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Lipodystrophy and adipose tissue recovery are mediated by the Wnt/lipogenesis axis during skin fibrosis.

Acquired lipodystrophy in the dermal white adipose tissue (DWAT) is an early phenotype of skin fibrosis, followed by the accumulation of extracellular matrix (ECM). Lipodystrophy syndromes are estimated to affect 1 in 20,000 people and are associated with metabolic comorbidities. Recently, we showed that fibrosis-associated lipodystrophy depended on sustained Wnt signaling, although the mechanism remains unclear. Transcriptomic profiling of mature dermal adipocytes in vivo revealed that Wnt activation downregulated the de novo lipogenesis (DNL) axis enzymes within 48 h. We further found that e…

Altered Lipolytic Protein Expression in Tumor-Associated Adipose Tissue Correlates with Aggressive Breast Cancer Features.

BACKGROUND: Adipose tissue (AT) has emerged as a metabolically active component of the breast tumor microenvironment that contributes to breast cancer (BC) progression. Adipocytes release adipokines and lipids that influence tumor growth; however, the specific lipolytic proteins involved in these interactions remain poorly characterized. METHODS: In this study, we analyzed the expression of perilipin 1, adipose triglyceride lipase (ATGL), and hormone-sensitive lipase (HSL) by Western blot and immunofluorescence in adipose tissue explants from BC patients and healthy donors, evaluating their a…

FNDC4 and FNDC5 Attenuate SARS-CoV-2 S1-Induced Inflammatory Responses in Human Adipose Tissue.

BACKGROUND: Adipose tissue is recognised as a SARS-CoV-2 reservoir and potential infection site. We herein characterised SARS-CoV-2 entry points in visceral (VAT) and subcutaneous (SAT) adipose tissue from people with obesity and determined whether the adipo-myokines FNDC4 and FNDC5 modulate SARS-CoV-2 spike glycoprotein subunit 1 (S1)-induced inflammation in adipocytes and macrophages. METHODS: Plasma concentrations of FNDC4, FNDC5 and angiotensin-converting enzyme 2 (ACE2) were measured in 183 participants with obesity and normal weight. Expression of SARS-CoV-2 host cell entry receptors wa…

High-fat overfeeding is associated with tissue-specific liver-adipose immunometabolic remodeling in rainbow trout.

The excessive accumulation of visceral adipose tissue is associated with ectopic lipid deposition, impairing the function of major metabolic organs, including the liver, and contributing to systemic inflammatory responses. In aquaculture, farmed fish have limited capacity to autonomously regulate feed intake, as caloric intake is largely determined by feeding practices, predisposing them to excessive energy consumption and metabolic imbalance. This study investigated how excessive feeding affects metabolic and immune responses in the liver and adipose tissue of rainbow trout and whether these …

Chronic binge alcohol dysregulates omental adipose tissue extracellular matrix in simian immunodeficiency virus-infected macaques.

BACKGROUND: Increased survival, prolonged antiretroviral treatment (ART), and lifestyle choices, including alcohol misuse, increase the risk for comorbid conditions, including cardiometabolic comorbidities among people with HIV (PWH). Published studies indicate that dysregulated adipose tissue phenotype, particularly of the visceral adipose depot, contributes to metabolic dysregulation. Using a nonhuman primate model of simian immunodeficiency virus (SIV) infection, we previously demonstrated that chronic binge alcohol (CBA) administration to ART-treated rhesus macaques decreases whole-body gl…

Subcutaneous adipose tissue radiodensity as a predictor of poor prognosis in advanced biliary tract cancer.

BACKGROUND: High subcutaneous adipose tissue radiodensity (SATr), an indirect surrogate marker of adipose tissue quality, was associated with poor prognosis in various cancers. The present study aimed to assess the association of SATr with survival outcomes in patients with advanced biliary tract cancer (BTC). METHODS: This retrospective, single-center study included patients with unresectable or recurrent BTC who underwent chemotherapy/chemoradiotherapy. Overall survival (OS) and progression-free survival (PFS) were assessed using the log-rank test and the Cox proportional hazards model acco…

Radiomic phenotype of epicardial adipose tissue derived from coronary artery calcium score predicts myocardial ischemia.

PURPOSE: To investigate the radiomic phenotype of epicardial adipose tissue (EAT) derived from coronary artery calcium score (CACS) and its predictive value for myocardial ischemia. MATERIALS AND METHODS: This retrospective study included patients with angina and intermediate-to-high pre-test probability of coronary artery disease who underwent CACS, dynamic CT myocardial perfusion imaging (CT-MPI) and coronary CT angiography (CCTA). All image acquisitions were performed with third generation dual source CT. Radiomic features of EAT derived from CACS were extracted. EAT volume, EAT density, C…

Visceral adipose tissue during pregnancy in women with overweight or obesity and offspring metabolic health.

BACKGROUND: Pre-pregnancy obesity is linked to an increased risk of adverse maternal and neonatal outcomes, and an increased likelihood of offspring obesity later in life. Accumulation of visceral adipose tissue (VAT) has been reported to be more detrimental to health outcomes than generalized obesity. Therefore, we investigated the association between maternal VAT and the metabolic health of offspring at birth. METHODS: This study was a secondary analysis of a dietary randomized controlled trial. Magnetic resonance imaging was performed in gestational weeks (GW) 15, 32, and at birth in a coh…

From bench to bedside: adipose tissue fibrosis in obesity, anti-diabetic therapies, and bariatric surgery.

This review provides a comprehensive examination of the recent research findings concerning the pathophysiology and clinical implications of adipose tissue fibrosis in obesity and metabolic diseases. Recent large-scale studies, including a longitudinal study spanning 24 years (Swedish Obese Subjects), have demonstrated that weight loss in obese patients is directly correlated with reduced metabolic complications and mortality. Nonetheless, instances of weight regain and subsequent loss of metabolic improvements have been observed in some patients, with adipose tissue dysfunction and fibrosis i…

Позвоните посредникам в Множественной миеломе: увязка ожирения с болезнями костей с помощью воспаленных путей.

У пациентов, у которых диагностирован множественный миелома (ММ), основные жалобы на момент диагностики часто связаны с костями, что существенно влияет на качество жизни и повышает заболеваемость и смертность. Ожирение ассоциируется с хроническим воспалительным состоянием, которое приводит к производству различных цитокинов и адипокинов, что может способствовать разрушению костей. Адипониктин, адипокин, в основном скрытый адипоцитами, значительно сокращается в обращении среди лиц с ожирением, что также наблюдается в MM. Это сокращение может привести к нарушению и без того скомпрометированной а

Совпадение в аннотации оригинала
In patients diagnosed with multiple myeloma (MM), the primary complaints at the time of diagnosis are often related to bone involvement, sig … ction may contribute to the disruption of an already compromised bone architecture. The increase in adipose tissue is associated with heightened leptin production, a key adipokine, which can play a significant role in the pathophysiology of MM and its related bone complications. Obesity is associated with hyperinsulinemia and increased levels of free IGF-1. In M …

Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ-producing lymphocytes.

Whereas visceral adipose tissue (VAT) primarily stores excess energy, brown adipose tissue (BAT) dissipates it in a process termed nonshivering thermogenesis. Several key VAT features, particularly murine epidydimal VAT, are regulated by a distinct population of regulatory T (Treg) cells, raising the question of whether BAT hosts an analogous population. Although Treg cells have been observed in BAT, their properties and mechanisms of action require elucidation. We found BAT Treg cells to be heterogeneous in subtissular localization and subtype composition. Punctual depletion of Treg cells unl…

Epicardial adipose tissue: an overtly concealed contributor to cardiovascular events in chronic kidney disease patients.

Epicardial adipose tissue, a metabolically active visceral fat depot surrounding the heart, is increasingly implicated as a key contributor to cardiovascular disease in patients with chronic kidney disease. This review explores how chronic kidney disease induced metabolic dysregulation, chronic inflammation and uremic toxin accumulation lead to epicardial adipose tissue dysfunction. Pathologically altered epicardial adipose tissue promotes atherosclerosis, myocardial fibrosis and arrhythmogenesis through paracrine signaling, oxidative stress and direct cellular interactions. Advanced imaging m…

Prognostic role of intramuscular adipose tissue content in patients with urothelial carcinoma treated with pembrolizumab.

BACKGROUND: Pembrolizumab is a standard treatment for previously treated advanced urothelial carcinoma (UC); however, individual differences in treatment responses remain a significant problem. This study aimed to evaluate the prognostic factors, particularly muscle mass, and quality, in patients with UC receiving pembrolizumab. METHODS: This retrospective study included 56 patients with UC treated with pembrolizumab between May 2017 and December 2024. The influence of neutrophil-to-lymphocyte ratio (NLR), albumin-bilirubin (ALBI) score, psoas major index, and intramuscular adipose tissue con…

Association of Systemic Inflammation with Inflammatory mRNA Expression in Visceral Adipose Tissue in Gestational Diabetes.

Background/Objectives: Gestational diabetes mellitus (GDM) is characterized by a systemic inflammatory response and the expression of inflammatory factors in visceral adipose tissue (VAT). However, the association between these two inflammatory processes has not been fully elucidated. Therefore, this study aimed to (1) investigate whether whole blood counts, the neutrophil-lymphocyte ratio (NLR), the monocyte-lymphocyte ratio (MLR), serum adiponectin levels, and the mRNA expression of inflammatory genes (TLR2, TLR4, pro-inflammatory cytokines: IL-1β, IL-6, and TNF-α, anti-inflammatory cytokine…

Creatinine promotes adipose tissue wasting in chronic kidney disease via creatine and futile creatine cycle.

OBJECTIVE: Cachexia in chronic kidney disease (CKD) is a wasting syndrome. The futile creatine cycle (FCC) contributes to energy waste in ad … erated creatinine (D-3 creatinine) were traced by mass spectrometer. To determine creatinine drives adipose tissue wasting in vivo, two mice models of CKD were established by unilateral ureteral obstruction or renal ischemia and reperfusion injury. 206 patients diagnosed CKD were collected to analyze correlationship between creatinine in serum and adiposity. RE …

Subcutaneous Adipose Tissue Radiation Attenuation Is Associated With Increased 1-Year Mortality in Polytrauma Patients.

BACKGROUND: Polytrauma patients with an Injury Severity Score (ISS) ≥ 16 have a high mortality rate. Early identification of patients at ris … ation attenuation (OR 1.053, 5.713, 3.711, 0. 563 and 0.533, respectively; p < 0.001), subcutaneous adipose tissue radiation attenuation (SATRA OR 1.253, p = 0.028) and visceral adipose tissue index (OR 1.242, p = 0.038) were significantly associated with 1-year mortality. In multivariable logistic regression, age, ISS and SATRA remained statistically significan …

Regenerative Potential of Adipose Tissue-Derived Exosomes in Treating Hair Shaft Abnormalities: A Case Report.

Hair shaft abnormalities, often linked to genetic or acquired conditions, present significant treatment challenges with limited and inconsistent therapeutic success. This report describes an eight-year-old female with severe hair shaft abnormality, unresponsive to standard treatments, including topical minoxidil and platelet-rich plasma therapy, who demonstrated marked improvement following a single session of adipose tissue (AT)-derived exosome therapy. The exosomes were administered via intradermal scalp injections, resulting in significant enhancement in hair structure, strength, and growth…

Autologous adipose tissue transfer in progressive hemifacial atrophy: From simple volume to regenerative cell therapy.

BACKGROUND: Progressive hemifacial atrophy (PHA), including en-coup-de-sabre morphea and Parry-Romberg syndrome, is a rare condition characterized by unilateral atrophy of facial tissues. The etiology of PHA remains unclear, though it is generally considered to be an autoimmune disease. Current treatment approaches typically involve systemic immunosuppression to stabilize the disease, followed by reconstructive surgery to restore facial symmetry, ranging from complex flap reconstruction to autologous fat transfer (AFT) and allogenic fillers. Recent evidence supports AFT not only as a volumetri

Predictive performance of the perivascular adipose tissue for endovascular recanalization of chronic carotid artery occlusion.

OBJECTIVES: The purpose of this study was to investigate the association between pericarotid fat (PCF) and the success of endovascular recanalization for chronic internal carotid artery occlusion (CICAO), and to establish a scoring system to predict the feasibility of the procedure. MATERIALS AND METHODS: Sixty-six patients (66 carotid arteries) with CICAO who underwent endovascular recanalization were retrospectively analyzed. Patients' clinical information, the density of PCF, digital subtraction angiography (DSA) characteristics, and procedural results were recorded. Factors related to tec