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Psoriasis and comorbidities. Epidemiological studies.

Psoriasis is a prevalent chronic inflammatory disease whose exact aetiology is not fully understood, but both genetic and environmental fact … n patients with psoriasis, the relationship between psoriasis and uveitis, and the risk of incident multiple sclerosis (MS) following the onset of psoriasis, respectively. The main results were a significantly increased risk of myocardial infarction, stroke, and CVD death in patients with psoriasis during stages of acute depression. Moreover, we found a bidirectiona …

Ofatumumab: a novel anti-CD20 monoclonal antibody for treatment of refractory chronic lymphocytic leukemia.

OBJECTIVE: To present the current clinical evidence on ofatumumab for use in refractory chronic lymphocytic leukemia (CLL). DATA SOURCES: A … er malignant and nonmalignant conditions, including non-Hodgkin lymphoma, rheumatoid arthritis, and multiple sclerosis. The most common adverse effect is grade 1 and 2 infusion reactions. Other adverse effects include infection, neutropenia, anemia, rash, fever, and diarrhea. CONCLUSIONS: Clinical evidence suggests that ofatumumab is an effective agent in patients …

Chemokines and their receptors in the central nervous system.

Chemokines are a family of proteins associated with the trafficking of leukocytes in physiological immune surveillance and inflammatory cell … infiltration. Their overexpression has been implicated in different neurological disorders, such as multiple sclerosis, trauma, stroke, Alzheimer's disease, tumor progression, and acquired immunodeficiency syndrome-associated dementia. An emerging area of interest for chemokine action is represented by the communication between the neuroendocrine and the immune syst …

Многоуровневый анализ генетических драйверов, связывающих аортальный стеноз и левую венерическую диастическую дисфункцию при сердечной недостаточности

Происходящий аортальный стеноз (AS) и левый желудочно-кишечный дисфункция (LVDD) часто сосуществуют в сердечной недостаточности (HF), однако механизмы, связывающие их, остаются неясными. В то время как СОС увеличивает после загрузки и поощряет миокардное ужесточение, появляющиеся данные, основанные на АИ, позволяют предположить, что ОДВД может предвосхищать разработку СОС или прогресс одновременно, указывая общие механобиологические и подстрекательские факторы вверх по течению. В этом исследовании анализируются генетические составители, соединяющие СОС и ЛДВД, с целью выявления ранних молекуля

Совпадение в аннотации оригинала
Background Aortic stenosis (AS) and left ventricular diastolic dysfunction (LVDD) often coexist in heart failure (HF), but the mechanisms li … phoblastic, and Oral Squamous Cell Carcinomas ) and rare genetic disorders (e.g., Hypophosphatasia, Multiple Sclerosis, Campomelic Dysplasia, Lymphatic Malformation ). We validated our results through state of science literature, gene-disease annotation databases, and electronic health records. Conclusions AS and LVDD share both clinical and genomic associations, wi …

Multi-omics analysis of genetic drivers linking aortic stenosis and left ventricular diastolic dysfunction in heart failure.

BACKGROUND: Aortic stenosis (AS) and left ventricular diastolic dysfunction (LVDD) often coexist in heart failure (HF), but the mechanisms l … ymphoblastic, and Oral Squamous Cell Carcinomas) and rare genetic disorders (e.g. Hypophosphatasia, Multiple Sclerosis, Campomelic Dysplasia, Lymphatic Malformation). We validated our results through state of science literature, gene-disease annotation databases, and electronic health records. CONCLUSIONS: AS and LVDD share both clinical and genomic associations, w …

CaNO and eCO Might Be Potential Non-Invasive Biomarkers for Disease Severity and Exacerbations in Interstitial Lung Disease.

Background: Interstitial lung diseases (ILDs) often progress quickly and are associated with a poor prognosis. New noninvasive biomarkers to assist in the classification and prognostication of ILD are needed. Exhaled nitric oxide (FeNO), Cavity nitric oxide (CaNO), and carbon monoxide (eCO) are biomarkers of airway inflammation, widely used in respiratory inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD). However, their value in ILD remains unclear. Objective: To evaluate the potential diagnostic and prognostic value of FeNO, CaNO, and eCO in ILD, and explor

Региональная уязвимость сетчатки при множественном склерозе: интеграция OCT, MRI и клинических данных для улучшения диагностики и автоматизированного мониторинга.

Множественный склероз (MS) — хроническое аутоиммунное заболевание центральной нервной системы, которое часто влияет на зрительные пути. В качестве ценного неинвазивного средства для оценки нейроаксональных повреждений в MS появилась томография оптической согласованности (OCT). В этом исследовании изучается процесс нейродегенерации сетчатки у пациентов с рассеянными клетками и внутренним плексиформным слоем (GCL+IPL), макулярным объемом (MV) и изменениями во волоконном слое сетчатки (RNFL) и их корреляцией с параметрами клинического и магнитного резонансного изображения (MRI). Всего 43 Психиатр

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system, often affecting the visual pathways. Optical coherence tomography (OCT) has emerged as a valuable, non-invasive imaging tool for assessing neuroaxonal damage in MS. This study investigates retinal neurodegeneration in MS patients, focusing on ganglion cell layer and inner …

FreeSurfer-Based MRI Volumetry Reveals Thalamic and Hippocampal Atrophy as Significant Correlates of Disability in Multiple Sclerosis.

Background and Objectives: Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease that progressively leads to brain atrophy and the accumulation of disability over time. In this study, we used FreeSurfer to compare subcortical volumes and cortical surface areas between patients with MS and healthy controls and to investigate how regional atrophy relates to both disease lasting and clinical disability. Materials and Methods: We included 80 participants in this study, 40 patients with clinically definite MS and 40 age- and sex-matched healthy controls, all imaged on a Ph…

A review of current rehabilitation practices and their benefits in patients with multiple sclerosis.

Multiple sclerosis (MS) is a chronic, debilitating disease characterised by demyelination of the nerves of the central nervous system that results in patients progressively losing the ability to perform daily tasks. As there is no cure for this disease, rehabilitation therapy is an important aspect of care; assisting patients to regain or retain function and improve their physical, mental and social wellbeing. At present there is no current consistent model of care for MS, likely due to the variable symptom presentation. Various forms of rehabilitation therapy are available, and these include …

The Scleroderma Patient-centered Intervention Network Self-Management (SPIN-SELF) Program: protocol for a two-arm parallel partially nested randomized controlled feasibility trial with progression to full-scale trial.

BACKGROUND: Systemic sclerosis (scleroderma; SSc) is a rare autoimmune connective tissue disease. We completed an initial feasibility trial of an online self-administered version of the Scleroderma Patient-centered Intervention Network Self-Management (SPIN-SELF) Program using the cohort multiple randomized controlled trial (RCT) design. Due to low intervention offer uptake, we will conduct a new feasibility trial with progression to full-scale trial, using a two-arm parallel, partially nested RCT design. The SPIN-SELF Program has also been revised to include facilitator-led videoconference gr

Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis.

BACKGROUND: Multiple sclerosis results from T-cell-dependent inflammatory demyelination of the central nervous system. Our objective was long-term suppression of inflammation with short-term monoclonal antibody treatment. METHODS: We depleted 95% of circulating lymphocytes in 27 patients with multiple sclerosis by means of a 5-day pulse of the humanised anti-CD52 monoclonal antibody, Campath-1H. Clinical and haematological consequences of T-cell depletion, and in-vitro responses of patients' peripheral-blood mononuclear cells were analysed serially for 18 months after treatment. FINDINGS: Ra…

[Expert consensus on the diagnosis and treatment of sleep-disordered breathing related to neuromuscular diseases].

Neuromuscular diseases are often accompanied by various types of sleep-related breathing disorders, which can exacerbate the underlying condition and are associated with a poor prognosis. Early identification is essential, and interventions such as non-invasive ventilation, oxygen therapy, and respiratory rehabilitation should be initiated promptly to mitigate disease progression and improve outcomes. Nevertheless, the rates of missed and misdiagnosed cases remain common in clinical practice. Currently, there are no standardized guidelines for the diagnosis and treatment of sleep-disordered br

Polypharmacy, Potential Drug-Drug Interactions and Medication Non-Adherence in Patients with Multiple Sclerosis: A Longitudinal Study.

INTRODUCTION: Multiple sclerosis (MS) is a chronic neuroinflammatory disease affecting approximately 2.9 million people worldwide. Disease-modifying therapies for MS effectively lower the risk of relapses and delay disability progression, but the increasing medication burden and ongoing adherence challenges complicate disease management. An improved understanding of predictors of medication-related risks is essential to optimize long-term safety, treatment effectiveness, and quality of life in patients with MS. METHODS: In this longitudinal observational study, 206 adults with MS or clinicall…

Decoding disease burden in multiple sclerosis: The role of IL-10 as biomarker of neuroinflammation and neurodegeneration.

BACKGROUND: Multiple sclerosis (MS) is a chronic neuroinflammatory disease with heterogeneous clinical presentations and progression rates that pose challenges to its management. Identifying prognostic biomarkers is crucial for individualized treatment approaches. Interleukin-10 (IL-10) has emerged as a key anti-inflammatory cytokine with neuroprotective effects, while Chitinase-3-like protein 1 (CHI3L1) reflects the pathogenic glial activation and neurodegeneration. OBJECTIVE: This study aimed to assess baseline serum IL-10 and CHI3L1 levels as biomarkers of disease burden and their correlat…

COVID-19-Related Bilateral Avascular Necrosis of the Femoral Head.

Osteonecrosis is a pathologic process that involves focal bone infarction and death of bone tissue caused by trauma, infections, autoimmune conditions, and chronic steroid use; however, most cases go undiagnosed. The link between bilateral osteonecrosis and coronavirus disease 2019 (COVID-19) infections has not been fully investigated. This is the case of a 42-year-old Caucasian woman who presented to the emergency department for bilateral hip pain, which started three months prior. Initially, the pain was mild; however, her symptoms worsened, causing her to have difficulty ambulating. Co-inci

A Spontaneous Model of Experimental Autoimmune Encephalomyelitis Provides Evidence of MOG-Specific B Cell Recruitment and Clonal Expansion.

The key role of B cells in the pathophysiology of multiple sclerosis (MS) is supported by the presence of oligoclonal bands in the cerebrospinal fluid, by the association of meningeal ectopic B cell follicles with demyelination, axonal loss and reduction of astrocytes, as well as by the high efficacy of B lymphocyte depletion in controlling inflammatory parameters of MS. Here, we use a spontaneous model of experimental autoimmune encephalomyelitis (EAE) to study the clonality of the B cell response targeting myelin oligodendrocyte glycoprotein (MOG). In particular, 94% of SJL/j mice expressing…

The potential role of mast cells and fibroblast growth factor-2 in the development of hypertension-induced renal damage.

Hypertension-induced renal injury is a multifactorial process which plays a crucial role in the development of chronic kidney disease. Multiple studies have demonstrated that interstitial rather than glomerular changes correlate better with renal functional capacity. Recent evidence indicates that mast cells and cell signaling proteins such as fibroblast growth factor-2 may contribute to the progression of interstitial changes under hypertensive conditions. The aim of our study was to determine the localization of mast cells in the renal cortex and report on the changes in their number, to ana

Patterns of Multimorbidity in Persons with Multiple Sclerosis: Belgrade Population Registry Data.

INTRODUCTION: Multimorbidity was defined as having at least two comorbidities in addition to the confirmed index diagnosis. The aim of the present study was to determine multimorbidity patterns in patients with multiple sclerosis (PwMS) from the Belgrade region, using population-based MS Registry data. Additionally, comparison of the prevalence of multimorbidity in PwMS and in the general population of Serbia was also performed. METHODS: The source for this study was Belgrade population-based MS Registry, established and maintained at the Clinic of Neurology, University Clinical Center of Ser…

Multiple sclerosis burden and quality of care index in China and the G20 (1990-2021): A cross-regional analysis using global burden of disease database 2021.

Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system with a growing global burden. While traditionally considered rare in Asia, China rising MS prevalence and disproportionate disability present major public health challenges. Comprehensive cross-regional comparisons between China, the group of 20 (G20), and global aggregates remain limited. Using data from the global burden of disease 2021 study, we quantified MS incidence, prevalence, mortality, and disability-adjusted life years (DALYs) in China, G20 countries, and worldwide from 1990 to 2021. Temporal …

Highly Sensitive 3-Tesla Real Inversion Recovery MRI Detects Leptomeningeal Contrast Enhancement in Chronic Active Multiple Sclerosis.

BACKGROUND: Leptomeningeal contrast enhancement (LME) on T2-weighted Fluid-Attenuated Inversion Recovery (T2-FLAIR) MRI is a reported marker of leptomeningeal inflammation, which is known to be associated with progression of multiple sclerosis (MS). However, this MRI approach, as typically implemented on clinical 3-tesla (T) systems, detects only a few enhancing foci in ~25% of patients and has thus been criticized as poorly sensitive. PURPOSE: To compare an optimized 3D real-reconstruction inversion recovery (Real-IR) MRI sequence on a clinical 3 T scanner to T2-FLAIR for prevalence, charact…