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Mining whole-brain information with deep learning to predict EGFR mutation and subtypes in brain-metastatic NSCLC: A multicenter study.

BACKGROUND: Epidermal growth factor receptor (EGFR) and its mutation subtypes play a pivotal role in the treatment of non-small cell lung ca … brain MRI scans before genetic testing. An EGFR site recognition network (ESR-Net) was developed by mining whole-brain information to predict EGFR mutations and subtypes. The ESR-Net integrated deformable convolution and an auxiliary network to seek informative mutation features and enhance tumor features, respectively. Predictive performances of deep le …

Machine Learning-Guided Design of MQ Silicone Resin Reinforced Addition-Curing Silicone Rubber: From Literature Data Mining to Experimental Validation.

MQ silicone resins are widely used reinforcing fillers for addition-curing liquid silicone rubber (LSR); however, establishing a quantitative composition-property relationship remains challenging because published data are fragmented across matrix chemistries, crosslinkers, catalyst systems and testing standards. Here we present a machine-learning-guided workflow integrating literature data mining, interpretable random-forest (RF) modelling and independent experimental validation for the design of MQ-reinforced LSR. An RF model trained on 55 curated literature points spanning RTV and LSR syste…

Lack of formal regulatory definitions of off-label medication use in children: an analysis using agency inquiry and text mining.

OBJECTIVES: This study investigates the formal definitions of "off-label" medication use among five major Western regulatory authorities-FDA, EMA, Health Canada, MHRA, and TGA. The primary research question is whether these agencies provide explicit, official definitions of off-label use. DESIGN: The study employs a mixed-methods design, combining direct inquiries via standardized questionnaires with AI-assisted text mining of publicly available regulatory documents. SETTING: Regulatory agencies at a national level across North America, Europe, and Oceania. PARTICIPANTS: Five agencies, with…

Rapid and exceptionally small-scale adaptation of the alpine plant Cardamine resedifolia to mining-contaminated soils in multi-stress condition.

The mechanisms by which plants tolerate soil contamination have been studied in details in controlled laboratory conditions, but they still … tial scales. It offers new insights into the short-term ecological and evolutionary consequences of mining activities in alpine ecosystems, particularly in relation to substrate-driven differentiation.

[Inversion of reclaimed soil organic carbon content in mining areas using unmanned aerial vehicle multispectral remote sensing and machine learning].

The rapid and accurate monitoring of soil organic carbon (SOC) is of great significance for evaluating the quality of reclaimed soils in mining areas. With reclaimed soils from the Xinglongzhuang Coal Mine as the object, we constructed five types of inversion variables based on drone multispectral imagery and sample SOC content: band mathematical transformation groups, traditional spectral index groups, improved spectral index groups, full-variable groups, and groups selected by the improved greedy algorithm (IGA). We further built SOC inversion models with six machine learning algorithms, Ada…

Source apportionment of potentially toxic elements (PTEs) in soils of the Huayuan Manganese Mining Area using PCA-IDW and PMF.

Under the long-term influence of mining activities, PTEs in surface soils of mining areas pose serious threats to human health. To investigate the pollution risks of PTEs in surface soils induced by manganese mining, this study takes the surface soils of a mining area as the research object. By integrating a coupled principal component analysis-inverse distance weighting (PCA-IDW) model with a positive matrix factorization (PMF) model, we conducted sampling, analysis, and source apportionment of PTEs in surface soils.The results indicate the following: Cd, Pb, and Zn are the core pollutants in…

Integrating mineral-scale evidence with PMF-SHAP to interpret geogenic reservoirs and mining-enhanced trace-element dispersion in agricultural soils.

Distinguishing geogenic reservoirs from mining-enhanced trace-element dispersion remains challenging in mineralized agricultural landscapes. This study focuses on the Aihui area of the northwestern Lesser Khingan Mountains (Xiaoxing'anling), China. Surface soils, ore samples, and host rocks were characterized by bulk geochemical analysis, scanning electron microscopy with energy-dispersive spectroscopy (SEM-EDS), laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS), positive matrix factorization (PMF) and random forest combined with Shapley additive explanations (RF-SHAP) an…

Depth-stratified zooplankton diversity in the central Indian Ocean Basin: An integrative pre-mining survey using morphology and DNA metabarcoding.

Zooplankton play a crucial role in marine food webs and biogeochemical cycles, and their rapid responses to environmental changes make them … Reference Zone (IRZ), the Preservation Reference Zone (PRZ), and BC20, located outside the proposed mining area. In total, 115 taxa comprising 81 genera were identified using both morphological and molecular analyses. Most taxa were shared across sites, with 13, 10, and 12 taxa unique to IRZ, PRZ, and BC20, respectively. Both methods revealed vertical st …

From algorithmic efficiency to cascading health burdens: a text-mining study of online food delivery riders in the platform economy.

Algorithmic management has markedly improved operational efficiency in the platform economy, yet its consequences for the occupational healt … protection deficits drew the strongest negative responses. The study contributes an integrated text-mining framework for occupational health research. It reframes rider health as a cascading system of mutually reinforcing burdens rather than a set of isolated risks, and it shows that the most central burden is not the one felt most acutely. These insight …

Medication patterns and therapeutic strategies in Traditional Chinese Medicine for coronary heart disease: A text mining analysis of clinical literature.

The incidence of coronary heart disease (CHD) has increased. This study employed scientific statistical methods to explore the medication rules of Chinese herbal medicines (CHMs) to treat CHD and provide a scientific and reliable theoretical basis for the improvement of patient symptoms. We systematically retrieved relevant studies related to CHMs used to treat CHD from the VIP, CNKI, Wanfang. We used Microsoft Excel 2019 to establish a database and the Ancient and Modern Medical Case Cloud Platform to conduct frequency, association rule, cluster analyses and complex network analysis. Summariz

Mechanistic insights into organic acid-mediated mitigation of nickel toxicity in maize (Zea mays L.) grown on mining-impacted soils.

BACKGROUND: The effects of oxalic acid, citric acid, and acetic acid (2.5 and 5 mmol) on nickel toxicity in maize (Zea mays L.) grown in nickel-contaminated soil from industrial and mining-affected sites were investigated in a pot experiment under controlled greenhouse conditions. While organic acids are commonly used as chelators to enhance metal uptake in phytoextraction strategies, this study demonstrates a contrasting mechanism: they reduced nickel bioavailability and uptake in maize, a non-hyperaccumulator crop, thereby promoting phytostabilization rather than phytoextraction. This distin…

Discovery of metallophore diversity in Microbulbifer in mixed culture with a coral pathogen using computational mass spectrometry and genome mining.

Iron is an essential component of cellular biology. Thus, iron's low bioavailability is a key evolutionary pressure guiding microbial dynami … ing unprecedented longer chain length acylation on the central spermidine moiety. We applied genome mining methods to describe the biosynthesis of these compounds. Using metal infusion mass spectrometry, we show that bulbichelins bind a variety of metals. Notably, neither of these compounds were produced in a co-culture of Microbulbifer with coral-derive …

In silico genome mining and characterization of putative horse feces-derived bacterial phytases as potential monogastric animal feed additive candidates.

Phytic acid exerts a significant antinutritional effect in poultry, swine, and fish, which can be mitigated by supplementing monogastric feeds with efficient microbial phytases. Accordingly, mining bacterial genomes for novel phytases represents a strategic computational approach to identifying candidates for improving monogastric animal nutrition. In this study, 162 bacterial genomes associated with horse feces were systematically mined using an in silico pipeline to identify and characterize putative phytases.A total of 69 non-redundant sequences were identified and classified as histidine a…

Signal mining and analysis of adverse events in children using growth hormones: A retrospective real-world study based on FAERS.

This study aims to analyze the adverse events (AEs) related to the use of growth hormone (GH) drugs in children through mining the FDA adverse event reporting system (FAERS) database, and provide references for clinical medication safety. Data on children under 18 years of age from the FAERS database, covering the first quarter of 2004 to the first quarter of 2024, were extracted via the OpenVigil 2.1 tool. The reporting odds ratio was employed to analyze AE signals related to GHs. A total of 10,559 AE reports for children using GHs were obtained, revealing 361 risk signals across 20 organ sys…

Seasonal variability and temperature-driven temporal dynamics of air pollutants in a mega coal mining zone of the talcher coalfield.

Air pollution poses a significant public health risk, as pollutants, emitted from both natural and anthropogenic sources, can penetrate deep into the respiratory system, leading to a wide range of respiratory diseases. While numerous studies have examined the role of meteorological factors in modulating air quality, limited research has focussed specifically on their effectiveness in regions characterized by intensive mineral extraction activities, particularly coal mining zones where emission loads remain persistently high. In this context, the concentration levels of PM10, PM2.5, SO2, and NO…

[Rules of acupoint selection for different stages, syndromes and symptoms of diabetic nephropathy treated with acupuncture based on data mining].

OBJECTIVES: To explore the rules of acupoint selection for different stages, syndrome types and symptoms of diabetic nephropathy (DKD) treated with acupuncture by means of data mining technology. METHODS: Literatures on acupuncture for DKD were retrieved from China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, VIP Chinese Journal Service Platform, SinoMed, Cochrane Library, Embase, Web of Science and PubMed databases from their inception to January 1, 2025. Frequency statistics were performed using the Traditional Chinese Medicine Inheritance Support System. Apri…

Электронная добыча медицинских карт свидетельствует о воздействии иммунного состояния пациента на клинические результаты имплантации биоматериалов после повреждения мышечной ткани скелета.

Имплантация медицинских устройств и биоматериалов может помочь восстановить форму и функцию отсутствующей или поврежденной ткани. Известно, что иммунная система играет важнейшую роль как в позитивном, так и в негативном исходе этих имплантированных материалов. Реакция иностранного организма характеризуется осаждением белка и свертыванием, за которым следуют макрофагенное воспаление, расстройство фагоцитоза, образование гигантских клеток и, в конечном счете, фиброз. Это может препятствовать функционированию имплантированных устройств (например. Инсулиновые насосы), а также космезис (например, к

Совпадение в аннотации оригинала
Implantation of medical devices and biomaterials can help restore form and function of missing or damaged tissue. It is known that the immun … oimmune and immunodeficiencies. This preliminary observational study using electronic health record mining showed increased complication odds for individuals with both autoimmune conditions and immunodeficiencies, with variations dependent upon the individual's sex and age as well as the type of material implanted. Future prospective studies could yield …

Applications of Machine Learning in Noninvasive Anemia Diagnosis: A Systematic Review Based on Cross-Industry Standard Process for Data Mining.

BACKGROUND AND AIMS: Anemia is a disorder caused by insufficient red blood cell count or hemoglobin concentration, affecting nearly a quarte … le records were included in the qualitative synthesis. The Cross-Industry Standard Process for Data Mining (CRISP-DM) phases guided the selection of the main characteristics of each paper. RESULTS: The contributions span a variety of algorithms and input data. The most frequent acquisition sites and data types were eye conjunctiva images, fingertip PPG …

Traditional Chinese Medicine Interventions for Antipsychotic-Induced Extrapyramidal Symptoms: A Data Mining-Based Integrative Review of Prescription Patterns and Evidence.

BACKGROUND: Antipsychotic-induced extrapyramidal symptoms (EPS), including drug-induced parkinsonism, akathisia, dystonia, and tardive dyski … were extracted. Narrative evidence synthesis was combined with frequency analysis, association rule mining, clustering, and network mapping to identify recurrent herbal combinations and therapeutic structures. RESULTS: Included studies involved patients with schizophrenia-spectrum disorders receiving first- or second-generation antipsychotics. Drug-indu …

Analysis of Prescription Medication Rules of Chinese Herbal Medicine for Acute Exacerbation of Idiopathic Pulmonary Fibrosis Based on Data Mining.

Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a life-threatening complication with limited effective therapeutic options a … by Professor Xu Zhiying for acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) using data-mining techniques. Medical records of patients diagnosed with AE-IPF treated at Zhejiang Provincial Hospital of Traditional Chinese Medicine from September 2019 to December 2020 were retrospectively reviewed. A total of 84 prescriptions from 42 patients we …