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Facial myokymia: a clue to the diagnosis of multiple sclerosis.

Three patients with multiple sclerosis in whom facial myokymia occurred are described. The clinical and electromyographic features of this phenomenon are reviewed. The phenomenon is most frequently associated with multiple sclerosis, and when it is transient and unassociated with progressive facial paresis and other signs of a pontine tumour, is a strong indication of this condition.

Profiling peripheral blood oxidative stress in multiple sclerosis.

BACKGROUND: Oxidative stress is implicated in the pathophysiology of multiple sclerosis (MS), but the potential of oxidative stress responses as MS biomarkers has not been systematically explored. METHODS: Over 12 months, we measured serial plasma concentrations or activity, and peripheral blood mononuclear cell (PBMC) expression of master antioxidant regulators, downstream antioxidant enzymes, and plasma end products of oxidation in blood from people with MS (pwMS), including a cohort commencing disease modifying therapy (DMT). Multivariable regression models were employed adjusting for age,…

Multiple sclerosis synaptic connectome: Insights from fluid biomarkers.

Multiple sclerosis is a chronic immune-mediated and degenerative disease of the central nervous system. Increasing evidence highlights the role of brain network disconnection in the pathogenesis of clinical progression and irreversible disability accumulation in people with multiple sclerosis. Several pathologic changes contribute to multiple sclerosis-related disconnection, ranging from focal areas of demyelination and axonal transection to atrophy of both cortical and subcortical gray matter structures. In the last years, increasing evidence also suggests a prominent role of synaptic dysfunc…

Herpes zoster and multiple sclerosis disease modifying therapies.

Not available.

Psychological resilience predicts medication adherence in multiple sclerosis.

INTRODUCTION: Sustained adherence to disease-modifying therapies is essential for preventing relapses and long-term disability progression in people with relapsing-remitting-multiple sclerosis (PwRRMS). Although psychological distress is associated with poor adherence, the independent contribution of psychological resilience remains unclear. This study aimed to determine whether psychological resilience is independently associated with medication adherence (MA) in PwRRMS who are in remission after accounting for psychological distress, disability level, quality of life (QoL), and clinical fact…

Association Between Genetic Ancestry and Multiple Sclerosis Severity.

OBJECTIVE: The objective of this study was to determine whether genetic ancestry is associated with differences in the clinical course of multiple sclerosis (MS). METHODS: Participants with MS living in the United Kingdom >18 years old were recruited from 2021 to 2025 and genotyped from saliva using a commercial array. Genetic ancestry was inferred using a random forest classifier trained on a diverse reference dataset. Participant-reported MS characteristics including the Age-Related Multiple Sclerosis Severity Score (ARMSS) and age at MS diagnosis were ascertained at recruitment. RESULTS: …

ПедиМС: набор данных о педиатрическом многоразовом спектре склероза.

Множественный склероз (MS) является хроническим аутоиммунным заболеванием, которое в первую очередь затрагивает центральную нервную систему и диагностируется преимущественно у взрослых, что делает педиатрические случаи редкими и недопредставленными в медицинских исследованиях. В настоящем документе представлен первый общедоступный набор данных МРТ, специально посвященный сегментации педиатрического множественных склерозов. Этот набор данных включает продольное МРТ-сканирование 9 педиатрических пациентов, каждый из которых имеет от одного до шести временных интервалов, и в общей сложности 28 МР

Совпадение в аннотации оригинала
Multiple Sclerosis (MS) is a chronic autoimmune disease that primarily affects the central nervous system and is predominantly diagnosed in adults, making pediatric cases rare and underrepresented in medical research. This paper introduces the first publicly available MRI dataset specifically dedicated to pediatric multiple sclerosis lesion segmentation. The…

Multiple sclerosis lesions exhibit sex-specific steroid changes.

Sex differences in disease susceptibility and progression in multiple sclerosis (MS) indicate hormonal influences. We previously found sex differences in steroidogenic enzyme expression in mixed active/inactive (mixed) and inactive lesions, suggesting increased synthesis and signalling of progesterone in females and of estradiol (E2) in males. Here we measured steroid levels in mixed and inactive MS lesions (14 males, 16 females) and control donor white matter (10 males, 10 females) by gas chromatography-mass spectrometry (GC/MS). In mixed and inactive lesions, we found a female-specific incre…

Health Care Use Before Multiple Sclerosis Symptom Onset.

IMPORTANCE: Health care use increases before multiple sclerosis (MS) onset. However, most studies have focused on the 5 to 10 years preceding the first demyelinating disease code from administrative data. Few studies have examined patterns before clinically determined MS symptom onset from clinical records. OBJECTIVE: To examine health care use 25 years before MS symptom onset in a clinical cohort from British Columbia, Canada. DESIGN, SETTING, AND PARTICIPANTS: This matched cohort study accessed data prospectively collected from January 1991 to September 2018. All data were released mid-202…

Отключение многоразового склероза Генетика: от удобочитаемости к терпимости.

Множественный склероз (MS) — клинически разнообразное и непредсказуемое расстройство CNS. Считается, что значительная неоднородность патологических процессов, происходящих на различных этапах заболевания, отражает различия в масштабах и масштабах патологического процесса. Генетические факторы, как известно, повышают риск развития НР и становятся прогнозерами клинических результатов. Они могут также давать представление о биологических процессах, влияющих на инвалидность. В этом обзоре мы оцениваем роль генетических факторов в MS от подверженности болезням до серьезности заболеваний. Мы рассмат

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a clinically diverse and unpredictable CNS disorder. The considerable heterogeneity in disease course between people with MS is believed to reflect the varying magnitude and extent of the pathologic processes present at different stages of the disease. Genetic factors are known to contribute to the risk of developing MS and are eme…