Результаты поиска

Определение концепций физической активности, которые имеют клиническое значение для пациентов и лиц, обеспечивающих уход: систематический обзор качественных исследований.

Физическая активность (ПА) необходима для общего здоровья. Неоптимальная ПА связана с снижением качества жизни (QOL) и преждевременной смертью. При проведении клинических исследований и разработке терапевтических методов определение тех аспектов ПО, которые имеют значение для пациентов и лиц, обеспечивающих уход, имеет важнейшее значение для разработки специальных мероприятий, выявления индивидуальных контекстуальных факторов и повышения степени удовлетворенности пациентов и их участия в обеспечении их собственного благополучия. По мере быстрого развития цифровых технологий здравоохранения (ДТ

Neuropathic cancer pain: What we are dealing with? How to manage it?

Cancer pain is a serious health problem, and imposes a great burden on the lives of patients and their families. Pain can be associated with delay in treatment, denial of treatment, or failure of treatment. If the pain is not treated properly it may impair the quality of life. Neuropathic cancer pain (NCP) is one of the most complex phenomena among cancer pain syndromes. NCP may result from direct damage to nerves due to acute diagnostic/therapeutic interventions. Chronic NCP is the result of treatment complications or malignancy itself. Although the reason for pain is different in NCP and non

Совпадение в полном тексте источника
… The acute symptomatology consists of painful muscle cramps, paresthesias in distal extremities and the perioral region and rarely priapism. These symptoms can be aggravated by cold exposure. … It can cause NCP, painful paresthesias in hands and feet, and muscle cramps. …

Burden of Disease, Treatment Patterns, and Healthcare Resource Utilization in Multiple Myeloma in the Middle East and North Africa Region: A Targeted Literature Review.

Globally, the multiple myeloma (MM) landscape varies widely, with incidence, treatment patterns, outcomes, and healthcare resource utilization (HCRU) differing across countries and regions. Many factors contribute to these differences, including ethnicity, awareness, and socioeconomic influences. This is the first analysis aiming to explore factors associated with myeloma incidence and patient characteristics in the Middle East and North Africa (MENA) region. A literature search was conducted using PubMed and Embase from 1 January 2015 to 30 May 2025. Articles reporting outcomes of interest in

Совпадение в полном тексте источника
… cramp: 23.6% Muscle weakness: 40.0% Skin dry: 7.3% Skin erythema: 1.8% – Generic lenalidomide 43 – Nausea: 48.8% Vomiting: 39.5% Fatigue: 41.9% Pyrexia: 46.5% URTI: 65.1% Pneumonia: 55.8% Back pain: 55.8% Muscle cramp: 51.2% Muscle weakness: 58.1% Skin dry: 27.9% Skin erythema: 16.3% – Soyer et al. … cramp: 23.6% Muscle weakness: 40.0% Skin dry: 7.3% Skin erythema: 1.8% | – | | Generic lenalidomide | 43 | – | Nausea: 48.8% Vomiting: 39.5% Fatigue: 41.9% Pyrexia: 46.5% URTI: 65.1% Pneumonia: 55.8% Back pain: 55.8% Muscle cramp: 51.2% Muscle weakness: 58.1% Skin dry: 27.9% Skin erythema: 16.3% | …

Оптический неурит, как необычные проявления гипопаратироидизма: редкий случай.

ОПТИЧЕСКИЙ неурит, обычно связанный с множественным склерозом (MS), может также происходить в контексте гипокальцемии в качестве редкого интригующего клинического сценария. В самых последних статьях сообщалось об ассоциации папилледемы и гипопаратироидизма, однако очень редко сообщения о случаях свидетельствовали о наличии оптического неврата, вызванного гипокальцемией, а также о нашем случае. КИСЛОТА: Мы сообщаем 43-летнюю женщину с гипокальцемией с оптическим невратом, для которой характерны внезапная потеря зрения, болезненные движения глаз и головная боль пульсатиля. Несмотря на нормализац

Совпадение в полном тексте источника
… Although muscle cramps, tetany, and seizures are commonly associated with hypocalcemia; ocular symptoms such as cataracts, papilledema, and optic neuritis may also occur [ 4 , 5 ]. Analyzing past cases uncovers some interesting similarities around the ocular manifestations. …

Acceptability and usefulness of the EORTC 'Write In three Symptoms/Problems' (WISP): a brief open-ended instrument for symptom assessment in cancer patients.

BackgroundThe use of open-ended questions supplementing static questionnaires with closed questions may facilitate the recognition of symptoms and toxicities. The open-ended 'Write In three Symptoms/Problems (WISP)' instrument permits patients to report additional symptoms/problems not covered by selected EORTC questionnaires. We evaluated the acceptability and usefulness of WISP with cancer patients receiving active and palliative care/treatment in Austria, Chile, France, Jordan, the Netherlands, Norway, Spain and the United Kingdom.MethodsWe conducted a literature search on validated instrum

Physical Activity in Multiple Myeloma: A Review of the Current Literature.

One of the major issues patients with multiple myeloma (MM) suffer from is bone instability and the resulting difficulties that come along with it, such as pain and immobility. Few studies have been performed in this patient group to investigate the effects of physical exercise on outcomes such as muscle strength, quality of life, fatigue, and pain. A PubMed search was conducted by entering the search terms "multiple myeloma" and "exercise," and "multiple myeloma" and "physical activity" that yielded 178 and 218 manuscripts, respectively. Limiting the search results to clinical trials left 13

Совпадение в полном тексте источника
… “I have fewer muscle cramps at night.” Therefore, the preliminary results of this trial have suggested that participation in a supervised training protocol can improve patients' QOL in immediate and tangible ways. …

Синдром неспокойных ног: сетевая модель нейромодуляции железа-депендента-Нарративный обзор.

Синдром нервных ног (RLS) традиционно концептуализируется как сенсорное расстройство, реагирующее на допамин; однако новые данные говорят о более сложной и неоднородной нейробиологической основе. Результаты нейроимации, генетических исследований, циркадийской биологии и клинических исследований свидетельствуют о том, что допаминергическая дисфункция происходит в более широком контексте нейромодуляционного дисбаланса, включая метаболизм железа, аденозингергическую сигнализацию, глютаматергию и, возможно, норадренергические пути. Наряду с этим количественное картирование уязвимости и связанные с

Modulation by Ozone Therapy of Oxidative Stress in Chemotherapy-Induced Peripheral Neuropathy: The Background for a Randomized Clinical Trial.

(1) Background: Chemotherapy-induced peripheral neuropathy (CIPN) decreases the quality of life of patients and can lead to a dose reduction and/or the interruption of chemotherapy treatment, limiting its effectiveness. Potential pathophysiological mechanisms involved in the pathogenesis of CIPN include chronic oxidative stress and subsequent increase in free radicals and proinflammatory cytokines. Approaches for the treatment of CIPN are highly limited in their number and efficacy, although several antioxidant-based therapies have been tried. On the other hand, ozone therapy can induce an ada

Совпадение в полном тексте источника
… At a lower frequency (one-third of patients), the acute CIPN by oxaliplatin can also include motor symptoms, such as muscle cramps, jaw stiffness, difficulty swallowing, or visible fasciculations [ 39 , 40 ]. … The earliest symptoms are usually symmetric paresthesias in the fingertips and feet, with or without pain, muscle cramps, and/or mild distal weakness. Other symptoms include muscle weakness, including wrist extensors, dorsiflexor weakness, and cramping. …

Translation research: 'Back on Track', a multiprofessional rehabilitation service for cancer-related fatigue.

OBJECTIVES: To assess the effectiveness and acceptability of an individually tailored rehabilitation intervention for patients with cancer-related fatigue (CRF). METHODS: Eighteen individuals, (16 female, two male, aged 40-83 years), who self-reported CRF (above four on a 10-point Likert scale) took part in an 8 week physical activity intervention weekly review and optional gym-based support. Fifteen participants had a primary diagnosis of breast cancer and along with the other participants had multiple myeloma, colorectal or prostate cancer. All participants took part in a goal-oriented walk

Treating Lows: Management of Orthostatic Hypotension.

AbstractOrthostatic hypotension is a prevalent clinical condition, caused by heterogenous etiologies and associated with significant morbidity and mortality. Management is particularly challenging in patients with uncontrolled hypertension. A thorough assessment is needed to draw an appropriate management plan. The treatment aims to improve postural symptoms while minimizing side effects and reducing iatrogenic exacerbation of supine hypertension. A personalized management plan including rationalizing medications, patient education, identification, and avoidance of triggers, as well as nonphar

Pharmacotherapy of Generalized Myasthenia Gravis with Special Emphasis on Newer Biologicals.

Myasthenia gravis (MG) is a chronic, fluctuating, antibody-mediated autoimmune disorder directed against the post-synaptic neuromuscular junctions of skeletal muscles, resulting in a wide spectrum of manifestations ranging from mild to potentially fatal. Given its unique natural course, designing an ideal trial design for MG has been wrought with difficulties and evidence in favour of several of the conventional agents is weak as per current standards. Despite this, acetylcholinesterases and corticosteroids have remained the cornerstones of treatment for several decades with intravenous immuno

Совпадение в полном тексте источника
… The nicotinic receptor side effects are less common and consist of muscle cramps and fasciculations. … Although considered minor, easily controlled hypertension, paraesthesia, gum sensitivity, altered taste, increased hair growth, headache, muscle cramps and diarrhoea were seen in 20% of patients on CsA. …

Risk Stratification in Multiple Myeloma: Putting the Pieces Together.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Neuropathy and cytopenias can also occur, as well as diarrhea, muscle cramps and fatigue. CBC should be checked regularly and patients should know the signs of a blood clot. …

A patient survey indicates quality of life and progression-free survival as equally important outcome measures in multiple myeloma clinical trials.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Эффективность транскутановой электрической стимуляции нервной системы в случае боли в тазе у женщин: систематический обзор.

Хроническая боль в тазе (КПГ) затрагивает примерно 26 процентов женщин и оказывает значительное воздействие на качество жизни. К числу общих причин относятся дисфункция дисменерреи и тазового пола. Транскутановая электрическая стимуляция нерва (TENS) широко используется для обезболивания в целях предотвращения обезболивания и стимулирования внутреннего опиоида. Цель этого исследования состоит в том, чтобы оценить эффективность ENS в деле реабилитации женщин, страдающих от боли в тазе, с помощью выборочных контролируемых испытаний (РКТ). Систематический поиск проводился в базах данных PubMed и

Воздействие кетогенного рациона питания на качество жизни взрослых людей с хроническими заболеваниями: систематический обзор случайных контролируемых испытаний.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Хронические заболевания отрицательно сказываются на качестве жизни (КОЛ). Кетогенное питание (КД) может улучшить КОЛ. ЦЕЛЬ: Цель этого систематического обзора заключалась в обобщении имеющихся данных о выборочных контролируемых испытаниях (РСТ) для определения воздействия KD на QOL у взрослых, страдающих хроническими заболеваниями. МЕТОДЫ: Представление докладов осуществлялось в соответствии с руководящими принципами ПРИСМА. Мы включали в себя выборочные контролируемые испытания (РСТ), проведенные на взрослых с хроническими заболеваниями, включая группу вмешательства, ко

Совпадение в полном тексте источника
… diet adherence: 3-day (2 weekdays, 1 weekend day) food record Assessment of ketosis: Bedtime ketone monitoring Serum BHB ≥ 0.6 mmol/L 85.7% of patients who completed KD achieved sustained physiological ketosis I: Increased irritability: 19%; Increased fatigue: 23%; Sugar craving: 8%; Insomnia: 4%; Muscle … cramp: 12%; Constipation: 4%; Feeling light headed: 15%; Increased back pain: 4%; Excessive hunger: 8%; Excessive thirst: 4%; Diarrhea: 4%; Palpitations: 4% C: Increased irritability: 35%; Increased fatigue: 27%; Sugar craving: 23%; Insomnia: 19%; Muscle cramp: 4%; Constipation: 15%; Feeling light headed …

Gender disparity in maintenance hemodialysis units in South India: a cross-sectional observational study.

BackgroundDiseases manifest differently according to gender in many medical specialties. However, sex differences in kidney diseases have not been well explored worldwide, especially in India. These differences could also be attributed to sociocultural factors. Although CKD is more prevalent in women worldwide, most men are initiated on kidney replacement therapy (KRT). This study aimed to examine sex disparities in patients on maintenance hemodialysis.Materials and methodsA cross-sectional observational study was conducted in two maintenance hemodialysis units at the Institute of Nephrourolog

Impact of Skeletal Muscle Depletion on Patients with Myelodysplastic Syndrome Treated with Azacitidine.

BackgroundAzacitidine (AZA) is the standard treatment for patients with high-risk myelodysplastic syndromes (MDS). The impact of skeletal muscle depletion (SMD), which is associated with outcomes of hematological malignancies, on the clinical course of MDS patients treated with AZA was investigated.MethodsThis retrospective, observational study included 50 MDS patients treated with AZA. Muscle mass was evaluated using the skeletal muscle index (SMI), which is the area of muscle mass at the third lumbar vertebra on CT images divided by the square of the height.ResultsOf the enrolled patients, 3

Lessons learnt from a process evaluation of an exercise intervention in patients treated with autologous stem cell transplantation.

This paper describes the process evaluation of an 18-week supervised exercise programme in 50 patients treated with high-dose chemotherapy followed by autologous stem cell transplantation. The intervention included 30 exercise sessions with six resistance exercises and interval training. We evaluated the context, dose delivered and received, and patients' and physiotherapists' satisfaction with the intervention. Ninety-two per cent of the patients trained within 15 km of their home address, with an average session attendance of 86%. Most patients trained at the prescribed intensity for four of

Физическая пригодность пациентов с хроническими лимфоидами, получающих терапию, основанную на Моноклональной антителной терапии: тематическое исследование.

Введение: Гематологическая недостаточность составляет значительную долю глобального бремени раковых заболеваний. Иммунотерапия в настоящее время one :: основные методы лечения, используемые при лечении этих заболеваний. Цель: Цель этого исследования заключалась в оценке физической пригодности пациентов с хроническими лимфоидными заболеваниями, получающих моноклонную антителную терапию, по сравнению с здоровыми людьми. Материалы и методы: Исследование включало в себя 99 амбулаторные пациенты лечатся от гематологии malignancies-33 с хронической лимфоцитной лейкемией, 32 с несколькими миэлома, и

Совпадение в полном тексте источника
… The most common adverse effects reported include anemia, fatigue, difficulty concentrating, memory impairment, bone and joint pain, muscle cramps, anxiety, and depression [ 4 , 5 , 6 ]. Ultimately, these symptoms can adversely affect both physical fitness and quality of life. …

Multiple myeloma and physical activity.

OBJECTIVE: Physical activity has been shown to improve quality of life in cancer patients with some evidence in multiple myeloma. This study aimed to determine myeloma patients' exercise levels, their perception of physical activity, and to explore correlations with quality of life. Myeloma outpatients were invited to complete a number of questionnaires, including the Godin leisure-time exercise questionnaire (GLTEQ) to determine their exercise levels, the Functional Assessment of Cancer Therapy-General (FACT-G) questionnaire to assess health related quality of life, and the Functional Assessm