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Randomized investigation of heart failure therapy in patients with advanced cancer at risk of cardiac wasting: Rationale and design of the EMPATICC trial.

AIMS: End-stage cancer may resemble a heart failure (HF)-like phenotype marked by cardiac wasting, dysfunction, and symptoms such as dyspnoea, congestion, and impaired physical function. The EMPATICC (EMPower the heArt of patients with TermInal Cancer using Cardiac medicines) trial evaluates the safety and efficacy of optimized HF therapy in patients with advanced cancer to improve self-care ability. METHODS: EMPATICC is a multicentre, investigator-initiated, randomized, double-blind, controlled, proof-of-concept trial employing a joint cardio-oncology care approach. Patients were randomized

Are we approaching the development of a novel calcium phosphate-based bioceramic dental material?

OBJECTIVES: Develop a sustainable bovine hydroxyapatite dental ceramic with the addition of titanium dioxide (TiO2) nanoparticles (5 % and 8 % by weight), analyzing the outcome of this addition to the microstructure, as well as its mechanical and chemical properties, in order to evaluate whether they satisfy the International Organization for Standardization (ISO) 6872:2015 for dental ceramics or not. METHODS: Disks were obtained through uniaxial followed by isostatic pressing from bovine hydroxyapatite powder and TiO2 nanoparticles and sintered at 1300ºC for 2 h. Three experimental groups we

Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation.

KEY POINTS: The maintenance of optimal mitochondrial content and function is critical for muscle health. Mitochondrial dynamics play key roles in mitochondrial quality control; however, the exact role that mitochondrial fission plays in skeletal muscle health remains unclear. Here we report knocking down Drp1 (a protein regulating mitochondrial fission) for 4 months in adult mouse skeletal muscle resulted in severe muscle atrophy (40-50%). Drp1 knockdown also led to a reduction in ADP-stimulated respiration, an increase in markers of impaired autophagy and increased muscle regeneration, denerv

Advances in Application of Mechanical Stimuli in Bioreactors for Cartilage Tissue Engineering.

Articular cartilage (AC) is the weight-bearing tissue in diarthroses. It lacks the capacity for self-healing once there are injuries or diseases due to its avascularity. With the development of tissue engineering, repairing cartilage defects through transplantation of engineered cartilage that closely matches properties of native cartilage has become a new option for curing cartilage diseases. The main hurdle for clinical application of engineered cartilage is how to develop functional cartilage constructs for mass production in a credible way. Recently, impressive hyaline cartilage that may h

Lead contamination in Uruguay: the "La Teja" neighborhood case.

Lead, ubiquitous in the environment as a result of mining and industrialization, is found as a contaminant in humans although it has no know … lers, leaded gasoline (before December 2003), lead water pipes in old houses, and scrap and smelter solid wastes, among others. Nonoccupational lead exposure usually results from living in or near current or former manufacturing areas or improper handling of lead-containing materials or solid wastes (a particularly important health risk for children). In this …

Novel Staged Free-Fall Reactor for the (Catalytic) Pyrolysis of Lignocellulosic Biomass and Waste Plastics.

Pyrolysis of lignocellulosic biomass and waste plastics has been intensely studied in the last few decades to obtain renewable fuels and chemicals. Various pyrolysis devices have been developed for use in a laboratory setting, operated either in batch or continuously at scales ranging from milligrams per hour to tenths of g per hour. We report here the design and operation of a novel staged free-fall (catalytic) pyrolysis unit and demonstrate that the concept works very well for the (catalytic) pyrolysis of pinewood sawdust, paper sludge, and polypropylene as representative feeds. The unit con

Pharmacogenetic analysis of interleukin-10 variants and tacrolimus metabolism in kidney transplant patients from Pakistani population.

BACKGROUND: End stage renal disease (ESRD) occurs when the kidneys are unable to filter the waste products and excessive fluids from the blood that results into the accumulation of toxins and fluid in the body. Tacrolimus is commonly used immunosuppressant while sirolimus and cyclosporin are rarely used drugs to stop solid organ transplant rejection. The host's immunological response following transplantation produces interleukin-10 (IL-10), which influences the varied CYP3A-dependent drug disposition of tacrolimus. The aim of this study was to determine the genetic polymorphisms of IL-10 (rs1

Состояние мер по защите переносчиков болезней и информированность о переносных заболеваниях в семьях, проживающих в деревне "Нирмальный Грам Пураскар" в Индии.

ВАЖНЕЙШИЕ ЦЕЛИ: Болезни москито-бомов обостряют проблемы в различных частях мира, вызывая высокий уровень смертности и заболеваемости среди людей. Это исследование было проведено для оценки мер по защите от переносчиков болезней, принимаемых сельскими семьями, находящимися за чертой бедности, и для оценки осведомленности о трансмиссивных болезнях наряду с Кампанией за полную санитарию в сельских семьях. МЕТОДЫ: В сельской местности было проведено перекрестное исследование, в ходе которого была присуждена премия «Нирмал Грам Пураскар», т.е. «Чистая деревня» из 96 семей, находящихся ниже БПБ, в

Совпадение в аннотации оригинала
BACKGROUND OBJECTIVES: Mosquito-bome diseases are increasing problems in various parts of the world, causing high mortality and morbidity fo … il we reached a sample size. Basic socio-demographic details, status of vector protection measures, solid waste management, vector-borne diseases and total sanitation campaign details were collected from the study participants. Pretested, semi-structured questionnaire was applied to the head of the families which included sanitation status at home by house-to …

Coal fly ash application as an eco-friendly approach for modulating the growth, yield, and biochemical constituents of Withania somnifera L. plants.

The solid waste known as fly ash, which is produced when coal is burned in thermal power plants, is sustainably used in agriculture. It is an excellent soil supplement for plant growth and development since it contains some desired nutrients (macro and micro), as well as being porous. The present study was done to evaluate the effect of different fly ash levels on Withania somnifera. The present study aimed to assess the impact of various fly ash (FA) concentrations on growth, yield, photosynthetic pigments, biochemical parameters, and cell viability of W. somnifera. The results showed that FA…

Fostering social innovation and building adaptive capacity for dengue control in Cambodia: a case study.

BACKGROUND: The social-ecological systems theory, with its unique conception of resilience (social-ecological systems & resilience, SESR), p … rged following our interaction with community members are 1) adult mosquito traps made locally from solid waste collections, 2) revised dengue curriculum with hands-on activities for transformative learning, 3) guppy distribution systems led by community members, 4) co-design of dengue prevention communication material by students and community members, 5) co …

Nutrient excretion and odorant production in manure from cattle fed corn wet distillers grains with solubles.

Twenty-four cross bred steers (BW 452.5 +/- 15.5 kg) were used to evaluate nutrient excretion and odorous compounds in urine and feces of feedlot steers fed diets containing corn wet distillers grains with solubles (WDGS). Cattle were weighed, blocked by BW, and assigned randomly to 1 of 4 dry-rolled corn-based diets containing 0, 20, 40, or 60% WDGS (DM basis). A 96-h total fecal and urine collection was conducted. Orts, feces, and urine were collected daily. Samples were analyzed for moisture, total N, total P, water soluble P, and total S. Fresh fecal samples were collected at the end of th

Sustainable synthesis of calcium propionate from postbiotic propionic acid produced by Schleiferilactobacillus harbinensis-Pichia kudriavzevii co-culture using alternative calcium sources: Physicochemical characterization and feed additive potential.

BACKGROUND AND AIM: Calcium propionate is a multifunctional feed additive widely used to improve energy metabolism, prevent metabolic disorders, and enhance feed preservation in livestock production. However, commercial calcium propionate is predominantly synthesized from petrochemical-derived propionic acid, raising concerns regarding sustainability and resource dependence. This study aimed to synthesize calcium propionate using bio-derived propionic acid produced by a co-culture of Schleiferilactobacillus harbinensis and Pichia kudriavzevii, compare four alternative calcium sources, and iden

Disintegration Fingerprinting: A Low-Cost and User-Friendly Tool for Identifying Substandard and Falsified Solid-Dosage Medicines.

Substandard and falsified medicines cause thousands of deaths and waste billions of dollars worldwide every year. There is an urgent need for low-cost and simple-to-use tools for identifying these "fake drugs." In this work we demonstrate "Disintegration Fingerprinting" (DF), a technique that identifies pills, tablets, caplets, and other solid-dosage drugs based on how the drug disintegrates and dissolves in liquid. The DF hardware consists of a water-filled transparent plastic cup atop a conventional magnetic stirrer. An inexpensive sensor mounted on the outside of the cup shines infrared lig

Cancer Incidence and Childhood Residence Near the Coldwater Creek Radioactive Waste Site.

IMPORTANCE: Beginning in the 1940s, radioactive waste from the effort to develop an atomic bomb was stored in the open near the St Louis, Missouri, airport, and over several decades contaminated nearby Coldwater Creek. OBJECTIVE: To evaluate whether living near Coldwater Creek in childhood was associated with self-reported cancer incidence in the St Louis Baby Tooth-Later Life Health Study (SLBT). DESIGN, SETTING, AND PARTICIPANTS: The SLBT cohort study was centered in St Louis and included individuals who donated their baby teeth from 1958 to 1970 to assess exposure to atmospheric nuclear w

Air quality and attributable mortality among city dwellers in Kampala, Uganda: results from 4 years of continuous PM2.5 concentration monitoring using BAM 1022 reference instrument.

BACKGROUND: Air pollution is a known risk factor for non-communicable diseases that causes substantial premature death globally. Rapid urban growth, burning of biomass and solid waste, unpaved sections of the road network, rising numbers of vehicles, some with highly polluting engines, contribute to the poor air quality in Kampala. OBJECTIVE: To provide evidence-based estimates of air pollution attributable mortality in Kampala city, with focus on ambient fine particulate matter (PM2.5). METHODS: We utilized a time series design and prospectively collected data on daily ambient PM2.5 concent…

An innovative ultrasound assisted extraction micro-scale cell combined with gas chromatography/mass spectrometry in negative chemical ionization to determine persistent organic pollutants in air particulate matter.

New clean technologies are needed to determine concentration of organic pollutants without generating more pollution. A method to extract Persistent Organic Pollutants (POPs) from airborne particulate matter was developed using a novel technology recently patented called ultrasound assisted extraction micro-scale cell (UAE-MSC). This technology extracts, filters, collects the sample, and evaporates the solvent, on-line. No sample transfer is needed. The cell minimizes sample manipulation, solvent consumption, waste generation, time, and energy; fulfilling most of the analytical green chemistry

The Combined Effect of Bioactive Coating With Pectin and Cymbopogon Citratus Essential Oil and Modified Atmosphere on Strawberry Quality.

Strawberries are highly nutritious but extremely perishable, leading to considerable postharvest losses. Sustainable preservation strategies such as Modified Atmosphere Packaging (MAP) and bioactive edible coatings are being increasingly investigated. This study examined the combined effects of CO2-enriched MAP and a pectin-based coating supplemented with Cymbopogon citratus essential oil (EO) on the physicochemical and nutritional quality of strawberries during cold storage. Six treatments were tested: (1) normal atmosphere without coating (control), (2) normal atmosphere with EO-coating (NEO

Quantifying micro- and nanoplastics in blood, urine, and soft tissues using optimized cascaded microfiltration and pyrolysis-GC/MS for exposomic investigations.

Microplastics (1 μm-5 mm) and nanoplastics (<1 μm) arise from the breakdown of larger plastic materials through thermal, photochemical, and mechanical degradation. Due to the wide use and haphazard disposal of plastic wastes, micro- and nano-plastics (MNPs) are ubiquitously detected in air, water, soil, and food, which leads to growing concern about chronic exposure and potential health impacts. MNPs have been detected across trophic levels and in more than 1000 species, indicating their extensive bioaccumulation. Recent studies have also detected MNPs in multiple human tissues and bodily flui

Thiobacillus denitrificans enhances nitrogen removal, growth performance, gut histomorphometry, and immunity in fish raised in recirculatory aquaculture systems.

Recirculatory aquaculture systems (RAS) are one of the most sustainable solutions for Nile tilapia, Oreochromis niloticus, production. Nitrogenous waste accumulation has been a major constraint to its usage, especially on water quality and fish health. Effects of Thiobacillus denitrificans on nitrogen removal, water quality, microbial abundance, and growth performance as well as the immunity of Nile tilapia cultured in RAS were examined in this study. Three treatments were prepared that comprised a control (CTR = no inoculation, standard biofiltration, and sulfur pellets as electron donor), a

Quality Maintenance and Increased Firmness of Fresh-Cut Strawberries Using Vacuum Infusion of Calcium Lactate and Pectin Methylesterase.

The demand for healthy foods has led to an increase in the consumption of fresh fruits, especially fresh-cut (FC) fruits. However, FC processing negatively affects fruit firmness, an important parameter for consumer acceptance. The objective of this work was to evaluate the effectiveness of the combined use of vacuum, calcium lactate, and pectin methylesterase (PME) to increase the shelf life and quality of FC strawberries. FC strawberry halves were subjected to vacuum infusion with water, PME (10UI), PME plus 1% calcium lactate, or 1% calcium lactate alone; FC strawberries without infusion we