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Immune System and DNA Repair Defects in Ovarian Cancer: Implications for Locoregional Approaches.

In the last few years, substantial progress has been made in the treatment of ovarian cancer, with increased knowledge about the biology of the disease. Ovarian cancer is a neoplasm strongly linked to defects in DNA repair mechanisms, where deficiency in the homologous recombination (HR) system results in a better response of ovarian cancers to therapy, whether platinum-based chemotherapy, anthracyclines, or poly (ADP-ribose) polymerase (PARP) inhibitors. More recently, it has been demonstrated that different ovarian cancer histotypes may have different immunogenicity. Interestingly, defects i

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… Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer N. Engl. J. Med. 2018 378 230 240 10.1056/NEJMoa1708618 29342393 21. Spiliotis J. Halkia E. Lianos E. Kalantzi N. Grivas A. Efstathiou E. Giassas S. … Time course of cytokines, hemodynamic and metabolic parameters during hyperthermic intraperitoneal chemotherapy Minerva Anestesiol. 2016 82 310 319 26184701 81. Muenyi C.S. Trivedi A.P. Helm C.W. States J.C. …

Perioperative restrictive versus goal-directed fluid therapy for adults undergoing major non-cardiac surgery.

BACKGROUND: Perioperative fluid management is a crucial element of perioperative care and has been studied extensively recently; however, 't … ominal surgery (including one study in participants undergoing cytoreductive abdominal surgery with hyperthermic intraperitoneal chemotherapy (HIPEC)), and one study was performed in participants undergoing orthopaedic surgery. In all studies, surgeries were elective. In five studies, crystalloids were used for basal infusion and colloids for boluses, and in one study, colloid was used fo …

Review of cancer therapies for the perioperative physician.

Advances in cancer treatments over the past decades combining chemotherapy with novel technologies in immunotherapies, radiation therapies, and interventional radiology have prolonged life expectancy. Patients have more options for treatments of their primary or metastatic diseases. Increased procedural techniques amid an aging population with multiple comorbidities present risks and challenges in the perioperative period.Chemotherapy remains the mainstay of cancer treatment, can be given intraoperatively, and is combined with other treatment modalities. Immunotherapy is particular to cancer c

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… A current systematic review of patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for colorectal cancer metastasis noted a low risk for postoperative bleeding and thrombotic events after 30 and 90 days, respectively (Lundbech et al. 2022 ). … Cisplatin treats many malignancies and may lead to acute kidney injury (AKI) or chronic kidney disease (CKD), especially during cytoreduction surgery with intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC). …

The Influence of Muscle Morphology on Oncological Outcomes: A Review.

Cancer is a common disease with significant impact on patients and society. Cancer and oncological treatment can negatively affect muscle, and muscle health impacts oncologic outcomes. This review studied the effect of different muscle parameters on oncologic outcomes. A systematic search was performed until April 2023. Parameters included were muscle thickness, cross-sectional area, skeletal muscle index, skeletal muscle mass, pennation angle, fascicle length, muscle density, echo intensity and elastography. Imaging methods included were computerized tomography, magnetic resonance imaging, ul

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… AE = adverse events; C3 = cervical vertebra 3; CSA = cross-sectional area; cont. = continuous; CT = computed tomography; CTCAE = Common Terminology Criteria for Adverse Events; DLT = dose-limiting toxicity; ES = erector spinae; 5-FU = 5-fluorouracil; HIPEC = hyperthermic intraperitoneal chemotherapy; … intraperitoneal chemotherapy for peritoneal metastases (34.3%, 57.6) | 28 months | L3 (all muscles) | SMI (CT) | • SMI-defined sarcopenia did not have a significant effect on LOS or duration of TPN. …

Ascites Index - an attempt to objectify the assessment of ascites.

IntroductionAscites is observed in cancer patients as well as in other non-neoplastic processes. In some patients, it may cause severe symptoms that can become directly life-threatening. The assessment of the degree of ascites seems useful in the determination of treatment effects as well as in the monitoring of fluid accumulation and early planning of decompression procedures.AimDetermination of the clinical usefulness of a quantitative method of determining the degree of ascites, so-called Ascites Index.Material and methodsThe Ascites Index is an ultrasonographic way of assessing the grade o

Critical considerations for targeting colorectal liver metastases with nanotechnology.

Colorectal cancer remains a significant cause of morbidity and mortality worldwide. Half of all patients develop liver metastases, presenting unique challenges for their treatment. The shortcomings of conventional chemotherapy has encouraged the use of nanomedicines; the application of nanotechnology in the diagnosis and treatment of disease. In spite of technological improvements in nanotechnology, the complexity of biological systems hinders the prospect of nanomedicines being applied in cancer therapy at the present time. This review highlights current biological barriers and discusses aspe

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… A recent meta‐analysis displayed that patients with mCRC show a tendency towards increased median overall survival after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy combined with resection of liver metastases, when compared to treatment with systemic chemotherapy (de Cuba et al … Drugs, carrier solutions and temperature in hyperthermic intraperitoneal chemotherapy . Journal of Surgical Oncology , 98 ( 4 ), 247 – 252 . 10.1002/jso.21051 18726886 Langhans , S. A. ( 2018 ). Three‐dimensional in vitro cell culture models in drug discovery and drug repositioning . …

Molecular Mechanisms and Biomarkers Associated with Chemotherapy-Induced AKI.

Acute kidney injury (AKI) is a life-threatening condition characterized by a rapid and transient decrease in kidney function. AKI is part of an array of conditions collectively defined as acute kidney diseases (AKD). In AKD, persistent kidney damage and dysfunction lead to chronic kidney disease (CKD) over time. A variety of insults can trigger AKI; however, chemotherapy-associated nephrotoxicity is increasingly recognized as a significant side effect of chemotherapy. New biomarkers are urgently needed to identify patients at high risk of developing chemotherapy-associated nephrotoxicity and s

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… Most surgical patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy are admitted to the ICU and frequently develop severe AKI [ 46 , 47 ]. … Acute Kidney Injury Following Hyperthermic Intraperitoneal Chemotherapy with Cisplatin Anticancer Res. 2021 41 1641 1646 10.21873/anticanres.14926 33788760 48. Robert C. A Decade of Immune-Checkpoint Inhibitors in Cancer Therapy Nat. …

Port site metastases a year after initial laparoscopic cholecystectomy. Should the use of retrieval bags during laparoscopic cholecystectomy be the new gold standard?

As a result of gallbladder cancer being rare, it is often an understudied disease. There is lack of information particularly about long-term … py port sites is advised in patients with peritoneal carcinomatosis after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) to ensure complete cytoreduction [18]. </br></br> It is clear from this standpoint that other solutions and ideas are needed. One of these could be permanent implementation of retrieval bags during cholecystectomies, especial …

Abstracts from the 13th International Conference for Healthcare and Medical Students (ICHAMS).

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… Intraperitoneal Chemotherapy” (HIPEC) was proposed as a method of increasing peritoneal chemotherapy concentration and uptake. … The search strategy involved using the terms “Ovarian Cancer”, “Ovarian Neoplasm”, “HIPEC” and “Hyperthermic Intraperitoneal Chemotherapy”. …

Case Report: Acute kidney injury due to minimal dilated obstructive nephropathy in the context of gastric cancer.

Postrenal obstruction is a rare but reversible cause of acute kidney injury (AKI), often underrecognized when hydronephrosis is mild or absent. We present a 55-year-old woman with gastric cancer who developed severe AKI requiring hemodialysis. Initial non-contrast abdominal CT revealed only mild bilateral hydronephrosis without obvious ureteral obstruction. Given these subtle radiologic findings and a history of chemotherapy and NSAID exposure. Initially, a multidisciplinary team attributed the AKI to intrinsic renal causes. Subsequent renal biopsy revealed only minimal glomerular changes, ins

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… Treatment of gastric cancer peritoneal metastases: role of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Br J Surgery. (2024) 111:znae149. doi: 10.1093/bjs/znae149, PMID: 25. Li W, Ng JM-K, Wong CC, Ng EKW, Yu J. …

From Early Diagnoses to New Treatments for Liver, Pancreatic, Gastric, and Colorectal Cancers Using Carbon Nanotubes: New Chances Still Underexplored.

Pancreatic, liver, gastric, colorectal, and rectal cancers (PC, LC, GC, CRC, and RC) are highly lethal tumours, with a 5-year survival rate of 10.5% (PC) and <20% (LC), and of 5%, 12%, and 13% for IV-stage GC, CRC, and RC, respectively. Currently, PC and LC represent the third leading cause of cancer-related death, while GCs and CRCs account for 4.8 million cancer cases and 4.4 million cancer deaths worldwide. Poor prognoses are mainly due to late diagnosis, limited efficacy of available treatments, tumour recurrence, as well as therapy-induced secondary tumorigenesis and drug resistance. In r

Astatine-211 based radionuclide therapy: Current clinical trial landscape.

Astatine-211 (211At) has physical properties that make it one of the top candidates for use as a radiation source for alpha particle-based radionuclide therapy, also referred to as targeted alpha therapy (TAT). Here, we summarize the main results of the completed clinical trials, further describe ongoing trials, and discuss future prospects.

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… The short- and long-term survival of hyperthermic intraperitoneal chemotherapy (HIPEC) in the advanced gastric cancer with/without peritoneal carcinomatosis: a systematic review and meta-analysis of randomized controlled trials . …

CD8+ CD28-нормативные T клетки после вводного лечения предсказывают, что пациенты миэломы выживут без прогрессирования: результат GMMG-HD6 Исследование по многоцентральной фазе III.

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… Adjuvant dendritic cell-based immunotherapy after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in patients with malignant peritoneal mesothelioma: a phase II clinical trial. J Immunother Cancer. 2023;11:e007070. 13. …

Prediction of Acute Kidney Injury in Oncology: From Clinical Risk Scores to AI-Enabled Precision Onco-Nephrology.

Background/Objectives: Acute kidney injury (AKI) is a common complication across the cancer care continuum and can compromise kidney function, delay or interrupt anticancer therapy, and worsen renal and oncologic outcomes. This state-of-the-art narrative review examines conventional clinical risk scores and artificial intelligence (AI)- and machine learning (ML)-based approaches to AKI prediction in oncology and identifies priorities for clinical translation. Methods: We conducted iterative searches of PubMed and Google Scholar through July 2026 and screened reference lists of relevant primary

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… Nephrectomy, cystectomy, hepatectomy, cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC), and major colorectal surgery expose patients to nephron loss, ischemia–reperfusion injury, blood loss, hemodynamic instability, dehydration, nephrotoxins, and postoperative complications … Acute Kidney Injury after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy—A Systematic Review Eur. J. Surg. Oncol. 2024 50 108622 10.1016/j.ejso.2024.108622 39216462 74. Li Y. Sperrin M. Ashcroft D.M. Van Staa T.P. …

The functional imperative in high-grade glioma.

Precision oncology has emerged as a promising strategy for treating high-grade gliomas, yet its clinical impact has been disappointing, with over 300 clinical trials on targeted therapies failing to yield substantial improvements in patient outcomes. Current approaches primarily focus on static, marker-driven tumor features, which capture only a small portion of the complex biology that governs therapeutic responses. Functional precision oncology (FPO) offers a complementary approach, enhancing treatment selection in a personalized manner by dynamically testing patient-derived tumor cells agai

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… Intraperitoneal Chemotherapy (HIPEC) for Colorectal Peritoneal Metastases (OrganoHIPEC) | Peritoneal metastases from colorectal cancer | Adults | 24 | NCT06057298 | Milan, Italy | Interventional | Recruiting | 15 June 2021 | 14 June 2025 | 117 Quadratic Phenotypic Optimization Platform (QPOP) utilization … Colorectal carcinoma peritoneal metastases-derived organoids: results and perspective of a model for tailoring hyperthermic intraperitoneal chemotherapy from bench-to-bedside. J. Exp. Clin. Cancer Res. 43 , 132 (2024). 118. …

Theranostic Potentials of Gold Nanomaterials in Hematological Malignancies.

Hematological malignancies (HMs) are a heterogeneous group of blood neoplasia generally characterized by abnormal blood-cell production. Detection of HMs-specific molecular biomarkers (e.g., surface antigens, nucleic acid, and proteomic biomarkers) is crucial in determining clinical states and monitoring disease progression. Early diagnosis of HMs, followed by an effective treatment, can remarkably extend overall survival of patients. However, traditional and advanced HMs' diagnostic strategies still lack selectivity and sensitivity. More importantly, commercially available chemotherapeutic dr

Colorectal Cancer at the Crossroads: The Good, the Bad, and the Future of Platinum-Based Drugs.

Colorectal cancer (CRC) remains a significant global health challenge, ranking third in incidence and second in mortality among cancers worldwide. This review addresses the complex landscape of CRC, focusing on incidence, mortality trends, preventive strategies, and the evolving therapeutic approaches, particularly highlighting the role of platinum-based drugs like oxaliplatin (OXP). It also underscores the increasing burden of CRC, with factors such as westernized diets, aging populations, and genetic predispositions contributing to its prevalence. Therapeutically, early detection greatly enh

A review of chemotherapeutic drugs-induced arrhythmia and potential intervention with traditional Chinese medicines.

Significant advances in chemotherapy drugs have reduced mortality in patients with malignant tumors. However, chemotherapy-related cardiotoxicity increases the morbidity and mortality of patients, and has become the second leading cause of death after tumor recurrence, which has received more and more attention in recent years. Arrhythmia is one of the common types of chemotherapy-induced cardiotoxicity, and has become a new risk related to chemotherapy treatment, which seriously affects the therapeutic outcome in patients. Traditional Chinese medicine has experienced thousands of years of cli

Using an integrated omics approach to uncover the mechanisms underlying chemotherapy-induced peripheral neuropathy (CIPN).

Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating side effect with limited treatment options. The primary challenge in developing therapies is the lack of identified neurotoxic mechanisms. To address this, an integrated omics approach, combining transcriptomics, proteomics, and metabolomics, is essential to map the biological changes underlying the condition. Here, we show how data from these complementary approaches converge on key mechanisms involved in CIPN through a critical summary of animal and human studies. Current research highlights several key drivers of CIPN, such

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… Study of oxaliplatin penetration into ovaries of patients treated with hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal metastases of colorectal and appendiceal origin using mass spectrometry imaging. Pleura Peritoneum 6 , 67–74 (2021). 98. …

Prophylaxis and Empirical Therapy of Infection in Cancer Patients

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