifesting as motor movements of va … ling evidence suggests that nocturnal eating may in some cases be another nonmotor manifestation of Restless Legs Syndrome (RLS). Initial management should focus upon decreasing the potential for sleep-related injury followed by treating comorbid sleep disorders and eliminating incriminating drugs. Sexsomnia is a subtype of disorders of arousal, where sexual behavior em …

Sleep disturbances in patients with amyotrophic lateral sclerosis: current perspectives.

Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease inevitably leading to generalized muscle weakness and premature death. Sleep disturbances are extremely common in patients with ALS and substantially add to the burden of disease for both patients and caregivers. Disruption of sleep can be caused by physical symptoms, such as muscle cramps, pain, reduced mobility, spasticity, mucus retention, and restless legs syndrome. In addition, depression and anxiety may lead to significant insomnia. In a small subset of patients, rapid eye movement (REM) sleep behavioral disorder m…

The Epidemiology of Patient-Reported Hypersomnia in Persons With Advanced Age.

OBJECTIVE: To examine the epidemiology and key demographic and clinical correlates of patient-reported hypersomnia in persons with advanced … ies Depression score, Mini-Mental State Examination score, Physical Activity Scale for the Elderly, restless legs syndrome (RLS), self-reported sleep-disordered breathing (SDB), medications, and Insomnia Severity Index. RESULTS: Mean ESS score for all participants was 6.4. Patient-reported hypersomnia (ESS score ≥10) was established in 82 participants (23.0%)-their mea …