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Radiofrequency Ablation of Painful Spinal Metastasis: A Systematic Review.

OBJECTIVE: To systematically evaluate the effectiveness and safety of radiofrequency ablation (RFA) for managing pain caused by spinal metastases. This review aimed to consolidate evidence on RFA's analgesic efficacy and associated risks to inform clinical practice in palliative cancer care. METHODS: A systematic review adhering to PRISMA guidelines was conducted. Databases were searched for studies evaluating RFA for spinal metastases pain. Inclusion criteria specified: randomized or non-randomized studies (prospective/retrospective); ≥3 adult patients; RFA used alone or combined with other

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… included temporary post-procedural radicular pain, asymptomatic spinal cord edema, transient neurological motor deficits, pulmonary embolism, difficulty urinating, erectile dysfunction due to spinal cord venous infarct, transient pain following epidural leaks during treatment, drug hypersensitivity, folliculitis …

Biology and Diseases of Dogs

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Cutaneous adverse events to systemic antineoplastic therapies: a retrospective study in a public oncologic hospital.

BackgroundMucocutaneous adverse events are common during anticancer treatment, with variable consequences for the patient and their therapeutic regimen.ObjectiveTo evaluate the most common adverse events, as well as the drugs associated with their appearance and the consequences for cancer treatment.MethodsA retrospective study was carried out through the analysis of patients treated at the Clinical Dermatology Unit of a public oncologic hospital.ResultsA total of 138 patients with 200 adverse events were evaluated. The most commonly identified adverse events were nail and periungual changes (

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… planopilaris secondary to imatinib use (one case); subacute lupus after paclitaxel use (one case); toxic epidermal necrolysis due to imatinib (one case); plaque psoriasis due to pembrolizumab (one case); keratosis pilaris due to sorafenib (one case); Sweet syndrome after filgrastin use (one case); perforating folliculitis …

Hereditary epidermolysis bullosa: clinical-epidemiological profile of 278 patients at a tertiary hospital in São Paulo, Brazil.

BACKGROUND: Epidermolysis bullosa (EB) is a group of rare hereditary diseases, characterized by fragility of the skin and mucous membranes. Epidemiological data on EB in Brazil are scarce. OBJECTIVES: To describe epidemiological aspects of patients with EB diagnosed in the Dermatology Department of a tertiary hospital, from 2000 to 2022. METHODS: An observational and retrospective study was conducted through the analysis of medical records. The evaluated data included clinical form, sex, family history, consanguinity, age at diagnosis, current age, time of follow-up, comorbidities, histopath

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… Folliculitis decalvans was identified in two individuals, both with dystrophic EB. Cicatricial alopecia affected two JEB patients. Table 4 shows other extracutaneous diseases found in patients in this cohort. …

Oral H1 antihistamines as 'add-on' therapy to topical treatment for eczema.

BACKGROUND: The symptoms of eczema can lead to sleeplessness and fatigue and may have a substantial impact on quality of life. Use of oral H … (MD -4.10, 95% CI -13.22 to 5.02); or adverse events. Study authors reported only one side effect (folliculitis with placebo) (RR 0.25, 95% CI 0.01 to 5.76). Evidence for this comparison was of low quality. Number of eczema flares was not measured for this comparison. AUTHORS' CONCLUSIONS: Based on the main comparisons, we did not find consistent evidence th …

Diagnosis and Management of Chronic Pruritus: An Expert Consensus Review.

The aim of this study is to formulate the best clinical practice in the diagnosis and management of chronic pruritus (CP). We searched PubMed, EMBASE, Scopus, Web of Science, and the WHO's regional databases, for studies on "Diagnosis and management of chronic pruritus" from January 1, 2014, to July 31, 2015. We included programmatic reports and hand-searched references of published reviews and articles. Two independent reviewers screened articles and extracted data. We screened 87 of 95 studies that contained qualitative data. Avoid: Dry climate, heat, alcohol compress, ice packs, frequent ba

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… Furthermore, pruritic papular eruption or eosinophilic folliculitis has been documented in patients infected with HIV.[ 19 20 ] Neurological and somatoform origin of chronic pruritus [ Table 4 ] Table 4 Category 3 and 4 – Neurological and somatoform origin of chronic pruritus Localized neuropathic …

Flat Warts (Verrucae Planae) Confined to the Pigment of a Tattoo: A Rare Tattoo-associated Complication.

Tattoos are a form of decorative body art in which pigment dyes of different colors are inoculated into the skin. It is estimated that 15-25 … quent, with the highest prevalence of Staphylococcus and Streptococcus infections causing impetigo, folliculitis, cellulitis, erysipelas, or sepsis (2), but recent improvement and efforts in using sterile techniques in tattooing has led to a significant drop in the number of tattoo-related infections. In this short report, we present a case of a different and …

Clinical, economic and organizational impact of pharmacist interventions on injectable antineoplastic prescriptions: a prospective observational study.

BackgroundPharmacists play a key role in ensuring the safe use of injectable antineoplastics, which are considered as high-alert medications. Pharmaceutical analysis of injectable antineoplastic prescriptions aims to detect and prevent drug related problems by proposing pharmacist interventions (PI). The impact of this activity for patients, healthcare facilities and other health professionals is not completely known. This study aimed at describing the clinical, economic, and organizational impacts of PIs performed by pharmacists in a chemotherapy preparation unit.MethodsA prospective 10-week

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… and of 80% in oxaliplatin omitted in a patient with toxic ileitis to 5 FU in his medical records | 1 | 0 Oncology day care unit | Supra-therapeutic dosage | Cetuximab | Dose adjustment | Expected reduction cetuximab 200 mg / m 2 instead of 500 mg / m 2 not appliedToxicity during previous treatments: folliculitis …

Infectious Diseases

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… doxycycline 100 mg PO q12 h and cefoxitin 2 g IV q6 h ×14 days, or clindamycin 900 mg IV q8h and gentamicin 1.5 mg/kg IV q8h ×14 days) Soft Tissue Infections NEJM 2004 350:9; NEJM 2007 357:4; CID 2005 41:10 Differential Diagnosis DISCRETE, LOCALIZED CUTANEOUS INFECTIONS — superficial (impetigo, folliculitis … anaerobes, Eikenella corrodens animal bite — Pasteurella multocida, Capnocytophaga canimorsus tick bite — Borrelia burgdorferi , Tularemia freshwater — Aeromonas hydrophila seawater — Vibrio vulnificus fish exposure — Erysipelothrix rhusiopathiae, Streptococcus iniae hot tub — Pseudomonas aeruginosa folliculitis …

Systemic adverse effects and toxicities associated with immunotherapy: A review.

Immunotherapy is rapidly evolving secondary to the advent of newer immunotherapeutic agents and increasing approval of the current agents by the United States Food and Drug Administration to treat a wide spectrum of cancers. Immunotherapeutic agents have gained immense popularity due to their tumor-specific action. Immunotherapy is slowly transforming into a separate therapeutic entity, and the fifth pillar of management for cancers alongside surgery, radiotherapy, chemotherapy, and targeted therapy. However, like any therapeutic entity it has its own adverse effects. With the increasing use o

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… Ipilimumab, a CTLA-4 inhibitor used in the treatment of melanoma, has a diverse range of dermatologic adverse effects associated with its use such as rashes, folliculitis, mucositis, rosacea, SJS and vitiligo[ 20 ]. …

Severe cutaneous adverse reactions induced by targeted anticancer therapies and immunotherapies.

With the increasing use of targeted anticancer drugs and immunotherapies, there have been a substantial number of reports concerning life-threatening severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug rash with eosinophilia and systemic symptoms, drug-induced hypersensitivity syndrome, and acute generalized exanthematous pustulosis. Although the potential risks and characteristics for targeted anticancer agent- and immunotherapy-induced SCAR were not well understood, these serious adverse reactions usually result in morb

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… The major histopathologic findings of acneiform eruption are superficial suppurative folliculitis with neutrophilic infiltrate with ectatic follicular infundibula and rupture of the epithelial lining. 94 In contrast, AGEP typically shows subcorneal and/or intraepithelial pustules, an edematous papillary …

Pseudomonas aeruginosa Infections in Cancer Patients.

Pseudomonas aeruginosa (P. aeruginosa) is one of the most frequent opportunistic microorganisms causing infections in oncological patients, especially those with neutropenia. Through its ability to adapt to difficult environmental conditions and high intrinsic resistance to antibiotics, it successfully adapts and survives in the hospital environment, causing sporadic infections and outbreaks. It produces a variety of virulence factors that damage host cells, evade host immune responses, and permit colonization and infections of hospitalized patients, who usually develop blood stream, respirato

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… The examples are: hot tub folliculitis, otitis externa (swimmer’s ear) and keratitis in individuals extendedly wearing contact lens [ 35 ]. In cancer patients, P. aeruginosa causes mainly BSI, respiratory infections, UTI, and skin and soft tissue infections [ 36 ]. …

Infectious Diseases

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… days, or clindamycin 900 mg IV q8h and gentamicin 1.5 mg/kg IV q8h × 14 days) http://www.phac-aspc.gc.ca/std-mts/sti-its/cgsti-ldcits/index-eng.php Soft Tissue Infections NEJM 2007 357:4; IDSA Guidelines 2014 Differential Diagnosis DISCRETE LOCALIZED CUTANEOUS INFECTIONS — superficial (impetigo, folliculitis … anaerobes, Eikenella corrodens animal bite — Pasteurella multocida , Capnocytophaga canimorsus tick bite — Borrelia burgdorferi , Tularemia freshwater — Aeromonas hydrophila seawater — Vibrio vulnificus fish exposure — Erysipelothrix rhusiopathiae , Streptococcus iniae hot tub — Pseudomonas aeruginosa folliculitis …

Ocular effects caused by viral infections and corresponding vaccines: An overview of varicella zoster virus, measles virus, influenza viruses, hepatitis B virus, and SARS-CoV-2.

Many viral infections can affect vision and the visual system. Vaccination to prevent diseases is commonplace today, acting by stimulating an immune response without developing the pathology. It involves the production of persisting antibodies against the pathogen and the activation of T cells. Certain diseases have already been eradicated by rigorous vaccination campaigns, while others are hoped to be eliminated soon. Vaccines currently available on the market are largely safe, even if they can rarely cause some adverse effects, such as ocular complications. Analyzing existing literature, we

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… HSV is responsible for several distinct medical disorders, such as orolabial herpes, HSV folliculitis, herpes gladiatorum, herpetic whitlow, herpes encephalitis, and eczema herpeticum. Ocular involvement can present as a primary infection or recurrence from latent disease. …

Skin-Directed Therapies in Mycosis Fungoides: An Update.

Mycosis fungoides (MF) is the most common subtype of cutaneous T cell lymphoma (CTCL), characterized by monoclonal proliferation of malignant T cells primarily involving the skin. The management of MF, especially in the early stages, involves skin-directed therapies (SDTs) to achieve disease control, alleviate symptoms, and enhance the quality of life (QoL). This review provides an updated overview of SDTs in MF treatment, including topical agents such as corticosteroids, retinoids, mechlorethamine, carmustine, imiquimod, as well as photodynamic therapy (PDT); phototherapy modalities including

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… | RR assessed by CAILS and mSWAT | Use of mechlorethamine gel led to increased and faster RR in comparison to mechlorethamine ointment; for CAILS study, RRs within the ITT population were higher in patients receiving chlormethine gel compared to those using ointment | Contact dermatitis, erythema, folliculitis …

Is Camphor the Future in Supporting Therapy for Skin Infections?

The aim of this review is to present the potential application of camphor-a bicyclic monoterpene ketone-in the prevention of skin infections. Skin diseases represent a heterogeneous group of disorders characterized by prolonged symptoms that significantly diminish the quality of life. They affect the dermis, the epidermis, and even subcutaneous tissue. They very often have a bacterial or fungal background. Therapy for dermatological skin disorders is difficult and long-term. Therefore, it is important to find a compound, preferably of natural origin, that (i) prevents the initiation of this in

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… In primary infections, the inflammatory process is localized in the dermis (e.g., erysipelas, impetigo), in the hair follicle (folliculitis, furuncle), in the area around the nail (paronychia), or in the subcutaneous tissue (cellulitis) [ 21 ]. …

Molecular Inhibitors of Growth Signals

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… General adverse effects comprise arthritis, dizziness, folliculitis, vasculitis, uveitis, and mild photosensitivity. QT prolongation resulting in atrial or ventricular fibrillations may occur. The drug is Pregnancy Category D. …

Pyoderma gangrenosum: pathogenetic mechanisms and their implications for treatment.

Pyoderma gangrenosum (PG) is a rare inflammatory skin disease belonging to the group of neutrophilic dermatoses. The pathogenesis of PG involves a predisposing genetic background that facilitates a dysregulated innate and adaptive immune response, with an imbalance between pro-inflammatory and anti-inflammatory mediators, leading to neutrophil-driven inflammatory damage. Several immunosuppressants and immunomodulatory drugs are currently available for the treatment of PG, in combination with topical therapies, wound management and pain control strategies. Systemic corticosteroids and cyclospor

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… The appropriate clinical setting and clinical correlation could differentiate PG lesions from its histopathological mimicker, i.e., Sweet syndrome (which is rarely folliculocentric), a severe vesicular-necrotic insect bite reaction, a pustular drug reaction, and neutrophilic folliculitis in the setting …

Molecular targeted therapy for anticancer treatment.

Since the initial clinical approval in the late 1990s and remarkable anticancer effects for certain types of cancer, molecular targeted therapy utilizing small molecule agents or therapeutic monoclonal antibodies acting as signal transduction inhibitors has served as a fundamental backbone in precision medicine for cancer treatment. These approaches are now used clinically as first-line therapy for various types of human cancers. Compared to conventional chemotherapy, targeted therapeutic agents have efficient anticancer effects with fewer side effects. However, the emergence of drug resistanc

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… RCC (2012) | | Angiogenic factor upregulation Stromal cell recruitment | Hypertension, diarrhea, fatigue | 220 VEGFR2 EGFR3 GFR ET | Vandetanib ZD6474) | Zactima aprelsa AstraZeneca) | Medullary thyroid cancer (2011) | | RET V804M/L mutation Activation of RAS/ RAF/MEK pathway | Diarrhea, skin rash, folliculitis …

Hematology

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… eosinophilia–myalgia syndrome and idiopathic eosinophilic synovitis, Churg–Strauss syndrome dermatologic —eosinophilic panniculitis, episodic angioedema with eosinophilia, Kimura disease and angiolymphoid hyperplasia with eosinophilia, eosinophilic fasciitis, eosinophilic cellulitis, eosinophilic pustular folliculitis …