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Внутреннее управление внеклеточными везиклами, получаемыми из адипозных стволовых клеток, оказывает терапевтическое воздействие на экспериментальный аутоиммунный энцефаломиэлит.

Адипозированные стволовые клетки (ASC) представляют собой подмножество мезенхимальных стволовых клеток с подтвержденными иммуномодулятивными и регенеративными возможностями, которые делают их привлекательными инструментами для лечения нейродегенеративных расстройств, таких, как множественный склероз (MS). Ряд исследований, проведенных по экспериментальному аутоиммунальному энцефаломиэлиту (EAE), т.е. Вместе с тем противоречивые данные об их эффективности были получены в ходе клинических испытаний на этапе I- и II у пациентов, страдающих НР, с уделением особого внимания вопросам стандартизации

Совпадение в аннотации оригинала
Adipose stem cells (ASCs) are a subset of mesenchymal stem cells with validated immunomodulatory and regenerative capabilities that make them attractive tools for treating neurodegenerative disorders, such as multiple sclerosis (MS). Several studies conducted on experimental autoimmune encephalomyelitis (EAE), the animal model of MS, have clearly shown a the…

Нальмефен повышает ремиелионирующую способность налфурафина при лечении при очень низких дозах во время экспериментального аутоиммунного энцефаломиелита.

ЦЕЛИ: Множественный склероз является иммунопосредованным воспалительным заболеванием центральной нервной системы. Недавно было обнаружено, что агонисты каппа-опиоидного рецептора (KOR) способствуют восстановлению и восстановлению моделей обезвоживания. Однако побочные эффекты многих агонистов KOR ограничивают клиническое использование. Активация KOR и муоопиоидных рецепторов (MOR) часто оказывает противоположное воздействие. Поэтому вполне вероятно, что активация KOR и антагонизирующая MOR может привести к полезному повышению терапевтической эффективности при меньших дозах.МЕТОДЫ: В этом иссле

Совпадение в аннотации оригинала
OBJECTIVES: Multiple sclerosis is an immune-mediated inflammatory disease of the central nervous system. Recently, kappa opioid receptor (KO … than additive benefits in the murine model of immune-driven demyelination, experimental autoimmune encephalomyelitis (EAE). RESULTS: We found that NalM alone reduced EAE disease severity when administered therapeutically although NalM at the most effective doses did not enhance myelination or reduce lesions in the spinal cord. Moreover, a combination of NalF/NalM …

ТИА1-Средний стресс Гранулы способствуют нейроинфламмации и обезвоживанию в экспериментальном аутоиммунном энцефаломилите посредством регулирования сигнала ИЛ-31RА.

Дефункция гранул стрессовой системы (ГГ) играет решающую роль в патогенезе различных неврологических расстройств, при этом Т клеточная внутриклеточная антигена 1 (TIA1) является ключевым компонентом SG. Вместе с тем роль и механизм ТИА1-посредников в экспериментальной аутоиммунной энцефаломиелите (ЕАЭ) по-прежнему неясны. В этом исследовании в нейронах спинного мозга мышей EAE отмечается повышение регулирования TIA1, их перемещение из ядра в цитоплазму и совместная локализация с G3BP1 (маркер SG). Изъятие ТИА1 в CNS смягчает нейроинфламмацию, подавляет обезвоживание и повреждение аксона, а так

Совпадение в аннотации оригинала
The dysfunction of stress granules (SGs) plays a crucial role in the pathogenesis of various neurological disorders, with T cell intracellular antigen 1 (TIA1) being a key component of SGs. However, the role and mechanism of TIA1-mediated SGs in experimental autoimmune encephalomyelitis (EAE) remain unclear. In this study, upregulation of TIA1, its transloca…

Blocking hippocampal voltage-gated potassium channel Kv1.3 by dalfampridine abrogates cognitive impairment in experimental autoimmune encephalomyelitis mouse model.

Multiple sclerosis (MS) is devastating motor disorders accompanied by cognitive impairments. Dalfampridine (Dal), was approved for treating MS via blocking voltage-gated potassium channel (Kv). Kv1.3 is one of Dals' targets that showed insults to cognitive function in preclinical and clinical cases. Yet, there is no study that has assessed the potentiality of Dal on Kv1.3-induced cognitive impairment in MS. Thus, the aim of the present study is to reveal the procognitive influence of Dal in the MS animal model. Mice were randomly assigned into four groups. Saline was administered to group 1, c

Sheng-Jiang Powder Alleviates Th17/Treg Immune Imadium of Experimental Autoimune Encephalomyelitis путем регулирования метаболизма жирных кислот.

Множественный склероз (MS) является одной из главных причин инвалидности среди молодежи, и иммунный дисбаланс между клеткой Т 17 (Th17) и клетками регулирования Т (Tregs) играет решающую роль в ее патогенезе. В настоящее время лечение MS в значительной степени зависит от иммунодепрессивных препаратов или глюкокортикоидов, которые часто имеют побочные эффекты и недостатки в эффективности. Порошок Шэн Цзян (SJP) — традиционная китайская медицина — продемонстрировал антивоспалительные эффекты и может предложить новый терапевтический вариант для MS.АИМ: Цель этого исследования заключалась в изучен

Совпадение в аннотации оригинала
BACKGROUND: Multiple sclerosis (MS) is one of the leading causes of disability among young people, and the immune imbalance between T helper … nism of SJP in myelin oligodendrocyte glycoprotein 35-55 (MOG35-55)-induced experimental autoimmune encephalomyelitis (EAE) mice. METHODS: The efficacy of SJP was assessed using the MOG35-55-induced EAE model. Disease severity was monitored based on the clinical symptoms, body weight, and pathological damage. Furthermore, Th17/Treg balance in the peripheral and ce …

2-Bromo-1,4-Naphthalenedione promotes CD8+ T cell expansion and limits Th1/Th17 to mitigate experimental autoimmune encephalomyelitis.

Treating Multiple sclerosis (MS), a well-known immune-mediated disease characterized by axonal demyelination, is challenging due to its comp … of 2-bromo-1,4-naphthalenedione (BrQ), a derivative of naphthalenedione, in experimental autoimmune encephalomyelitis (EAE), an animal model of MS, and to elucidate its underlying mechanisms. We observed that mice treated with BrQ exhibited reduced severity of EAE symptoms, including lower clinical scores, decreased leukocyte infiltration, and less extensive demyel …

How to understand the overlap of long COVID, chronic fatigue syndrome/myalgic encephalomyelitis, fibromyalgia and irritable bowel syndromes.

Long COVID should be limited to patients with multiple, persistent symptoms not related to well-defined organ damage. Once redefined, a focused review of long COVID demonstrates striking similarity to chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), fibromyalgia (FM) and irritable bowel syndrome (IBS). Research in long COVID has revealed similar findings to those noted in CFS/ME and FM, characterized by central nervous system organ dysfunction. Long COVID, like CFS/ME, FM and IBS, is best understood as a bidirectional mind-body, neuroimmune illness.

Acute disseminated encephalomyelitis following the COVID-19 Vaccine Sinopharm in low- and middle-income country: a case report.

INTRODUCTION AND IMPORTANCE: Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and various vaccines against it have been developed. Acute disseminated encephalomyelitis (ADEM) is a disease of the central nervous system that cause inflammation and demyelination and manifests as a multi-symptom acute neurological condition. Although infections are usually the cause of ADEM, vaccines may cause 5-10% of cases. CASE PRESENTATION: A 40-year-old woman had received a second dose of the Sinopharm COVID-19 vaccine 4 months before her…

[A case of anti-myelin oligodendrocyte glycoprotein antibody-positive multiphasic disseminated encephalomyelitis showing significant recovery after immunoadsorption plasmapheresis].

The patient is an 18-year-old female. She had a history of acute disseminated encephalomyelitis at the age of 6 and 7. She visited our hospital due to acute disturbance of consciousness, quadriplegia, and numbness of left upper and lower extremities. Brain MRI showed multiple DWI/FLAIR high-signal lesions in the bilateral cerebral hemispheres, cerebellum, and brainstem. Qualitative test indicated that serum anti-MOG antibodies was positive, and she was diagnosed with anti-MOG antibody-positive polyphasic disseminated encephalomyelitis. Intravenous mPSL pulse therapy was performed twice, but th…

Acute Vaccine-Related Encephalopathy and Acute Disseminated Encephalomyelitis (ADEM) After COVID-19 Vaccination: A Case Series From Bangladesh.

There are several reported cases of various neurological adverse effects following the COVID-19 vaccination globally. Acute vaccine-related encephalopathy and acute disseminated encephalomyelitis (ADEM) are included among them. Here we are reporting three cases of ADEM and one case of acute vaccine-related encephalopathy from Bangladesh, which have a possible association with COVID-19 vaccines. All three ADEM cases were elderly; two cases developed symptoms after receiving the second dose of the Sinopharm vaccine, and another case after receiving the second dose of the Sinovac vaccine. We have…

Лечение метаформина уменьшает воспаление, дисмиелинацию и остроту заболеваний в мышиной модели множественного склероза, экспериментального аутоиммунного энцефаломиелита.

Множественный склероз (MS) — аутоиммунная болезнь, характеризующаяся воспалением, смертью или повреждением олигодендроцитов и аксоновой дегенерацией. Нынешние методы лечения синдрома MS являются неаккуратными, сопряженными с нежелательными побочными эффектами и дорогостоящими, что подчеркивает необходимость расширения терапевтических возможностей для пациентов. Существует большой интерес к разработке мер вмешательства с использованием лекарственных средств или терапевтических средств в целях сокращения числа симптомов и защиты ранее существовавшего миелина. Метформин является хорошо терпимым л

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is an autoimmune disease characterized by inflammation, death or damage of oligodendrocytes, and axonal degeneration … ls (OPCs), and reduce inflammation in a well-established mouse model of MS- experimental autoimmune encephalomyelitis (EAE). Male and female mice received metformin treatment at the time of EAE induction ("acute") or upon presentation of disease symptoms ("delayed"). We found that acute metformin treatment improved functional outcomes, concomitant with reduced micr …

Dose-dependent effect of myelin oligodendrocyte glycoprotein on visual function and optic nerve damage in experimental autoimmune encephalomyelitis.

Female Dark Agouti rats were immunized with increasing doses of myelin oligodendrocyte glycoprotein (MOG) to develop experimental autoimmune encephalomyelitis (EAE), a preclinical model of multiple sclerosis. Typical EAE motor impairments were assessed daily and noninvasive visual evoked potentials (VEPs) were recorded at baseline and 5 weeks after immunization, with final histopathology of optic nerves (ONs). Immunized rats exhibited a relapsing-remitting clinical course. Both VEP and histological abnormalities were detected in a MOG dose-dependent gradient. Increasing MOG dosage augmented vi…

Circadian rhythm disruption in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for the post-acute sequelae of COVID-19.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a common and disabling disorder primarily characterized by persistent fatigue and exercise intolerance, with associated sleep disturbances, autonomic dysfunction, and cognitive problems. The causes of ME/CFS are not well understood but may coincide with immune and inflammatory responses following viral infections. During the current SARS-CoV2 coronavirus pandemic, ME/CFS has been increasingly reported to overlap with persistent "long COVID" symptoms, also called the post-acute sequelae of COVID-19 (PASC). Given the prominence of ac…

Immunomodulatory effects of cyclotides isolated from Viola odorata in an experimental autoimmune encephalomyelitis animal model of multiple sclerosis.

BACKGROUND: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that causes chronic inflammation. Cyclotides are small plant proteins with a wide range of biological activity, making them a target for researchers to investigate. This study was conducted to investigate the possible effects of cyclotide-rich fractions from Viola odorata as an immunomodulatory agent in an experimental autoimmune encephalomyelitis (EAE) model of MS. METHODS: At room temperature, the plant materials were subjected to maceration in methanol: dichloromethane (1:1; v/v) for 3 days. The ex…

Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Here the hypothesis is advanced that maladaptive mechanisms that prevent recovery in some intensive care unit (ICU) patients may also underlie Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Specifically, these mechanisms are: (a) suppression of the pituitary gland's pulsatile secretion of tropic hormones, and (b) a "vicious circle" between inflammation, oxidative and nitrosative stress (O&NS), and low thyroid hormone function. This hypothesis should be investigated through collaborative research projects.

[Aquaporin 4 antibody-positive neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis. A brief review].

Aquaporin 4 (AQP4) immunoglobulin (Ig)G-associated neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein immunoglobulin (Ig)G-associated encephalomyelitis (MOG-EM, also termed MOG antibody-associated disease, MOGAD) are important autoimmune differential diagnoses of multiple sclerosis (MS), which differ from MS with respect to optimum treatment and prognosis. AQP4 IgG-positive NMOSD take a relapsing course in virtually all cases and MOG-EM in at least 80% of adult cases. Both diseases can quickly lead to permanent disability if left untreated, although MOG-EM …

The Clinical, Radiologic, and Prognostic Differences Between Pediatric and Adult Patients With Myelin Oligodendrocyte Glycoprotein Antibody-Associated Encephalomyelitis.

Purpose: To evaluate the clinical differences between pediatric and adult patients with myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis (MOG-EM). Methods: We retrospectively reviewed the clinical features of pediatric and adult patients with MOG-EM in our center between November 2015 and October 2020. Results: Twenty-eight pediatric patients and 25 adults were admitted to our study. Bilateral optic neuritis (BON) was the most common initial phenotype in the pediatric group but less common in the adult group (28.57 vs. 0%, p = 0.0119). Almost half of the adult patients…

Low Frequency Ultrasound With Injection of NMO-IgG and Complement Produces Lesions Different From Experimental Autoimmune Encephalomyelitis Mice.

Neuromyelitis optica spectrum disorder (NMOSD), a relapsing autoimmune disease of the central nervous system, mainly targets the optic nerve … and complement to mice suffering pre-existing neuroinflammation produced by experimental autoimmune encephalomyelitis (EAE). In this study, we showed that ultrasound with NMO-IgG and complement caused marked inflammation and demyelination of both spinal cords and optic nerves compared to blank control group, as well as glial fibrillary acidic protein (GFAP) and aqu …

Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling.

Rationale: Optic neuritis is one of main symptoms in multiple sclerosis (MS) that causes visual disability. Astrocytes are pivotal regulator … (MS-ON) remains unclear. Methods: To assess the functions of YAP in MS-ON, experimental autoimmune encephalomyelitis (EAE, a common model of MS) was established, and mice that conditional knockout (CKO) of YAP in astrocytes, YAPGFAP-CKO mice, were successfully generated. Behavior tests, immunostaining, Nissl staining, Hematoxylin-Eosin (HE) staining, TUNEL stainin …

Risks for Developing Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in College Students Following Infectious Mononucleosis: A Prospective Cohort Study.

BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) involves severe fatigue, unrefreshing sleep, and cognitive impairment, leading to functional difficulties; prior studies have not evaluated risk factors with behavioral and immune data collected before developing ME/CFS. Up to 5% of university students develop infectious mononucleosis (IM) annually, and 9-12% meet criteria for ME/CFS 6 months later. We sought to determine predictors of ME/CFS. METHODS: We enrolled college students at the start of the school year (time 1), identified those who developed IM (time 2), and fo…