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[Symptomatic acute Q fever: a series of 87 cases in an area of Mallorca].

INTRODUCTION: Q fever is a widespread zoonotic infection caused by Coxiella burnetii (C. burnetii). Acute infection varies from a self-limited flu-like illness to pneumonia or hepatitis. METHODS: A retrospective case study from March 2003 to December 2011 was conducted in the Hospital Son Llàtzer in Palma de Mallorca. Acute Q-fever was diagnosed in a patient with clinical suspicion and IgM in phase ii positive (≥ 1/40), with a positive IgG (≥1/80), or when IgG seroconversion was observed during convalescence. A total of 87 cases of acute Q fever were diagnosed. The median age was 50 years (ra…

Implementation of a Q fever vaccination program for high-risk patients in the Netherlands.

BACKGROUND: Between 2007 and 2011 the Netherlands was faced with an unprecedented Q fever outbreak with more than 4000 people affected. Dairy goats were considered the main source of infection. In addition to taking veterinary measures, the Dutch government offered an unlicensed vaccine against the causative bacterium Coxiella burnetii to patient groups at high-risk of Q fever complications. This article describes the complexity of the vaccination program for Q fever in 2010-2011. METHODS: High-risk patients were selected and referred mainly by their general practitioner to a publicly funded …

Antibody kinetics in serological indication of chronic Q fever: the Greek experience.

BACKGROUND: Q fever caused by the pathogen Coxiella burnetii may have both acute and chronic manifestations. Although paired sera are not required for the diagnosis of chronic Q fever, monitoring of antibody titers can be used to examine the course of treatment. Monitoring both phase II and phase I antibodies may be of limited diagnostic value, but it is a useful means of determining the response to treatment and possible disease relapses. METHODS: In the current survey we determined IgG and IgM of both phase I and phase II for 35 patients suffering from chronic Q fever in an attempt to draw …

Q fever as a cause of recurrent soft-tissue nodules and abscesses in a child.

A 3-year-old boy from a cattle property in Queensland, Australia developed chronic, multifocal, recurrent subcutaneous nodules and abscesses during a period of 2 years. Serologic and histologic findings and management options are discussed.

Chronic Q fever: review of the literature and a proposal of new diagnostic criteria.

A review was performed to determine clinical aspects and diagnostic tools for chronic Q fever. We present a Dutch guideline based on literature and clinical experience with chronic Q fever patients in The Netherlands so far. In this guideline diagnosis is categorized as proven, possible or probable chronic infection based on serology, PCR, clinical symptoms, risk factors and diagnostic imaging.

Histopathology of a granulomatous lobular panniculitis in acute Q fever: a case report.

Q fever is a zoonotic infection caused by Coxiella burnetii. Two forms of the disease have been described: an acute form with pneumonia, hepatitis or a flu-like syndrome; and a chronic form in which endocarditis is the most frequent clinical expression. We report a 77 year old male with fever and an erythematous nodule on the right leg. Biopsy revealed a granulomatous lobular panniculitis with some granulomas rimmed by an eosinophilic material, giving a "doughnut" or "fibrin-ring" appearance. Q fever serological studies were positive. Cutaneous signs, among them panniculitis, are probably unde…

Q fever in the Netherlands: a concise overview and implications of the largest ongoing outbreak.

Two outbreaks of Q fever were reported in the Netherlands in 2007 and 2008. The ongoing 2008 outbreak in the south-eastern part of the Netherlands is the largest community outbreak ever described, with 808 cases reported until August 2008. The changing epidemiology of Q fever is most likely related to intensive goat farming, and has important implications for the clinical care of patients in endemic areas. Treatment of community-acquired pneumonia has to take possible Q fever into account, and the high incidence of Q fever endocarditis and other manifestations of chronic Q fever require a spec…

Brachial plexopathy associated with Q fever: case report and review of the literature.

Neurologic manifestations of Q fever are predominantly central. We report the case of a 35-year-old man with recurrent fever and motor and sensory deficits in the right C5, C6 territories. Electrophysiological findings were consistent with a right upper-trunk brachial plexopathy or with suprascapular and axillary neuropathies. The patient had full resolution of neurologic symptoms with antibiotic treatment. The association of brachial plexopathy with Q fever infection, described in other rare instances, may merit consideration in individual cases, depending on clinical context.

Q fever osteoarticular infection: four new cases and a review of the literature.

Q fever is a worldwide-occurring zoonosis caused by Coxiella burnetii. Better knowledge of the disease and of evolving diagnostics can enable recognition of unusual manifestations. Reported here are four cases of Q fever osteoarticular infections in adults: two cases of Q fever tenosynovitis, which represent the first two reports of this infection, and two cases of Q fever spondylodiscitis complicated by paravertebral abscess. In addition, the literature is reviewed on the 15 previously reported cases of Q fever osteoarticular infection, six of which were vertebral infections. Osteomyelitis is…

Q fever cases in the Northern Territory of Australia from 1991 to 2006.

Q fever (infection with Coxiella burnetii) has been uncommon in Australia's Northern Territory, with no reported cases until 2002. Since then, twelve cases of Q fever have been reported, representing a much lower notification rate than in surrounding Australian states. Three cases were identified in Central Australia during 2006, prompting this review of clinical and epidemiological features of all notified Northern Territory cases. Three patients required Intensive Care admission, 1 died, 5 had moderately severe illness, 2 were treated as outpatients and 2 were excluded as unlikely Q fever ca…

Acute hepatitis associated with Q fever in a man in Greece: a case report.

Coxiella burnetii is the causative agent of Q fever. Q fever is a worldwide zoonosis that is responsible for various clinical manifestations. However, in Greece hepatitis due to Coxiella is rarely encountered. A case of Q fever associated with hepatitis is reported here. Diagnosis was made by specific serological investigation (enzyme-linked immunosorbent and indirect immunofluorescene assays) for Coxiella burnetii.

[Q fever outbreak in an urban area following a school-farm visit].

BACKGROUND AND OBJECTIVE: The aim of this study was to describe an outbreak of Q fever in a group of people (day care centre for mental-handicapped individuals) previously exposed to animals in a school-farm. PATIENTS AND METHOD: A retrospective cohort study among the 25 mental-handicapped individuals and the 30 workers of the centre was performed. The information about symptoms and signs and antecedents of exposition was obtained by an epidemiological survey and a clinical-epidemiological case definition was established. Serum samples from 29 people (5 mental-handicapped individuals and 24 w…

Q fever in the Southern California desert: epidemiology, clinical presentation and treatment.

Despite the absence of a natural reservoir for Q fever in the desert of Southern California, six cases have been identified during the past 32 years. During that period of time, two areas have been used by northern sheep ranchers from Idaho and Wyoming to import sheep to an area in the Coachella Valley through 1985. Thereafter, because of housing development, the sheep area was moved to Blythe along the Colorado River. All but two of these patients probably acquired infection by Coxiella burnetii by living or working in close proximity to these grazing areas but not directly involved with the …

[Clinical manifestation of Q fever and tuberculosis, similarly caused by intracellular parasites].

Q fever is a generic term for pneumonia, bronchitis, etc. caused by infection with Coxiella burnetii, a rickettsia-related species of bacteria, in humans. Q-fever is a transient and acute febrile illness that takes a course similar to influenza, and its clinical picture greatly differs from that of tuberculosis that takes a chronic course. The reason for this is thought to be because the generation time of C. burnetii is extremely short (several tens of minutes) compared with Mycobacterium tuberculosis, though those are similar intracellular parasites. Q fever is fourth- or fifth-ranked among …

Эпидемия лихорадки у работников фабрики в пригороде Задара, Хорватия.

AIM: Изучение роли ветра в распространении Q лихорадки (Coxiella signetii) от источника инфекции (овца на пастбищах) до фабрики, где среди работников произошла вспышка Q лихорадки. МЕТОДЫ: Мы провели клиническую (фестиваль, кашляние, миальгии, артральгии), лабораторию (полный анализ крови, аминопереносазы, антитела к коксиеллскому горению ii), радиографическую (честный рентгеновский) и эпидемиологический (вопросник) анализ 47 из 110 работников завода в пригороде Задара. Сера из 182 овец была испытана на антитела до C. signetii с помощью дополнительной фиксационной реакции.РЕЗУЛЬТАТЫ: В первой

Совпадение в аннотации оригинала
AIM: To examine the role of wind in the spread of Q fever (Coxiella burnetii) from the source of infection (sheep on the pastures) to the factory where there was an outbreak of Q fever among the employees. METHODS: We performed clinical (fever, coughing, myalgias, arthralgias), laboratory (complete blood test, aminotransferases, antibodies to Coxiella burne…

[Epidemiological investigations transmisssion of Q fever among humans in Bosnia and Herzegovina].

Appearance of an acute disease by Coxiella burnetii in humans in Bosnia and Herzegovina is very big epidemiological problem because incidence rate is among the highest incidence rates in Europe. Incidence rate of Q fever in Federation Bosnia and Herzegovina was very high during 1998. year 5.68% and the highest in 2000, with 115 diseases with acute clinical form of the disease and incidence rate of 6.95%. The incubation period varied from 9 to 28 days. Real incidence rate because of asymptomatic appearance of the disease is very much higher, at least 40-50 times higher. Chronic infection with C…

Ongoing queries: Interpretation of serology in asymptomatic or atypical chronic Q fever.

Chronic Q fever, predominantly associated with endocarditis, can develop insidiously. Although the diagnosis may be straightforward with a typical clinical presentation, incidental discovery of positive Coxiella burnetii serology poses a difficult clinical challenge. We describe the cases of two such patients and review the literature on the serological diagnosis of chronic Q fever.

Structural and functional characterization of the glycan antigens involved in immunobiology of Q fever.

Coxiella burnetii is the causative agent of Q fever. The bacterium is extremely infectious and is classified as a category biological weapon. A lipopolysaccharide I (LPS I) belongs to the main components of the C. burnetii outer membrane and its structure-function relationship studies are of potential interest. Size-exclusion chromatography revealed noticeable differences in distribution and chemical composition of the O-polysaccharide chains in LPS I. It is likely that C. burnetii is capable of synthesizing chemically distinct subclasses of O-specific polysaccharide molecules differing in the…