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Bone Health for Gynaecologists.

Osteoporosis, the most common bone disorder, profoundly impacts women's health, especially during postmenopausal phases. Characterised by diminished bone mineral density (BMD), it increases the risk of fractures, affecting mobility, quality of life, and potentially mortality. The present review analyses the intricate interactions among physiological alterations, diseases, and medications that lead to bone mineral density reduction in women. It underscores the importance of gynaecologists in the prevention, diagnosis, and management of osteoporosis via early risk assessment, suitable hormone tr

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… Calcium-rich foods encompass milk, cheese, and other dairy products; green leafy vegetables such as broccoli, cabbage, and okra, excluding spinach; soybeans; tofu; plant-based beverages (e.g., soy milk) fortified with calcium; almonds; bread and products produced with fortified flour; and fish. …

Структура и состав микробных сообществ в водной толще Южного залива Мексики и обнаружение предполагаемых микроорганизмов, деградирующих углеводороды.

В ходе этого исследования была проведена оценка сообщества бактериопланктонов и его связи с экологическими переменными, включая общую концентрацию нефтяных углеводородов (ТПГ), в районе шельфа Юкатан в Южном заливе Мексики. Анализ разнообразия бета на основе последовательности 16S rRNA показал различия в структуре общины бактериопланктона между участками отбора проб. ПЕРМАНОВА указала, что эти изменения могут быть связаны главным образом с глубокими изменениями (см.5 в адрес 180 m), концентрация растворенного кислорода (2.06 в адрес 5.93 мг L-1), и концентрация хлорофилла (0.184 в адрес 7.65 м

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… EXPERIMENTAL PROCEDURES Study site and environmental variables Surface and bottom water samples were collected between August 23 and September 10, 2016, from four transects (C, G, K, and O), including four sites per transect in a depth gradient (Table 1 ) respect to sea flour, during the GOMEX V oceanographic …

Management of Severe Acute Pancreatitis.

Sepsis‑induced abnormalities in brain function or sepsis‑associated encephalopathy (SAE) can manifest as cognitive dysfunction and other neuropsychiatric symptoms; however, the underlying mechanisms remain unclear. The aim of the present study was to elucidate the possible effects and mechanism of capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, on the pathological features of SAE. A model of SAE in C57BL/6 mice was generated using cecal ligation and puncture (CLP). Capsaicin (1 mg/kg) was injected subcutaneously before surgery. Cognitive function in mice was evaluated us

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… After washing with PBS, secondary antibody conjugated with Alexa Flour 488 (cat. no. A-11055; 1:500; Thermo Fisher Scientific, Inc.) was added for incubation for 2 h at room temperature. Slices were counterstained with DAPI (cat. no. …

Clinical Manifestations of Human Exposure to Fungi.

Biological particles, along with inorganic gaseous and particulate pollutants, constitute an ever-present component of the atmosphere and surfaces. Among these particles are fungal species colonizing almost all ecosystems, including the human body. Although inoffensive to most people, fungi can be responsible for several health problems, such as allergic fungal diseases and fungal infections. Worldwide fungal disease incidence is increasing, with new emerging fungal diseases appearing yearly. Reasons for this increase are the expansion of life expectancy, the number of immunocompromised patien

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… . | Pulping contaminated wood Malt worker’s lung | A. clavatus P. granulatum P. citrinum R. stolonifer | Handling moldy grain Wine grower’s lung | B. cinerea | Mold contamination Baker’s lung disease | A. fumigatus | Handling contaminated flour Cheese worker’s lung | P. roqueforti P. casei P. notatum … Baker’s lung disease is induced by inhaling A. fumigatus spores in workers from bakeries who handle flour (e.g., maize and oat) [ 109 ]. …

Effect of the BH3 Mimetic Polyphenol (-)-Gossypol (AT-101) on the in vitro and in vivo Growth of Malignant Mesothelioma.

Malignant mesothelioma (MM) is a primary tumor arising from mesothelial cells. The survival of MM patients following traditional chemotherapy is poor, thus innovative treatments for MM are needed. (-)-gossypol (AT-101) is a BH3 mimetic compound which possesses anti-tumoral activity by targeting multiple signaling transduction pathways. Several clinical trials employing AT-101 have been performed and some of them are still ongoing. Accordingly, we investigated the in vitro effects of AT-101 on cell proliferation, cell cycle regulation, pro-survival signaling pathways, apoptosis and autophagy of

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… known as 1,1′,6,6′,7,7′-hexahydroxy-5,5′-diisopropyl-3,3′-dimethyl (2,2′-binaphthalene)-8,8′-dicarboxaldehyde, is a natural polyphenolic aldehyde produced by a pigment of cotton ( Gossypium spp.) found in the seeds of plants and in cotton plant by-products, such as cottonseed oil and cottonseed meal flour …

Связанный с K27 ROR__t Уничтожение Nedd4 потенциалами Th17-посредованная автонепроницаемость.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Было продемонстрировано, что THCT E3 Ubriquitin ligase Nedd4 позитивно регулирует реакцию клеток Т, однако его роль в дифференциации клеток и автономном иммунитете Т неизвестна. Считается, что 17 клеток играют ключевую роль в развитии и патогенезе аутоиммунных заболеваний. Тем не менее, правила, регулирующие активацию РОРТ в ходе дифференциации клеток TH17 с помощью сигнала TCR, пока еще не уточнены. Эти неизведанные аспекты вдохновляют нас на изучение потенциальной роли Nedd4 в автоматическом иммунитете Th17.МЕТОДЫ: Мы провели оценку воздействия дефицита Nedd4 на развит

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… AlexaFlour® 700 anti-CD3 (557,943, BD Biosciences), PE-conjugated anti-CD4 (555,347, BD Biosciences) and PacificBlue-conjugated anti-CD45RO (304,216, BioLegend) followed by intracellular staining with anti-NEDD4 (H-135, sc-25508) and APC conjugated anti-RORγT (17–6988-82, eBioscience) followed by Alexa Flour …

Microorganisms Associated with the Marine Sponge Scopalina hapalia: A Reservoir of Bioactive Molecules to Slow Down the Aging Process.

Aging research aims at developing therapies that delay normal aging processes and some related pathologies. Recently, many compounds and extracts from natural products have been shown to slow aging and/or extend lifespan. Marine sponges and their associated microorganisms have been found to produce a wide variety of bioactive secondary metabolites; however, those from the Southwest of the Indian Ocean are much less studied, especially regarding anti-aging activities. In this study, the microbial diversity of the marine sponge Scopalina hapalia was investigated by metagenomic analysis. Twenty-s

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… France) 20 g, yeast extract 1 g, sea salts 30 g), Potato Dextrose Broth (PDB) (BD Difco TM , Le Pont de Claix, France), R2A (Fisher Scientific, Waltham, MA, USA), SCAM (maize starch (Fisher Chemical, Loughborough, UK) 10 g, casein (VWR Chemicals, Leuven, Belgium) 1 g, sea salts 30 g), SFM (soybean flour …

Antioxidant Intake and Antitumor Therapy: Toward Nutritional Recommendations for Optimal Results.

The role of the induction of oxidative stress as the mechanism of action of many antitumor drugs is acquiring an increasing interest. In such cases, the antitumor therapy success may be conditioned by the antioxidants present in our own body, which can be synthesized de novo (endogenous) or incorporated through the diet and nutritional supplements (exogenous). In this paper, we have reviewed different aspects of antioxidants, including their classification, natural sources, importance in diet, consumption of nutritional supplements, and the impact of antioxidants on health. Moreover, we have f

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… Anti-inflammatory and antioxidant activities, functional properties and mutagenicity studies of protein and protein hydrolysate obtained from Prosopis alba seed flour. Food Chemistry. 2014;161:391–399. doi: 10.1016/j.foodchem.2014.04.003. 43. Oliveira C. F., Coletto D., Correa A. P. F., et al. …

Targeting neuroinflammation: 3-monothiopomalidomide a new drug candidate to mitigate traumatic brain injury and neurodegeneration.

BACKGROUND: Traumatic Brain Injury (TBI) is a major risk factor for neurodegenerative disorders such as Parkinson's disease (PD) and Alzheimer's disease (AD), with neuroinflammation playing a critical role in the secondary cell death that exacerbates the initial injury. While targeting neuroinflammation holds significant therapeutic promise, clinical trials of available anti-inflammatory agents have fallen short. 3-Mono-thiopomalidomide (3-MP), a novel immunomodulatory imide drug (IMiD), was designed to curb inflammation without the adverse effects of traditional IMiDs and was evaluated across

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… After washing, the sections were treated with secondary antibodies (conjugated with Alexa Flour 488 or 555) for 3 h at room temperature. Subsequently, the sections were washed, mounted with Antifade Mounting Medium with DAPI (Vector Laboratories), and cover-slipped. …

Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases.

Bone serves to maintain the shape of the human body due to its hard and solid nature. A loss or weakening of bone tissues, such as in case of traumatic injury, diseases (e.g., osteosarcoma), or old age, adversely affects the individuals quality of life. Although bone has the innate ability to remodel and regenerate in case of small damage or a crack, a loss of a large volume of bone in case of a traumatic injury requires the restoration of bone function by adopting different biophysical approaches and chemotherapies as well as a surgical reconstruction. Compared to the biophysical and chemothe

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… In another study, Nogi et al. (2009) studied the fabrication of wood flour-derived nanocellulose-based transparent paper and found a high modulus (13 GPa) and strength (223 MPa) and minimal thermal expansion (8.5 ppm K 1 ) of the optically transparent nanocellulose paper. …

Antibiotic-Free Gene Vectors: A 25-Year Journey to Clinical Trials.

Until very recently, the major use, for gene therapy, specifically of linear or circular DNA, such as plasmids, was as ancillary products for viral vectors' production or as a genetic template for mRNA production. Thanks to targeted and more efficient physical or chemical delivery techniques and to the refinement of their structure, non-viral plasmid DNA are now under intensive consideration as pharmaceutical drugs. Plasmids traditionally carry an antibiotic resistance gene for providing the selection pressure necessary for maintenance in a bacterial host. Nearly a dozen different antibiotic-f

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… Its name is derived from the species from which it was isolated, the red flour beetle T ribolium c astaneum [ 140 ]. …

Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications.

Curcumin, a yellow polyphenolic pigment from the Curcuma longa L. (turmeric) rhizome, has been used for centuries for culinary and food coloring purposes, and as an ingredient for various medicinal preparations, widely used in Ayurveda and Chinese medicine. In recent decades, their biological activities have been extensively studied. Thus, this review aims to offer an in-depth discussion of curcumin applications for food and biotechnological industries, and on health promotion and disease prevention, with particular emphasis on its antioxidant, anti-inflammatory, neuroprotective, anticancer, h

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… Laokuldilok et al. (2016) investigated the masking properties of turmeric combined with a binary mixture of wall material, i.e. brown rice flour (BRF) and beta-cyclodextrin (b-CD). …

Polyphenols as Antitumor Agents Targeting Key Players in Cancer-Driving Signaling Pathways.

Polyphenols constitute an important group of natural products that are traditionally associated with a wide range of bioactivities. These are usually found in low concentrations in natural products and are now available in nutraceuticals or dietary supplements. A group of polyphenols that include apigenin, quercetin, curcumin, resveratrol, EGCG, and kaempferol have been shown to regulate signaling pathways that are central for cancer development, progression, and metastasis. Here, we describe novel mechanistic insights on the effect of this group of polyphenols on key elements of the signaling

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… Isoflavones represent the most abundant flavonoids in soybeans, in soy-derived products (tofu, soymilk, soybean flour) ( Jung et al., 2000 ; Preedy, 2013 ; Terahara, 2015 ), and in green and mung beans. …

Impact of physical exercise in cancer survivors during and after antineoplastic treatments.

Cancer patients experience symptoms and adverse effects of treatments that may last even after the end of treatments. Exercise is a safe, non-pharmacological and cost-effective therapy that can provide several health benefits in cancer patient and survivors, reducing cancer symptoms and cancer treatment side effects. The purpose of this review is to describe how the physical exercise is capable to reduce cancer symptoms and cancer treatment side effects. We realized a pragmatic classification of symptoms, dividing them into physical, psychological and psycho-physical aspects. For each symptom

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… Weight gain and increase of fat mass can be controlled by following a diet (that has to prefer fruits, vegetables, and whole grains and to limit fat, sugar, and refined flour) and by exercise (see next paragraph). …

63rd Annual Conference of the Indian Society of Gastroenterology, ISGCON 2022-January 5th - 8th, 2023 in Jaipur.

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… the gastroenteritis caused by basic slag poisoning. c. sulfate the main component of plaster of Paris; also used as a dietary source of calcium and inorganic sulfate sulfur. c. sulfide, c. polysulfide see lime-sulfur . c. supplements include calcium carbonate, gluconate, lactate and phosphate; bone flour …

Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation.

Cancer is one of the main causes of death globally and considered as a major challenge for the public health system. The high toxicity and the lack of selectivity of conventional anticancer therapies make the search for alternative treatments a priority. In this review, we describe the main plant-derived natural products used as anticancer agents. Natural sources, extraction methods, anticancer mechanisms, clinical studies, and pharmaceutical formulation are discussed in this review. Studies covered by this review should provide a solid foundation for researchers and physicians to enhance basi

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61st Annual Conference of Indian Society of Gastroenterology, Virtual Diamond Jubilee ISGCON 2020, 19-20th December 2020.

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62nd Annual Conference of the Indian Society of Gastroenterology, February 10th - 13th, 2022, Pune.

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