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Isatuximab in the Treatment of Multiple Myeloma: A Review and Comparison With Daratumumab.

Multiple myeloma (MM) is a hematologic malignancy characterized by the proliferation of clonal plasma cells. Although advances in treatment have markedly improved survival outcomes for patients with MM, this disease is still considered incurable owing to its high incidence of relapse and refractoriness. Isatuximab is an anti-CD38 monoclonal antibody that can induce apoptosis in myeloma cells through a variety of mechanisms. Many clinical studies have demonstrated the efficacy and efficiency of isatuximab in both relapsed/refractory multiple myeloma (RRMM) and newly diagnosed multiple myeloma,

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… Most AEs were moderate and occurred during the first infusion. 13 , 19 IRRs mostly included symptoms such as nasal congestion, dry cough, rhinitis, sore throat, and dyspnea. 34 To prevent IRRs, patients received standard prophylactic medications, including diphenhydramine, methylprednisolone, ranitidine …

Кислотная терапия и риск излечения в случае воспламенительной болезни лопатки: сравнительное исследование в целях информирования о личностном лечении в мире.

Предыстория/цели: Известно, что ингибиторы протонных насосов (ИПЦ) изменяют состав кишечника микробиота; однако их связь с курсами заболеваний и результатами у пациентов с воспалительным кишечным заболеванием (ИБД) остается неопределенной. Наши цели заключались в оценке связи между использованием ИЦП и эскалацией лечения, диффицией Клостридиодов и использованием медицинских услуг в ИБД. Методы: Мы провели ретроспективное когортное исследование на платформе TriNetX. Пациенты IBD с ИЦП или histamine-2 Совпадали антагонисты рецептора (H2RA) one- чтобы...one с помощью баллов склонности. Итогом это

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… required to have a documented diagnosis of IBD, including ulcerative colitis (UC, ICD-10 code K51) or Crohn’s disease (CD, ICD-10 code K50), and subsequent exposure to either PPI (omeprazole, pantoprazole, esomeprazole, lansoprazole, or rabeprazole) or H2RAs (cimetidine, famotidine, nizatidine, or ranitidine …

Isatuximab in combination with cemiplimab in patients with relapsed/refractory multiple myeloma: A phase 1/2 study.

BACKGROUND: Given the incurable nature of multiple myeloma (MM), efforts are made to improve the efficacy of anti-CD38 monoclonal antibodies via combinations with other potentially synergistic therapies. This Phase 1/2 trial (NCT03194867) was designed to determine whether cemiplimab (anti-PD-1) enhances the anti-myeloma activity of isatuximab (anti-CD38) in patients with relapsed and refractory multiple myeloma (RRMM), to confirm the feasibility of the combination, determine its efficacy, and further evaluate its safety. METHODS: Patients received isatuximab 10 mg/kg once weekly for 4 weeks f

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… Premedication with acetaminophen (650–1000 mg orally), ranitidine (50 mg IV), diphenhydramine (25–50 mg IV), and methylprednisolone (100 mg IV) was administered 30–60 minutes prior to isatuximab infusion. …

A Phase I First-in-Human Study of ABBV-383, a B-Cell Maturation Antigen × CD3 Bispecific T-Cell Redirecting Antibody, in Patients With Relapsed/Refractory Multiple Myeloma.

PurposeABBV-383, a B-cell maturation antigen × CD3 T-cell engaging bispecific antibody, has demonstrated promising results in an ongoing first-in-human phase I study (ClinicalTrials.gov identifier: NCT03933735) in patients with relapsed/refractory multiple myeloma (RRMM). Herein, we report safety and efficacy outcomes of this phase I dose escalation/expansion study.MethodsPatients with RRMM (≥ three prior lines including a proteasome inhibitor, an immunomodulatory drug, and an anti-CD38 monoclonal antibody) were eligible. ABBV-383 was administered intravenously over 1-2 hours once every 3 week

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… Patients are also routinely premedicated with diphenhydramine 25-50 mg IV (once on day 1) or equivalent, oral acetaminophen 650-1,000 mg (once on day 1), and ranitidine 150 mg oral/IV (once on day 1) or equivalent, 15-60 minutes before the ABBV-383 infusion (once every 3 weeks) to reduce the risk and …

Ferret coronavirus-associated diseases.

A novel coronavirus of ferrets was first described in 1993. This coronavirus caused an enteric disease called epizootic catarrhal enteritis (ECE). Recently, a ferret systemic coronavirus (FRSCV)-associated disease was discovered. This new systemic disease resembles the dry form of feline infectious peritonitis (FIP) and has been reported in the United States and Europe. This article addresses the clinical signs, pathology, pathogenesis, diagnosis, treatment, and prevention of this ferret FIP-like disease.

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… Sucralfate (Carafate oral suspension) can be administered orally at a dose of 75 to 100 mg/kg, 10 to 15 minutes before each feeding and before prednisolone administration. 56 , 57 Antacids such as cimetidine hydrochloride (Tagamet), famotidine (Pepcid AC), ranitidine (Zantac), and omeprazole (Prilosec …

Isatuximab: A Review in Transplant-Ineligible Newly Diagnosed Multiple Myeloma.

Isatuximab (isatuximab-irfc; SARCLISA®) is an anti-CD38 monoclonal antibody approved in the EU and the USA for use in combination with bortezomib, lenalidomide and dexamethasone for the treatment of adults with newly diagnosed multiple myeloma (NDMM) who are ineligible for autologous stem cell transplantation (ASCT). In a phase III study in this patient population, isatuximab-bortezomib-lenalidomide-dexamethasone significantly prolonged progression-free survival (PFS) and generally improved the depth of tumour response versus bortezomib-lenalidomide-dexamethasone. Overall survival (OS) data we

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… Patients receiving isatuximab–bortezomib–lenalidomide–dexamethasone at any point during the study received premedication [acetaminophen, dexamethasone, diphenhydramine and ranitidine (or equivalent)] directly prior to isatuximab infusion. …

Hematology

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… eosinophilic vasculitis, eosinophilic ulcers of the oral mucosa Allergies nasal —allergic rhinitis, asthma, nasal polyposis medications — cytokine mediated (GM-CSF, IL-2), pulmonary (NSAIDs), gastroenteritis (NSAIDs), interstitial nephritis (penicillins, cephalosporins), necrotizing myocarditis (ranitidine … bronchoalveolar lavage or lung biopsy causes — infectious (Loeffler’s syndrome [ Ascaris , hookworms, strongyloides], Paragonimus lung flukes, tropical pulmonary eosinophilia [ Wuchereria bancrofti, Brugia malayi ], coccidioidal), medications (NSAIDs, nitrofurantoin, ampicillin, minocycline, phenytoin, ranitidine …

Hematology

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… eosinophilic vasculitis, eosinophilic ulcers of the oral mucosa A llergies nasal —allergic rhinitis, asthma, nasal polyposis medications — cytokine mediated (GM-CSF, IL-2), pulmonary (NSAIDs), gastroenteritis (NSAIDs), interstitial nephritis (penicillins, cephalosporins), necrotizing myocarditis (ranitidine … bronchoalveolar lavage or lung biopsy causes — infectious (Loeffler’s syndrome [ Ascaris , hookworms, strongyloides], Paragonimus lung flukes, tropical pulmonary eosinophilia [ Wuchereria bancrofti , Brugia malayi ], coccidioidal), medications (NSAIDs, nitrofurantoin, ampicillin, minocycline, phenytoin, ranitidine …

The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of multiple myeloma.

Outcomes in multiple myeloma (MM) have improved dramatically in the last two decades with the advent of novel therapies including immunomodulatory agents (IMiDs), proteasome inhibitors and monoclonal antibodies. In recent years, immunotherapy for the treatment of MM has advanced rapidly, with the approval of new targeted agents and monoclonal antibodies directed against myeloma cell-surface antigens, as well as maturing data from late stage trials of chimeric antigen receptor CAR T cells. Therapies that engage the immune system to treat myeloma offer significant clinical benefits with durable

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… prescribing information for elotuzumab recommends the premedication regimen developed during ELOQUENT-2: oral dexamethasone 28 mg 3–24 hours prior to each elotuzumab infusion and then an additional 8 mg administered intravenously 30–90 min before the infusion along with diphenhydramine (25–50 mg), ranitidine … Ranitidine 50 mg IV or equivalent. Acetaminophen 650–1000 mg oral administration. In patients with respiratory disease (eg, asthma or reduced forced expiratory volume in 1 s), consider adding an adrenergic bronchodilator (albuterol inhaler/nebulizer) as premedication. …

Многомерное пространственное воздействие на толщину сетчатки АИ с высоким разрешением.

Толщина сетчатки является показателем здоровья сетчатки и в более широком плане рассматривается как перспективный биомаркер многих системных заболеваний. Измерения толщины сетчатки производятся на основе оптической последовательности томографии (OCT) в рамках плановой клинической офтальмологии. Мы обработали снимки Biobank OCT в Великобритании с помощью нервной сети для проведения мелких измерений толщины сетчатки по всей стране. > 29,000 Очки в макуле, часть сетчатки, ответственная за центральное зрение человека. Макула в непропорционально большой степени страдает от таких серьезных заболеван

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… The traits showing the largest magnitude correlations included ranitidine use (used to treat gastro-oesophageal reflux, FPCs 1 and 5), alcohol-related mental health problems (FPC6), cataract (FPC2), and having received psychiatric care (FPC4). …

Oral Presentation

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… Tramadol, Ondansetron, Hyoscine, Haloperidol and Ranitidine injections along with Lorazepam tablets (singly packed and labelled well) packed with a 23 gauge butterfly cannula, an alcohol swab and syringes in a seal proof package along with an anticipatory prescription, phone helpline number and video …

Emergency Care

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Safety and Tolerability of Antibody-Drug Conjugates in Cancer.

Antibody-drug conjugates are monoclonal antibodies attached to biologically active drugs through chemical linkers that deliver and release cytotoxic agents at the tumor site, reducing the likelihood of systemic exposure and therefore toxicity. Currently, there are about 110 ongoing studies implementing antibody-drug conjugates in the treatment of multiple human malignancies. Antibody-drug conjugates carry a feature of the specificity of a monoclonal antibody and the anti-neoplastic potential of a cytotoxin. The first antibody-drug conjugate was approved in 2001, and the field of antibody-drug

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… Three weeks later, BV therapy was continued after premedication (prednisolone, dimetindene, ranitidine, acetaminophen) with no further complications. …

Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications.

Curcumin, a yellow polyphenolic pigment from the Curcuma longa L. (turmeric) rhizome, has been used for centuries for culinary and food coloring purposes, and as an ingredient for various medicinal preparations, widely used in Ayurveda and Chinese medicine. In recent decades, their biological activities have been extensively studied. Thus, this review aims to offer an in-depth discussion of curcumin applications for food and biotechnological industries, and on health promotion and disease prevention, with particular emphasis on its antioxidant, anti-inflammatory, neuroprotective, anticancer, h

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… However, when associated with antacids, such as cimetidine (Tagamet), famotidine (Pepcid), ranitidine (Zantac) and omeprazole, it can inhibit their effectiveness. Contra-Indications Turmeric use is not recommended for individuals allergic to Zingiberaceae plants. …

A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin.

Curcuma longa Linn. (C. longa), popularly known as turmeric, belongs to the Zingiberaceae family and has a long historical background of having healing properties against many diseases. In Unani and Ayurveda medicine, C. longa has been used for liver obstruction and jaundice, and has been applied externally for ulcers and inflammation. Additionally, it is employed in several other ailments such as cough, cold, dental issues, indigestion, skin infections, blood purification, asthma, piles, bronchitis, tumor, wounds, and hepatic disorders, and is used as an antiseptic. Curcumin, a major constitu

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… Kim et al. (2005) found that orally administered ethanolic C. longa extract decreased stomach acid, gastric juice secretion, and ulcer initiation in male rats by inhibiting H2 histamine receptors, which is similar to the effects of ranitidine. …

The prince and the pauper. A tale of anticancer targeted agents.

Cancer rates are set to increase at an alarming rate, from 10 million new cases globally in 2000 to 15 million in 2020. Regarding the pharmacological treatment of cancer, we currently are in the interphase of two treatment eras. The so-called pregenomic therapy which names the traditional cancer drugs, mainly cytotoxic drug types, and post-genomic era-type drugs referring to rationally-based designed. Although there are successful examples of this newer drug discovery approach, most target-specific agents only provide small gains in symptom control and/or survival, whereas others have consiste

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… Active renal secretion is the major elimination pathway for procainamide and utilizes the base-secreting system responsible for secretion of metformin, cimetidine, ranitidine, triamterene, and flecainide; thus, there is a potential for drug-drug interactions at this level [ 177 , 178 ]. …

Abstracts from the 8th Drug Hypersensitivity Meeting (DHM)

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Molecular Inhibitors of Growth Signals

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… Therefore, co-administration of high doses of ranitidine or sodium bicarbonate (which maintain the gastric pH above pH 5.0) reduces the mean gefitinib area under the concentration-time curve by 45 %. …

ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts

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Biology and Diseases of Dogs

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