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The effect of conjugated linoleic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans.

Despite extensive research on conjugated linoleic acid (CLA) showing multiple beneficial effects in animal models, little is known about the … effects on platelet function. The prothrombin time, activated partial thromboplastin time, and the antithrombin III levels in the subjects were determined. Again, there was no statistically significant difference in these three parameters when pre- and post-CLA consumption values were compared. The in vivo bleeding times were also unaffected by CLA supplementatio …

[Deep venous thrombosis: epidemiologic, diagnostic and therapeutic aspects].

Deep vein thrombosis (DVT) has a high social and economic cost disease being its prevalence in the general population elevated and producing … .1%, immobilization 19.9% trauma 17.1%, tumors 9.6%. A hypercoagulation was detected in 4 patients: antithrombin III deficit in 2, post-splenectomy thrombocytosis in 1 and antiphospholipid antibodies syndrome in the last one. The Pisa territory epidemiologic data showed a male 0.51 and female 0.38/1000 subject/year DVT incidence, with significantly higher values i …

Autotransfusion in coronary artery bypass grafting: disparity in laboratory tests and clinical performance.

OBJECTIVE: Autotransfusion during and after cardiac surgery is widely performed, but its effects on coagulation, fibrinolysis, and inflammatory response have not been known in detail. METHODS: Hemostatic and inflammatory markers were extensively studied in 40 coronary artery bypass patients undergoing a consistent intraoperative and postoperative autotransfusion protocol. An identical autotransfusion protocol was applied to 4916 consecutive coronary patients and the overall clinical results were evaluated in this large patient population. RESULTS: The autologous blood pooled before bypass re

Complicated COVID-19 in pregnancy: a case report with severe liver and coagulation dysfunction promptly improved by delivery.

BACKGROUND: It has been proposed that pregnant women and their fetuses may be particularly at risk for poor outcomes due to the coronavirus (COVID-19) pandemic. From the few case series that are available in the literature, women with high risk pregnancies have been associated with higher morbidity. It has been suggested that pregnancy induced immune responses and cardio-vascular changes can exaggerate the course of the COVID-19 infection. CASE PRESENTATION: A 26-year old Somalian woman (G2P1) presented with a nine-day history of shortness of breath, dry cough, myalgia, nausea, abdominal pain

A study of the association between the early pregnancy thrombosis-thyroid axis and pregnancy outcomes in patients with recurrent spontaneous abortion.

BACKGROUND: Recurrent spontaneous abortion (RSA) is a severe, yet common, pregnancy complication. Thrombophilia and thyroid dysfunction are … cators. RESULTS: In intergroup comparison, the pregnancy loss group exhibited significantly higher antithrombin III (AT), protein C (PC), protein S (PS), thrombin time (TT), adenosine diphosphate (ADP), arachidonic acid (AA), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) levels (P < 0.05), whereas the successful pregnancy group had higher D-dimer (D …

Effect of a Combined Drug Approach on the Severity of Ischemia-Reperfusion Injury During Liver Transplant: A Randomized Clinical Trial.

IMPORTANCE: In a porcine model of liver transplant, a combined drug approach that targeted the donor graft and graft recipient reduced ische … al vein); recipients were given oral α-tocopherol and melatonin prior to anesthesia and intravenous antithrombin III, infliximab, apotransferrin, recombinant erythropoietin-β, C1-inhibitor, and glutathione during the anhepatic and reperfusion phase. MAIN OUTCOMES AND MEASURES: The primary outcome was the posttransplant peak serum aspartate aminotransferase (AST) …

The effects of low-dose testosterone treatment on lipid metabolism, clotting factors and ultrasonographic ovarian morphology in women.

INTRODUCTION: Low doses of androgen are used in women for the symptomatic treatment of sexual dysfunction and premenstrual syndrome (PMS). However, little is known about the long-term safety of androgen use in women. This study investigated the effects of low dose exogenous testosterone (T) on lipid metabolism, markers of activation of the coagulation system and ultrasonographic ovarian morphology in women. PATIENTS: Twenty-two patients with severe PMS (age 39.6 +/- 3.1 years, mean +/- SD) treated with subcutaneous T implants (100 mg six monthly) for at least two years (mean duration 3.3 (+/-

[Prevention of hemorrhagic complications after operations performed on the background of anticoagulant therapy].

BACKGROUND: According to the literature, the frequency of pacemaker (PM) pocket hematomas ranges from 0.2 to 16%. In patients on antiplatele … factors II (FII), V (FV), VII, VIII, IX, X (FX), XI (FXI), XII, von Willebrand factor, plasminogen, antithrombin III, protein C, additionally determining the parameters of total blood count: the level of platelets, thrombocrit, platelet distribution width, mean platelet volume. The postoperative wound was examined daily, with an ultrasound examination of the soft …

Coagulation dysfunction in term neonatal sepsis: a prospective cohort study.

OBJECTIVE: To characterize clinical features, conventional coagulation profiles, and rotational thromboelastometry (ROTEM) parameters in ter … latelet counts, prolonged PT/INR and aPTT ratio, lower fibrinogen levels, and reduced protein S and antithrombin III activities. ROTEM analyses revealed reduced clot strength (lower A5, A10, and maximum clot firmness) and impaired clot propagation (prolonged clot formation time and reduced alpha angle) across INTEM, EXTEM, and FIBTEM assays. In multivariable logis …

Open surgical and endovascular treatment of superior vena cava syndrome caused by nonmalignant disease.

OBJECTIVES: The purpose of this study was to evaluate the role of endovascular and open surgical reconstructions in patients with superior v … (n = 4), or post-surgery (n = 1). Two patients were heterozygous for factor V Leiden; 1 patient had antithrombin III deficiency. Twenty-nine patients underwent surgical reconstruction with 31 bypass grafts: spiral saphenous vein (n = 20), superficial femoral vein (n = 4), human allograft (n = 1), or expanded polytetrafluoroethylene (ePTFE, n = 6). Eleven patients …

Freeze-dried whole plasma: evaluating sucrose, trehalose, sorbitol, mannitol and glycine as stabilizers.

Several groups report stability results for freeze-dried whole plasma intended for use as a transfusion product [Hellstern P, Sachse H, Schw … the coagulation factors V, VII, VIII, IX, X and the coagulation inhibitors protein C, protein S and antithrombin III were recorded. Factors V and VIII were most prone to degradation. Factor V and VIII activities, in control plasma, were approx. 44+/-3.5% and 58+/-2.3%, at the end of storage. In contrast, much higher factor V and VIII activities were maintained in …

Prevalence of moderate hyperhomocysteinemia in patients with early-onset venous and arterial occlusive disease.

OBJECTIVE: To evaluate the prevalence of moderate hyperhomocysteinemia and inherited thrombophilia disorders (congenital defects of the natu … ditions affecting methionine metabolism. MEASUREMENTS: Total plasma homocysteine (fasting levels), antithrombin III, protein C, protein S, activated protein C resistance, plasminogen, and heparin cofactor II were measured at least 3 months after the event. In 87 patients, total plasma homocysteine levels were also measured 8 hours after an oral methionine load wa …

Construction of a Bayesian network-based risk prediction model for hepatocellular carcinoma in cirrhotic patients.

OBJECTIVE: To investigate clinical data of hospitalised cirrhosis patients, identify risk factors for cirrhosis progression to hepatocellula … ncy(OR = 0.532, OR95% CI = 0.297-0.952); while hepatitis B, elevated total cholesterol, and reduced antithrombin III activity were risk factors for progression to hepatocellular carcinoma (OR = 4.080, OR95%CI = 2.443-6.814;OR = 2.308, OR95%CI = 1.132-4.707, OR = 2.982, OR 95% CI = 1.389-6.402) (P < 0.05); The LASSO regression model ultimately identified 14 variabl …

Doppler velocimetry and non stress test in severe fetal growth restriction.

OBJECTIVE: The aim of our study was to evaluate the efficacy of Doppler velocimetry and cardiotocography in surveillance of the fetus affected by severe fetal growth retardation (FGR) and hence their capacity in predicting adverse perinatal outcome. This could therefore permit the timing of delivery thus reducing perinatal morbidity and mortality. METHODS: 53 women with high risk pregnancies, all suffering from various pathologies such as gestational hypertension, preeclampsia, HELLP syndrome, Antithrombin III deficit, and in whom FGR (fetal abdominal circumference < 2.5th percentile for gest…

[Clinical study on the effect of glycosaminoglycans on vascular endothelial glycocalyx in sepsis].

OBJECTIVE: To explore the protective effect of glycosaminoglycans (GAG) on vascular endothelium in patients with sepsis. METHODS: A prospective study was conducted on adult patients with sepsis admitted to the intensive care unit (ICU) of Hangzhou Normal University Affiliated Hospital from December 2022 to December 2023. Patients were randomly divided into conventional treatment group and GAG intervention group. Both groups were treated according to the 2021 Surviving Sepsis Campaign Guidelines. The GAG intervention group was additionally treated with GAG (2 mL of sulodexide intramuscular inj

Diagnosis and treatment of peripartum haemorrhage, consensus of the interdisciplinary working group by the modified ACCORD method.

of recommendations Preventive measures and procedures We recommend monitoring of blood loss in women with risk factors for PPH during labor … nt is suspected or demonstrated. (Strong recommendation) We do not recommend routine measurement of antithrombin III levels in patients with PPH. (Strong recommendation) We do not recommend routine antithrombin III replacement in patients with PPH. (Strong recommendation) We recommend initiating pharmacological prophylaxis for thromboembolic disease as soon as pos …

[Preeclampsia and thrombin generation test].

OBJECTIVE: Acquiring new information to allow prediction of the development of diseases associated with impaired coagulation. Design effective preventive measures most serious diseases (TEN) in the fields of gynecology and obstetrics. For pregnant women with preeclampsia, hypertension compared with women with normal pregnancies could lead to increased thrombin generation due to the synergistic effect of thrombotic risk factors. Based on the results and found statistically significant differences between the groups among pregnant can select for a higher risk of developing deep vein thrombosis.

Clinical Outcomes after Biologic Graft Use for the Creation of Blalock-Taussig Shunt in Critically Ill Patients with Thrombophilia.

BACKGROUND: The modified systemic to pulmonary artery shunt (mSPS) is an effective palliative procedure in children with cyanotic congenital … V Leiden mutation. We also investigated D-dimer, positivity of prothrombin G20210A, factor XII and antithrombin III deficiency, and homocysteinemia in both groups. The mean age of patients was 4.6 ± 1.09 months (range 1 day to 6 months) in the BMVG group and 3.9 ± 1.02 months (range 2 days to 9 months) in the PTFE group (P = .67). mSPS procedures were performed v …

Klinefelter's syndrome presenting with leg ulcers.

A 54-year-old man of Persian origin presented to our department with a 1-year history of ulcers on the right leg that had been unresponsive … ]), anticardiolipin IgM antibody (9.0 monophosphoryl lipid U/mL [normal range 0-7.00 MPL U/mL]) and antithrombin III activity (135% [normal range 74%-114%]). Results of other blood tests were within normal limits or negative, including lupus anticoagulant, beta2 glycoprotein, anticardiolipin IgG Ab, anti-ss DNA Ab, C3, C4, anti-RO, anti-LA, anti-SC-70, anti-SM Ab, …

Research Advances on Targets and Mechanisms in Cancers Complicated by Cardiovascular Diseases.

PurposeCancers complicated by cardiovascular diseases (CVDs) are increasingly becoming major limiting factors affecting patients' long-term quality of life and clinical outcomes. Systematic identification of therapeutic targets and their clinical development status is crucial for optimizing treatment strategies. Therefore, this study aimed to establish a target-based analytical framework to systematically map the distribution, developmental stage, maturity, and mechanistic characteristics of clinical trials investigating tumors co-occurring with CVD, thereby identifying potential therapeutic t

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… Clinical studies show that DOACs effectively prevent and manage CAT; reduce VTE recurrence; and offer advantages over traditional vitamin K antagonists, including rapid onset of action, less frequent monitoring, and fewer drug interactions. 21 , 22 SERPINC1, which encodes antithrombin III (ATIII), acts … Antithrombin III levels in critically ill surgical patients: do they correlate with VTE? Trauma Surg Acute Care Open . 2023;8(1):e001009. doi: 10.1136/tsaco-2022-001009 25. Boedtkjer E, Pedersen SF. The acidic tumor microenvironment as a driver of cancer. …