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Насилие со стороны партнеров среди женщин с множественным склерозом.

AIM: Насилие со стороны партнера (IPV), которое широко распространено среди женщин с хроническими расстройствами, редко обсуждается и остается непризнанным, особенно среди пациентов с множественным склерозом (MS). Цель этого исследования состоит в том, чтобы оценить распространенность и характеристики ПМС среди женщин, страдающих ПМС. МЕТОДЫ: Это перекрестное исследование проводилось с января по июнь 2024 года среди замужних женщин, у которых был диагностирован множественный склероз (МС) в возрасте от 15 до 50 лет с минимальным сроком диагноза в один год в центре " Исфахан " . Опыт М

Совпадение в аннотации оригинала
AIM: Intimate partner violence (IPV), a highly prevalent issue in women with chronic disorders, is rarely discussed and remains unrecognized, especially among patients with Multiple Sclerosis (MS). The objective of this study is to assess the prevalence and characteristics of IPV among female patients with MS. METHODS: This cross-sectional study was conduct…

Множественный увит, связанный со склерозом, успешно контролируется с помощью атумумаба.

ЦЕЛЬ: Сообщить о трех случаях заболевания множественным склерозом (MS), связанным с увеитом, у которого окулярное воспаление хорошо отреагировало на атумумаб. Дело 1: 26-летний мужчина, имеющий двусторонний окклюзный сетчаточный васкулит, содержащий 1 + витреозную клетку как в глазах, так и диффузную сосудистую утечку в обоих взглядах на ангиографию флуорессеина (FA). После лечения с помощью атумумаба в течение 19 месяцев произошло значительное улучшение состояния витроустойчивой клетки и утечки сосудистой воды на двусторонней основе. Дело 2: 41-летний мужчина с двусторонним промежуточным увеи

Совпадение в аннотации оригинала
PURPOSE: To report three cases of patients with multiple sclerosis (MS)-associated uveitis whose ocular inflammation responded well to ofatumumab. CASE PRESENTATIONS: Case 1: A 26-year-old male with bilateral MS-associated occlusive retinal vasculitis presented with 1 + vitreous cell in both eyes and diffuse vascular leakage in both eyes on fluorescein angi…

Multiple sclerosis relapse risk factors across treatment eras.

BACKGROUND: Age and sex were shown to influence multiple sclerosis (MS) relapse activity in the 1990s. Whether relapse risk factors are the same with new treatment paradigms is unclear. We evaluate predictors of clinical relapse following the first clinic visit (FV) across different treatment eras in a large, retrospective cohort. METHODS: Adults with clinically isolated syndrome or relapsing-onset MS were divided into cohorts with FV at the Brigham Multiple Sclerosis Center (Boston, MA) from 1997 to 2010 ("early") and 2010 to 2020 ("recent"). Risk factors for relapse in 3 years after the FV …

Нейрофильтрационная тяжелая цепочка в вторичном прогрессивном множественном склерозе.

Для отслеживания прогресса в испытаниях MS необходимы биомаркеры. Нейрофильтрационная тяжелая цепочка (NfH) используется недостаточно из-за ограничений на анализ. ЦЕЛЬ: Изучение дополнительной ценности церебрально-пинальной жидкости (CSF) NfH в вторичном прогрессивном множественном склерозе (SPMS) с использованием современных иммуномасс. Это исследовательское исследование было частью судебного процесса по делу MS-SMART. Клинические оценки (включая расширенную шкалу показателей инвалидности, функцию верхней и нижней частей конечностей, визуальную акумуляцию и проверку параметров символических з

Совпадение в аннотации оригинала
BACKGROUND: Biomarkers are needed to track progression in MS trials. Neurofilament heavy chain (NfH) has been underutilized due to assay limitations. OBJECTIVE: To investigate the added value of cerebrospinal fluid (CSF) NfH in secondary progressive multiple sclerosis (SPMS) using contemporary immunoassays. METHODS: This exploratory study was part of the M…

Updated Multiple Sclerosis Incidence in France, 2011-2021.

BACKGROUND AND OBJECTIVES: Multiple sclerosis (MS) is a chronic neurologic disorder with significant implications for public health as being the first cause of nontraumatic neurologic disability in young adults. Although the global prevalence of MS has been increasing, recent temporal trends in incidence remain unclear. We aimed to evaluate current MS incidence trends in France over 11 years using the Système National des Données de Santé, a nationwide administrative database covering 99% of the French population. METHODS: We used a published algorithm that incorporates multiple data sources,…

Графики контроля тенденций для определений случаев мультиплексной склероза.

Введение Валидность определений случаев хронических заболеваний для административных данных о здоровье может изменяться со временем из-за изменений в качестве данных. Графики контроля трендов для выявления наблюдений вне контроля (OOC; т. е. неожиданных) в временных рядах могут указывать, где оценки заболеваний влияются изменениями в качестве данных. Цель Применить и сравнить методы графиков контроля трендов для оценок инцидентности и распространенности множества склероза (МС) с использованием ранее проверенных определений случаев для Манитоба, Канада. Методы Было выявлено восемь определений с

Совпадение в аннотации оригинала
IntroductionThe validity of chronic disease case definitions for administrative health data may change over time due to changes in data qual … e influenced by changes in data quality.ObjectiveApply and compare trend control charts methods for multiple sclerosis (MS) incidence and prevalence estimates using previously-validated case definitions for Manitoba, Canada.MethodsEight case definitions were identified from published literature and applied to Manitoba administrative health data from January 1, 1972 …

Spinal Segmental Myoclonus in Primary Progressive Multiple Sclerosis.

BACKGROUND: A wide variety of associated movement disorders has been described in multiple sclerosis. PHENOMENOLOGY SHOWN: A 57-year-old woman with primary progressive multiple sclerosis developed spinal segmental myoclonus associated with focal myelitis. EDUCATIONAL VALUE: Movement disorders in multiple sclerosis are phenomenologically diverse and have varied pathophysiological mechanisms, making it essential to identify them to initiate appropriate treatment.

Idiopathic Multiple Localized Lipoatrophy Mimicking Amyotrophic Lateral Sclerosis.

Localized lipoatrophy is a rare condition characterized by the localized loss of subcutaneous adipose tissue. It may occur idiopathically without specific triggers. The pathogenesis of idiopathic localized lipoatrophy remains largely unknown. We present the case of a 53-year-old Japanese woman with multiple localized lipoatrophy who exhibited upper motor neuron signs clinically and panniculitis histologically. She was initially suspected to have amyotrophic lateral sclerosis due to progressive left limb volume loss. Histologically, the lesions showed adipocyte destruction accompanied by predom

Epstein-Barr virus flare: A multiple sclerosis attack.

BACKGROUND: Multiple sclerosis (MS)-Epstein-Barr virus (EBV) relation is similar to doing a complicated puzzle: it consists of many pieces that become more and more clear as the issue is viewed from different sides. Based on the research findings, there is powerful evidence that EBV and MS have a strong relation where high levels of EBV DNA are able to be shown in all the spinal cord and the blood of the MS patients, but these are shown during disease relapses, and this implies a role in these illnesses. It kind of narrows the choices that you have to look for, just like how gathering evidence…

Ocrelizumab in highly disabled progressive multiple sclerosis patients

BACKGROUND: Ocrelizumab is a commonly used anti-CD20 monoclonal antibody with efficacy in the treatment of both relapsing-remitting (RRMS) and primary progressive (PPMS) multiple sclerosis. Real world use of ocrelizumab in MS patients with higher levels of motor disability requiring a walker or a wheelchair is not well characterized as these populations were excluded from initial studies. Higher levels of disability may be a barrier to treatment access. This study aimed to describe the access to, and tolerability and therapeutic outcomes of ocrelizumab in highly disabled MS patients in a real-…

Increased White Matter Aerobic Glycolysis in Multiple Sclerosis.

OBJECTIVE: Despite treatments which reduce relapses in multiple sclerosis (MS), many patients continue to experience progressive disability accumulation. MS is associated with metabolic disruptions and cerebral metabolic stress predisposes to tissue injury and possibly impaired remyelination. Additionally, myelin homeostasis is metabolically expensive and reliant on glycolysis. We investigated cerebral metabolic changes in MS and when in the disease course they occurred, and assessed their relationship with microstructural changes. METHODS: This study used combined fluorodeoxyglucose (FDG) po…

Rituximab vs Ocrelizumab in Relapsing-Remitting Multiple Sclerosis.

IMPORTANCE: Ocrelizumab, a humanized monoclonal antibody targeted against CD20+ B cells, reduces the frequency of relapses by 46% and disability worsening by 40% compared with interferon beta 1a in relapsing-remitting multiple sclerosis (MS). Rituximab, a chimeric monoclonal anti-CD20 agent, is often prescribed as an off-label alternative to ocrelizumab. OBJECTIVE: To evaluate whether the effectiveness of rituximab is noninferior to ocrelizumab in relapsing-remitting MS. DESIGN, SETTING, AND PARTICIPANTS: This was an observational cohort study conducted between January 2015 and March 2021. P…

Multiple Sclerosis: An Emergency Medicine-Focused Narrative Review.

BACKGROUND: Multiple sclerosis (MS) is a rare but serious condition associated with significant morbidity. OBJECTIVE: This review provides a focused assessment of MS for emergency clinicians, including the presentation, evaluation, and emergency department (ED) management based on current evidence. DISCUSSION: MS is an autoimmune disorder targeting the central nervous system (CNS), characterized by clinical relapses and radiological lesions disseminated in time and location. Patients with MS most commonly present with long tract signs (e.g., myelopathy, asymmetric spastic paraplegia, urinary…

Vitamin D genetic risk scores in multiple sclerosis.

BACKGROUND: Low serum 25(OH)D3 (vD) is an environmental risk factor for multiple sclerosis (MS). Lower vD levels during early disease may be associated with long-term disability. Determinants of serum vD levels in healthy individuals include supplementation behaviour and genetic factors. These determinants have been less well studied in people with MS (pwMS). METHODS: We developed a vD-weighted genetic risk score (GRS) and validated this in 373,357 UK Biobank participants without MS. We measured serum 25(OH)D3 and genotyped six vD-associated SNPs (rs12785878, rs10741657, rs17216707, rs1074574…

Gadolinium-enhanced brain lesions in multiple sclerosis relapse.

OBJECTIVE: To study the clinico-radiological paradox in multiple sclerosis (MS) relapse by analyzing the number and location of gadolinium-enhanced (Gd+) lesions on brain MRI before methylprednisolone (MP) treatment. METHODS: We analyzed brain MRI from 90 relapsed MS patients in two Phase IV multicenter double-blind randomized clinical trials that showed the noninferiority of different routes and doses of MP administration. A 1.5- or 3-T brain MRI was performed at baseline before MP treatment and within 15 days of symptom onset. The number and location of Gd+ lesions were analyzed. Associatio…

Pro-inflammatory adiponectin in pediatric-onset multiple sclerosis.

BACKGROUND: Being obese is associated with both increased risk of developing multiple sclerosis (MS) and greater MS disease activity. OBJECTIVES: The objective of this study is to investigate levels and potential pathophysiologic contribution of serum adipose-hormones (adipokines) in pediatric-onset MS. METHODS: Following a Luminex adipokine screen, adiponectin (APN) and its isoforms were quantified by enzyme-linked immunosorbent assay (ELISA) in 169 children with incident acquired demyelinating syndromes (ADS), prospectively ascertained as having either MS or other forms of inflammatory cen…

[Disease-modifying treatment of secondary progressive multiple sclerosis].

BACKGROUND: Multiple sclerosis (MS) is a disease continuum from a clinically isolated syndrome through relapsing remitting MS to secondary progressive MS (SPMS). There are numerous therapeutic approaches with proven efficacy on relapse and focal inflammatory disease aspects, whereas treatment of secondary progression and associated neuropathological aspects continues to be a challenge. OBJECTIVE: Overview of the current options for disease-modifying treatment of SPMS. MATERIAL AND METHODS: Results of randomized clinical trials are presented and evaluated on a substance-specific basis. RESUL…