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Hyperthermia and postmortem biochemical investigations.

The postmortem diagnosis of heat-related deaths presents certain difficulties. Firstly, preterminal or terminal body temperatures are often not available. Additionally, macroscopic and microscopic findings are nonspecific or inconclusive and depend on survival duration after exposure. The diagnosis of hyperthermia is therefore essentially based on scene investigation, the circumstances of death, and the reasonable exclusion of other causes of death. Immunohistochemistry and postmortem biochemical investigations have been performed by several authors in order to better circumstantiate the physi

Carnitine palmitoyltransferase II deficiency: molecular and biochemical analysis of 32 patients.

The authors investigated 32 patients with the muscle form of CPT II deficiency. Total carnitine palmitoyltransferase enzyme system (CPT) activity was normal but abnormally inhibited by malonyl-CoA, palmitoyl-CoA, and the detergents Triton X and Tween 20. Mutation analysis identified three described mutations (S113L, P50H, and F448L) and two novel mutations (M214T and Y479F). Using modeling techniques, a structure could be identified anchoring the protein in the membrane. Only one of the five mutations (Y479F) is located within this region.

A Retrospective Study of Chronic Kidney Disease Burden in Saskatchewan's First Nations People.

BackgroundChronic kidney disease is more prevalent among First Nations people than in non-First Nations people. Emerging research suggests that First Nations people are subject to greater disease burden than non-First Nations people.ObjectiveWe aimed to identify the severity of chronic kidney disease and quantify the geographical challenges of obtaining kidney care by Saskatchewan's First Nations people.DesignThis study is a retrospective analysis of the provincial electronic medical record clinical database from January 2012 to December 2013.SettingThe setting involved patients followed by th

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… Codes Excluded From the Analysis for the Regina CKD Patients 38.42 Septicemia due to Escherichia Coli ( E coli ) 38.9 Unspecified Septicemia 584.5 Acute kidney failure with lesion of tubular necrosis 584.9 Acute kidney failure, unspecified 593.6 Postural proteinuria 728.88 Rhabdomyolysis 791.3 Myoglobinuria …

Acute Kidney Injury in Oncology Patients.

With rapid progress in cancer diagnosis and treatment in the last two decades, outcomes in oncological patients have improved significantly. However, the incidence of acute kidney injury (AKI) in this population has also increased significantly. AKI complicates many aspects of patients' care and adversely affects their prognoses; thus, accurately diagnosing the risk factors for AKI ensures appropriate management. AKI may be caused by pre-renal, intrinsic renal, and post-renal reasons, as well as for combined reasons. This review summarizes the potential etiologies of AKI according to the three

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… Some scholars inferred that thermal ablation could cause oliguric AKI, myoglobinuria, and TLS. Ding et al 46 reported that 23.6% of patients had AKI after microwave ablation of large liver tumors (≥ 5 cm), among whom, 89.4% had non-oliguric AKI, and 10.6% had oliguric AKI. …

Musculoskeletal Chronic Graft versus Host Disease-A Rare Complication to Allogeneic Hematopoietic Stem Cell Transplant: A Case-Based Report and Review of the Literature.

Musculoskeletal graft versus host disease (GVHD) is a rare manifestation of chronic GVHD (cGVHD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Left untreated, the disease can cause extensive damage to muscle tissue and joints. We describe a 62-year-old male with musculoskeletal GVHD and generalized muscle pain and stiffness. In addition, we performed a systemic literature review based on published cases of musculoskeletal GVHD between 1983 and 2019. We identified 85 cases, 62% male and 38% female with an age of 4-69 years and median age of 39 years at diagnosis. The

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… Measurement of the myoglobin or myoglobinuria could be another approach, although, in very few cases, this was measured. General markers of inflammation such as CRP and ferritin could be used, although would in general reflect unspecified inflammatory conditions [ 44 , 45 ]. …

Rhabdomyolysis secondary to COVID-19 infection and vaccination: a review of literature.

Rhabdomyolysis (RML), characterized by the breakdown of skeletal muscle fibers and the release of muscle contents into the bloodstream, has emerged as a notable complication associated with Coronavirus disease 2019 (COVID-19) infection and vaccination. Studies have reported an increased incidence of RML in individuals with severe COVID-19 infection. However, the exact mechanisms remain unclear and are believed to involve the host's immune response to the virus. Furthermore, RML has been documented as a rare adverse event following COVID-19 vaccination, particularly with mRNA vaccines. Proposed

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… Additional diagnostic methods for RML include myoglobinuria and positive urine dipstick tests with an orthotolidine (OT) test ( 27 ). Management of RML Addressing the root cause of muscle injury is the initial step in managing RML. …

Viruses

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… to congestive heart failure Meningoencephalitis Fever, encephalopathy and seizure with abnormal CSF findings, and a positive PCR for influenza in some children [ 155 ] Myositis Myalgia with tenderness of the affected muscles (most commonly the legs), with elevation of serum creatinine phosphokinase, myoglobinuria … congestive heart failure Meningoencephalitis | Fever, encephalopathy and seizure with abnormal CSF findings, and a positive PCR for influenza in some children [ 155 ] Myositis | Myalgia with tenderness of the affected muscles (most commonly the legs), with elevation of serum creatinine phosphokinase, myoglobinuria …

Сердечно-сосудистые заболевания

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… Other signs of white muscle disease such as stiffness, difficulty in prehension or swallowing, inhalation pneumonia, and myoglobinuria may or may not be present. Dyspnea may be directly related to the cardiac lesions or may be caused by Zenker's degeneration in the diaphragm or intercostal muscles. …

Сердечно-сосудистые заболевания

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… Other signs of white muscle disease such as stiffness, difficulty in prehension or swallowing, inhalation pneumonia, recumbency, and myoglobinuria may or may not be present. …

Emergency Care

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KDIGO Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors.

The 2017 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors is intended to assist medical professionals who evaluate living kidney donor candidates and provide care before, during and after donation. The guideline development process followed the Grades of Recommendation Assessment, Development, and Evaluation (GRADE) approach and guideline recommendations are based on systematic reviews of relevant studies that included critical appraisal of the quality of the evidence and the strength of recommendations. However, m

Abstracts cont.

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Abstracts from the 37th Annual Meeting of the Society of General Internal Medicine, 2014, San Diego, CA, USA.

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42nd International Symposium on Intensive Care & Emergency Medicine

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Резюме докладов 53rd Конференция Европейского общества генетики человека: интерактивные электронные постеры.

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Abstracts of the 36th Annual Meeting of the Society of General Internal Medicine. April 24-27, 2013. Denver, Colorado, USA.

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