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Enhanced care by generalists for functional somatic symptoms and disorders in primary care.

BACKGROUND: Patients with medically unexplained or functional somatic symptoms are common in primary care. Previous reviews have reported be … MD 0.07 (95% CI -0.05 to 0.20) and anxiety (2 studies) SMD -0.07 (95% CI -0.38 to 0.25). Effects on sick leave could not be estimated. Three studies of patient satisfaction with care all showed positive but non-significant effects, and measures were too heterogeneous to allow meta-analysis. Results on healthcare utilisation were inconclusive. We analysed stu …

Identification of phytochemical compounds of Fagopyrum dibotrys and their targets by metabolomics, network pharmacology and molecular docking studies.

Acute lung injury (ALI) is a clinically severe lung illness with high incidence rate and mortality. Especially, coronavirus disease 2019 (COVID-19) poses a serious threat to world wide governmental fitness. It has distributed to almost from corner to corner of the universe, and the situation in the prevention and control of COVID-19 remains grave. Traditional Chinese medicine plays a vital role in the precaution and therapy of sicknesses. At present, there is a lack of drugs for treating these diseases, so it is necessary to develop drugs for treating COVID-19 related ALI. Fagopyrum dibotrys (

Marantodes pumilum (Blume) Kuntze Inhibited Secretion of Lipopolysaccharide- and Monosodium Urate Crystal-stimulated Cytokines and Plasma Prostaglandin E2.

BACKGROUND: Marantodes pumilum is traditionally used for dysentery, gonorrhea, and sickness in the bones. Previous studies revealed its antibacterial and xanthine oxidase inhibitory activities. OBJECTIVE: To evaluate the inhibitory effects of three M. pumilum varieties on the secretion of lipopolysaccharide (LPS)- and monosodium urate crystal (MSU)-induced cytokines and plasma prostaglandin E2 (PGE2) in vitro. MATERIALS AND METHODS: The leaves and roots of M. pumilum var. alata (MPA), M. pumilum var. pumila (MPP), and M. pumilum var. lanceolata (MPL) were successively extracted with dichloro

WITHDRAWN: Multidisciplinary bio-psycho-social rehabilitation for chronic low-back pain.

BACKGROUND: Chronic low back pain is, in many countries, the main cause of long term disability in middle age. Patients with chronic low back pain are often referred for multidisciplinary treatment. Previous published systematic reviews on this topic included no randomised controlled trials and pooled together controlled and non-controlled studies. OBJECTIVES: To assess the effect of multidisciplinary bio-psycho-social rehabilitation on pain, function, employment, quality of life and global assessment outcomes in subjects with chronic disabling low back pain. SEARCH STRATEGY: We searched MED

Multidisciplinary bio-psycho-social rehabilitation for chronic low back pain.

BACKGROUND: Chronic low back pain is, in many countries, the main cause of long term disability in middle age. Patients with chronic low back pain are often referred for multidisciplinary treatment. Previous published systematic reviews on this topic included no randomised controlled trials and pooled together controlled and non-controlled studies. OBJECTIVES: To assess the effect of multidisciplinary bio-psycho-social rehabilitation on pain, function, employment, quality of life and global assessment outcomes in subjects with chronic disabling low back pain. SEARCH STRATEGY: We searched MED

The effect of maternal exposure to psychosocial job strain on pregnancy outcomes and child development.

Psychological stress at work is a rising problem in Denmark. Nearly one third of the women reported in 2005 that they had difficulties completing their work tasks, and 17 % found that they had only limited or no influence on their work tasks. The corresponding numbers for 1987 were 18.3 % and 16 %, respectively. Work-related stress shortens the life expectancy and reduces the number of years without prolonged disease. For the society work-related stress amounts to more than 30,000 hospital admissions each year, half a million extra days on sick-leave for women, 500,000 contacts to general prac

Non-medical interventions to enhance return to work for people with cancer.

BACKGROUND: People with cancer are 1.4 times more likely to be unemployed than people without a cancer diagnosis. Therefore, it is important … ons enhancing RTW in people with cancer. The primary outcome was RTW measured as either RTW rate or sick leave duration measured at 12 months' follow-up. The secondary outcome was quality of life (QoL). DATA COLLECTION AND ANALYSIS: Two review authors independently assessed RCTs for inclusion, extracted data and rated certainty of the evidence using GRADE. …

Work Ability in Patients with Chronic Myeloid Leukemia: A Danish Nationwide Cohort Study.

Background/Objectives: Patients with chronic myeloid leukemia (CML) have a long life expectancy due to modern treatment. However, treatment may have adverse effects that hamper work ability. Methods: Patients aged 25-60 years diagnosed in 2002-2020 were included in this nationwide matched cohort study examining work ability from diagnosis (index date), including the need for permanent disability compensation (flexible job or disability pension). Each patient was matched 1:5 on sex, birth year, and level of comorbidity with citizens from the general Danish population without CML. The risks of r

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… Table 2 Proportion of patients with CML and matched comparators working or receiving sick leave, flexible job compensation, or disability pension. Abbreviations: CML, chronic myeloid leukemia. 1 Sick leave only includes temporary sick leave payments. … However, the proportions of sick leave after ten years were not significantly different between patients with CML and the matched comparators, which argues against this being the only explanation for the increased rates of sick leave. …

Воздействие Натальизумаба на производительность и способность работать у пациентов с множественным склерозом во Франции: исследование ТИТАН.

ВВЕДЕНИЕ: В исследовании ТИТАН были рассмотрены изменения в производительности, способности к труду и качестве жизни (QoL) до и после лечения с помощью высокоэффективной терапии (TYSABRY) у пациентов с множественным склерозом (MS) во Франции. МЕТОДЫ: Пациенты в возрасте ≥ 18 и < 65 годы с повторным выделением эмиссий MS, либо наивно в натализумб, либо с ≤ 1 :: оценка производительности труда (количество рабочих часов) в период беременности и родов, а также оплачиваемой работы 12 - месяцев до и после начала беременности. Были оценены изменения в годовом показателе рецидива и в шкале расширенног

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… leave, and whether the sick leave was related to MS. … At 12 months, the proportion of patients having ≥ 1 period of sick leave was equivalent to the proportion with any sick leave at baseline (64.2% vs. 66% at baseline); however, the proportion of patients with ≥ 3 periods of sick leave increased (19.1% vs. 10.5% at baseline). …

Epidemiology of Tumor-Induced Osteomalacia in Germany Based on Real World Data.

Tumor-induced osteomalacia (TIO) is an ultra-rare disease caused mostly by benign tumors that secrete fibroblast growth factor-23. Because of nonspecific symptoms, the diagnostic delay is long, and therapy can be challenging. Moreover, epidemiological data on TIO are scarce owing to its rarity. Therefore, this study aimed to quantify TIO's incidence rates and prevalence in Germany. Retrospective longitudinal and cross-sectional analyses were conducted using anonymized German claims data from the statutory health insurance (SHI) database. This database, which comprises the data of approximately

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… Up to 80% of the patients had at least one sick leave day within one year, with an average sick leave between 40 and 300 days within a year. More than every second patient received at least one prescription for analgesia, with an average DDD of approx. 20 (Table 5 ). … Up to 80% of the patients had at least one sick leave day, with an average of 40 to 300 sick leave days. In comparison, published sick leave days for the German population on average are 10.9 sick leave days per year, showing that TIO patients on sick leave took a longer time to recover [ 38 ]. …

Work-break schedules for preventing musculoskeletal symptoms and disorders in healthy workers.

BACKGROUND: Work-related musculoskeletal disorders are a group of musculoskeletal disorders that comprise one of the most common disorders related to occupational sick leave worldwide. Musculoskeletal disorders accounted for 21% to 28% of work absenteeism days in 2017/2018 in the Netherlands, Germany and the UK. There are several interventions that may be effective in tackling the high prevalence of work-related musculoskeletal disorders among workers, such as physical, cognitive and organisational interventions. In this review, we will focus on work breaks as a measure of primary prevention, …

Mindfulness and bodily distress.

We have created a mindfulness approach to treat patients who experience multiple, persistent, and disabling physical symptoms that cannot be explained by a well-defined medical or surgical condition. Randomized controlled trials in this area are few, and research is hampered by the lack of clear definitions. Bodily distress syndrome (BDS) or bodily stress is an empirically defined definition unifying various conditions such as fibromyalgia, chronic fatigue syndrome, and somatization disorder. In the present PhD, we explored whether patients suffering from BDS may be committed to mental trainin

Healthcare Resource Utilization and Cost of Patients with Multiple Myeloma in Germany: A Retrospective Claims Data Analysis.

ObjectiveThis study aimed to analyze the healthcare resource use (HCRU) and associated costs of multiple myeloma (MM) using German claims data.MethodsAnonymized claims data from one of the largest sickness funds in Germany were analyzed. Costs and HCRU were calculated from the perspective of the statutory health insurance. To analyze MM-associated incremental costs in a most recent calendar period for an overall MM population (31 March 2018-31 March 2019), a prevalent cohort of MM patients (continuously insured during 01 January 2010 until 31 March 2019 or death; two or more outpatient and/or

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… Indirect costs due to sick leave days were calculated by multiplying the number of sick leave days by the mean daily loss of productivity for a working person in Germany in the related calendar year [ 23 ]. … It is, therefore, expected that our target population comprises, on average, retired individuals, where sick leave and the associated forgone earnings are rather irrelevant. …

Return to work experiences of patients treated with stem cell transplantation for a hematologic malignancy.

PurposeThis qualitative study aimed to identify hematopoietic stem cell transplantation (HSCT) survivors' (1) work perceptions; (2) barriers to and facilitators of return to work (RTW); and (3) possible solutions to improve RTW.MethodFifteen patients treated with HSCT 1-5 years ago participated in face-to-face semi-structured interviews. Interviews were analyzed following the steps of thematic content analyses.ResultsRTW was often characterized as a complex and prolonged trajectory, and it was frequently incomplete in working hours, tasks, and/or responsibilities. Work perceptions varied betwe

Analysis of medico-social factors for return to work among patients presenting with haematological malignancy (adamantine): results of a 'pilot study'.

ObjectiveThe aim of this study was to describe return to work determinants in patients with haematological malignancy.ResultsThis medico-social pilot study included patients with haematological malignancy in the département of Calvados, aged 18 to 55 years, diagnosed between 1st January and 31st December 2010 and alive at 1st January 2015. Patients were identified via consultation of the Lower Normandy haematological malignancy Registry. They completed a specially developed self-questionnaire, in addition to validated questionnaires for anxiety-depression, quality of life and fatigue. Of the p

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… Only 64.9% of subjects reported a sick leave at diagnosis, no significant difference being observed in terms of age or sex. The average duration of sick leave for the entire study population was 19.9 months. … Table 2 Occupational situation AFTER diagnosis Total Men Women p-value* Disease-associated sick leave 1.0 Yes: n (%) 37 (64.9) 19 (63.3) 18 (66.7) No: (%) 18 (31.6) 9 (30.0) 9 (33.3) Missing data 2 (3.5) 2 (6.7) – Duration of sick leave (months): mean 19.9 22.0 17.7 0.33 Occupational physician informed …

Return to Work After Hematopoietic Stem Cell Transplantation: A Longitudinal Analysis of Fatigue and Organ-Specific Chronic Graft-versus-Host Disease.

BACKGROUND: Return to work (RTW) indicates long-term functional recovery following hematopoietic stem cell transplantation (HSCT), yet the impact of organ-specific chronic graft-versus-host disease (cGvHD) remains understudied. OBJECTIVE: To determine the probability and timing of RTW and identify its predictors, specifically fatigue and organ-specific cGvHD, using longitudinal nursing data. METHODS: This retrospective cohort study analyzed 2,334 longitudinal nursing assessment records from 80 HSCT recipients (2016-2021). The probability of RTW over time was estimated using the Kaplan-Meier

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… This aligns with Kurosawa et al. (2023), who identified respiratory and musculoskeletal issues as key determinants of sick leave and prolonged unemployment 12 . … This finding differs from prior research, such as Eriksson et al. (2023), which linked overall symptom burden—particularly eating difficulties and appetite loss—to full-time sick leave. …

Экономическое бремя множественного склероза в Словакии 2015 в адрес 2020.

Множественный склероз (MS) является хроническим, подстрекательским заболеванием центральной нервной системы, которое обычно диагностируется в молодом возрасте. Доля прямых и косвенных расходов на НР варьируется в зависимости от условий. Международное исследование по множественным склерозам, охватывающее 1152 пациенты, имеющие MS от 19 страны, сообщили, что среднегодовые расходы на одного пациента составляют евро41,212, с прямыми расходами на медицинское обслуживание в евро21,093, прямые немедицинские расходы в евро2110и евро16,318 , помеченные в качестве косвенных расходов. Однако точных данны

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… Similarly, the indirect costs also escalate caused by reduced work productivity due to short- or long-term sick leave, disability pension, early retirement, or premature death. The proportion of direct and indirect costs of MS vary across settings. … Productivity loss due to absenteeism was estimated as the number of days spent on paid sick leave from work due to G35.XX diagnosis multiplied by the national average salary in the years 2015–2020 (Additional file 1 ). …

Уровень рабочей способности определяет конкретный профиль обесценения комплексного основного набора МКФ для множественных склерозов.

Множественный склероз (МС) неблагоприятно влияет на трудоспособность. Комплекс комплексных международных классификаций функционирования, инвалидности и охраны здоровья для НР (КМГС-МС), опубликованный Всемирной организацией здравоохранения, еще не был расширен для оценки уровня работоспособности (ВКК). Оценить относительную значимость категорий CICF-MS в сравнении с WCL. Лица, имеющие MS (PwMS), N = 129, которые были направлены в Литовское управление по оценке инвалидности и рабочей способности для определения WCL, были разделены на три группы в зависимости от процентной доли оставшегося WCL (

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… Patients on sick leave had difficulties maintaining their jobs in the long term. … Currently known the single case of usage of ICF application in sick leave procedural administration is in Sweden: The Swedish Social Insurance Agency already uses ICF items on sick leave forms to describe PwMS’ impairment of body functions and activity limitations 24 . …

Healthcare Resource Utilization and Cost Burden of BCG-Treated Non-Muscle Invasive Bladder Cancer Patients in Germany: A Retrospective Claims Analysis.

BackgroundIntermediate and high-risk non-muscle-invasive bladder cancer (NMIBC) is typically managed with transurethral resection of the bladder tumour (TURBT) followed by intravesical Bacillus Calmette-Guérin (BCG) immunotherapy; however, NMIBC patients can become refractory or unresponsive to BCG treatment, and/or progress to muscle-invasive bladder cancer (MIBC). Healthcare resource utilization (HCRU) and costs in these patient populations are high.MethodsA retrospective longitudinal cohort design of adult (≥18 years) patients with bladder cancer and BCG treatment (01/01/2012-31/12/2017) wa

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… Healthcare Resource Utilization HCRU data were captured for the following categories: inpatient care (overnight stays and day cases); outpatient care; medication used; and sick leave. … Cost Total cost and cost for each HCRU category and sickness leave were computed based on the actual costs reimbursed in euros during the study period. Costs were presented for the entire cohort and for each subgroup, per patient and per patient-year. …

Experience of life quality from patients with aplastic anemia: a descriptive qualitative study.

BackgroundDespite the increasing incidence of aplastic anemia in China, few studies have explored its effect on the patients' quality of life from the perspective of these patients. In fact, patients with aplastic disorder live with the disease for a long time, and need to face a variety of difficult realities, including multiple disease symptoms and drug side effects, heavy burden of medical costs, difficulties in social reintegration, and negative emotional distress. Therefore, this study used descriptive qualitative research to explore the direct and rich quality-of-life experiences of pati

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… (P1) Later, the company representative came to visit me, in fact, implied that I should leave, because I asked for sick leave for a long time, the company has to pay “five insurance and one fund”. I don’t know what I’m gonna do, and I don’t think they’re gonna hire me again. …