Результаты поиска

Surgical management of medically refractory epilepsy due to early childhood stroke.

UNLABELLED: OBJECT.: The risk of developing epilepsy after perinatal stroke, hypoxic/ischemic injury, and intracerebral hemorrhage is significant, and seizures may become medically refractory in approximately 25% of these patients. Surgical management can be difficult due to multilobar or bilateral cortical injury, nonfocal or poorly lateralizing video electroencephalography (EEG) findings, and limited functional reserve. In this study the authors describe the surgical approaches, seizure outcomes, and complications in patients with epilepsy due to vascular etiologies in the perinatal period a

Identification of Target Body Composition Parameters by Dual-Energy X-Ray Absorptiometry, Bioelectrical Impedance, and Ultrasonography to Detect Older Adults With Frailty and Prefrailty Status Using a Mobile App in Primary Care Services: Descriptive Cross-Sectional Study.

BACKGROUND: Frailty syndrome in older adults represents a significant public health concern, characterized by a reduction in physiological reserves and an increased susceptibility to stressors. This can result in adverse health outcomes, including falls, hospitalization, disability, and mortality. The early identification and management of frailty are essential for improving quality of life and reducing health care costs. Conventional assessment techniques, including dual-energy X-ray absorptiometry (DXA), bioelectrical impedance analysis (BIA), and muscle ultrasound (US), are efficacious but

Desloratadine: A preclinical and clinical overview.

A new competitive histamine H(1)-receptor antagonist with superior binding affinity at this receptor as compared with other common antihistamines, desloratadine is the active metabolite of loratadine, the most extensively used agent of this class. Under development for the treatment of allergic rhinitis and urticaria and currently awaiting regulatory approval in the United States, desloratadine was recently approved and became commercially available in Europe for the treatment of allergic disease. Desloratadine is at least 50-fold more potent in vitro and appears to be 10-fold more potent in v

[The application of submental island flap in head and neck surgery].

Ulcerative colitis (UC) and Crohn disease (CD) are chronic intestinal inflammatory diseases that can present as bloody diarrhea, abdominal pain, and malnutrition. Collectively, these disorders are referred to as inflammatory bowel disease (IBD). All patients with IBD share a common pathophysiology. However, there are a number of developmental, psychosocial, and physiologic issues that are unique to the approximate, equals 20% of patients that present during childhood or adolescence. These include the possibility of disease-induced delays in linear growth or physical development, differences in

Geriatric Assessment-Based Stratification to Evaluate Treatment Intensity, Quality of Life, and Survival in Older Patients With Metastatic Colorectal Cancer: Protocol for a Prospective Observational Study.

BACKGROUND: Older patients with metastatic colorectal cancer (mCRC) are a heterogeneous population with wide variability in functional status, frailty, cognition, nutritional reserve, and comorbidity burden. Treatment decisions are often guided primarily by chronological age and performance status, which may not adequately capture vulnerability or patient-centered outcomes in this population. OBJECTIVE: The primary aim of this study is to prospectively evaluate the association of baseline geriatric assessment (GA)-derived frailty with overall survival in older patients with mCRC receiving fir

A Prospective Study of Ultrasonographic and FNAC Correlation of Thyroid Swellings with Histopathology.

Recombinant preparations of the cytokine interferon (IFN)-alpha are increasingly used to treat a number of medical conditions, including chronic viral hepatitis and several malignancies. Although frequently effective, IFN alpha induces a variety of neuropsychiatric adverse effects, including an acute confusional state that develops rapidly after initiation of high-dose IFN alpha, a depressive syndrome that develops more slowly over weeks to months of treatment, and manic conditions most often characterised by extreme irritability and agitation, but also occasionally by euphoria. Acute IFN alph

American Medical Society for Sports Medicine position statement: concussion in sport.

UNLABELLED: PURPOSE OF THE STATEMENT: ▸ To provide an evidence-based, best practises summary to assist physicians with the evaluation and management of sports concussion. ▸ To establish the level of evidence, knowledge gaps and areas requiring additional research. IMPORTANCE OF AN AMSSM STATEMENT: ▸ Sports medicine physicians are frequently involved in the care of patients with sports concussion. ▸ Sports medicine physicians are specifically trained to provide care along the continuum of sports concussion from the acute injury to return-to-play (RTP) decisions. ▸ The care of athletes with spo

[Peritoneal dialysis in the aged].

INTRODUCTION: Patients older than 65 years represent the group of patients affected by end-stage renal failure characterized by the most rapid growth. The prevalent causes of end-stage renal disease (ESRD) in the elderly are diabetes mellitus and nephrosclerosis due to long-term arterial hypertension. There are a number of physiologic changes which occur with aging that might have an impact on the choice of renal replacement modality for an elderly patient: clinical or subclinical diminished cardiovascular reserve due to atherosclerosis or impaired baroreceptor function, slow deterioration of

Association of Frailty With Risk of Suicide Attempt in a National Cohort of US Veterans Aged 65 Years or Older.

IMPORTANCE: Frailty is associated with reduced physiological reserve, lack of independence, and depression and may be salient for identifying older adults at increased risk of suicide attempt. OBJECTIVES: To examine the association between frailty and risk of suicide attempt and how risk differs based on components of frailty. DESIGN, SETTING, AND PARTICIPANTS: This nationwide cohort study integrated databases from the US Department of Veterans Affairs (VA) inpatient and outpatient health care services, Centers for Medicare & Medicaid Services data, and national suicide data. Participants in

International Society of Sports Nutrition position stand: effects of dietary antioxidants on exercise and sports performance.

Following a comprehensive review, the International Society of Sports Nutrition (ISSN) has developed an official position on the role of dietary antioxidants in exercise and sport. Antioxidants play a complex, context-dependent role in vivo; they can facilitate recovery from exercise but may also hinder training adaptations when consumed at supraphysiological doses. While endogenous antioxidant systems can effectively maintain redox balance, dietary sources, particularly whole foods, can help mitigate excessive oxidative stress following intense/heavy training or inadequate recovery. The influ

Correction to "An uncontrolled trial of couple HOPES: A guided online couple intervention for PTSD and relationship enhancement" by Monson et al. (2022).

Reports an error in "An uncontrolled trial of couple HOPES: A guided online couple intervention for PTSD and relationship enhancement" by Candice M. Monson, Anne C. Wagner, Alexander O. Crenshaw, Kristen M. Whitfield, Cait Martin Newnham, Robert Valela, Sonya Varma, Alyssa A. Di Bartolomeo, Lindsay Fulham, Alexis Collins, Victoria Donkin, Desiree H. Mensah, Meredith S. H. Landy, Christina Samonas, Leslie Morland, Brian D. Doss and Skye Fitzpatrick (Journal of Family Psychology, 2022[Sep], Vol 36[6], 1036-1042; see record 2022-41008-001). In the article, analyses involving the anger variable we

Intensive and comprehensive aphasia therapy-a survey of the definitions, practices and views of speech and language therapists in the United Kingdom.

BACKGROUND: Research evidence suggests aphasia therapy must be delivered at high intensity to effect change. Comprehensive therapy, addressing all domains of the International Classification of Functioning, Disability and Health, is also called for by people with aphasia and their families. However, aphasia therapy is rarely intense or comprehensive. Intensive Comprehensive Aphasia Programmes (ICAPs) were designed to address this challenge, but such programmes are not widely implemented. AIMS: This study surveyed the views of UK-based speech and language therapists (SLTs) regarding intensive

Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport.

IMPORTANCE: Mutations in APP, PSEN1, and PSEN2 lead to early-onset Alzheimer disease (EOAD) but account for only approximately 11% of EOAD overall, leaving most of the genetic risk for the most severe form of Alzheimer disease unexplained. This extreme phenotype likely harbors highly penetrant risk variants, making it primed for discovery of novel risk genes and pathways for AD. OBJECTIVE: To search for rare variants contributing to the risk for EOAD. DESIGN, SETTING, AND PARTICIPANTS: In this case-control study, whole-exome sequencing (WES) was performed in 51 non-Hispanic white (NHW) patie

[Neurobiology and pharmacotherapy of social phobia].

Social phobia (also known as social anxiety disorder) is still not clearly understood. It was not established as an authentic psychiatric entity until the diagnostic nomenclature of the American Psychiatric Association DSM III in 1980. In recent years, increasing attention among researchers has contributed to provide important information about the genetic, familial and temperamental bases of social phobia and its neurochemical, neuroendocrinological and neuroanatomical substrates, which remain to be further investigated. Up to date, there have been several findings about the possible influenc

Для лечения когнитивного упадка при множественном склерозе необходим междисциплинарный подход: да.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Throughout the disease course, there are also multiple time points when cognitive reserve can be addressed by multiple team members. How effectively cognitive reserve can be addressed to impact decline in MS remains an important research priority. … The emphasis on the importance of enhancing cognitive reserve stems from the need to preserve neural network connectivity. …

The concept of multidimensional frailty in geriatric oncology: a systematic scoping review.

BACKGROUND: One of the major challenges in geriatric oncology is to estimate the risk-benefit balance of any therapeutic proposal for each patient and frailty is one of the key components of Comprehensive Geriatric Assessment (CGA)and can also be assessed using stand-alone screening tools that predicts functional decline, treatment-related complications and mortality. This study aimed to provide an overview of the existing literature on the concept of multidimensional frailty in older adults with cancer, to clarify the dimensions included in multidimensional frailty, and the components of frai

Multical Sclerosis Severity Alle res10191329A и Когнитивная функция: UK Biobank Study.

В рамках исследования, проведенного в рамках всей ассоциации генома по вопросу о жесткости множественных склерозов, генетический вариант rs10191329A увязывался с долгосрочной инвалидностью и в качестве одного из определяющих факторов исхода учитывала устойчивость мозга. Мы гипотезали, что rs10191329A может повлиять на когницию других неврологических заболеваний и здоровый контроль. Мы изучили связь между rs10191329A и когницией с использованием времени реакции, жидкого интеллекта и возможных тестов памяти в Биобанке Великобритании. Мы наблюдали слабые, но последовательные связи между rs1019132

Совпадение в полном тексте источника
… M., et al., “Erratum: Brain Reserve and Cognitive Reserve in Multiple Sclerosis: What You've Got and How You Use It,” Neurology 81 (2013): 604. 10. Vemuri P., Weigand S. D., Przybelski S. … A., et al., “Cognitive Reserve and Alzheimer's Disease Biomarkers Are Independent Determinants of Cognition,” Brain 134 (2011): 1479–1492. 11. …

Нынешние проблемы, связанные со вторичным прогрессивным множественным склерозом: диагностика, выявление активности и лечение.

Примерно 50% диагностировали повторное склерозное склерозное излучение (RRMS), переходя к вторичному прогрессивному множественным склерозу (SPMS) в течение 20 лет после возникновения болезни. Однако ранняя диагностика СМПС и эффективное лечение по-прежнему являются важными клиническими проблемами. Отсутствие установленных диагностических критериев часто приводит к задержкам с определением СМПС. Кроме того, для прогрессивных форм MS имеется ограниченный доступ к методам лечения, позволяющим сглаживать заболевания (DMT), и эти методы требуют подтверждения активности заболеваний, которая должна б

Совпадение в полном тексте источника
… The balance of such mechanisms, together with repair capacity and brain and cognitive reserve influences clinical progression during the disease course. … Importantly, aging is associated with a decline in brain reserve and cognitive reserve, rendering the CNS less resilient to the cumulative effects of MS pathology ( 45 ). Indeed, it has been hypothesized that loss of neurologic reserve explains the onset of progressive MS ( 46 ). …

Association of Coronary Microvascular Dysfunction With Cerebrovascular Risk and Cognitive Decline in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study.

BackgroundType 2 diabetes mellitus is associated with microvascular complications that may contribute to both cardiovascular and neurological morbidity.ObjectiveTo evaluate the association of coronary microvascular dysfunction with stroke risk, cognitive decline, and selected hematologic/metabolic biomarkers in patients with type 2 diabetes mellitus without major vessel occlusion.MethodsThis analytical cross-sectional study was conducted at the Department of Cardiology, Jinnah International Hospital, Abbottabad, Pakistan, from May 2025 to November 2025. A total of 255 patients with type 2 diab

Remote assessment of cognitive dysfunction in hematologic malignancies using web-based neuropsychological testing.

BackgroundCognitive impairment is a frequent adverse effect of cancer and its therapies. As neuropsychological assessment is not often standard of care for patients with non-CNS disease, efficient, practical assessment tools are required to track cognition across the disease course. We examined cognitive functioning using a web-based cognitive testing battery to determine if it could detect differences between patients with cancer and controls.MethodsWe enrolled 22 patients with multiple myeloma (MM) or non-Hodgkin lymphoma (NHL) and 40 healthy controls (mean age = 56 ± 11 years, 52% male). Pa

Совпадение в полном тексте источника
… Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: impact of age and cognitive reserve. J Clin Oncol. 2010;28(29):4434‐4440. doi: 10.1200/JCO.2009.27.0827 27. Phillips NS, Kesler SR, Scoggins MA, et al. … Cognitive reserve. Neuropsychologia. 2009;47(10):2015‐2028. doi: 10.1016/j.neuropsychologia.2009.03.004 33. Jones D, Vichaya EG, Wang XS, Sailors MH, Cleeland CS, Wefel JS. Acute cognitive impairment in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplant. …