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Access to Chimeric Antigen Receptor T Cell Therapy for Diffuse Large B Cell Lymphoma.

IntroductionGeographic access to novel oncology therapies, and the extent to which it may vary by potential sites of care, regions, and population characteristics, is poorly understood. We examined how expanding access to chimeric antigen receptor (CAR) T cell therapy administration sites impacts patient travel distances and time.MethodsWe used geographic information system techniques to calculate shortest travel distance and time between patients with relapsed/refractory diffuse large B cell lymphoma (DLBCL) and the nearest CAR T cell therapy administration site in three scenarios: academic h

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… We used geographic information system techniques for this analysis. This article does not contain any new studies with human participants or animals performed by any of the authors. … By developing a detailed geographic information systems database of NHL incidence combined with a specific site of care, we estimated more precise measures of access to novel oncology therapies than those previously described [ 31 – 33 ]. …

Leptospirosis Outbreak After the 2014 Major Flooding Event in Kelantan, Malaysia: A Spatial-Temporal Analysis.

Severe floods increase the risk of leptospirosis outbreaks in endemic areas. This study determines the spatial-temporal distribution of leptospirosis in relation to environmental factors after a major flooding event in Kelantan, Malaysia. We conducted an observational ecological study involving incident leptospirosis cases, from the 3 months before, during, and three months after flood, in reference to the severe 2014 Kelantan flooding event. Geographical information system was used to determine the spatial distribution while climatic factors that influenced the cases were also analyzed. A tot

IMU-Driven Dynamic Spine Model Based on Kinematics and CT for Home-Based PSSE of Idiopathic Scoliosis.

Idiopathic scoliosis (IS) is a prevalent spinal deformity that impairs posture and psychosocial health. Physiotherapeutic scoliosis-specific exercise (PSSE) is an effective conservative treatment that needs long-term and regular training. However, academic demands, geographic barriers, and time constraints limit frequent clinic visits, making home-based PSSE the mainstay of care. Also, the lack of supervision makes correct execution and sustained adherence difficult, posing a major challenge in spinal rehabilitation. To address this issue, we innovatively equate the spine as an open-chain spat

Epidemiology of Infectious Pathogens in Horses with Acute Respiratory Disease, Abortion, and Neurological Signs: Insights Gained from the Veterinary Surveillance System for Horses in The Netherlands (SEIN).

Monitoring infectious diseases is essential for safeguarding equine health and ensuring the sustainability of the horse industry. In 2019, the Royal Veterinary Association of the Netherlands (KNMvD) and Royal GD (GD Animal Health) launched SEIN (Surveillance of Equine Infectious diseases in the Netherlands), a voluntary surveillance system for laboratory-confirmed outbreaks of equid alphaherpesvirus 1 (EHV-1), equid alphaherpesvirus 4 (EHV-4), equine influenza virus (EIV), and Streptococcus equi subsp. equi. This retrospective study analyzed 364 confirmed outbreaks reported through SEIN betwee

An examination of housing interventions among youth experiencing homelessness: an investigation into racial/ethnic and sexual minority status.

OBJECTIVES: The purpose of this study is to explore main and interaction effects of minority and multiple minority statuses on exits from homelessness and the stability of homelessness exits overtime. METHODS: This study utilized the Homeless Management Information System administrative data of 10 922 youth experiencing homelessness collected from a convenience sample of 16 geographically diverse communities across the USA between 2015-17. Using multinomial logistic regression analyses and logistic regression, main effects and interaction effects of racial/ethnic minority identity and sexual/

Surveillance for cancers associated with tobacco use--United States, 1999-2004.

PROBLEM/CONDITION: Tobacco use is the leading preventable cause of disease and premature death in the United States. The 2004 Surgeon General report found convincing evidence for a direct causal relationship between tobacco use and the following cancers: lung and bronchial, laryngeal, oral cavity and pharyngeal, esophageal, stomach, pancreatic, kidney and renal pelvis, urinary bladder, and cervical cancers and acute myelogenous leukemia (AML). This report provides state-level cancer incidence data and recent trends for cancers associated with tobacco use. Because information on tobacco use was

Health-seeking behaviour in adults with musculoskeletal conditions: A scoping review.

BACKGROUND: Musculoskeletal conditions, such as osteoarthritis and low back pain, are among the leading causes of disability worldwide. Individuals often delay or avoid seeking healthcare due to personal, social, and systemic factors. Existing research on health-seeking behaviour is fragmented and lacks synthesis across diverse contexts and populations. OBJECTIVE: This scoping review systematically maps the literature on health-seeking behaviour in adults with musculoskeletal conditions, highlighting knowledge gaps and generating insights for future research, clinical practice, and policy. M

Strengthening health systems through NTD integration: Key insights from a multi-country webinar.

The integration of Neglected Tropical Disease (NTD) control and elimination into national health systems is a strategic imperative, driven by shifting global health priorities and evolving funding landscapes. A webinar hosted by the Global Onchocerciasis Network for Elimination (GONE) taken place on 8 July 2025 synthesizes nine country experiences demonstrating innovative models for embedding NTD interventions within established platforms, ranging from integrating mass drug administration (MDA) into maternal and child health weeks in Rwanda to leveraging national polio vaccination campaigns in

"FBT Is for the Rich": A Qualitative Study Examining Clinicians' Experiences and Perceptions of Treatment Access and Engagement for Diverse Families in Family-Based Treatment.

OBJECTIVE: Family-based treatment (FBT) is the leading evidence-based treatment for adolescent eating disorders, but research exploring access and engagement in FBT is sparse. This paper focuses on findings from a broader study, specifically addressing the social determinants of health (SDH) impeding access and engagement in FBT for diverse families (i.e., families belonging to identity groups subject to systemic barriers and prejudices). METHODS: Forty-one FBT clinicians were recruited globally using purposive and snowball sampling. Clinicians participated in individual interviews or focus g

Misclassification of opioid-involvement in drug-related overdose deaths in the United States: A scoping review.

PURPOSE: Most drug-related deaths in the United States (US) in 2022 involved opioids. However, methodological challenges in overdose surveillance may contribute to underestimation of opioid involvement in the overdose crisis. This scoping review aimed to synthesize existing literature to examine the breadth and contributing sources of misclassification of opioid-related overdose deaths. METHODS: In October 2022, we searched PubMed, Web of Science, and Scopus for studies on overdose surveillance, death certificates, and medicolegal death investigation (MDI) systems in the US published in 2013-

Pre-operative conjunctival flora in patients with local and/or systemic risk factors for post cataract surgery infection in Northern Italy.

PURPOSE: To investigate the pre-operative conjunctival flora in patients undergoing cataract surgery with major local and/or systemic risk factors for developing post-operative infection. METHODS: A total of 83 patients underwent bacterial culture and sensitivity testing of conjunctival swabs obtained from both eyes because of local risk factors at the pre-operative visit (i.e. chronic blepharitis, conjunctivitis, or lacrimal system disease), and/or systemic risk factors (i.e. autoimmune or skin disorders) for developing post-operative infection. If the swab was found positive, an antimicrobi

An evaluation of health protection practices for the investigation and management of Cryptosporidium in England and Wales.

BACKGROUND: Cryptosporidium is a major cause of gastroenteritis (cryptosporidiosis). Case and outbreak report rates vary geographically, which may in part reflect public health practice. METHODS: To examine the public health management of cryptosporidiosis, an online questionnaire was administered to the 28 Health Protection Teams (HPTs) in England and Wales in 2014. Practices for investigation and management of cases and outbreaks were compared. RESULTS: Practice varied among the 24 (86%) respondents in terms of who undertook actions (HPT or Local Authority) to investigate and manage crypto

Hospital morbidity due to paracoccidioidomycosis in Brazil (1998-2006).

OBJECTIVE: To analyse hospital morbidity records due to paracoccidioidomycosis in Brazil, including its nationwide distribution in time and space, as well as key epidemiological and sociodemographic characteristics. METHODS: Descriptive analysis of hospital morbidity records due to paracoccidioidomycosis covering the period January 1998 to December 2006. Hospital records were obtained from the Hospital Information System of the Brazilian Unified Health System (SIH/SUS). RESULTS: There were 6732 hospitalisations (82% male) due to paracoccidioidomycosis in the period, representing 4.3 per 1.0

Ecological niche modeling for visceral leishmaniasis in the state of Bahia, Brazil, using genetic algorithm for rule-set prediction and growing degree day-water budget analysis.

Two predictive models were developed within a geographic information system using Genetic Algorithm Rule-Set Prediction (GARP) and the growing degree day (GDD)-water budget (WB) concept to predict the distribution and potential risk of visceral leishmaniasis (VL) in the State of Bahia, Brazil. The objective was to define the environmental suitability of the disease as well as to obtain a deeper understanding of the eco-epidemiology of VL by associating environmental and climatic variables with disease prevalence. Both the GARP model and the GDDWB model, using different analysis approaches and

[Co-infections of leishmania/HIV in south Europe].

The Leishmania/HIV co-infection has emerged as a result of the increasing overlap between leishmaniasis (mainly visceral, more rarely cutaneous) and AIDS, which is due to the spread of the AIDS pandemic to rural areas and that of visceral leishmaniasis to suburban areas. Cases of co-infection have so far been reported from 33 countries around the world, most of the cases have been notified in south-western Europe. 1,627 cases have been notified from Spain, France, Italy and Portugal. While Leishmania/HIV co-infection is increasing in eastern Africa, cases of co-infection are expected to dimini

The Mistreatment of Women during Childbirth in Health Facilities Globally: A Mixed-Methods Systematic Review.

BACKGROUND: Despite growing recognition of neglectful, abusive, and disrespectful treatment of women during childbirth in health facilities, there is no consensus at a global level on how these occurrences are defined and measured. This mixed-methods systematic review aims to synthesize qualitative and quantitative evidence on the mistreatment of women during childbirth in health facilities to inform the development of an evidence-based typology of the phenomenon. METHODS AND FINDINGS: We searched PubMed, CINAHL, and Embase databases and grey literature using a predetermined search strategy t

Technology acceptance of the video game-based swallowing function training system among healthcare providers and dysphagia patients: A qualitative study.

OBJECTIVE: Dysphagia is highly prevalent worldwide, causing serious complications. Video-game based rehabilitation training can increase dysphagia patient motivation and adherence. However, the acceptance of video game systems by patients and healthcare providers is still not fully explored. This study aimed to explore the acceptance of the video game swallowing training system among potential users. METHODS: The in-depth interviews were conducted face-to-face between July and October 2023 at a rehabilitation center in China, with a sample size based on the principle of information saturation

'The evidence is out there…': perspectives of healthcare providers on improving asthma and COPD prevention and care within a major health authority region of British Columbia, Canada.

INTRODUCTION: Asthma and chronic obstructive pulmonary disease (COPD) impose substantial morbidity and health system burden in Canada. Within Vancouver Coastal Health (VCH), a large and geographically diverse health authority in British Columbia, variation in service availability, access and care coordination creates barriers to prevention and high-quality chronic respiratory disease management. This project sought to document healthcare professionals' (HCPs') experiences and recommendations to inform a regional strategy to improve asthma and COPD care. METHODS: We conducted a qualitative qua

Spatial and Temporal Distribution of Febrile Illnesses in Uganda: Case Studies of Brucellosis, Malaria and Typhoid Fever (2016-2023).

BACKGROUND: Febrile illnesses can have devastating effects on the health, wellbeing and productivity of infected individuals. Fever is one of the most frequent reasons for seeking medical care globally. In Uganda, malaria is a major cause of fever and other nonmalarial causes such as typhoid and brucellosis. The aim of this study was to improve our understanding of the spatial and temporal distribution of malaria, typhoid fever and brucellosis in Uganda in order to inform the management and control of these diseases. METHODS: A retrospective analysis of data was conducted on human brucellosis

The Importance of Improving Promotion of Kidney Health and Access to Kidney Care: Perspectives From Leaders of Patient Organizations in Honduras.

Accessibility to kidney care is an essential component to ensure that patients with chronic kidney disease receive the necessary treatment in a timely and equitable manner. From our perspective as patients and/or leaders of patient organizations, we have observed how geographic, economic, informational, and psychosocial barriers negatively affect timely access to kidney health services, especially in Latin America. Improving access to kidney care is a complex challenge that requires a comprehensive approach, with an inclusive and equitable assertiveness. This includes not only the elimination