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Beyond Joint Hypermobility: Investigating Bladder Dysfunction in Hypermobile Ehlers-Danlos Syndrome.

INTRODUCTION AND OBJECTIVES: Hypermobile Ehlers-Danlos Syndrome (hEDS) is the most common subtype of Ehlers-Danlos Syndrome, a group of conn … n 14.8% (n = 4), frequent urinary tract infections in 25.9% (n = 7), bladder pain in 33.3% (n = 9), nocturia in 48.1% (n = 13), and weak stream in 51.8% (n = 14) of patients. UDS findings revealed no evidence of detrusor overactivity, stress urinary incontinence, or abnormalities in compliance. 1 patient had incomplete emptying with a pre-study post-void r …

The Real Impact of De Novo Bladder Dysfunction After Transvaginal Tension-Free Vaginal Tape-Obturator (TVT-O): A Prospective Study.

Introduction: Transobturator midurethral slings (MUSs) are commonly used to treat female stress urinary incontinence (SUI). Despite their hi … was 0 in 80.9% of patients. De novo urgency was reported in 44% of patients. Urge incontinence and nocturia occurred, respectively, in 33% and 8% of patients. Patient-reported voiding symptoms, defined as LS ≥1, were observed in 58.4% of patients. Among patients with LS ≥1, 38/52 (73.1%) reported tolerable bother (VAS < 5), whereas 14/52 (26.9%) reported …

Low-Grade Papillary Urothelial Carcinoma of the Bladder Presenting as Persistent Genital Arousal Disorder/Genito-Pelvic Dysesthesia: A Case Report.

UNLABELLED: Persistent genital arousal disorder/genito-pelvic dysesthesia (PGAD/GPD) is a rare and distressing condition characterized by un … uring masturbation. She also noted dysuria, urinary frequency, urgency, intermittent hematuria, and nocturia two to three times per night, pelvic floor hypertonicity, and restless legs. She denied any smoking history but did report a history of occasional resin exposure while making jewelry as a hobby. She underwent a bladder ultrasound that revealed a 7 × …

Машинное прогнозирование качества сна у пациентов с множественным склерозом.

Предыстория/задачи: нарушения сна являются распространенными, но часто недооцениваются при множественном склерозе (МС), независимо предсказывая снижение качества жизни и усиливая усталость, когнитивное расстройство и депрессию. В то время как боль, ноктура, усталость и симптомы настроения являются известными причинами, кардиометаболические и подстрекательские факторы остаются в основном неизученными, несмотря на их известные связи с плохим сном в других группах населения. В этом исследовании используется интерпретируемое машинное обучение для определения относительного вклада связанных с болез

Совпадение в аннотации оригинала
Background/Objectives: Sleep disturbances are common but frequently underrecognized in multiple sclerosis (MS), independently predicting reduced quality of life and worsening fatigue, cognitive impairment, and depression. While pain, nocturia, fatigue, and mood symptoms are established contributors, cardiometabolic, and inflammatory factors remain largely un…

Longitudinal Evaluation of Lower Urinary Tract Symptoms up to Six Months after COVID-19 Infection in a Jordanian Cohort.

BACKGROUND: Aortic Lower Urinary Tract Symptoms (LUTS) refer to a range of urinary symptoms affecting both men and women. These symptoms include increased frequency of urination, urgency, weak urine flow, incomplete emptying of the bladder, and nocturia. OBJECTIVE: LUTS encompass various urinary issues, with emerging evidence suggesting a potential connection to COVID-19. This study aimed to evaluate the occurrence and long-term effects of COVID-19 on LUTS and IPSS across different infection severities. METHODS: The prospective observational study enrolled 85 COVID-19 patients. IPSS was used…

Predictors of treatment failure with parasacral transcutaneous electrical nerve stimulation in children and adolescents with bladder and bowel dysfunction.

INTRODUCTION: Parasacral Transcutaneous Electrical Nerve Stimulation (parasacral TENS) has emerged as a promising treatment for children wit … me IV criteria. Potential predictive clinical factors evaluated included age, daytime incontinence, nocturia, history of urinary tract infection (UTI), enuresis, pre-treatment DVSS scores, frequency, Rome IV sum, and fecal incontinence. RESULTS: Fifty-two patients were included in the study. The mean age (± standard deviation) was 7.8 ± 2.7 years, with a …

Association between enlarged genital hiatus and prolapse with overactive bladder 1 year after vaginal delivery.

BACKGROUND: Genital hiatus enlargement is associated with pelvic organ prolapse and overactive bladder 5 to 10 years after first delivery. I … tpartum. We defined overactive bladder as the presence of urinary urgency plus urinary frequency or nocturia, or urgency incontinence on the Epidemiology of Prolapse and Incontinence Questionnaire. Enlarged genital hiatus was defined as ≥4 cm, and anatomic pelvic organ prolapse was defined as vaginal descent at or beyond the hymen. We evaluated association …

[Botkin classification of urinary incontinence in men: MI-CRONS].

AIM: To develop a new practical classification of urinary incontinence (UI) in men based on clinical features and disease severity. MATERIALS AND METHODS: The Botkin classification MI-CRONS is a system based on clinical features of patients and the degree of UI. Clinical assessment of the degree of UI is based on urination frequency, the ratio of spontaneous and involuntary urine output, the use of absorbent underwear, the level of physical efforts causing urine loss, and nocturia. The system uses five capital Russian or Latin letters: MI (Male Incontinentce) - C (cancer), R (radiation), O (o…

Combined healthy lifestyles and overactive bladder: a cross-sectional study of NHANES 2007-2020.

OBJECTIVES: The relationship between adherence to a combined healthy lifestyle and the risk of overactive bladder (OAB) remains unclear. Thi … d optimal waist circumference. OAB was defined using self-reported urinary urgency incontinence and nocturia symptoms. Weighted multivariable logistic regression models were employed to assess the association between the healthy lifestyle score and risk of OAB, adjusting for demographic, socioeconomic, and clinical covariates. RESULTS: Among the 20,195 pa …

ASSESSMENT OF THE RELATIONSHIP BETWEEN OVERACTIVE BLADDER AND FUNCTIONAL CONSTIPATION, IN QASSIM REGION, SAUDI ARABIA.

INTRODUCTION: Urinary urgency that is abrupt and uncontrollable, sometimes accompanied by increased frequency of voiding during the day and nocturia, is a set of symptoms known as an overactive bladder (OAB). An increasing number of people are concerned about the health effects of overactive bladder and symptoms of functional constipation, such as straining and painful, irregular bowl movements. METHODS: A sample of 556 members of the general population of the Qassim region of Saudi Arabia were used in this randomized descriptive cross-sectional survey study. Online surveys were filled out by…

Utilizing Bladder Diaries to Prevent Unnecessary Treatment in Patients With Storage Dysfunction: A Retrospective Study.

Introduction A frequency volume chart (FVC) or bladder diary (BD) is used to diagnose lower urinary tract symptoms and to determine the effe … nd nighttime frequency and number of leaks recorded in their BD, and there were fewer patients with nocturia and habitual caffeine consumption. Baseline OABSS and ICIQ-UI SF scores were lower and there were no significant changes in storage symptoms after BD recording. The cut-off value for the baseline total score of OABSS that did not desire treatment fo …

Identification of Molecular Mechanisms in Radiation Cystitis: Insights from RNA Sequencing.

Pelvic cancer survivors who were treated with radiation therapy are at risk for developing (hemorrhagic) radiation cystitis (RC) many years after completion of radiation therapy. Patients with RC suffer from lower urinary tract symptoms, including frequency, nocturia, pelvic pain, and incontinence. In advanced stages, hematuria can occur, potentially escalating to life-threatening levels. Current therapeutic options for RC are limited, partly due to ethical concerns regarding bladder biopsy in patients with fragile bladder tissue. This study aimed to leverage our established preclinical model …

How can we reduce maternal mortality due to preeclampsia? The 4P rule.

OBJECTIVE: To prospectively evaluate the effects of transcutaneous tibial nerve electrical stimulation (TTNS) on urinary symptoms and qualit … isodes (13.32 to 0.97; 1.35 at follow-up), urge incontinence (9.19 to 0.26; 0.58 at follow-up), and nocturia (2.99 to 0.40; 0.64 at follow-up) (all p < 0.001). Significant improvements were observed across all KHQ domains, including general health perception (58.06 ± 24.48 to 30.65 ± 22.09), incontinence impact (60.22 ± 24.97 to 11.83 ± 22.02), physical an …

Patient-Reported Outcomes 12 Years after Localized Prostate Cancer Treatment.

BACKGROUND: Long-term patient-reported outcomes are needed to inform treatment decisions for localized prostate cancer. METHODS: Patient-rep … e monitoring and 27% in the radiotherapy groups; all converged to low levels of potency by year 12. Nocturia (voiding at least twice per night) occurred in 34% in the prostatectomy group compared with 48% in the radiotherapy group and 47% in the active monitoring group at 12 years. Fecal leakage affected 12% in the radiotherapy group compared with 6% in th …

Impact of Weight Gain on Surgical Outcomes and Quality of Life among Women after Sling Surgeries.

STUDY OBJECTIVE: To investigate the impact of body weight gain after sling surgeries on outcomes in women with stress urinary incontinence. … udies. De novo overactive bladder (OAB) was defined as the appearance of urgency, frequency, and/or nocturia, with or without urinary incontinence after midurethral sling surgery persisting after 6 months. Quality of life evaluations included the short forms of the Urogenital Distress Inventory-6 and Incontinence Impact Questionnaire-7. A total of 248 wome …

Stimulation of the Tibial nerve Repetitively to Improve Incontinence in Parkinson's Electronically (STRIPE trial): a randomised control trial of tibial nerve stimulation for bladder symptoms in Parkinson's disease using a self-contained wearable device.

BACKGROUND: Bladder symptoms are common in Parkinson's disease (PD), affecting half of all individuals. These have significant impact on qua … ondary outcomes will include pre- and post-intervention bladder diary (frequency, urgency episodes, nocturia), patient perception of global change, bowel function and bladder-related quality of life. Participants will be recruited from the Proactive Integrated Management and Empowerment (PRIME) cross-sectional trial in which participants have been screened …

Percutaneous posterior tibial nerve stimulation (PTNS) for lower urinary tract symptoms (LUTSs) treatment in patients with multiple sclerosis (MS): A systematic review and meta-analysis.

BACKGROUND: Lower urinary tract symptoms (LUTSs) are common in patients with multiple sclerosis (MS). Percutaneous posterior tibial nerve st … me (post-treatment - pre-treatment) was 1.21 (95% CI:0.94-1.49) (I2:0%, p = 0.4). The pooled SMD of nocturia (post-treatment - pre-treatment) was -1.10 (95% CI:-1.33, -0.87) (I2:86.4%, p<0.001). The pooled SMD of leakage per day (post-treatment - pre-treatment) was -0.69 (95% CI:-0.93, -0.45) (I2:84.3%, p<0.001). The pooled frequency of responders was 66%( …

Photodynamic Diagnosis-Assisted En Bloc Transurethral Resection of Bladder Tumor for Nonmuscle Invasive Bladder Cancer: Short-Term Oncologic and Functional Outcomes.

Background: We describe the oncologic and functional outcomes and the surgical technique of the photodynamic diagnosis (PDD)-assisted en blo … roup had Ta low-grade recurrent tumors (8 months). Postoperatively, scores of daytime frequency and nocturia were increased in both groups. QoL assessment using the FACT-BL and SF-8 revealed that postoperative deterioration of bladder-specific subscale and emotional/mental scores was found in the EBTUR group but not in the cTURBT group. Conclusions: Based …

Exogenous intoxication by non-prescribed use of vitamin D, a case report.

BACKGROUND: This case report, unlike the current literature related to vitamin D intoxication, aims to highlight the risk of self-medication … ia, weight loss of 18 kg in the same period, severe pruritus, musculoskeletal pain in the limbs and nocturia. The physical examination showed hypertension (160/80 mmHg) and itchy macules in the lower limb. Initially, the main diagnostic hypotheses were multiple myeloma, hyperparathyroidism and pancreatitis secondary to hypercalcemia, osteolytic neoplasms a …

Late Side Effects After Image Guided Intensity Modulated Radiation Therapy Compared to 3D-Conformal Radiation Therapy for Prostate Cancer: Results From 2 Prospective Cohorts.

PURPOSE: Technical developments in the field of external beam radiation therapy (RT) enabled the clinical introduction of image guided inten … t, rectal incontinence, proctitis, and genitourinary (GU) obstruction, increased urinary frequency, nocturia, urinary incontinence, and dysuria. The Cox proportional hazards regression model was used to compare grade ≥2 toxicities between both techniques, adjusting for other modifying factors. RESULTS: The 5-year cumulative incidence of grade ≥2 GI toxici …