Результаты поиска

Biological characteristics of chronic eosinophilic leukemia cells with a t(2;5)(p23;q35) translocation.

We studied the biological features of eosinophils in a patient with chronic eosinophilic leukemia and a unique t(2:5)(p23;q35) translocation. Microscopic and cytochemical studies revealed no particular abnormalities, although more than 90% of the peripheral eosinophils had a density lighter than 1.080 g/ml. Clonogenic assay disclosed that myeloid progenitor cells possessed the translocation, although in vitro eosinophilopoiesis seemed normal, and there were also hematopoietic cells with a normal karyotype. In a surface marker study, EG1 was positive on 34.0% of the eosinophils, while EG2 posit

A Case of Noonan Syndrome and Kyrle's Disease: Coincidence or Causality?

A 39-year-old Caucasian woman affected by Noonan Syndrome (NS) mutated in RAF1 was referred to us with itchy lesions on her limbs that had a … onally recognized: reactive perforating collagenosis, elastosis perforans serpiginosum, perforating folliculitis, and KD (1). The typical skin manifestation of KD is an eruption of dome-shaped papules and nodules with a whitish central keratotic plug, mainly localized on the extremities and the buttocks. Described by Kyrle in 1916, KD is frequently associated …

A Case of Noonan Syndrome and Kyrle Disease: Casualty or Causality?

A 39-year-old Caucasian woman affected by Noonan Syndrome (NS) mutated in RAF1 was referred to us with itchy lesions on her limbs that had a … onally recognized: reactive perforating collagenosis, elastosis perforans serpiginosum, perforating folliculitis, and KD (1). The typical skin manifestation of KD is an eruption of dome-shaped papules and nodules, with a whitish central keratotic plug, mainly localized on the extremities and the buttocks. Described by Kyrle in 1916, KD is frequently associated …

Autoimmune Progesterone Dermatitis Diagnosed by Lymphocyte Transformation Test and Progesterone Provocation Test.

Autoimmune progesterone dermatitis (APD) is rare autoimmune response to endogenous progesterone or to earlier exposure to exogenous progeste … are skin lesions such as eczema, erythema multiforme, prurigo, stomatitis, papulopustular lesions, folliculitis, urticaria, angioedema, and rarely anaphylaxis (2) that develop 3-10 days before and subside 1-2 days after menses, with recurrent cyclic aggravation (1,3,4). Frequently, patients have a history of exogenous progesterone intake (1,5,6), as in our pa …

Natural language processing for abstraction of cancer treatment toxicities: accuracy versus human experts.

ObjectivesExpert abstraction of acute toxicities is critical in oncology research but is labor-intensive and variable. We assessed the accuracy of a natural language processing (NLP) pipeline to extract symptoms from clinical notes compared to physicians.Materials and methodsTwo independent reviewers identified present and negated National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) v5.0 symptoms from 100 randomly selected notes for on-treatment visits during radiation therapy with adjudication by a third reviewer. A NLP pipeline based on Apache clinical Text Analys

Совпадение в полном тексте источника
… NLP demonstrated good performance in identifying some symptoms that had previously demonstrated low human inter-rater reliability, including radiation dermatitis, fatigue, noninfectious cystitis, and folliculitis. Precision was also more limited for documentation of pain (0.36; F1 0.45). … Pain | 24 | 0.36 | 0.63 | 0.45 | 0.65 Nausea | 13 | 0.92 | 0.85 | 0.88 | 0.86 Pruritus | 11 | 0.91 | 0.91 | 0.91 | 0.67 Cystitis, noninfectious | 9 | 0.60 | 1.00 | 0.75 | 0.00 Diarrhea | 8 | 0.28 | 0.63 | 0.38 | 0.92 Mucositis | 8 | 0.83 | 0.63 | 0.71 | 0.62 Urinary urgency | 8 | NA | 0.00 | NA | 0.83 Folliculitis …

Chemotherapy-Mediated Complications of Wound Healing: An Understudied Side Effect.

Significance: Chemotherapy is a primary method to treat cancer. While chemotherapeutic drugs are designed to target rapidly dividing cancer cells, they can also affect other cell types. In the case of dermal cells and macrophages involved in wound healing, cytotoxicity often leads to the development of chronic wounds. The situation becomes even more severe when chemotherapy is combined with surgical tumor excision. Recent Advances: Despite its significant impact on patients' recovery from surgery, the issue of delayed wound healing in individuals undergoing chemotherapy remains inadequately ex

Совпадение в полном тексте источника
… Folliculitis is observed in 85% of patients receiving chemotherapy. 5 Dryness of the epidermis may manifest even a few weeks after the treatment. Excessive dryness brings about constant pain in the fingers and cracks in the skin, increasing the risk of bacterial infections. … MEK inhibitors are associated with an increased risk of inflammatory skin rash characterized by papulopustular eruptions and dermatitis acneiform. 7 A rash, or folliculitis, is a typical response to systemic treatment. …

Current epidemiology of atopic dermatitis in south-eastern Nigeria.

BACKGROUND: Atopic dermatitis (AD) is a common pruritic, eczematous skin disorder that runs a chronic and relapsing course. In Nigeria, it i … only as minor features. Infective complications were very common and included bacterial infections (folliculitis, impetiginized dermatitis and pyodermas) in 425 (41.7%) patients, fungal infections in 377 (37%) patients, parasitic infections (scabies) in 90 (8.8%) patients and viral infection (herpes simplex and molluscum contagiosum) in 29 (2.9%) patients. Thi …

Cancer-Related Alopecia Risk and Treatment.

Opinion statementCancer-related alopecia (CRA) presents a significant challenge for many patients undergoing cancer treatment, often affecting their psychological well-being and sense of identity. In my opinion, the optimal management of CRA requires a proactive, personalized approach that prioritizes both prevention and regrowth, while taking into account the type of cancer therapy, patient goals, and overall clinical context. For patients receiving chemotherapy, especially taxane- or anthracycline-based regimens, scalp cooling should be offered as a first-line preventative option whenever fe

Совпадение в полном тексте источника
… EGFR inhibitors are associated with a less than 10% incidence [ 28 – 30 ] of mild hair loss in an androgenetic [ 31 ], frontal [ 32 ], or diffuse [ 12 ] pattern, although cicatricial alopecia [ 33 ], folliculitis decalvans [ 34 ], and inflammatory nonscarring [ 35 ] and scarring alopecia have also been … Folliculitis decalvans associated with erlotinib. Clin Exp Dermatol. 2010;35(8):916–8. 10.1111/j.1365-2230.2010.03852.x. 35. Pongpudpunth M, Demierre MF, Goldberg LJ. A case report of inflammatory nonscarring alopecia associated with the epidermal growth factor receptor inhibitor erlotinib. …

Evaluating the Application of Nail Polish as an Ostomy Baseplate: A Comparative Analysis With Conventional Ostomy Pastes in the Market and a Clinical Trial.

BACKGROUND: Peristomal skin complications are prevalent among patients with ostomies and significantly impact their quality of life. Ostomy … e, none of the patients in the intervention or control group experienced rare complications such as folliculitis, candidiasis, contact dermatitis, or pyoderma gangrenosum. LIMITATIONS: Single institution. CONCLUSIONS: The utilization of nail polish as a baseplate reduces skin allergies, peristomal skin complications, and the time and financial resources spen …

Efficacy and safety of gluten peptide-based antigen-specific immunotherapy (Nexvax2) in adults with coeliac disease after bolus exposure to gluten (RESET CeD): an interim analysis of a terminated randomised, double-blind, placebo-controlled phase 2 study.

BACKGROUND: A gluten-free diet is insufficient to treat coeliac disease because intestinal injury persists and acute reactions with cytokine … with exacerbation of asthma and appendicitis, and one who had forehead abscess, conjunctivitis, and folliculitis) and one (1%) patient in the non-homozygous Nexvax2 group developed a pulmonary embolism. The most frequent adverse events in all 92 patients who received Nexvax2 compared with all 86 patients who received placebo were nausea (44 [48%] of 92 patient …

Eosinophilic Dermatosis of Hematological Malignancy.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… The clinical differential diagnosis includes arthropod bite, dermatitis herpetiformis, drug reaction, eosinophilic cellulitis, eosinophilic folliculitis, leukemia cutis, papular urticaria, scabies, and urticarial stage of bullous pemphigoid.[ 2 ] Atopic dermatitis may present as prurigo or prurigo-like …

Pyoderma gangrenosum у пациента с множественным склерозом при лечении в ходе родовспоможения: отчет по делу.

Пёдерма Гангреносум (PG) часто рассматривается в качестве иммунной болезни. До 50% случаев ПГ - редкое, неинфекционное воспалительное заболевание кожи, характеризующееся болезненными некротическими язвами, - связано с такими основополагающими системными заболеваниями, как ремуматуидный артрит (RA) и инфламматический болезень Боулинга (IDB), а также с моноклональной антителной терапией. Мы описали 38-летнюю пациентку с множественным склерозом (MS), которая три года лечилась от Натализумаба. Myalgia, лихорадка и эритимные доски, сопровождаемые болезненными повреждениями в обеих верхних конечност

Совпадение в полном тексте источника
… Additionally, Daclizumab may induce skin reactions, such as psoriasis, alopecia, pruritus, pityriasis roses, exfoliated dermatitis, seborrheic dermatitis, eczema, urticaria, contact dermatitis, folliculitis and erythema nodosum [ 31 ]. …

Skin manifestations associated with systemic diseases - Part II.

The skin, by reflecting internal processes, externalizes what happens inside the body in many diseases. Thus, the skin, as an organ, extrapolates its functions of protection, barrier and signals the existence of systemic diseases, expanding the importance of the dermatologist beyond the skin surface. Thus, the dermatologist investigates diagnostic hypotheses for conditions related to all systems and refers patients to the appropriate specialty. Combined with examination by a trained eye, the skin, due to its easy access, is still the ideal place for performing biopsies, which often clarify the

Совпадение в полном тексте источника
… Figure 3 Staphylococcus aureus can cause pyoderma (folliculitis, abscesses and impetigo). Streptococci are associated with ecthyma, cellulitis and contagious streptococcal impetigo (in this case, Streptococcus haemolyticus ). … Other acquired perforating dermatoses, such as perforating folliculitis and reactive perforating collagenosis may also occur ( Fig. 2 ). 13 Systemic nephrogenic fibrosis: it is a rare manifestation related to gadolinium contrast (gadodiamide and gadopentetate) used in MRI scans and associated with genetic …

Immune-Mediated Dermatoses in Patients with Haematological Malignancies: A Comprehensive Review.

Haematological malignancies induce important alterations of the immune system, which account for the high frequency of autoimmune complications observed in patients. Cutaneous immune-mediated diseases associated with haematological malignancies encompass a heterogeneous group of dermatoses, including, among others, neutrophilic and eosinophilic dermatoses, autoantibody-mediated skin diseases, vasculitis and granulomatous dermatoses. Some of these diseases, such as paraneoplastic pemphigus, are associated with an increased risk of death; others, such as eosinophilic dermatoses of haematological

Совпадение в полном тексте источника
… In Asian countries, a distinct presentation of EDHM includes “eosinophilic pustular folliculitis of HM”. … Eosinophilic pustular folliculitis associated with hematological disorders: a report of two cases and review of Japanese literature. J Dermatol. 2016;43:432–435. doi: 10.1111/1346-8138.13088. 116. Owen RL, Shah KK, Sosis AC, Purcell SM. …

Успешное лечение трифаротена типичной болезни Кирла с обзором тематической терапии.

Болезнь Кирла - это редкое кожное расстройство, связанное с диагностикой трансэпидермального кератина, обычно связанного с системными заболеваниями. Мы сообщаем об уникальном случае, когда здоровый 26-летний человек сопротивляется стандартной терапии. В течение восьми недель была достигнута ремиссия с ежедневным тематическим трифаротеном 0,005%. Это первый, о котором сообщалось, случай КД, успешно обработанный трифаротином, избирательным RAR-__ retinoid, ориентированным на дифференциацию кератиноцитов и воспаление. Его эффективность и безопасность дают возможность пациентам, не пригодным для с

Совпадение в полном тексте источника
… It is classified within the spectrum of acquired perforating dermatoses (APD), alongside entities such as perforating folliculitis and elastosis perforans serpiginosa. …

"Look Beyond the Skin": A case report about chronic pruritus.

A healthy 23-year-old female developed generalized pruritus over a year that began on her feet and gradually progressed to involve more than 50% of her entire body surface area. Punch skin biopsies were inconclusive, whereas a two-view chest x-ray was suspicious for lymphadenopathy. A chest computed tomography scan with contrast identified an anterior mediastinal mass which was biopsied and diagnosed as a nodular sclerosis type of Hodgkin's lymphoma. Subsequently, appropriate therapy was initiated resulting in complete resolution of the patient's chronic itch. This case underscores the clinica

Совпадение в полном тексте источника
… She was empirically treated for scabies, tinea pedis, staphylococcal folliculitis, allergic contact dermatitis, and prurigo nodularis without any considerable improvement. Several antihistamines, along with topical and systemic steroids, were trialed without benefit. …

Acute Liver Failure due to Disseminated Varicella Zoster Infection.

Acute liver failure (ALF) can be due to numerous causes and result in fatality or necessitate liver transplantation if left untreated. Possible etiologies of ALF include ischemia, venous obstruction, medications, toxins, autoimmune hepatitis, metabolic and infectious causes including hepatitis A-E, varicella-zoster virus (VZV), cytomegalovirus (CMV), herpes simplex virus (HSV), Epstein-Barr virus (EBV), and adenovirus with VZV being the most rarely reported. Pathognomonic skin lesions facilitate diagnosis of VZV hepatitis, but definitive diagnosis is secured with liver biopsy, tissue histopath

Совпадение в полном тексте источника
… She was diagnosed with pancreatitis, thrush, and folliculitis and was discharged home with clear liquid diet orders and prescriptions for nystatin oral solution and oral doxycycline for possible secondary skin infection. …

Adult onset atopic dermatitis with secondary follicular mucinosis with cyclosporine induced spiny follicular hyperkeratosis and hair casts.

Secondary follicular mucinosis developing in adult patient with atopic dermatitis (AD) was observed on histology. Due to severity of disease, patient was started on oral cyclosporine 300 mg daily in 3 divided doses. Two weeks later patient started developing multiple spiny follicular keratoses mainly on face but also on extremities and trunk along with hair casts on scalp. Repeat biopsy from such keratotic lesions confirmed diagnosis spiny follicular hyperkeratosis (SFH). On investigations no evidence of multiple myeloma or any other malignancy was found. Cyclosporine was stopped and lesions c

Совпадение в полном тексте источника
… numerous conditions including lymphomas like mycosis fungoides, Hodgkin's disease, cutaneous B-cell lymphoma, syringolymphoid hyperplasia with cutaneous T cell lymphoma, inflammatory conditions like chronic discoid lupus erythematosus, alopecia areata, angiolymphoid hyperplasia, eosinophilic pustular folliculitis …

Клинические и гистологические модели и лечение пёдермы гангреносума.

Pyoderma gangrenosum (PG) является редким воспрещающим нейтрофильным дерматозом, в отношении которого точные эпидемиологические данные ограничены, а лечение по-прежнему является сложной задачей. Основная цель исследования состояла в том, чтобы изучить все случаи, когда в нашем департаменте было замечено, что 6-year - период для описания соответствующих характеристик и результатов лечения. Fourteen (Включены пациенты)5 женщины, 9 Мужчины). Средний возраст наших пациентов был 40,15 Годы. Классическая, язвительная форма была найдена в 10 в случаях71.42%), пастулярная форма в 4 в случаях27.57%) и

Совпадение в полном тексте источника
… The initial lesions show a deep suppurative folliculitis with dense neutrophilic infiltrate. In about 40% of cases, leukocytoclastic vasculitis is present as was in four of our cases. PG with (necrotizing) granulomatous inflammation has been described [ 15 - 17 ]. …

Efficacy and safety of reduced-dose daratumumab plus bortezomib and dexamethasone (DVd-lite) in newly diagnosed MGRS patients.

BackgroundClone-directed therapy is essential for managing monoclonal gammopathy of renal significance (MGRS), as it reduces the nephrotoxic monoclonal protein burden and preserves renal function. However, due to the rarity and frequent misdiagnosis of MGRS, there is no evidence-based standard first-line treatment for MGRS.MethodsThis open-label, single-arm, prospective clinical trial assessed the efficacy and safety of the combination of reduced-dose daratumumab (Dara), bortezomib, and dexamethasone (DVd-lite) in ten newly diagnosed MGRS patients. The treatment protocol consisted of six cycle

Совпадение в полном тексте источника
… frequency (%) Infusion reaction | 7 (70%) Peripheral neuropathy | 4 (40%) Constipation | 3 (30%) Upper respiratory infection | 2 (20%) Herpes zoster | 2 (20%) abdominal distension | 1 (10%) Diarrhea | 1 (10%) Bronchospasm caused by an allergy | 1 (10%) Pustular rash | 1 (10%) Muscle pain | 1 (10%) Facial folliculitis …