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Classification of Dystonia.

Dystonia is a hyperkinetic movement disorder characterized by abnormal movement or posture caused by excessive muscle contraction. Because of its wide clinical spectrum, dystonia is often underdiagnosed or misdiagnosed. In clinical practice, dystonia could often present in association with other movement disorders. An accurate physical examination is essential to describe the correct phenomenology. To help clinicians reaching the proper diagnosis, several classifications of dystonia have been proposed. The current classification consists of axis I, clinical characteristics, and axis II, etiolo

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… The disease course is progressive and speech articulation difficulties, muscle cramping and pain, orofacial dyskinesia, and swallowing dysfunction were described. In a French family, late onset parkinsonism with prominent bradikynesia, dysarthria, and frequent falls was described [ 117 ]. 4.2.4. …

Chemotherapy-Induced Peripheral Neuropathy: Epidemiology, Pathomechanisms and Treatment.

PurposeThis review provides an update on the current clinical, epidemiological and pathophysiological evidence alongside the diagnostic, prevention and treatment approach to chemotherapy-induced peripheral neuropathy (CIPN).FindingsThe incidence of cancer and long-term survival after treatment is increasing. CIPN affects sensory, motor and autonomic nerves and is one of the most common adverse events caused by chemotherapeutic agents, which in severe cases leads to dose reduction or treatment cessation, with increased mortality. The primary classes of chemotherapeutic agents associated with CI

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… The main anatomical structure injured by platinum agents is the dorsal root ganglion, and manifests as a sensory neuropathy with prominent pain accompanied by cold-induced allodynia and muscle cramps due to peripheral nerve hyperexcitability or neuromyotonia. … A longitudinal study following 346 participants undergoing FOLFOX chemotherapy demonstrated a 3-day peak in acute OIPN, with sensory symptoms including cold-induced hypersensitivity (71%), sensitivity to swallowing cold food and drink (71%), throat discomfort (63%) and muscle cramps (42%) [ 25 ]. …

Acute Foot Drop in the Initial Presentation of Systemic Lupus Erythematosus.

The case of a 20-year-old woman with newly diagnosed systemic lupus erythematosus (SLE) who developed acute foot drop secondary to mononeuritis multiplex is presented. Peripheral neuropathy etiology is broad, but in the setting of SLE, it should raise concern for vasculitis, as seen in this case with mononeuritis multiplex. Diagnosis requires an understanding of SLE pathology as seen with muscle and nerve biopsy. Prompt diagnosis and high-dose corticosteroids are critical, but pain may persist despite immunosuppression. Cite this article as: Gabriel M, Chavez X. Acute foot drop in the initial

Improvement of primary vulvar Langerhans cell histiocytosis with lenalidomide.

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… She initiated thalidomide 100 mg daily with rapid improvement of her vulvar and cutaneous LCH, although she experienced side effects of fatigue and muscle cramping. Thalidomide was decreased to 50 mg daily, but 1 month later she developed a distal thrombus in her left peroneal vein. …

Fatigue and Its Related Factors Among Iranian Cancer Survivors.

Introduction: Cancer-related fatigue (CRF) is one of the major problems experienced by cancer patients. Identifying the prevalence and factors associated with CRF may be effective in designing appropriate interventions to reduce this problem. This study aimed to examine the prevalence of CRF and its related factors among Iranian cancer survivors. Methods: The samples of this descriptive cross-sectional study included 131 cancer survivors referred to outpatient clinic of Shahid Gazi Hospital affiliated to Tabriz University of Medical Sciences. Brief fatigue inventory (BFI) questionnaire was use

Chemotherapy-induced peripheral neuropathy in children and adolescent cancer patients.

Brain cancer and leukemia are the most common cancers diagnosed in the pediatric population and are often treated with lifesaving chemotherapy. However, chemotherapy causes severe adverse effects and chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting and debilitating side effect. CIPN can greatly impair quality of life and increases morbidity of pediatric patients with cancer, with the accompanying symptoms frequently remaining underdiagnosed. Little is known about the incidence of CIPN, its impact on the pediatric population, and the underlying pathophysiological mecha

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… , muscle cramps, muscle aches | Diarrhea, arrhythmias, orthostatic hypotension | Kerckhove et al. (2017) , Bjornard et al. (2018) , Tamburin et al. (2019) Ixabepilone | Paresthesia, dysesthesia, numbness and pain in the hands and feet | Mild motor impairment with muscle weakness such as foot drop, difficulty … Phase I and II studies in pediatric patients have shown that oxaliplatin causes neurotoxicity that manifested as cold dysesthesia, laryngopharyngeal and limb paresthesia and dysesthesia, muscle cramps and jaw pain. …

An approach to treating older adults with chronic kidney disease.

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Chemotherapy-induced peripheral neuropathy in adults: a comprehensive update of the literature.

Commonly used chemotherapeutic agents in oncology/hematology practice, causing toxic peripheral neuropathy, include taxanes, platinum compounds, vinca alkaloids, proteasome inhibitors, and antiangiogenic/immunomodulatory agents. This review paper intends to put together and discuss the spectrum of chemotherapy-induced peripheral neuropathy (CIPN) characteristics so as to highlight areas of future research to pursue on the topic. Current knowledge shows that the pathogenesis of CIPN still remains elusive, mostly because there are several sites of involvement in the peripheral nervous system. In

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… cramps, mild distal weakness Suramin | Sensorimotor; subacute demyelinating and inflammatory polyneuropathy | Bilateral and symmetrical painful paresthesia and hyperesthesia, distally attenuated Taxanes (paclitaxel/docetaxel) Pathogenesis Conventionally, the mechanisms underlying the pathogenesis … Muscle cramps and mild distal weakness are frequently seen. Neurological examination reveals proprioception and DTR abnormalities. Autonomic dysfunction is frequently seen in vincristine-treated patients, with evidence of orthostatic hypotension, constipation, and erectile impotence. …

Эффективность образовательной программы по самоуправлению для лиц с множественным склерозом: предварительное исследование после тестирования.

Помимо фармакологической терапии, направленной на коррекцию заболеваний, имеющиеся данные свидетельствуют о том, что структурированные меры по самоуправлению могут оптимизировать функциональную независимость, уменьшить вторичные осложнения и повысить качество жизни. Вместе с тем по-прежнему ощущается нехватка данных, полученных от различных групп населения Ближнего Востока, особенно в отношении программ самостоятельного управления телемедициной. В связи с этим мы провели текущее исследование для оценки эффективности программы самостоятельного управления телемедициной по вопросам качества жизни

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… The most common symptoms were cognitive difficulties and fatigue, whereas muscle cramps were the least reported (Table 2 ). … cramps 34 34 22 21 18 16 13 7 80.9 80.9 52.3 50 42.8 38 30.9 16.6 Number of attacks in the last year ▪ No ▪ 1–2 ▪ 3–4 22 17 3 52.3 40.4 7.3 Duration of attack ▪ No attacks ▪ 3–5 days ▪ 7–10 days 22 10 10 52.3 23.8 23.8 Table 2 Socio-demographic and clinical data of the recruited sample ( n = 42) at …

Когнитивное функционирование у выживших жертв токсического синдрома нефти: изучение конкретных случаев через четыре десятилетия после эпидемии.

Фон: Синдром токсического масла (СТО) является одной из основных эпидемий, передаваемых через продукты питания, которая произошла в Испании в мае 1981 года и была вызвана перевариванием изнасилованного масла анилиной. Хотя соматические последствия ГС хорошо задокументированы, ее долгосрочные когнитивные последствия остаются недостаточно понятными более чем через четыре десятилетия после воздействия. Методы: В рамках данного исследования по вопросам контроля 50 лиц, имеющих клинически подтвержденную ГС, были сопоставлены с 50 мерами контроля за состоянием здоровья, соответствующими возрасту, по

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… Other long-term complications included myalgias, muscle cramps [ 7 ], severe weight loss, pulmonary hypertension, scleroderma-like syndromes, joint contractures, Sjögren’s syndrome, alopecia, pruritus, and chronic hepatitis [ 3 ]. … In cohorts followed for 8 to 12 years, a substantial proportion of patients reported persistent fatigue, muscle cramps, arthralgias, Raynaud’s phenomenon, subjective cognitive complaints, and psychiatric symptoms [ 6 , 9 ]. …

Randomized phase 2 study of valproic acid combined with simvastatin and gemcitabine/nab-paclitaxel-based regimens in untreated metastatic pancreatic adenocarcinoma patients: the VESPA trial study protocol.

BackgroundMetastatic pancreatic ductal adenocarcinoma (mPDAC) patients have very poor prognosis highlighting the urgent need of novel treatments. In this regard, repurposing non-oncology already-approved drugs might be an attractive strategy to offer more-effective treatment easily tested in clinical trials. Accumulating evidence suggests that epigenetic deregulation is a hallmark of cancer contributing to treatment resistance in several solid tumors, including PDAC. Histone deacetylase inhibitors (HDACi) are epigenetic drugs we have investigated preclinically and clinically as anticancer agen

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… If grade 2 muscular cramp continues after dosage decrease, or if grade 3 muscle cramp occurs, SIM will be definitively stopped. In the case of grade 2 somnolence or fatigue, the VPA dose will be reduced by -500 mg/day steps until it reaches grade 1, regardless of the actual serum level. …

Targeted therapy for advanced Basal-cell carcinoma: vismodegib and beyond.

Basal-cell carcinoma is a commonly occurring skin malignancy that has the potential to progress into locally invasive or resistant disease, as well as spread distantly. Due to advances in the molecular understanding of the disease over the last two decades, it has been discovered that the Hedgehog pathway plays an important role in the pathogenesis of this disease and can be exploited as a treatment target. Several agents that inhibit the Hedgehog pathway have reached clinical studies and one drug, vismodegib, has recently been US Food and Drug Administration (FDA) approved based on clinical a

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… Common side-effects from vismodegib included dysgeusia, muscle cramps, hair loss, and weight loss [ 30 ]. Histologic and molecular studies confirmed the anti-BCC effect and molecular pathway targeting of vismodegib. … Common side-effects included fatigue, nausea, vomiting, anorexia, muscle cramps, and dysgeusia. …

Effect of exercise training on functional capacity & quality of life in head & neck cancer patients receiving chemoradiotherapy.

Background & objectivesPatients with head and neck cancer (HNC) undergoing chemoradiotherapy (CRT) suffer from fatigue causing a decrease in functional capacity and quality of life (QoL). Limited research in the field of exercise training among these patients demanded the need for this study to assess the effects of exercise training on functional capacity and quality of life.MethodsA randomized controlled trial was conducted on 48 patients with HNC undergoing CRT. The exercise group received an individually tailored, supervised, exercise programme for six weeks, while the control group did no

Acupuncture in Multiple Myeloma Peripheral Neuropathy: A Systematic Review.

BackgroundPeripheral neuropathy (PN) is a prevalent complication of multiple myeloma (MM), due to the disease itself or its treatment. Despite extensive research, the optimal treatment for multiple myeloma peripheral neuropathy (MMPN) remains unclear. Clinical practice has shown the potential efficacy of acupuncture in managing MMPN. This study aimed to conduct a comprehensive analysis of the literature to assess the effectiveness and safety of acupuncture as a treatment for MMPN.MethodsThe PubMed, Web of Science, MEDLINE, Cochrane Library, and Embase databases were comprehensively searched fr

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… However, there was no observed improvement in joint pain, muscle cramps, or weakness. …

Therapeutic Plasma Exchange Using Membrane Plasma Separation Across a Broad Spectrum of Indications: An Eight-Year Single-Center Retrospective Cohort Study.

BACKGROUND: Therapeutic plasma exchange (TPE) removes pathogenic plasma constituents such as autoantibodies, immune complexes and monoclonal proteins. Plasma can be separated by centrifugation or by membrane plasma separation (MPS); although MPS predominates in many centers because it can be delivered at the bedside on standard renal replacement platforms, most published outcome data derive from centrifugal techniques. OBJECTIVE: To describe the indications, complications, laboratory changes and clinician-assessed treatment response of MPS-based TPE in an unselected single-center cohort. MET

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… Table 4 Complications Recorded During Therapeutic Plasma Exchange Complication Patients, n (%) Hypocalcemia 34 (26.0) Allergic reaction 13 (9.9) Hypotension 9 (6.9) Nausea 6 (4.6) Coagulopathy 2 (1.5) Headache 2 (1.5) Muscle cramps 1 (0.8) Hyperthermia 1 (0.8) Thrombocytopenia 1 (0.8) Notes : Values … Complication | Patients, n (%) Hypocalcemia | 34 (26.0) Allergic reaction | 13 (9.9) Hypotension | 9 (6.9) Nausea | 6 (4.6) Coagulopathy | 2 (1.5) Headache | 2 (1.5) Muscle cramps | 1 (0.8) Hyperthermia | 1 (0.8) Thrombocytopenia | 1 (0.8) Clinician-assessed treatment response could be retrieved for …

Prevention and management of adverse events of novel agents in multiple myeloma: a consensus of the European Myeloma Network.

During the last few years, several new drugs have been introduced for treatment of patients with multiple myeloma, which have significantly improved the treatment outcome. All of these novel substances differ at least in part in their mode of action from similar drugs of the same drug class, or are representatives of new drug classes, and as such present with very specific side effect profiles. In this review, we summarize these adverse events, provide information on their prevention, and give practical guidance for monitoring of patients and for management of adverse events.

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… TiPNP also includes numbness, and mild motor involvement with muscle cramps and weakness [ 49 ]. … Muscle cramps and seizures Several drugs such as lenalidomide, thalidomide, PIs, and dexamethasone can induce subtle perturbations of muscle fibers and/or of neurogenic structures, but the detailed pathogenesis of muscle cramps is still unknown [ 49 ]. …

Bortezomib.

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… Pulmonary: Cough (17–21%), dyspnea (21–25%) Pain: Limb pain (15%), musculoskeletal pain (10%) Musculoskeletal: Arthralgia (15–28%), muscle cramps (24%) Neurological: Dizziness (14–21%), headache (28%), insomnia (18–27%), anxiety (14%) Dermatology: Rash urticaria (24–28%) Hematology: Anemia (26–32% …

Expert panel consensus statement on the optimal use of pomalidomide in relapsed and refractory multiple myeloma.

In this report, a panel of European myeloma experts discuss the role of pomalidomide in the treatment of relapsed and refractory multiple myeloma (RRMM). Based on the available evidence, the combination of pomalidomide and low-dose dexamethasone is a well-tolerated and effective treatment option for patients with RRMM who have exhausted treatment with lenalidomide and bortezomib. The optimal starting dose of pomalidomide is 4 mg given on days 1-21 of each 28-day cycle, whereas dexamethasone is administered at a dose of 40 mg weekly (reduced to 20 mg for patients aged >75 years). The treatment

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… cramps and rash. … Anecdotally, calcium and magnesium supplementation or quinine may ameliorate muscle cramps. Caution is warranted when using pomalidomide in patients who developed rash during prior treatment with thalidomide or lenalidomide. …

Safety and efficacy of lenalidomide in relapsed or refractory multiple myeloma.

Lenalidomide is an oral immunomodulatory drug that has helped improve outcomes in multiple myeloma (MM) patients. Combination lenalidomide and dexamethasone (Len+Dex) has been shown to increase response rates and prolong survival compared with dexamethasone alone in patients with relapsed or refractory MM (RRMM). Clinical benefit may be greatest when Len+Dex is given at first relapse, and continued treatment appears to provide greater depth of response and improved survival outcomes. The most common adverse events associated with Len+Dex are cytopenias, which are predictable and manageable. Le

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… Submitted to Leukemia and Lymphoma , 2011). 34 Safety The primary adverse events associated with Len+Dex in RRMM are cytopenias, VTE, rash, fatigue, and muscle cramps. 23 In phase III trials, Len+Dex was associated with a significantly higher incidence of severe neutropenia, thrombocytopenia, anemia … The primary adverse events associated with Len+Dex in RRMM are myelosuppression and VTE; other common adverse effects include rash, fatigue, and muscle cramps. Lenalidomide does not appear to cause or exacerbate peripheral neuropathy. …

Bibliometric and visualization analyses of cancer-related fatigue research published worldwide from 2001 to 2023.

ObjectiveCancer seriously endangers human health and represents a global public health issue. Cancer-related fatigue (CRF) is a distressing and persistent sense of exhaustion caused by cancer or cancer treatment, widely prevalent among cancer patients. This study aims to summarize emerging trends and provide directions for future research of CRF through bibliometric and visualization analyses.MethodsA systematic search in the Web of Science Core Collection database from 2001-01-01 to 2023-05-18 were conducted. Only reviews and articles written in English were considered. CiteSpace and the R we