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Transcutaneous electrical nerve stimulation and acupuncture for primary dysmenorrhoea.

BACKGROUND: Dysmenorrhoea is the occurrence of painful menstrual cramps of the uterus. Medical therapy for dysmenorrhoea commonly consists of nonsteroidal anti-inflammatory drugs or the oral contraceptive pill both of which work by reducing myometrial (uterine muscle) activity. However, these treatments are accompanied by a number of side effects, making an effective non-pharmacological method of treating dysmenorrhoea of potential value. Transcutaneous electrical nerve stimulation (TENS) is a treatment that has been shown to be effective for pain relief in a variety of conditions. Electrodes

Transcutaneous electrical nerve stimulation (TENS) for pain control in women with primary dysmenorrhoea.

BACKGROUND: Transcutaneous electrical nerve stimulation (TENS) is a non-pharmacological treatment that works by delivering electrical currents via electrodes attached to the skin at the site of pain. It can be an alternative to pharmacological treatments. The mechanism of action of TENS for pain relief is related to the inhibition of the transmission of painful stimuli, release of endogenous opioids, and reduced muscle ischaemia of the uterus. Although it has been used for primary dysmenorrhoea ((PD); period pain or menstrual cramps), evidence of the efficacy and safety of high-frequency TENS,

Drug treatment for myotonia.

BACKGROUND: Abnormal delayed relaxation of skeletal muscles, known as myotonia, can cause disability in myotonic disorders. The main myotonic disorders are non-dystrophic myotonia and myotonic dystrophy. Non-dystrophic myotonia is a genetic muscle channelopathy predominantly causing myotonia. Myotonic dystrophic is a more systemic neuromuscular disorder causing myotonia as well as progressive myopathy and systemic manifestations, such as arrhythmias and cataracts. Myotonia manifests as stiffness, cramps, locking, pain, and fatigue, and can cause marked morbidity and disability. Sodium channel

Rhythmic Foot Embrocation According to Wegman/Hauschka for Alleviating Symptoms of Chemotherapy-Induced Peripheral Neuropathy: A Randomized Controlled Trial.

BackgroundChemotherapy-induced peripheral neuropathy (CIPN) in patients treated with platinum-, taxane- or vinca alkaloid-based chemotherapy may cause symptoms such as tingling, numbness, pain, and paresthesia, particularly in patients' hands and feet. This study aimed to evaluate rhythmic embrocation (RE) of the feet according to Wegman/Hauschka in addition to an exercise program (EP) as a complementary treatment for CIPN symptoms.MethodsThis study was a prospective, randomized controlled, 2-center trial. A total of 57 patients with CIPN symptoms were randomly allocated into 2 groups, with 52

Omega-3 fatty acid supplementation for depression in children and adolescents.

BACKGROUND: Mental health disorders including major depressive disorder (MDD) are well recognized as major contributors to the global burden … lementation may result in little to no difference in adverse effects, with one study reporting more muscle cramps in the fish oil group (13/27 participants) compared to the placebo group (6/29 participants); one study reported more frequent defecation in the omega-3 group (1/29 participants) and one study identified mild skin rash and unusual/manic behavior in …

Treatment of early-stage diabetic nephropathy with Siddha drug Sirupeelai Kudineer: A case series.

Diabetic Nephropathy is one of the major microvascular complications of Diabetes Mellitus, which can be detected in the earlier stage by investigating urinary microalbumin excretion levels and estimating ACR and GFR. Early treatment can delay or prevent the progression of diabetic Nephropathy. Monoherbal Siddha formulation Sirupeelai Kudineer indicated for the complications of Diabetes Mellitus is selected for this Case study. The efficiency of the drug was assessed by measuring the change in renal function throughout the treatment period and the KD QOL assessment. Four patients presented with

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… cramps in calf muscles, especially during the night, and generalized, persistent itchy skin for two years, which was aggravated for one month. … The severity of the subjective parameters, such as bilateral pedal edema, General weakness, itching, excessive thirst, joint pain, frequent nocturnal micturition, and muscle cramps, were significantly reduced during medication. …

Эффективность моделей машинного обучения для прогнозирования симптомов высокой чувствительности при множественном склерозе.

Текущий уход за многочисленными склерозами (МС) в первую очередь опирается на редко получаемые данные, такие, как магнитно-резонансная съемка, клинические лабораторные тесты или клиническая история, что приводит к незначительным изменениям, которые могут произойти в период между посещениями. Мобильные технологии позволяют осуществлять постоянный сбор данных и прокладывают путь к прогнозированию сложных аспектов НР, таких, как симптомы и заболевания. С этой целью мы провели первое в своем роде исследование по наблюдению под названием MS Mosail. Во-первых, мы разработали и публично запустили моб

Low BMI, blood calcium and vitamin D, kyphosis time, and outdoor activity time are independent risk factors for osteoporosis in postmenopausal women.

AIM: To explore the risk factors of osteoporosis in postmenopausal women in China. METHOD: This study collected all patient data from January 2014 to December 2015. Basic information and questionnaires were collected from 524 postmenopausal women in Sanya and Hainan Province. The questionnaire was administered to the enrolled participants by endocrinologists. Biochemical parameters were measured using fasting blood samples, and bone density was measured by dual energy X-ray absorptiometry at the department of radiology of Hainan hospital, PLA General Hospital. Participants with an R-value of

Common Non-Rheumatic Medical Conditions Mimicking Fibromyalgia: A Simple Framework for Differential Diagnosis.

Fibromyalgia (FM) is a chronic non-inflammatory disorder mainly characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and a constellation of other symptoms. For this reason, delineating a clear distinction between pure FM and FM-like picture attributable to other common diseases can be extremely challenging. Physicians must identify the most significant confounders in individual patients and implement an appropriate diagnostic workflow, carefully choosing a minimal (but sufficient) set of tests to be used for identifying the most plausible diseases in the specific case

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… Consequently, magnesium deficiency often manifests with an FM-like clinical picture including pain, fatigue, weakness, muscle cramps, impaired concentration and attention, sleep disturbances, anxiety, restlessness, palpitations/arrhythmia, and headaches [ 44 , 45 ]. … These adverse drug reactions (ADRs) are extremely common [ 138 ] and can affect virtually all organs and systems in the body—including the musculoskeletal system—ranging from mild (e.g., muscle cramps) to life-threatening conditions (e.g., severe rhabdomyolysis) [ 139 ]. …

Acupuncture for Bortezomib-Induced Peripheral Neuropathy: Not Just for Pain.

BackgroundBortezomib-induced peripheral neuropathy (BIPN) is a common and debilitating side effect. Our pilot study demonstrated that acupuncture is safe and can decrease total neuropathic symptoms. However, there is lack of knowledge in which individual BIPN symptoms benefited from acupuncture.PurposeTo characterize individual symptoms reduced by acupuncture in patients with BIPN.MethodsPatients with multiple myeloma treated with bortezomib who developed BIPN grade 2 or above, based on National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE), were enrolled and rece

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… The FACT/GOG-Ntx symptoms include numbness and tingling in the hands (Ntx 1) and feet (Ntx 2), discomfort in the hands (Ntx 3) and feet (Ntx 4), joint pain/muscle cramps (Ntx 5), feeling weak all over (HI 12), trouble hearing (Ntx 6), ringing/buzzing in the ears (Ntx 7), trouble buttoning buttons (Ntx … The motor symptoms, including joint pain/muscle cramps and feeling “weak all over,” also increased over time but were not statistically significant ( P = .41 and .26, respectively). …

Osteoporosis Drug Treatment Update.

The Brazilian population is aging and the prevalence of chronic degenerative diseases, including osteoporosis, is increasing. The diagnosis and treatment of osteoporosis have made significant advances in the last decade. The orthopedist and traumatologist can no longer be detained only in the surgical treatment of osteoporotic fracture. It is extremely important that we know: 1) what risk factors to evaluate, and the Fracture Risk Assesment Tool (FRAX) can be used; 2) which complementary tests should be requested, such as densitometry, radiography of the spine and pelvis, blood and urine tests

Genetic and Mechanistic Insights Inform Amyotrophic Lateral Sclerosis Treatment and Symptomatic Management: Current and Emerging Therapeutics and Clinical Trial Design Considerations.

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting both upper and lower motor neurons. ALS is classically characterized by painless progressive weakness, causing impaired function of limbs, speech, swallowing, and respiratory function. The disease is fatal within 2-4 years, often the result of respiratory failure. The pathologic hallmark for a majority of ALS cases is aberrant cytoplasmic accumulations of the nuclear protein TAR-DNA binding protein (TDP-43). A total of 10-15% of ALS can be attributed to a single gene mutation, known as genetic or "familia

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… Cramps Up to 95% of patients with ALS experience muscle cramps [ 192 ]. A phase 2 trial of mexiletine, a sodium channel blocker, demonstrated dose-dependent reduction in muscle cramps, though 300 mg doses were associated with fewer adverse events. …

Patient Perceptions Regarding Multiple Myeloma and Its Treatment: Qualitative Evidence from Interviews with Patients in the United Kingdom, France, and Germany.

BACKGROUND: The current standard of care for multiple myeloma requires several regimens of treatment, with patients experiencing high symptom burden and side effects, which negatively impact health-related quality of life (HRQoL). Thus, it is crucial to understand patient perceptions of multiple myeloma and how patients value different treatment options. OBJECTIVE: The purpose of this study was to conduct an exploratory investigation into concepts that could form attributes that influence treatment choices for patients with multiple myeloma and to identify trade-offs that patients are willing

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… cramps 3 (10.0) 2 (11.0) 1 (8.0) Headache 3 (10.0) 0 3 (25.0) Insomnia 3 (10.0) 3 (17.0) 0 Data are presented as n (%). … During certain phases, depending on what medications I’m taking, I have an increase in ‘ muscle cramps. ’ I’ve got ‘ polyneuropathy with a variety of symptoms. ’” (TE NDMM, Germany) Patients referenced the frequency or duration of symptoms when thinking about the acceptability of side effects. …

Evaluation of Exposure to Toluene and Xylene in Gasoline Station Workers.

The main volatile organic compounds found at gasoline stations are benzene, toluene, ethylbenzene, and xylene isomers (BTEX). They cause several harmful effects on human health. Regulatory Norm 7 (1978) provides that, in Brazil, biological monitoring of toluene and xylene is carried out by measuring the urinary metabolites hippuric acid (HA) and methylhippuric acid (MHA), respectively. The objective of this study was to assess the exposure to toluene and xylene and to identify related signs and symptoms in gasoline station workers. A cross-sectional epidemiological study was conducted with wor

Therapeutic plasma exchange across multiple organ systems in an Egyptian tertiary center: A seven-year real-world cohort study.

BACKGROUND: Real-world evidence on therapeutic plasma exchange (TPE) from low- and middle-income countries remains limited. Egyptian data across multiple organ systems are scarce. This study aimed to evaluate the indications, safety, efficacy, and predictors of outcomes in patients undergoing TPE at a tertiary center in Egypt over 7 years. METHODS AND FINDINGS: This retrospective cohort study included 221 consecutive patients who underwent TPE (2016-2022) at Zagazig University Hospitals, Egypt. Patients were stratified into renal, neurologic, hematologic, and metabolic groups. Primary outcome

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… For intra-procedural events (hypotension, allergic reactions, muscle cramps), the proportion of total sessions affected is also reported to provide procedural safety context. … When calculated per session, these events occurred in 2.4% of sessions for hypotension, 1.9% for allergic reactions, and 0.7% for muscle cramps, reflecting the low per-procedure risk. …

Trends in Kampo Medicine Usage as Supportive Care During Anticancer Drug Treatment in Japanese Patients: A Nationwide Cohort Analysis from Fiscal Years 2015 to 2021.

The adverse effects of anticancer drugs significantly impact the quality of life of patients undergoing chemotherapy, necessitating evidence-based supportive therapies. In Japan, Kampo medicines, traditional Japanese herbal therapies used for relief of various symptoms, have been widely used as complementary and alternative treatments for cancer, despite limited evidence regarding their efficacy and safety. Thus, we investigated the actual use of Kampo medicines as supportive care in patients undergoing anticancer drug treatment and evaluated the trends in prescription according to year. We an

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… For example, Daikenchuto, one type of Kampo medicine, is used for constipation and intestinal obstruction [ 17 , 18 ], Goshajinkigan is used for lower back pain [ 19 ], and Shakuyakukanzoto is used for skeletal muscle cramps and intestinal cramps [ 20 ]. … Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: Role of the active constituents of Glycyrrhizae radix J. Ethnopharmacol. 2013 145 286 293 10.1016/j.jep.2012.11.005 23164761 21. Ohno T. Yanai M. Ando H. Toyomasu Y. Ogawa A. Morita H. Ogata K. Mochiki E. …

Chemotherapy-induced neuropathies-a growing problem for patients and health care providers.

IntroductionChemotherapy-induced neuropathies are one of the most common side effects of cancer treatment, surpassing bone marrow suppression and kidney dysfunction. Chemotherapy effects on the nervous system vary between different classes of drugs and depend on specific chemical and physical properties of the drug used. The three most neurotoxic classes of anti-cancer drugs are: platinum-based drugs, taxanes, and thalidomide and its analogs; other, less neurotoxic but also commonly used drugs are: bortezomib, ixabepilone, and vinca alkaloids.MethodsHere, in this paper, based on our experience

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… Neurotoxic effects of thalidomide are predominately observed in lower extremities neuropathies, such as foot and leg dysesthesia, sensory loss, tingling, impaired reflexes, and painful muscle cramps. …

Post hip fracture orthogeriatric care-a Canadian position paper addressing challenges in care and strategies to meet quality indicators.

INTRODUCTION: Osteoporosis is a major disease state associated with significant morbidity, mortality, and health care costs. Less than half of the individuals sustaining a low energy hip fracture are diagnosed and treated for the underlying osteoporosis. OBJECTIVE: A multidisciplinary Canadian hip fracture working group has developed practical recommendations to meet Canadian quality indicators in post hip fracture care. METHODS: A comprehensive narrative review was conducted to identify and synthesize key articles on post hip fracture orthogeriatric care for each of the individual sections

Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people.

Osteoporosis, a common chronic metabolic bone disease is associated with considerable morbidity and mortality. As the prevalence of osteoporosis increases with age, a paralleled elevation in the rate of incident fragility fractures will be observed. This narrative review explores the origins of bone and considers physiological mechanisms involved in bone homeostasis relevant to management and treatment. Secondary causes of osteoporosis, as well as osteosarcopenia are discussed followed by an overview of the commonly used pharmacological treatments for osteoporosis in older people.

Диагностика амиотропического бокового склероза: до настоящего времени.

Амиотрофический боковой склероз (ALS) — прогрессивное нейродегенеративное заболевание, характеризующееся постепенной потерей верхних и нижних моторных нейронов и их путей, обычно без воздействия на экстракулярные и сфинктерные мышцы. Причины этого заболевания пока не известны. Это цепь последующих событий, заканчивающихся запрограммированной клеточной смертью в селективных нейронных поднаселениях. Прогнозы на выживание довольно коротки с медианой 2 в адрес 4 Годы. Выживание может быть продлено на основе оперативной диагностики, подтипа ALS и надлежащего управления с помощью поддерживающего леч

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… The disease often begins with an asymmetric weakness in a focal muscle group, most often in the upper limb, with difficultly in writing or unlocking the door, impaired chewing or swallowing, slurred and nasal speech, fasciculations (muscle twitches) in the arm, leg, shoulder or tongue, muscle cramps, …