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[Two cases of primary intracerebral malignant lymphoma (author's transl)].

Two cases of primary intracerebral malignant lymphoma were reported. Case 1 was a 42-year-old man who had been suffering from headache and m … e frontal lobe was removed together with the tumors. After the operation his consciousness remained stupor. Thereafter consciousness and clinical pictures gradually worsened, and he died on May 30. Autopsy was performed, and gross examinations revealed tumors in the bilateral frontal and temporal lobes, right parietal lobe, and left cerebellar hemisphere …

Safety and Efficacy of Monoamine Oxidase Inhibitors in Patients Who Use Psychoactive Substances: Potential Drug Interactions and Substance Use Disorder Treatment Data.

Monoamine oxidase inhibitors (MAOIs) remain an important option for patients with treatment-resistant depression (TRD) and other psychiatric … mphetamine), mania/psychosis (DMT), rhabdomyolysis (5-MeO-DMT, DMT, and propoxyphene), and sedation/stupor/loss of consciousness (amobarbital, amphetamine, cocaine, dextroamphetamine, and propoxyphene). Fatalities have been reported for MAOIs in combination with 5-MeO-DMT, amphetamine, dextroamphetamine, dextromethorphan (in overdose), MDMA, methamphetam …

Narrative survival: personal and institutional accounts of asylum confinement.

This essay has been conceptually eclectic in that we have integrated concepts from genre theory and discourse analysis. In our interpretatio … ods of waiting for a resolution, by peaks of conflict and turmoil alternating with valleys of dazed stupor or inaction. Time in their accounts is also recursive; events are re-lived, sometimes more than once, as the patients recount their feelings about their confinement. Time for Merivale and Marshall (and presumably other patients as well) acquires a s …

[Functional pathophysiology of consciousness].

Consciousness (Latin conscientia "moral conscience"), according to the English philosopher John Locke (1632-1704) [103], is the awareness of … l state of wakefulness), 3. somnolence or lethargy, 4. obtundation with tendency to fall asleep, 5. stupor, 6. coma and its subtypes, like akinetic mutism, apallic syndrome or persistent vegative state, locked-in syndrome, delirium, and catatonia. They are caused by damages in various functional levels of the brain, by psychogenic factors or experimental …

[Acute catatonic syndrome after neuroleptic malignant syndrome].

We report the case of a young woman who deve-loped catatonic syndrome a few days after neuroleptic mali-gnant syndrome (NMS), arising the pr … was described in psychosis before the advent of neuroleptic drugs. It's characterized by hyperexia, stupor alternated with exctement, rigidity. Many etiolologic factors have been reported for this affection: psychogenic, organic or toxic. Neuroletic malignant syndrome is a potentially fatal complication of neuroleptic treatment occuring in about 1% of pa …

Gamma aminobutyric acid (GABA) receptor agonists for acute stroke.

BACKGROUND: Gamma aminobutyric acid (GABA) receptor agonists have been shown to have a neuroprotectant effect in reducing infarct size and improving functional outcome in animal models of cerebrovascular disease. However, the sedative effects of GABA receptor agonists have limited their wider application in people with acute stroke, due to the potential risk of stupor. This is an update of a Cochrane Review first published in 2013, and previously updated in 2014 and 2016. OBJECTIVES: To determine the efficacy and safety of GABA receptor agonists in the treatment of acute stroke. SEARCH METHO…

PRISM III: an updated Pediatric Risk of Mortality score.

OBJECTIVES: The relationship between physiologic status and mortality risk should be reevaluated as new treatment protocols, therapeutic int … most predictive of mortality were minimum systolic blood pressure, abnormal pupillary reflexes, and stupor/coma. Other risk factors, including two acute and two chronic diagnoses, and four additional risk factors, were used in the final predictors. The PRISM III score and the additional risk factors were applied to the first 12 hrs of stay (PRISM III-12) …

Sinking Skin Flap Syndrome following Posttraumatic Hydrocephalus.

INTRODUCTION: Complications following craniotomy are not uncommon and Sinking Skin Flap Syndrome (SSFS) constitutes a rare entity that may p … h hemiparesis of the side opposite to sunken flap while 1 other patient was brought by relatives in stuporous state. All 3 were subjected to VP shunt tie, rehydration, and cranioplasty using flattened artificial bone flap and showed gradual recovery in postoperative period without any complications. CONCLUSION: Various factors like nursing in Trendelenb …

Comparing Traumatic Brain Injury Diagnoses, Intensive Care Utilization, Length of Stay, and Costs Between Department of Defense and Veterans Affairs Hospitals: A Long-term Impact of Military-Relevant Brain Injury Consortium Study.

INTRODUCTION: The paucity of health economics studies on traumatic brain injury (TBI) was highlighted in a recent report from the National A … ion without complications/comorbidities or major complications/comorbidities (16.1%), and traumatic stupor and coma <1 hour with complications/comorbidities in VA facilities (27.5%). In diagnosis-adjusted models, the odds of ICU utilization were higher (OR 2.19, 95% CI 1.47, 3.25), although LOS was lower (-3.67, 95% CI -5.43, -1.9) for SMVs treated in Do …

Cefiderocol versus standard therapy for hospital-acquired and health-care-associated Gram-negative bacterial bloodstream infection (the GAME CHANGER trial): an open-label, parallel-group, randomised trial.

BACKGROUND: Bloodstream infections caused by bacteria with carbapenem resistance are associated with high mortality. Cefiderocol has broad i … ere either probably or possibly related to the study drug (all in the cefiderocol group): delirium, stupor, rigors, abnormal liver chemistry, and rash, all of which resolved without treatment (except for the rash, which required hydrocortisone and anti-histamines). INTERPRETATION: Among patients with a hospital-acquired or health-care-associated Gram-ne …

[Catatonia: resurgence of a concept. A review of the international literature].

Catatonia was first described in 1874 by Kahlbaum as being a cyclic disease mixing motor features and mood variations. Because most cases en … is three or more signs with sensitivity of 100% and specificity of 99%. These signs are: immobility/stupor (extreme passivity, marked hypokinesia); mutism (includes inaudible whisper); negativism (resistance to instructions, contrary comportment to whose asked); oppositionism, other called gegenhalten (resistance to passive movement which increases with …

[A 56-year-old man with fever, backache and tetraparesis].

We report a 56-year-old man who developed progressive paraparesis. He was apparently well, except for left Bell's palsy which developed on M … received steroid hormone for his Bell's palsy. On admission, his consciousness varied from alert to stupor. His BP was 150/100 mmHg, HR 98/min and regular, BT 39.4 degrees C. The bulbar conjunctiva appeared somewhat icteric. Otherwise, general physical examination was unremarkable. On neurologic examination, there was no apparent dementia. Higher cerebra …

Assessing and Management of Neurotoxicity After CAR-T Therapy in Diffuse Large B-Cell Lymphoma.

Chimeric antigen receptor T-cell (CAR-T) therapy represents the most important advances in cancer immunotherapy, especially in hematological malignancies such as B-cell lymphomas. CAR-T cell therapy has significant activity in poor risk B-cell lymphomas. CAR-T cell therapy is associated with potentially life-threatening toxicities such as cytokine release syndrome (CRS) and neurotoxicity (NT). While CRS pathophysiology and management are well established, the understanding and treatment of NT continues to develop. All current CAR-T products approved for DLBCL have been associated with NT with

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… Stupor or coma Seizure N/A N/A Any clinical seizure focal or generalized that resolves rapidly or nonconvulsive seizures on EEG that resolve with intervention Life-threatening prolonged seizure (>5 min); or Repetitive clinical or electrical seizures without return to baseline in between Motor findings … Stupor or coma Seizure | N/A | N/A | Any clinical seizure focal or generalized that resolves rapidly or nonconvulsive seizures on EEG that resolve with intervention | Life-threatening prolonged seizure (>5 min); or Repetitive clinical or electrical seizures without return to baseline in between Motor …

CAR T-cell therapy and critical care : A survival guide for medical emergency teams.

Chimeric antigen receptor (CAR) T‑cells are genetically engineered to give T‑cells the ability to attack specific cancer cells, and to improve outcome of patients with refractory/relapsed aggressive B‑cell malignancies. To date, several CAR T‑cell products are approved and additional products with similar indication or extended to other malignancies are currently being evaluated. Side effects of CAR T‑cell treatment are potentially severe or even life-threatening immune-related toxicities, specifically cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (

Совпадение в полном тексте источника
… Stupor or coma Seizure N/A N/A Any clinical seizure, focal or generalized, that resolves rapidly or non-convulsive seizures on EEG that resolve with intervention Life-threatening prolonged seizure (> 5 min); or repetitive clinical or electrical seizures without return to baseline in between Motor findings … Stupor or coma Seizure | N/A | N/A | Any clinical seizure, focal or generalized, that resolves rapidly or non-convulsive seizures on EEG that resolve with intervention | Life-threatening prolonged seizure (> 5 min); or repetitive clinical or electrical seizures without return to baseline in between Motor …

Assessment of Psychiatric Disorders in Consultation-Liaison Setting.

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… | History of | Presentation of Stuporous condition with a history of antipsychotic exposure is the trickiest condition between NMS and psychogenic presentation | Head injury-fall | Catatonia to be established by motoric signs of altered muscle tone like rigidity-lead-pipe/gegenhalten-resistance, waxy … is a diagnostic problem | | Psychogenic stupor is a rarity | Table 2 Assessment of acute onset sensory disturbances MS – Multiple sclerosis; NOVL – Nonorganic visual loss | Organic | Psychogenic Visual loss | Detailed ophthalmological and neurological workup (visual evoked potential) is a must …

Posterior Reversible Encephalopathy Syndrome and Eclampsia.

AUDIENCE: Emergency medicine residents, fellows, and recent graduates. Emergency medicine-bound senior medical students. INTRODUCTION: Posterior reversible encephalopathy syndrome (PRES) is an illness in which a person can present with acutely altered mentation, drowsiness or sometimes stupor, visual impairment, seizures (focal or general tonic-clonic), and sudden or constant, non-localized headaches.1 Patients at risk for developing PRES include those with underlying hypertension, preeclampsia, kidney disease, liver disease, exposure to cytotoxic medications or immunosuppressants, autoimmune…

Sudden severe hyperammonemia and status epilepticus -a case report-.

There are various causes to a low level of consciousness in patients in the intensive care unit. Neurological injury, infection, and metabolic disarray are considered as some of the causes. A 39 year-old female patient was transferred to our hospital with septic shock due to ascending colon perforation. The patient had previously received ovarian cancer surgery and a cycle of chemotherapy at another hospital. Emergent operation for colon perforation was successful. After the operation, she was treated in the intensive care unit for infectious and pulmonary complications. She suddenly showed de

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… Clinical manifestations of hyperammonemia include hypotonia, seizures, emesis, and abnormal neurologic changes (including stupor). Ammonia levels above 200 µmol/L are reported to be associated with brain edema and herniation [ 3 , 4 ]. …

Acute hepatic encephalopathy presenting as cortical laminar necrosis: case report.

We report on a 55-year-old man with alcoholic liver cirrhosis who presented with status epilepticus. Laboratory analysis showed markedly elevated blood ammonia. Brain magnetic resonance imaging (MRI) showed widespread cortical signal changes with restricted diffusion, involving both temporo-fronto-parietal cortex, while the perirolandic regions and occipital cortex were uniquely spared. A follow-up brain MRI demonstrated diffuse cortical atrophy with increased signals on T1-weighted images in both the basal ganglia and temporal lobe cortex, representing cortical laminar necrosis. We suggest th

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… CASE REPORT A 55-year-old man was admitted to the emergency room with generalized tonic-clonic seizures and stuporous mentality, without regaining consciousness for two hours. He was a chronic alcoholic with alcoholic liver cirrhosis. …

Adoptive Cell Therapies: Keeping Pace With New and Emerging Advances.

At JADPRO Live 2019, Patricia Mangan, RN, MSN, CRNP, and Edward Stadtmauer, MD, discussed the emerging world of chimeric antigen receptor (CAR) T-cell therapy, including the CAR T-cell process, approved indications and studies in hematologic malignancies, strategies for monitoring and managing emerging toxicities, and future directions in the use of this novel therapy.

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… Grade 4 ICE score | 7–9 | 3–6 | 0–2 | 0 (patient is unarousable and unable to perform ICE) Depressed LOC attributed to no other cause | Awakens spontaneously | Awakens to voice | Awakens only to tactile stimulus | Patient is unarousable or requires vigorous or repetitive tactile stimuli to arouse; stupor …

Neuropsychiatric Adverse Events with Monoclonal Antibodies Approved for Multiple Myeloma: An Analysis from the FDA Adverse Event Reporting System.

Background/Objectives: Monoclonal antibodies (mAbs) have revolutionized multiple myeloma (MM) treatment. However, post-marketing data on their neuropsychiatric safety are limited. This study aimed to evaluate neuropsychiatric adverse events (AEs) related to mAbs used for MM through a retrospective pharmacovigilance analysis using the Food and Drug Administration (FDA) Adverse Events Reporting System (FAERS) database. Methods: Individual case safety reports (ICSRs) from 2015 to 2023 with at least one neuropsychiatric AE and one of the MM-approved mAbs as the suspected drug (i.e., daratumumab, e

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… Neurotoxicity | 17 | 1.69 (1.05–2.72) | 1.16 (0.35–1.73) | No Peripheral motor neuropathy | 14 | 14.48 (8.53–24.58) | 3.93 (3.02–4.55) | Uk (peripheral sensory neuropathy) Incoherent | 12 | 2.61 (1.48–4.61) | 1.68 (0.71–2.35) | No Orthostatic intolerance | 10 | 12.54 (6.71–23.43) | 3.75 (2.67–4.48) | No Stupor … Specifically, a depressed or altered level of consciousness, an incoherent state, stupor, and a worsening of senile dementia had higher RORs for daratumumab. Alterations in consciousness and mental status were also SDRs for belantamab mafodotin, along with neurological decompensation. …