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Fatigue in Sjögren's Disease - Integrating Biomedical and Psychosocial Aspects: A Narrative Review.

Fatigue is a prevalent and disabling symptom in Sjögren's disease (SjD), yet its pathogenesis remains poorly understood and inadequately managed. This narrative review addresses a critical gap in knowledge by conceptualizing SjD-related fatigue as a bidimensional phenomenon driven by both biomedical and psychosocial mechanisms, and framed within the model of persistent somatic symptoms (PSS). In this narrative review, findings from immunology, neuroendocrinology, psychology, and clinical research were synthesized to examine predisposing, triggering, and maintaining factors contributing to SjD-…

Functional connectivity dynamics of monoaminergic circuits related to fatigue in multiple sclerosis.

INTRODUCTION: Monoaminergic neurotransmitters help regulate the interplay between the central nervous system and the immune system. Aberrant monoaminergic functional connectivity is presumably involved in MS-related fatigue, but mechanisms remain unclear. AIM: To investigate how static and dynamic functional connectivity of monoaminergic circuits relate to fatigue in MS. METHODS: 60 healthy controls (HC) and 217 people with MS (pwMS) completed the Fatigue Scale for Motor and Cognitive Functions (FSMC) and underwent functional brain MRI. Brain regions were assigned to resting-state networks. …

Peripheral redox biomarkers in multiple sclerosis: associations with phenotype, cognition, and fatigue.

BACKGROUND: Oxidative stress (OS) plays a pivotal role in MS pathogenesis, but its relationship with cognitive impairment, mood disorders, and fatigue remains underexplored. This study assessed blood OS markers and their association with clinical and symptomatic measures. METHODS: This cross-sectional study included 67 adults (>18 years) with definite MS (2017 revised McDonald criteria). Measured oxidative markers included total oxidative status (TOS), TAS (total antioxidant status), prooxidative-antioxidative balance (PAB), malondialdehyde (MDA), advanced oxidation protein products (AOPP), s…

Прогнозируемая эффективность показателей внимания при многоразовом склерозе.

ЦЕЛЬ: В настоящем исследовании изучается взаимосвязь между когнитивными характеристиками, депрессией, тревогой и факторами, связанными с медицинским бременем (т.е. МЕТОД: Было проведено ретроспективное исследование, в ходе которого были собраны данные о 106 пациентах, проходящих курс лечения (87 женщин; 19 мужчин), которые были направлены в амбулаторную, больничную нейропсихологическую клинику. Участники прошли всестороннюю нейропсихологическую оценку, которая включала в себя показатели внимания, скорости обработки, исполнительного функционирования, языка, моторной функции, виуопространственны

Совпадение в аннотации оригинала
OBJECTIVE: The present study investigates the relationship between cognitive performance, depression, anxiety, and factors of medical burden (i.e., polypharmacy, medical comorbidities, disease duration, disability level, and self-reported fatigue level) in a population of multiple sclerosis (MS) patients. METHOD: A retrospective investigation was conducted …

Does muscle fatigue change motor synergies at different levels of neuromotor control?

We investigated the effects of static and dynamic fatigue on motor synergies, focusing on their hierarchical control. Specifically, we examined whether changes in fatigue influence the central nervous system's ability to preserve movement stability. In addition to exploring the direct impact of fatigue on motor synergies, we also analyzed its effects at two distinct levels of hierarchical control, aiming to elucidate the mechanisms by which fatigue alters motor coordination and stability. Thirteen healthy, young and right-handed male participants took part in the study. Participants performed …

Cognitive Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Aetiology and Potential Treatments.

Systemic infection and inflammation impair mental function through a combination of altered attention and cognition. Here, we comprehensively review the relevant literature and report personal clinical observations to discuss the relationship between infection, peripheral inflammation, and cerebral and cognitive dysfunction in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Cognitive dysfunction in ME/CFS could result from low-grade persistent inflammation associated with raised pro-inflammatory cytokines. This may be caused by both infectious and non-infectious stim…

Fatigue in inflammatory bowel disease: Prevalence, risk factors, assessment, outcomes, and management.

Fatigue is a prevalent and often debilitating symptom in individuals with inflammatory bowel disease (IBD), affecting a substantial proportion of patients, even during periods of disease remission. The prevalence of fatigue in IBD remains high, affecting around half of the IBD patients and being more common in patients with active disease than those in remission. Several risk factors contribute to fatigue in IBD, including active disease and pro-inflammatory state, nutritional deficiencies and anemia, sleep disturbances, psychological comorbidities, microbiota changes and the gut-brain axis, m…

Postacute COVID-19 fatigue, dyspnea and reduced activity in children and adolescents.

BACKGROUND: This study aimed to quantify fatigue, dyspnea, and physical activity and identify associated factors in children and adolescents with postacute COVID-19 syndrome. METHODS: A prospective cohort study included 74 participants aged 6-18 years with postacute COVID-19 symptoms and 120 age- and sex-matched controls without SARS-CoV-2 antibodies. Participants completed questionnaires assessing fatigue, dyspnea, and physical activity and underwent pulmonary function tests. RESULTS: Children with postacute COVID-19 syndrome reported significantly greater fatigue (parent-rated scores: mean…

Fatigue in patients with inflammatory bowel disease: A descriptive cross-sectional study.

AIM: To identify factors associated with the presence of fatigue in patients with inflammatory bowel disease. PATIENTS AND METHOD: Prospective cross-sectional descriptive study conducted in a multidisciplinary centre for the treatment of immune-mediated inflammatory disease (IMID). Participants were patients diagnosed with inflammatory bowel diseases (IBD) under follow-up in an advanced practice nurse (APN) consultation. Sociodemographic and clinical variables, biochemical parameters, disease activity, quality of life, severity of fatigue, anxiety and depression were collected. A multivariate…

Contested and neglected: Social and medical marginalization in severe Chronic Fatigue Syndrome.

This study addresses the persistent invisibility of people with severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) in research by centering their voices and examining how social and institutional forces shape their lives. As a medically contested illness, ME/CFS-especially in its severe form-renders patients both physically incapacitated and socially invisible. Drawing on qualitative content analysis of 342 tweets under the hashtag #severeME, we identify how contested legitimacy, gendered stigma, and systemic marginalization structure the daily realities of 161 individuals with…

Cholinergic basal forebrain degeneration is associated with central fatigue in Parkinson's disease.

BACKGROUND: Central fatigue is a prevalent and debilitating non-motor symptom in Parkinson's disease (PD), yet its neurobiological basis remains poorly understood. While cholinergic basal forebrain (CBFB) degeneration has been implicated in various PD symptoms, its specific relationship with central fatigue has not been systematically investigated using neuroimaging. METHODS: In this cross-sectional study, 49 patients with PD underwent 3.0 T brain structural magnetic resonance imaging (MRI) and completed the Fatigue Severity Scale (FSS). Gray matter density (GMD) and gray matter volume (GMV) …

Biological sex differences in fatigue in resistance-trained individuals: A scoping review.

Females may experience less neuromuscular fatigue and improved recovery following resistance training than males; however, it is unclear whether this applies to resistance-trained individuals. A systematic scoping review was performed to map the evidence on sex differences in fatigue during and following resistance training in trained participants. PubMed, CINAHL and SPORTDiscus were searched following PRISMA-ScR guidelines. The protocol was prospectively registered. Of the 4,020 identified articles, 34 were included. These studies assessed sex differences in fatigue using various measures dur…

Individual and Occupational Factors Associated with Work-Related Vocal Fatigue in Teachers.

BACKGROUND: Vocal fatigue is an individual-perceived, measurable symptom that influences vocal task performance. AIM: Characterize the work-relatedness of vocal fatigue in teachers by determining individual and occupational associated factors of the Vocal Fatigue Index (VFI). METHODS: All subjects (122 elementary and middle school teachers) provided informed consent before participation in the study protocol. Participating teachers completed questionnaires that documented voice-related working conditions, the VFI, and the Big Five Inventory-10. Additionally, subjects performed a spirometry t…

Italian adaptation of Listening Effort Assessment Scale and Fatigue Assessment Scale questionnaires.

OBJECTIVE: The purpose of this study is to adapt linguistically and culturally the Listening Effort Assessment Scale (EAS) and Fatigue Assessment Scale (FAS) questionnaires into Italian (EAS-IT and FAS-IT) and to investigate the reliability and validity of these scales in normal hearing and hearing-impaired subjects. METHODS: The Italian adaptation of the EAS and FAS questionnaires was conducted based on back and forward translation methodology. Both questionnaires were administered to 101 normal hearing (NH) subjects and 88 hearing-impaired subjects including 19 hearing aid users (HA), 50 co…

Compassion satisfaction and fatigue: emotional responses to nursing professionals' work and health.

OBJECTIVES: to analyze the association between emotional responses in health work and physical and mental health conditions with compassion satisfaction and compassion fatigue in nursing professionals from a Brazilian capital. METHODS: a cross-sectional study, carried out from August 2023 to July 2024 with 95 nursing professionals from a public hospital. Professional Quality of Life, Depression, Anxiety, and Stress scales and characterization questionnaires were applied. The analysis was carried out by effect size and multiple linear regression. RESULTS: satisfaction was associated with depr…

Anti-Fatigue Activity of Corn Protein Hydrolysate Fermented by Lactic Acid Bacteria.

OBJECTIVES: This study aimed to clarify the effect of lactic acid bacteria-fermented corn protein hydrolysate (FCH) on fatigue in mice and explore the connection between fatigue-related indicators and intestinal microbial flora. METHODS: The fatigue model of mice was constructed by exercise endurance experiment. The anti-fatigue level of FCH was evaluated by measuring physiological and biochemical indexes in mouse serum, liver and skeletal muscle. The relationship between FCH, intestinal flora and fatigue was explored through the analysis of intestinal microbial diversity in mice, and the ant…

Pain and Fatigue Interrelations in Terminally Ill Inpatients: A PCOC-Based Analysis.

CONTEXT: Pain and fatigue are among the most common and burdensome symptoms experienced by patients with advanced serious illness. However, few studies have captured their daily fluctuations using standardized, multidimensional tools. OBJECTIVES: This study aimed to examine the factors associated with daily pain and fatigue severity among patients with advanced serious illness using the palliative care outcomes collaboration (PCOC) framework in a Taiwanese palliative care setting. METHODS: A retrospective observational study was conducted at a medical center in central Taiwan between July 20…

Study on Multi-Factor Coupling Fatigue Properties of Weathering Steel Welded Specimens.

Environmental factors significantly affect the fatigue performance of weathering steel welded components in high-altitude, low-temperature corrosive environments. This study conducted multi-factor-coupled constant-amplitude fatigue tests on Q500qENH weathering steel V-groove welded joints and built an equivalent finite element model using test data to explore key influencing factors under multi-condition coupling. Results show that stress level most significantly affects fatigue performance, followed by corrosion duration, then ambient temperature, with influences decreasing in turn. Analyzing…

Anti-central fatigue effects of myelophil in 5-HTergic hyperactivity mice model.

BACKGROUND: Myelophil is a standardized ethanol extract of Astragali Radix and Salviae Miltiorrhizae Radix, which has been developed based on clinical experience in traditional Korean medicine practices for patients with unexplained chronic fatigue, including myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Our previous studies demonstrated Myelophil's clinical efficacy in ME/CFS, as well as its brain-related activities in animal models. However, the underlying pharmacological mechanisms remain unclear. Recently, we identified serotonergic hyperactivity as a key pathophysiological …

Challenges of symptom management in interstitial lung disease: dyspnea, cough, and fatigue.

INTRODUCTION: Interstitial lung disease (ILD) is a broad group of conditions characterized by fibrosis of the lung parenchyma. Idiopathic pulmonary fibrosis (IPF) is the most common subvariant. IPF is marked by considerable symptom burden of dyspnea, cough and fatigue that is often refractory to optimal disease-directed treatment. AREAS COVERED: In this narrative review, we searched MEDLINE for articles related to the current evidence regarding management of chronic dyspnea, cough, and fatigue as three of the most prevalent and distressing symptoms associated with IPF and other ILDs. Each sym…