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Additional human Q-fever studies on the Cape Verde Islands--2nd report.

The MAR-test results including titer levels of 1:4 and higher revealed 92% positive reactions in the district of Santa Cruz/Santiago and 77% positive reactions in 6 villages of Santo Antao. The submitted examinations prove the agent Coxiella burnetti's existence responsible for different clinical pictures observed on the Cape Verde Islands.

Ribonucleic acid and protein synthesis in guinea pig liver during Q fever.

Protein and ribonucleic acid (RNA) syntheses increase in the liver during Q fever, coincident with progressive increments in cortisol levels. Cell-free protein-synthesizing systems indicate that the pH 5 enzyme fraction was chiefly responsible for enhanced activity. Although the polysome profiles from normal and infected livers were similar, the number of liver ribosomes doubled during infection. There was a concomitant increase in orotate incorporation in the 28s, 18s, and 4s RNA species of infected liver.

Apparent recurrence of Q fever endocarditis following homograft replacement of aortic valve.

A 39-year-old man with aortic stenosis and regurgitation developed Q fever endocarditis. After 15 weeks of chemotherapy with tetracycline the damaged aortic valve was replaced with a homograft. Organisms were present in the excised valve. Some months later the valve began to leak and the endocarditis recurred fatally. Because of the nature of rickettsial infection neither a course of chemotherapy nor an operation can guarantee a cure of Q fever endocarditis. Chemotherapy should be continued indefinitely even after operation.

Knowledge, Attitudes and Practices Towards Spotted Fever Group Rickettsioses and Q Fever in Laikipia and Maasai Mara, Kenya.

Many factors contribute to misdiagnosis and underreporting of infectious zoonotic diseases in most sub-Saharan Africa including limited diagnostic capacity and poor knowledge. We assessed the knowledge, practices and attitudes towards spotted fever group rickettsioses (SFGR) and Q fever amongst local residents in Laikipia and Maasai Mara in Kenya. A semi-structured questionnaire was administered to a total of 101 respondents including 51 pastoralists, 17 human health providers, 28 wildlife sector personnel and 5 veterinarians. The pastoralists expressed no knowledge about SFGR and Q fever. Abo…

Epidemiological features of Mediterranean spotted fever, murine typhus, and Q fever in Split-Dalmatia County (Croatia), 1982-2002.

We determined the epidemiological features of three zoonoses in hospitalized patients in southern Croatia. Patients were diagnosed by serological testing. Clinical and epidemiological data were also collected. Between 1982 and 2002, Mediterranean spotted fever (MSF) was diagnosed in 126 (incidence rate 1.27/100,000 per year), murine typhus (MT), in 57 (incidence rate 0.57/100,000 per year), and Q fever in 170 (incidence rate 1.7/100,000 per year) patients. MSF and Q fever were characterized by a marked seasonality. Incidences of Q fever and of MSF were higher for males than for females (P<0.00…

Prevalence and Risk Factors of Q Fever in Smallholder Dairy Farms in Kenya.

BACKGROUND: Q fever is a neglected zoonotic disease of global concern. In Kenya, it ranks among the top priority zoonoses, yet data on its prevalence and associated risk factors in smallholder dairy farms are limited. OBJECTIVES: To estimate the seroprevalence and molecular prevalence of Coxiella burnetii and identify risk factors for exposure in dairy cattle on smallholder farms in Kenya. METHODS: A cross-sectional study was conducted on 448 smallholder dairy farms across Nandi County and nearby dairy-producing areas. Serum (n = 1829), vaginal swabs (n = 1783) and preputial swabs (n = 52) w…

Subarachnoid Hemorrhage, CNS Vasculitis and Stroke as a Sequela of Q Fever Infection.

A 64-year-old female with a history of Subarachnoid Hemorrhage (SAH) of non-aneurysmal origin underwent 4 cerebral Digital Subtraction Angio … unofluorescence Assay (IFA) testing revealed a high titer of IgG phase II Coxiella indicating acute Q fever. CDC lab findings from 10 years earlier also showed a high titer IgG phase II Coxiella, indicating untreated Q fever prior to the SAH event. A whole-body Positron Emission Tomography (PET) scan was negative for systemic or CNS vasculitis. The patien …

Серологические данные о лихорадке Q у тибетских овец в провинции Цинхай, Китай.

Q лихорадка, вызванная внутриклеточной бактерией Coxiella signetii (C. signetii), является глобальной зоонотической болезнью. Данные о заражении тибетских овец в Цинхае, Китай, отсутствуют. В ходе этого исследования было собрано 1043 образца тибетской сыворотки овец (421 женщина и 622 мужчины) из 8 районов провинции Цинхай, которые были обследованы на предмет выявления антитела против С. Общая распространенность инфекции C. gretii составила 5,9% (62/1043, 95% CI 4.5-7.4). Интересно отметить, что показатели инфицирования тибетскими овцами (C. sergetii) не свидетельствуют о наличии статистически

Совпадение в аннотации оригинала
Q fever, caused by the obligate intracellular bacterium Coxiella burnetii (C. burnetii), is a global zoonotic disease. No data is available about C. burnetii infection in Tibetan sheep in Qinghai, China. In this study, 1043 Tibetan sheep serum samples (421 females and 622 males) were collected from 8 regions in Qinghai Province and examined for antibodies ag…

Immune landscape and biomarker identification in Q fever: a comprehensive diagnostic analysis.

OBJECTIVES: Q fever (QF), a zoonotic disease caused by Coxiella burnetii, exhibits highly heterogeneous clinical manifestations-ranging from asymptomatic infection to acute febrile illness and persistent complications. The immune-related molecular mechanisms underlying its diverse disease stages remain incompletely elucidated. This study aimed to dissect the gene expression dynamics across different QF phases via bioinformatics approaches, thereby uncovering key immune-regulatory molecular mechanisms. METHODS: Gene expression profiles of QF were retrieved from the Gene Expression Omnibus (GEO…

Histopathologic changes of the placenta in Q fever infection: An Australian case series.

OBJECTIVES: Q fever is a zoonotic infectious disease with a particular tropism for the placenta. Some studies have suggested associated adverse outcomes including intrauterine growth restriction (IUGR) and intrauterine fetal demise (IUFD). Despite this, data on corresponding histologic features of the placenta are sparse. The aim of this study was to describe histopathologic findings of the placenta in cases of Q fever infection with their associated pregnancy outcomes. METHODS: Patients were identified in a database search of Queensland cases between January 2000 and January 2025. The study …

Острая лихорадка Q, выявленная синдромом антифосфолипида: отчет о деле.

ВВЕДЕНИЕ: Q лихорадка - это зооноз, вызванный коксиеллой печени. Острая инфекция носит в основном асимптомический характер. В других случаях он вызывает в основном болезнь, похожую на грипп, пневмонию или гепатит. Мы представляем нетипичный случай острой Q лихорадки, обнаруженной массивным плевральным эфлуцией. Мы сообщаем о случае, когда 43-летний мужчина поступил в больницу из-за острого дыхательного расстройства. Дальнейшие анализы показали, что эосинофильное плефилирование, связанное с легочным эмболизмом и глубоким феморальным тромбозом вены. Этиологические исследования выявили острую Q л

Совпадение в аннотации оригинала
INTRODUCTION: Q fever is a zoonosis caused by Coxiella burnetii. Acute infection is mainly asymptomatic. In other cases it mainly causes a flu-like illness, a pneumonia, or an hepatitis. We present an atypical case of an acute Q fever revealed by a massive pleural effusion. CASE REPORT: We report the case of a 43-year-old man referred to our hospital for an…

Q-Fever endocarditis: Prosthetic valve infection in the absence of zoonotic exposure.

Background: Q-Fever is a rare condition with an often insidious presentation. Endocarditis is a serious complication of up to 5% of Q-Fever cases, with a higher incidence and mortality in patients with prosthetic valves.Case-history: A 67-year-old man presented with a 6-weeks history of breathlessness on a background of previous bioprosthetic aortic valve replacement in 2018. Subsequent echocardiograms showed severe eccentric aortic regurgitation, a 2 cm vegetation, and severely impaired biventricular function. Routine blood cultures were negative, but later PCR testing for non-culturable micr