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Uveitis in Parry-Romberg syndrome: A case report and review of literature.

Parry-Romberg syndrome (PRS) is a rare, acquired condition characterized by progressive atrophy of the skin and soft tissue of one side. A 35-year-old female with a 4-year history of recurrent uveitis and hypotony in the right eye, previously diagnosed with granulomatous anterior uveitis and pars planitis, was referred to our clinic. Despite treatment, she continued to develop recurrences of inflammation, with intraocular pressure dropping to 0 mmHg twice. She was managed with periocular injection triamcinolone acetonide with systemic anti-inflammatory treatment. A dermatology consultation was…

Patient Characteristics, Diagnoses, and Management in a Combined Uveitis-Rheumatology Clinic.

INTRODUCTION: Combined uveitis-rheumatology clinics (combined clinics) are a relatively recent clinical care model. Here we report the demographics, ocular and systemic disease characteristics, and medications utilized in patients seen in a combined clinic at a tertiary care hospital in the USA. METHODS: Medical records were reviewed of patients seen at the Combined Clinic at the University of Colorado Hospital between January 1, 2016 and November 1, 2023. Data including age, sex, referral indication, ocular and systemic inflammatory disease diagnosis, and therapies utilized were obtained. R…

Clinical characteristics and outcomes of pediatric anterior and intermediate uveitis in China.

PURPOSE: To summarize the clinical characteristics of pediatric anterior and intermediate uveitis (PAIU) and evaluate the effectiveness of vitreous cell (VC) grading and multimodal imaging techniques in the diagnosis and management of PAIU cases. METHODS: This retrospective study analyzed data on demographic characteristics, clinical features, treatment methods, and responses. Imaging tests included optical coherence tomography (OCT) and ultra-widefield fluorescein angiography (UWFFA) to assess retinal thickness, peripheral vascular leakage (PVL), and other inflammatory indicators. RESULTS: …

Efficacy of Intravitreal Dexamethasone Implant in the Treatment of Immune Recovery Uveitis.

PURPOSE: To evaluate the efficacy of intravitreal dexamethasone in immune recovery uveitis (IRU) diagnosed with worsening of visual symptoms after recovery of cytomegalovirus (CMV) retinitis caused by acquired immunodeficiency syndrome (AIDS). METHODS: A single case report was obtained from a tertiary referral center and retrospectively evaluated. RESULTS: A 53-year-old male patient with known AIDS was admitted to our clinic with vision loss that started 1 month before and was diagnosed with CMV retinitis based on clinical findings (CD4  +  T lymphocyte count 38 cells/μL). Two months after C…

A systemic review of the utility of antituberculosis therapy for presumed tuberculous uveitis.

BACKGROUND: Uveitis presumed to be secondary to Mycobacterium tuberculosis is a rare but potentially blinding condition. Difficulty in making an accurate diagnosis and the low incidence of TB uveitis (TBU) contribute to the lack of evidence regarding the best management of this condition. This systematic review aims to analyse existing research to provide a summary of the literature regarding the utility of TB therapy for the management of TBU. METHODS: This systematic review was prospectively registered on PROSPERO (PROSPERO 2021 CRD42021273379). We searched Medline, Embase and Central datab…

Uveitis and blindness in a closed herd of Equidae following leptospiral infection.

OBJECTIVE: To describe the ocular findings, chronology of disease, and serum leptospiral titers in a group of horses, mules, and donkeys following an outbreak of leptospirosis. METHODS: Fifty Equidae in central North Carolina had ophthalmic examinations and serum leptospiral microscopic agglutination test (MAT) titers performed every 3-6 months for 24 months followed by a final examination at 34 months. RESULTS: Throughout the nearly three-year study period, 17 horses (34%; 17/49 horses) developed signs of uveitis; 20 eyes (20/34; 58.8%) of these 17 horses were visual at the initial examinat…

[Literature data mining on the current research status of uveitis in China].

Objective: To analyze the current research status of uveitis in China. Methods: It was a bibliometric analysis study. Using search formulas covering uveitis and its multiple subtypes, uveitis-related literature in English with publication dates from 2013 to 2022 was retrieved in Web of Science core databases through certain search strategies. This study used the latent Dirichlet allocation (LDA) algorithm to build topic models and analyzed the trends of research topics in recent years. Bibliometric analysis was used to analyze and visualize the bibliometric indicators (e.g., number of publicat…

AAV-mediated gene therapies for glaucoma and uveitis: are we there yet?

Glaucoma and uveitis are non-vascular ocular diseases which are among the leading causes of blindness and visual loss. These conditions have distinct characteristics and mechanisms but share a multifactorial and complex nature, making their management challenging and burdensome for patients and clinicians. Furthermore, the lack of symptoms in the early stages of glaucoma and the diverse aetiology of uveitis hinder timely and accurate diagnoses, which are a cause of poor visual outcomes under both conditions. Although current treatment is effective in most cases, it is often associated with low…

[Results of clinical and immunomorphological analysis in chronic post-traumatic uveitis].

PURPOSE: This study was conducted to identify the group at highest risk for autoimmune inflammation through a comparative analysis among patients with chronic post-traumatic uveitis (CPTU). MATERIAL AND METHODS: The clinical group included 50 patients (aged 18 to 87 years, mean age 41±2.6 years) with CPTU resulting from penetrating injury, contusion, or intraocular surgery. All patients underwent comprehensive clinical and diagnostic evaluation, including immunological assessments: leukocyte migration inhibition test (LMIT), analysis of lymphocyte subpopulation composition, and cytokine profi…

Acute neuroretinitis as a delayed manifestation of tubulointerstitial nephritis and uveitis syndrome.

PURPOSE: Tubulointerstitial nephritis syndrome with uveitis (TINU) is a rare, acquired syndrome characterized by interstitial nephritis with bilateral uveitis. We report a case of TINU with typical bilateral anterior uveitis complicated by an atypical, delayed-onset neuroretinitis in a 12-year old patient. OBSERVATION: A 12-year-old female with a 21-month history of TINU featuring chronic bilateral anterior uveitis presented with one week of blurred vision in her left eye. On exam she was found to have new-onset disc edema in the right eye and neuroretinitis in the left eye. After a negative …

Paediatric Uveitis - the uniqueness in clinical presentation and the efficacy of biologics treatment.

AIMS: To evaluate unique clinical characteristics of paediatric uveitis in our locality and treatment outcomes especially the efficacy of biologics. METHODS: This was a retrospective cohort. RESULTS: 37 paediatric uveitis cases involving 67 eyes were included. Male-to-female ratio was 1:1.3. Mean age of uveitis onset was 11 ± 3.7 (4-18). 81.1% cases suffered from bilateral uveitis. 75.7% cases were chronic uveitis. Nearly half of the cases (40.5%) presented with anterior uveitis. The predominant diagnosis of uveitis in our cohort was idiopathic. Unlike studies from other populations, the ass…

Humanistic Burden of Noninfectious Uveitis: A Systematic Review and Meta-Analysis.

PURPOSE: This study aimed to evaluate the humanistic burden of noninfectious uveitis (NIU). DESIGN: Systematic review and meta-analysis. METHODS: A comprehensive search was conducted across Medline, Embase, and Scopus databases from inception to March 2023. Studies pertaining to the health-related quality of life (HRQoL) of patients with NIU in both adult and pediatric populations were included. Identified studies were critically appraised and assessed for bias using the Joanna Briggs Institute Critical Appraisal tools. RESULTS: A total of 68 studies involving 8403 participants met the incl…

The Role of Complement System's C3 and C4 Fractions in the Pathogenesis of Uveitis.

PURPOSE: To study the role of the complement system's C3 and C4 fractions in the pathogenesis of different types of uveitis. METHODS: A prospective case-control study. 118 patients were enrolled. The control group comprised 60 patients who were otherwise healthy people undergoing cataract or pterygium surgery, whereas the uveitis patients group consisted of 58 people. The levels of C3 and C4 fractions in the blood and in the aqueous humor for both groups were evaluated and compared. RESULTS: No statistically significant differences were found in the levels of the C3 and C4 fractions in the b…

Clinical characteristics and aetiology of uveitis in a viral haemorrhagic fever zone.

BACKGROUND/OBJECTIVES: Studies on uveitis in Sierra Leone were conducted prior to the Ebola Virus Disease epidemic of 2013-16, which was associated with uveitis in 20% of survivors. They did not include imaging or investigation of tuberculosis and used laboratory services outside the country. We performed a cross-sectional study on patients presenting with uveitis to establish their clinical characteristics and identify the impact of in-country laboratory diagnoses. METHODS: We invited uveitis cases presenting to Eye Clinics in Sierra Leone from March to September 2022 to participate in the s…

Ассоциация увеита с педиатрическими аутоиммунными заболеваниями на основе исследования TriNetX.

Расследовать риск увеита среди таких пациентов. В ретроспективном когортном исследовании использовалась база данных TriNetX и были приняты на работу педиатрические аутоиммунные пациенты, диагностированные в период с января 1st 2004 и декабрь 31st 2022. Неавтоиммунная группа была произвольно выбрана пациентами-контролями в разбивке по полу, возрасту и индексу года. Главным результатом этого является появление новых увеитов. 175,328 Пациенты педиатрии с аутоиммунными заболеваниями (средний возраст) 10.7 +/- 5.1 годы; 55.8% - женщины; 66.2% Белый) и 175,328 Пациенты педиатрии без аутоиммунных заб

Совпадение в аннотации оригинала
To investigate for the risk of uveitis among such patients. A retrospective cohort study utilized the TriNetX database and recruited pediatric autoimmune patients diagnosed between January 1st 2004 and December 31st 2022. The non-autoimmune cohort were randomly selected control patients matched by sex, age, and index year. The main outcome is the incidence o…

Stepwise approach for fundus imaging in the diagnosis and management of posterior uveitis.

An array of retinochoroid imaging modalities aid in comprehensive evaluation of the immunopathological changes in the retina and choroid, forming the core component for the diagnosis and management of inflammatory disorders such as uveitis. The recent technological breakthroughs have led to the development of imaging platforms that can evaluate the layers of retina and choroid and the structural and functional alteration in these tissues. Ophthalmologists heavily rely on imaging modalities such as dye-based angiographies (fluorescein angiography and indocyanine green angiography), optical cohe…

Systematic review of studies comparing infliximab and adalimumab in autoimmune uveitis.

OBJECTIVE: This study aimed to review effectiveness studies comparing two biological anti-tumour necrosis factor agents, adalimumab (ADA) and infliximab (IFX), in the management of autoimmune uveitis. METHODS: A systematic search was conducted across PubMed, Scopus, Web of Science and Google Scholar from 2014 until February 2022. The search included the following keywords "Adalimumab", "Infliximab", "Autoimmune", "Anterior", "Intermediate", "Posterior", "Panuveitis", "Refractory" and "Uveitis". Primary studies comparing both ADA and IFX in a population of autoimmune uveitis patients were cons…

Clinical and therapeutic characteristics of childhood uveitis in a tertiary center in Tunisia.

INTRODUCTION: Childhood uveitis is a rare condition with various associated diagnostic and therapeutic challenges. AIM: We proposed to describe the distribution, clinical findings, treatment, complications, and visual outcomes of uveitis in children at a tertiary referral center in Sfax, Tunisia. METHODS: A retrospective study of 33 children (54 eyes) with uveitis collected over the period from January 2009 to December 2018 was carried out at the Ophthalmology Department of Habib Bourguiba University Hospital, Sfax, Tunisia. The data from the clinical examination, the etiological assessment,…

A Case of Uveitis-Glaucoma-Hyphema Syndrome Related to a Hydrus Microstent.

Uveitis-Glaucoma-Hyphema (UGH) syndrome is characterized by episodes of anterior chamber inflammation, elevated intraocular pressure and hyphema. It is caused by a mechanical chafing of the iris or ciliary body typically by a malpositioned intraocular lens. We present a rare case of UGH syndrome related to the insertion of a Hydrus Microstent. Because of the increased number of microinvasive glaucoma surgeries being performed and a reduction of UGH syndrome patients related to the insertion of intraocular lenses, it is an important diagnosis to consider in patients with recurrent postoperative…