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Longitudinal assessments of motor performance and musculoskeletal abnormalities in preschool children with esophageal atresia.

BACKGROUND: Children with esophageal atresia (EA) may have impaired motor performance and musculoskeletal abnormalities, but when and in whom these abnormalities develop is still unknown. AIMS: To study motor performance and musculoskeletal abnormalities from infancy to pre-school age, and to assess risk factors for poor motor performance at 24 and 48 months. STUDY DESIGN: Prospective cohort study at 12, 24, and 48 months. SUBJECTS: Forty-six children with EA. OUTCOME MEASURES: Total and subtest scores and percentile ranks describing motor skills were obtained by using the Alberta Infant M…

Residual Disease Activity and Burden of Disease in Canadian Patients With Axial Spondyloarthritis: Results From a Multiregistry Analysis (UNISON-Axial SpA).

OBJECTIVE: There is a key knowledge gap in quantifying residual disease activity in Canadian patients with axial spondyloarthritis (axSpA). The objective of this study was to evaluate and describe residual disease activity and burden of disease in Canadian patients with axSpA. METHODS: This was an observational, retrospective analysis of data extracted from the Rhumadata (Québec), Spondyloarthritis Research Consortium of Canada (SPARCC; East/Atlantic and West regions, as well as Ontario), and Follow-up Research Cohort of Ankylosing Spondylitis (FORCAST; Alberta) registries. The primary endpoi…

Evaluation of rayleigh jet atomizer for intranasal delivery of lipid nanoparticle-siRNA formulations: stability, deposition, and device performance.

The COVID-19 pandemic has emphasised the need for innovative and efficient drug delivery systems, particularly for nucleic acid-based therap … et size, were analyzed before and after aerosolisation. Deposition patterns were assessed using the Alberta Idealized Nasal Inlet (AINI) model to determine the distribution of aerosolized LNPs. The results demonstrate that the Rayleigh Jet Nasal Atomizer efficiently delivers all the three formulations to the nasal cavity, primarily targeting the nasophary …

Pediatric Sharp Foreign Body Aspiration: Revealing Unexpected Risk Factors.

OBJECTIVE: Characterize the demographic and clinical features of pediatric sharp foreign body aspiration (FBA). STUDY DESIGN: Twenty-four-year retrospective chart review. SETTING: Four tertiary-care centers across four Canadian provinces. METHODS: A retrospective chart review was conducted on pediatric patients who underwent rigid bronchoscopy for sharp FBA below the vocal cords at the McGill University, McMaster University, University of Alberta, and Dalhousie health centers from January 1, 2000, to November 30, 2023. RESULTS: In total, 48 patients (27 males and 21 females, mean age of 10…

Multi-model assessments to characterize occurrences of emerald ash borer (Coleoptera: Buprestidae).

Introduction and spread of nonindigenous species present a formidable threat to forest health. The emerald ash borer (EAB), Agrilus planipen … nt predictors of EAB presence. Random forest and ensemble model forecasts for the city of Edmonton, Alberta, Canada, indicated an area of potential concern for EAB. Our research strongly underscores the utility of comparative multi-model approaches in invasive risk assessments that could have important implications for pest surveillance and management.

A Cross-Sectional Survey of Reproductive, Gynecological, and Breast Health Outcomes Among People in Provincial Prisons for Women in Atlantic Canada.

OBJECTIVES: Previous quantitative research on reproductive health needs among women in prison in Canada has been limited to Ontario and Alberta. We conducted this cross-sectional survey of reproductive, gynecological, and breast health outcomes of people experiencing provincial incarceration in the 4 provinces of Atlantic Canada. METHODS: We adapted a survey instrument with consultation from lived experience experts. Fifty questions were asked about demographics and reproductive, gynecological, and breast health. The survey was administered on paper, in person at each of the 4 provincial pris…

Serologic Follow-Up of Infants Exposed to Maternal Syphilis During Pregnancy.

BACKGROUND: For infants born to those with infectious syphilis during pregnancy, guidelines recommend monitoring nontreponemal titers every 2 to 3 months until nonreactive. The primary objective was to determine when nontreponemal titers become nonreactive in this setting. METHODS: This retrospective cohort study included infants born to mothers in Alberta with infectious syphilis during pregnancy from January 1, 2015, to December 31, 2021, who had at least one follow-up rapid plasma reagin (RPR) beyond 1 month of age. Cumulative incidence curves for RPR, enzyme immunoassay, and Treponema pal…

Характеристики магнитного резонансного изображения миэлина олигодендроцита гликпротеина антител - подтверждение нынешних диагностических критериев.

В 2023 году в рамках Международной группы по диагностике MOGAD были использованы магнитно-резонансные изображения (MRI), которые помогают отличать миелин олигодендроциты от антителных заболеваний (MOGAD) от имитаций, особенно в тех случаях, когда антителные титеры MOG являются низкими. Мы оценили диагностические характеристики этих элементов МРТ в большой, ранее диагностировавшейся группе. МЕТОДЫ: В период с июля 2017 года по июль 2023 года были извлечены все анализы, проведенные лабораторией Mitgen Dx в Альберте на основе клеток MOG IgG. Все MOG-позитивные при представлении MOGAD и => одно ис

Совпадение в аннотации оригинала
BACKGROUND: Magnetic resonance imaging (MRI) features in the 2023 MOGAD International Panel diagnostic criteria help distinguish myelin olig … sly diagnosed cohort. METHODS: All MOG IgG cell-based assays performed by Mitogen Dx laboratory in Alberta from July 2017 to July 2023 were retrieved. All MOG positive with a MOGAD presentation and => one MRI study of brain, spine, or optic nerves were identified. MRIs were re-evaluated by two neuroradiologists and a neurologist for MOGAD-like features. …

The value of radiomics-based hyperdense middle cerebral artery sign in predicting hemorrhagic transformation in acute ischemic stroke patients undergoing endovascular treatment.

OBJECTIVE: To establish and validate a model based on hyperdense middle cerebral artery sign (HMCAS) radiomics features for predicting hemor … 3 (95% CI 0.797-0.935) in the training cohort and 0.851 (95%CI 0.721-0.942) in the test cohort. The Alberta Stroke Program Early CT score (ASPECTS) was the only independent predictor among 24 clinical and 4 radiological variables. The combined model further improved the predictive performance, with an AUC of 0.911 (95%CI 0.850-0.960) in the training cohor …

Advancing Parkinson's Disease Research in Canada: The Canadian Open Parkinson Network (C-OPN) Cohort.

BACKGROUND: Enhancing the interactions between study participants, clinicians, and investigators is imperative for advancing Parkinson's disease (PD) research. The Canadian Open Parkinson Network (C-OPN) stands as a nationwide endeavor, connecting the PD community with ten accredited universities and movement disorders research centers spanning, at the time of this analysis, British Columbia, Alberta, Ontario, and Quebec. OBJECTIVE: Our aim is to showcase C-OPN as a paradigm for bolstering national collaboration to accelerate PD research and to provide an initial overview of already collected…

Discrepancies in ASPECTS obtained by artificial intelligence and experts: Associated factors and prognostic implications.

PURPOSE: The differences between the Alberta Stroke Program Early CT Score (ASPECTS) obtained by experts and artificial intelligence (AI) software require elucidation. We aimed to characterize the discrepancies between the ASPECTS obtained by AI and experts and determine the associated factors and prognostic implications. METHODS: This multicenter, retrospective, observational cohort study included patients showing acute ischemic stroke caused by large-vessel occlusion in the anterior circulation. ASPECTS was determined by AI software (RAPID ASPECTS) and experts from the core laboratory. Inte…

Why You Gamble Matters: A Systematic Review and Meta-analysis of the Association Between Gambling Motivation and Problem Gambling.

The propensity for individuals to experience problem gambling (PG) varies depending on their motivation to gamble. The present meta-analysis assessed the effect sizes associated with various gambling motives identified in representative population samples. Studies were sourced through PsycINFO, PudMed, and databases maintained by the Alberta Gambling Research Institute and the Greo Evidence Insights. Quantitative studies and technical studies were included if they reported on gambling motivation as a correlate of PG; were published in English, French, or Spanish; used valid and reliable measur…

Impact of COVID-19 pandemic in children using non-invasive ventilation: a thematic analysis of caregivers answers to a survey study.

PURPOSE: The COVID-19 pandemic has resulted in drastic changes in people's lives, more so in individuals with chronic conditions, such as children with chronic respiratory disorders requiring home non-invasive ventilation. Our research question was: How has the COVID-19 pandemic affected the daily lives of children using home NIV and their families and their NIV adherence? METHODS: An anonymous online survey was administered to caregivers of pediatric patients using home NIV followed at the Stollery's Pediatric NIV Program in Alberta, Canada, between September 2020 and September 2021. Themati…

Assessment of immunosuppression induction with basiliximab compared to antithymocyte-globulin in adult heart transplant patients.

BACKGROUND: Patients undergoing heart transplants are at risk of rejection which can have significant morbidity and mortality. Induction immunosuppression at the time of transplant reduces the early risk and has additional benefits. The induction agent of choice within our program was changed from rabbit antithymocyte-globulin (rATG) to basiliximab, so it was necessary to evaluate whether this had any impact on patient outcomes. OBJECTIVES: Our primary objective was to describe rejection, infection, and other outcomes in adult heart transplant patients at the University of Alberta Hospital in…

Exposure to air pollutants and subclinical carotid atherosclerosis measured by magnetic resonance imaging: A cross-sectional analysis.

OBJECTIVES: Long-term exposure to air pollution has been associated with higher risk of cardiovascular mortality. Less is known about the as … NTS: Canadian adults (n = 6645) recruited between 2014-2018 from the provinces of British Columbia, Alberta, Ontario, Quebec, and Nova Scotia, were studied, for whom averages of exposures to nitrogen dioxide (NO2), ozone (O3), and fine particulate matter (PM2.5) were estimated for the years 2008-2012. MAIN OUTCOME MEASURE: Carotid vessel wall volume (CWV …

Health Services Utilization and Specialist Care in Pediatric Inflammatory Bowel Disease: A Multiprovince Population-Based Cohort Study.

BACKGROUND: Patterns of health services utilization among children with inflammatory bowel disease (IBD) are important to understand as the number of children with IBD continues to increase. We compared health services utilization and surgery among children diagnosed <10 years of age (Paris classification: A1a) and between 10 and <16 years of age (A1b). METHODS: Incident cases of IBD diagnosed <16 years of age were identified using validated algorithms from deterministically linked health administrative data in 5 Canadian provinces (Alberta, Manitoba, Nova Scotia, Ontario, Quebec) to conduct …

Development and validation of machine learning algorithms based on electrocardiograms for cardiovascular diagnoses at the population level.

Artificial intelligence-enabled electrocardiogram (ECG) algorithms are gaining prominence for the early detection of cardiovascular (CV) con … epartments or hospitals, who underwent at least one 12-lead ECG from February 2007 to April 2020 in Alberta, Canada, and considered 15 CV diagnoses, as identified by International Classification of Diseases, 10th revision (ICD-10) codes: atrial fibrillation (AF), supraventricular tachycardia (SVT), ventricular tachycardia (VT), cardiac arrest (CA), atriov …

Impact of inherited bleeding disorders on maternal bleeding and other pregnancy outcomes: A population-based cohort study.

INTRODUCTION: Increasing rate of postpartum haemorrhage (PPH) has been observed between 2003 and 2010 in Canada. Inherited bleeding disorders contribute to the risk of PPH. AIM: To identify the trend in PPH in the last decade, assess the impact of bleeding disorders on pregnancy outcomes and evaluate their coagulation workup during pregnancy. METHODS: We conducted a population-based retrospective cohort study using the Alberta Pregnancy Birth Cohort from 2010 to 2018. We included women with von Willebrand disease (VWD) and haemophilia, identified by previously validated algorithm and matched…

Patterns and utility of myelin oligodendrocyte glycoprotein (MOG) antibody testing in cerebrospinal fluid.

BACKGROUND: Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is an idiopathic central nervous system (CNS) demyelinating disease gaining recognition with wider availability of cell-based assay (CBA) testing and recently published diagnostic criteria. However, uncertainty remains regarding the interpretation of antibody titers, particularly cerebrospinal fluid (CSF) MOG antibody titers. METHODS: All MOG IgG CBA results performed by the provincial MitogenDx laboratory in Alberta from July 2017 to July 2023 were retrieved. Chart review was performed in patients with …

Post liver transplantation delirium assessment using the CAM-ICU-7 scale: A cohort analysis.

BACKGROUND: We applied the Confusion Assessment Method (CAM)-Intensive Care Unit (ICU)-7 delirium scale to patients who underwent liver transplant (LT). METHODS: Retrospective cohort including patients who underwent LT for cirrhosis admitted to the ICU from June 2013 to June 2016 at the University of Alberta Hospital, Canada. Delirium was assessed using the CAM-ICU-7 scale (0-7 points) twice daily on days one and 3 post LT, with the highest score being considered. Primary endpoint was hospital mortality. RESULTS: Among all patients, 101/150 (67.3%) were men and mean age was 52.4 (SD 11.8) ye…