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Proceedings of the Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2018

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… For the desensitization process, defatted peanut powder is mixed in oat flour or lactose powder, and encapsulated by the hospital outpatient pharmacy. Patients are administered an initial dose of 1 mg of peanut flour (containing 0.5 mg peanut protein) under clinical observation. … There have been no reactions upon transition from peanut flour to Peanut M&M ® . Conclusions: Compared to the 6 month induction period in published protocols, our thirteen-month long protocol is conservative. …

Нейропзащитное воздействие грелина на крысиную модель множественных склерозов.

Множественный склероз (MS) является воспалительным заболеванием центральной нервной системы, характеризующимся обезвоживанием и аксонной потерей, и является основной причиной нетравматических неврологических расстройств у молодых людей. Несмотря на то, что существует несколько методов лечения этого заболевания, не существует окончательного средства для лечения множественных склерозов. Известно, что воспаление и окислительный стресс играют важную роль в патофизиологии MS. Грелин, пептид, скрытый желудком, обладает нейрозащитными свойствами по нескольким путям, включая ослабление окислительного

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… (Standard diet: Bayramoglu Feed and Flour Industry Trade Inc., Turkey) Y-maze test Y-maze test was conducted according to the previous studies at the end of the experiment (for DM and Control 35 groups 35 days of age and for the other groups 42 days of age) (Ergul Erkec et al. 2024a , b ). …

Investigations of Possible Multistate Outbreaks of Salmonella, Shiga Toxin-Producing Escherichia coli, and Listeria monocytogenes Infections - United States, 2016.

PROBLEM/CONDITION: Salmonella, Shiga toxin-producing Escherichia coli (STEC), and Listeria monocytogenes are the leading causes of multistat … ost foodborne outbreak-related illnesses (134). Three outbreaks involved novel food-pathogen pairs: flour and STEC, frozen vegetables and L. monocytogenes, and bagged salad and L. monocytogenes. Eleven outbreaks were attributed to contact with animals (10 attributed to contact with backyard poultry and one to small turtles). Thirteen of 18 multistate fo …

Лупин (Lupinus angustifolius) Протеин гидролизат уменьшает остроту экспериментального аутоиммунного энцефаломелита: предварительное исследование.

Множественный склероз (MS) — нейродегенеративное заболевание, основным источником которого является воспаление и окислительный стресс в центральной нервной системе. Существует много лекарств, которые уменьшают клинические признаки MS, но ни один из них не лечит болезнь. Было доказано, что пищевые белки содержат зашифрованные пептиды, которые могут высвобождаться после гидролиза и осуществлять многочисленные биологические виды деятельности. Недавно мы продемонстрировали антивоспалительные и антиоксидантные действия волчьего белка гидролизата (LPH) как in vitro, так и in vivo. Поэтому цель этого

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… LPH Preparation Lupinus angustifolius protein isolate (LPI) was obtained as follows: defatted lupin flour was extracted with 0.25% Na 2 SO 3 ( w / v ) at pH 10.5 for 1 h. After centrifugation, the supernatant was collected, and the pellet was subjected to a second extraction. …

Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

Curcumin has been credited with a wide spectrum of pharmacological properties for the prevention and treatment of several chronic diseases such as arthritis, autoimmune diseases, cancer, cardiovascular diseases, diabetes, hemoglobinopathies, hypertension, infectious diseases, inflammation, metabolic syndrome, neurological diseases, obesity, and skin diseases. However, due to its weak solubility and bioavailability, it has limited potential as an oral medication. Numerous factors including low water solubility, poor intestinal permeability, instability at alkaline pH, and fast metabolism contri

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… silymarin 75 mg, choline bitartrate 35 mg, curcumin 35 mg, d -α-tocopherol 10 mg for a total of 830 mg | ( 122 ) ArtemiC oral spray (1 mL) | 6 mg artemisinin, 20 mg curcumin, 15 mg frankincense, 60 mg vitamin C | ( 127 ) BCM-95 | Curcuma longa extract with essential oils from turmeric rhizome, rice flour … tongue protruding ability in OSF patients. 113 , 114 However, this combination was shown to provide no effects on paracetamol metabolization in healthy subjects. 115 BCM-95 is a novel well established curcumin formulation wherein curcumin is complexed with essential oils from turmeric rhizome, rice flour …

Генетическая вариация генотипов ячменя с использованием морфологических признаков, содержания амилозы и молекулярных маркеров.

Для того чтобы любая работа по разведению растений была эффективной, необходимо обеспечить наличие и доступность различных генетических ресурсов. Использование простых последовательности повторения (ССР) маркеров, содержания амилозы и агроморфологической характеристики генетического разнообразия 50 Была проведена оценка генотипов ячменя. Поперечный 50 Генотипы, анализ разницы выявили весьма значительные колебания (p) < 0.01) в каждом признаке. Генотипы G20, G7, G18, G28, G41, G45, G50, G13, G39 и G47 продемонстрировали наивысшую урожайность. Была выявлена положительная корреляция между количес

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… The variation in amounts of amylose and amylopectin is responsible for its unique physical and chemical properties, with strong influences on the functional properties of flour or semolina and its specific uses in food 10 , 11 . … Estimation of amylose and amylopectin Flour sample preparation Following grinding, grain samples were processed using the JFS-13A milling machine from Tekpa Laboratory (which has a 0.5 mm sieve). In between each sample, the mill was cleaned. …

The 11th NORDIC NUTRITION CONFERENCE NNC2016.

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Repurposing Disulfiram as an Anti-Obesity Drug: Treating and Preventing Obesity in High-Fat-Fed Rats.

Background and objectivesA drug repurposing strategy is an approach for identifying new therapeutic uses for approved or investigational drugs. Thanks to the moderate cost of repurposing a drug compared to bringing new chemical entity to the market, drug repurposing is rapidly gaining ground. The aim of this work is to study the anti-obesity effect of disulfiram (DSF), an irreversible aldehyde dehydrogenase inhibitor approved by the Food and Drug Administration (FDA) to treat chronic alcoholism since 1951.MethodsThirty male Albino rats were randomly assigned to six groups. G1, the control grou

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… Materials and Methods Diet Standard diet (SD) was purchased from Grains Silos & Flour Mills Organization, SA, Item No. F1005. SD is composed of 20% protein, 4% fat and 50% carbohydrates. …

Food-derived compounds targeting ferroptosis for cancer therapy: from effects to mechanisms.

Ferroptosis is distinctive type programmed cell death. Tumor cells, with their higher iron levels, render them more susceptible to ferroptosis Inducing ferroptosis can activate immune cells, regulate immune evasion, and inhibit the biology activity of cancer cells. Therefore, ferroptosis-induced cancer cell death could become a promising approach for cancer treatment. Dietary compounds are an important source for drug discovery, and there has been an increasing amount of literature on food-derived ferroptosis inducers and their applications in cancer treatment. This review provides an overview

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… | Lung cancer A549 and H1299 cells | 0, 20, 40, 60, 80, and 100 µM for 72 h | Downregulating the key target tsRNA-13502 and GPX4, SLC7A11 and ACSL4; accumulation of iron, MDA, and ROS↑ | Wang et al. ( 117 ) Epigallocatechin-3-Gallate | green tea leaves, apples, blackberries and carob flour | A549 cells … EGCG is also naturally present in foods such as apples, blackberries, and carob flour, among many other foods ( 164 ). Previous studies have identified EGCG as a novel inducer of ferroptosis. …

Nutrition-specific interventions for preventing and controlling anaemia throughout the life cycle: an overview of systematic reviews.

BACKGROUND: Anaemia is a prevalent health problem worldwide. Some types are preventable or controllable with iron supplementation (pills or … rease in two reviews investigating MMN fortification versus placebo or no treatment, iron fortified flour versus control, double fortified salt versus iodine only fortified salt, and rice fortification with iron alone or in combination with other micronutrients versus unfortified rice or no intervention. Each review suggested that fortified versus non-f …

Adaptive NK cells undergo a dynamic modulation in response to human cytomegalovirus and recruit T cells in in vitro migration assays.

Human cytomegalovirus (HCMV) reactivation remains a relevant complication after hematopoietic stem cell transplantation (HSCT) despite the great progress made in prophylaxis and treatment. Adaptive Natural Killer (NK) cells undergo a persistent reconfiguration in response to HCMV reactivation however, the exact role of adaptive NK cells in HCMV surveillance is currently unknown. We studied the relationship between HCMV reactivation and adaptive NK cells in 70 patients monitored weekly until day +100 after HSCT. Absolute cell counts of adaptive NK cells increased significantly after resolution

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… The bottom chamber was washed twice with PBS and cells were stained with anti-CD3 (PerCP clone: OKT3, BioLegend) and anti-CD8a (Alexa Flour 700 clone: HIT8a, BioLegend). Prior to acquisition, fluorescent counting beads (FlowCount Fluorospheres™, Beckman Coulter) were added to each sample. …

The biogenesis and biological function of PIWI-interacting RNA in cancer.

Small non-coding RNAs (ncRNAs) are vital regulators of biological activities, and aberrant levels of small ncRNAs are commonly found in precancerous lesions and cancer. PIWI-interacting RNAs (piRNAs) are a novel type of small ncRNA initially discovered in germ cells that have a specific length (24-31 nucleotides), bind to PIWI proteins, and show 2'-O-methyl modification at the 3'-end. Numerous studies have revealed that piRNAs can play important roles in tumorigenesis via multiple biological regulatory mechanisms, including silencing transcriptional and posttranscriptional gene processes and a

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… goldfish, gray mouse lemur, gray short-tailed opossum, great pond snail, Herbst’s burying beetle, horse, house mouse, housefly, human, Japanese rice fish, large earth bumblebee, large milkweed bug, migratory locust, northern tree shrew, oriental fruit fly, Pacific oyster, pea aphid, pig, platypus, red flour … goldfish, gray mouse lemur, gray short-tailed opossum, great pond snail, Herbst’s burying beetle, horse, house mouse, housefly, human, Japanese rice fish, large earth bumblebee, large milkweed bug, migratory locust, northern tree shrew, oriental fruit fly, Pacific oyster, pea aphid, pig, platypus, red flour …

The sirtuin family in health and disease.

Sirtuins (SIRTs) are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous biological processes. Currently, seven mammalian homologs of yeast Sir2 named SIRT1 to SIRT7 have been identified. Increasing evidence has suggested the vital roles of seven members of the SIRT family in health and disease conditions. Notably, this protein family plays a variety of important roles in cellular biology such as inflammation, metabolism, oxidative stress, and apoptosis, etc., thus, it is considered a

Cobalamin deficiency, hyperhomocysteinemia, and dementia.

IntroductionAlthough consensus guidelines recommend checking serum B12 in patients with dementia, clinicians are often faced with various questions: (1) Which patients should be tested? (2) What test should be ordered? (3) How are inferences made from such testing? (4) In addition to serum B12, should other tests be ordered? (5) Is B12 deficiency compatible with dementia of the Alzheimer's type? (6) What is to be expected from treatment? (7) How is B12 deficiency treated?MethodsOn January 31st, 2009, a Medline search was performed revealing 1,627 citations related to cobalamin deficiency, hype

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… It is less clear whether or not low dose folic acid masks B12 deficiency. 285 , 401 Although the United States FDA requires 140 μg of folic acid per 100 g of grain or flour, 424 , 425 an amount chosen because it was considered high enough to prevent NTDs, but low enough to not mask B12 deficiency, some …

Food fortification with multiple micronutrients: impact on health outcomes in general population.

BACKGROUND: Vitamins and minerals are essential for growth and maintenance of a healthy body, and have a role in the functioning of almost e … ren; 20 studies were conducted in LMICs. Food vehicles used included staple foods, such as rice and flour; dairy products, including milk and yogurt; non-dairy beverages; biscuits; spreads; and salt. Fourteen of the studies were fully commercially funded, 13 had partial-commercial funding, 14 had non-commercial funding and two studies did not specify th …

Следует ли улучшить сопоставление между рационами питания?

Питание считается возможным кофактором, который влияет на иммунную систему и потенциально вызывает дисрегулирование кишечного гомеостаза и воспаления. Цель этого исследования заключалась в анализе качества данных о воздействии конкретного состава рациона питания на симптомы иммунопосредованных подстрекательских заболеваний (ИМИД), включая ревматоидный артрит (RA), спондилоартрит, множественный склероз (MS), воспалительный кишечник (IBD) [восстановление болезни Крона и язвительный колит], псориоз и псориатический артрит у взрослых пациентов. Мы провели обзор метаанализов и систематических обзор

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… Studies with the best results excluded or reduced saturated fats, white flour, dairy, sugar, and meat and recommended the intake of sufficient fruits, vegetables, and fish. A 12-h fast at night provided good results. …

APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression.

Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) DNA cytosine deaminase 3B (A3B) is a DNA editing enzyme which induces genomic DNA mutations in multiple myeloma and in various other cancers. APOBEC family proteins are highly homologous so it is especially difficult to investigate the biology of specifically A3B in cancer cells. To easily and comprehensively investigate A3B function in myeloma cells, we used CRISPR/Cas9 to generate A3B reporter cells that contain 3×FLAG tag and IRES-EGFP sequences integrated at the end of the A3B gene. These reporter cells stably express

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… Subsequently, cells were incubated with a goat anti-mouse IgG (H+L)-Alexa Flour ® 594 preadsorbed antibody (Abcam, ab150120) for 30 min in the dark. All antibodies were diluted with 3% BSA and 0.5% Tween in PBS. …

The Anti-Cancer Effect of Cinnamon Aqueous Extract: A Focus on Hematological Malignancies.

Cinnamon is an evergreen and tropical plant of the family Lauraceae, growing particularly in Sri Lanka, whose aqueous extract has been tested in different studies to evaluate its possible use as an anti-cancer compound. Both in vitro and in vivo experiments seem to confirm that it acts on various cellular pathways, contributing to down-regulating the activity of molecules that stimulate the proliferation and survival of cells such as the transcription factors NF-KB and AP-1, COX-2, dihydrofolate reductase and pro-angiogenic substances such as VEGF, while up-regulating the function of immune ce

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… In this trial, whose recruitment was completed in August 2021, there are two arms: an active comparator in which patients received 500 mg of cinnamon in the form of two capsules before meals three times per day and a placebo comparator in which patients received 500 mg of wheat flour before meals three …

Summary for clinicians: ERS guidelines on pulmonary alveolar proteinosis.

Pulmonary alveolar proteinosis (PAP) is a rare lung disease caused by accumulation of surfactant in the alveoli, leading to debilitating respiratory symptoms and impaired gas exchange. The recent European Respiratory Society guidelines provide evidence-based recommendations for its diagnosis and management. Autoimmune PAP (aPAP) is the most common form, driven by granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibodies. Recommended diagnostic tools include bronchoalveolar lavage and quantitative GM-CSF antibody testing. Whole lung lavage and inhaled GM-CSF are first-line treatm

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… chronic inflammatory conditions | Acquired immunodeficiency syndrome, amyloidosis, Fanconi's syndrome, agammaglobulinaemia, juvenile dermatomyositis, renal tubular acidosis, severe combined immunodeficiency disease Occupational and environmental exposures | Aluminium, cement, silica, titanium, indium, flour …

The annual conference of National Cancer Institute - Cairo University "Bridging Gaps in Oncology" : InterContinental Citystars Cairo hotel. 3 - 5 November, 2021.

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… The binding affinity between the Spike protein and CNPs was evaluated and assessed using a monoclonal antibody and a secondary antibody conjugated to Alexa Flour 647 dyes protocol. The viral inhibition was assessed using varying concentrations of CNPs (1, 5, 10, 20, 30, and 50 μg/ml). …