Результаты поиска

Perspectives on returning to work of multiple myeloma patients: A qualitative interview study.

ObjectiveMultiple myeloma (MM) is a rare and incurable disease. Because new treatments improved survival rates, return to work (RTW) became more relevant to MM patients of working age. Also, (health care) experts may be confronted with specific obstacles in guiding MM patients' RTW. Therefore, we aimed to qualitatively explore perspectives and experiences of MM patients and (health care) experts regarding RTW and participation at work.MethodsSemi-structured interviews were conducted with patients (N = 9) and (health care) experts (N = 15). Interviews were transcribed verbatim and analysed usin

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… Others stopped working as soon as they received the diagnosis and were on sickness leave until they recovered from treatment. Time to RTW after ASCT was variable in the interviewed MM patients. … Self‐employed patients generally RTW earlier, because they often lack sick leave insurance. However, experts explained that it poses these patients more at the risk of crossing boundaries and drop‐out later on in the trajectory. …

Множественная миелома у людей трудоспособного возраста в Германии, Польше и Чехии: результаты качественного исследования.

ЦЕЛЬ: Цель исследования состояла в том, чтобы понять опыт взрослых трудоспособного возраста с миеломой и их партнерами/членами семьи, проживающими в Германии, Чешской Республике и Польше. МЕТОДЫ: КОНСУЛЬТАТИВНЫЕ СООБРАЖЕНИЯ 36 взрослых трудоспособного возраста, живущих с миеломой, и three Члены семьи. Данные были собраны в период с мая по октябрь 2022. К данным был применен тематический анализ. Результаты: Описано медицинское обслуживание и государственная поддержка в каждой стране. Степень участия в трудовой деятельности зависит от бремени симптомов пациентов, потребностей в лечении, государс

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… Being of working age also presents opportunities for some, such as employment-funded health insurance, paid sick leave, and a non-illness focus for life. … Respondents drew on a mixture of paid sick leave, family support, and state benefits: At first I used my sick leave, then there was a rehabilitation benefit, and then there was an unpleasant moment which we call renta [disability allowance], because I wanted it, and I did not want it … I mean, probably …

Living with pain-a systematic review on patients' subjective experiences.

BACKGROUND: Understanding the subjective experiences of patients living with chronic, acute, and cancer pain can significantly enhance the selection of treatment approaches, care, and support, ultimately improving their quality of life. This qualitative systematic review aimed to analyze if the patients' subjective experiences of living with pain differ between acute, chronic, and cancer pain states. METHODS: After registration in PROSPERO (CRD42023491745), an electronic search was conducted in the databases Medline (Ovid), Embase (embase.com), Cochrane (Wiley), Web of Science (Clarivate Anal

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… Three patients worked full-time, one worked part-time and studied part-time, three worked part-time and received gov-ernment health insurance benefits for sick leave or a disability pension for the remaining time. … You come to a point when you have to stop [working] because you’re totally exhausted and have to be on sick leave more and more often. It isn’t worth it [ 57 ] It has had a huge impact on my work. I can’t continue my original work anymore [ 88 ]. …

Экономическое бремя вторичного прогрессивного множественного склероза: исследование DISCOVER.

ОКРУЖАЮЩАЯ СРЕДА: Оценить социально-экономическое бремя людей со вторичным прогрессивным множественным склерозом (ПВСПМС), принимая во внимание прямое медико-санитарное обслуживание, прямое немедицинское обслуживание и косвенные издержки, а также оценить взаимосвязь между издержками и функциональными результатами пациентов. МЕТОДЫ: Изучение наблюдений, перекрестных и многоцентральных исследований с ретроспективным сбором данных о реальной клинической практике, полученных в ходе посещения служб неврологии 34 Больницы в период 2019-2020. Клинические данные включали в себя оценки по расширенной ш

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… Mean (SD) - - 2.4 (3.0)   - Presenteeism (hours/week), Mean (SD) - - 14.1 (11.2)   - Work disability due to SPMS/MS. n (%) - - 14 (45.2)   - Permanent partial disability due to SPMS/MS. n (%) - - 9 (29.0)   - Permanent total disability due to SPMS/MS. n (%) - - 5 (16.1)   - Sick leave due to SPMS/MS … Six (19.4%) active participants were on sick leave due to SPMS for a total of 46.2 (66.2) days on average during the last 6 months. For pwSPMS inactive at work, 41 (15.4%) took early retirement due to SPMS/MS. …

Quality-of-life issues and symptoms reported by patients living with haematological malignancy: a qualitative study.

BackgroundOur aim was to identify health-related quality-of-life (HRQoL) issues and symptoms in patients with haematological malignancies (HMs) and develop a conceptual framework to reflect the inter-relation between them.MethodsA total of 129 patients with HMs were interviewed in a UK multicentre qualitative study. All interviews were audio recorded, transcribed and analysed using NVivo-11.ResultsOverall, 34 issues were reported by patients and were grouped into two parts: quality of life (QoL) and symptoms. The most prevalent HRQoL issues were: eating and drinking habits; social life; physic

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… Furthermore, there was also no or limited support for the self-employed who were greatly affected financially, as they did not have any employer providing paid sick leave. …

ON THE FORMATION OF PRECIPITATES AFTER THE INTRAVENOUS INJECTION OF SALVARSAN.

The results of these experiments are definite. There is, in the first place, a very striking difference with regard to precipitate formation between the acid and alkaline solutions of salvarsan when injected intravenously. Intravenous injections of alkaline solutions of salvarsan produce no precipitate in the blood, while injections of the acid solution nearly always give a precipitate. Furthermore, after injections of the acid solution, there is a striking difference between the blood from the right side of the heart and that from the left side. At the end of injections of an acid solution of

Low-, moderate-, and high-risk obesity in association with cost drivers, costs over the lifecycle, and life expectancy.

BackgroundThe prevalence of low-, moderate-, and high-risk obesity has been increasing globally. Our aim was to estimate the societal burden of these three obesity classes in the Austrian population by taking a societal-annual perspective and an individual-life-cycle perspective. Secondly, we sought to identify the respective cost drivers and the effects on life expectancy.MethodsWe used population-weighted survey data on the distribution of body mass index (BMI) and data on relative risks regarding 83 diseases. Using fractional polynomial regressions, we estimated relative risks per BMI unit

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… In our model, indirect costs arose from absenteeism due to sick leave, entry into the disability pension, or death during working age. … Two thirds are lost due to sick leave and one third due to disability and death. …

Financial Toxicity in Patients With Breast Cancer Treated at Private Medicine Institutions in Brazil.

Financial toxicity (FT) refers to the negative impact of the financial burden of cancer diagnosis and treatment on patients' well-being. With rising global costs of oncologic therapies, diagnostics, and supportive care, FT has become a key concern in cancer care, influencing adherence, quality of life, and outcomes. Breast cancer, given its high prevalence and socioeconomic implications, is notably associated with FT. Beyond direct medical expenses, patients often face income loss and out-of-pocket costs for supportive care, which can significantly affect their therapeutic trajectory. Addressi

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… Patients on sick leave and those who were unemployed had the lowest COST scores. Retired individuals had significantly higher scores than both groups, as well as compared to self‐employed patients. …

Bilateral prophylactic mastectomy in BRCA mutation carriers: what surgeons need to know.

Aim of this paper is to allows to analyze a topic of great relevance and media interest such as the role of prophylactic mastectomy in healthy women with BRCA mutation proposing to the surgeons some useful informations for decision-making. Less than 15% of all breast cancers are associated with germline genetic mutations. The majority of hereditary breast tumors are due to mutations in BRCA1 and BRCA2 genes that are responsible for only one third of hereditary cases. The risk estimates are extremely heterogeneous with a mean cumulative lifetime breast cancer risk of approximately 72% in BRCA1

Productivity losses in patients with newly diagnosed multiple myeloma following stem cell transplantation and the impact of maintenance therapy.

OBJECTIVE: This study examined productivity losses in European patients with newly diagnosed multiple myeloma (NDMM) undergoing autologous stem cell transplantation (ASCT), to better understand and model the impact of NDMM and lenalidomide maintenance therapy on productivity from a patient and societal perspective. METHODS: A cross-sectional online patient survey was conducted across the UK, Germany, France, Spain and Italy. A partitioned survival model was used to estimate productivity loss and the impact of maintenance therapy, using human capital (HC) and friction cost approaches. RESULTS

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… Patients who were unemployed, homemakers or on sick leave were categorised as economically inactive. Those in full‐time/part‐time employment or self‐employed were categorised as economically active. … Productivity loss was greater in patients aged 50‐65 years vs those <50 years: 87% switched from full‐time employment to retirement, part‐time employment or sick leave. Overall WPAI instrument results were similar across the age groups. …

Effects from treating moderate- to high-risk obesity patients with anti-obesity medication from a societal perspective.

Obesity is a global health concern with new medication treatment options. So far, research on how programs with newer anti-obesity medication (AOM) for the moderate- to high-risk population can mitigate the prevalence of obesity and reduce the economic burden of society is limited. We aimed to assess such impacts of AOM and lifestyle intervention with the GLP-1 receptor agonist semaglutide on patients with different obesity classes, i.e. risks (and no diabetes), based on clinical trial data. We estimated the treatment effect on prevalence, medical and indirect costs using the population-attrib

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… In 2019, 4264 (95% CI 4256.76–4271.58) employees (in full-time equivalents, FTE) were lost due to obesity-associated sick leave, disability, or death; 40% of them were in obesity class II or III. … Fig. 2 provides the corresponding results regarding direct medical costs as well as indirect costs arising from sick leave, disability, or death during working age, by sex and over age groups. Life-cycle costs increase up to the age of 60, according to our findings. …

Ключевые результаты мероприятий по профессиональной реабилитации лиц с множественным склерозом: Номинальное техническое исследование группы.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Мероприятия по профессиональной реабилитации лиц с множественным склерозом (МС) в целях удержания рабочих мест могут оказать позитивное воздействие на независимость человека и непосредственно повлиять на результаты в области здравоохранения и занятости. Вместе с тем оценка эффективности мероприятий в области ПР может быть сопряжена с трудностями в силу их весьма индивидуализированного характера и разнообразных потенциальных последствий для здоровья и занятости, которые могут быть затронуты. AIM: Определение наиболее важных результатов деятельности по сохранению рабочих м

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… This was particularly important to our participants with MS because of the lack of understanding around invisible symptoms and how MS fluctuates, which led to challenges at work following organisational policies (e.g., sick leave) and employers' preferences (e.g., not allowing breaks during the day). … Even though we recruited participants with diverse employment (employed, on sick leave and recently unemployed), from a range of jobs with different levels of seniority and from secretarial or administrative to professional occupations, this sample is arguably small. …

Symptom burden and health-related quality of life six months after hyperbaric oxygen therapy in cancer survivors with pelvic radiation injuries

Abstract Purpose Late radiation tissue injuries (LRTIs) after treatment for pelvic cancer may impair health related quality of life (HRQoL). Hyperbaric oxygen therapy is an adjuvant therapy for LRTIs, but limited studied. The aim of this study was to explore the development and association between symptoms of LRTI and HRQoL following hyperbaric oxygen treatment. Methods A pretest–posttest design was used to evaluate the changes in pelvic LRTIs and HRQoL from baseline (T1), immediately after treatment (T2) and at six-month follow-up (T3). EPIC and EORTC-QLQ-C30 were used to assess LRTIs and HRQ

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… Table 1 Sample characteristics ( N = 95) n (%) Gender Male 50 (52.6) Female 45 (47.4) Age, years (mean (SD, range)) 65 (11.6, 32–84) Work status Sick leave/disability pension/retired 78 (82.1) Full time/part time employment 17 (17.9) Civil status Married/cohabiting 67 (70.5) Single 28 (29.5) Children … However, most participants in working age were on sick leave or disability pension. Research shows that physical late effects and fatigue after cancer treatment continue to impair work ability among cancer survivors, affect career and increase economical stress [ 40 ]. …

Financial toxicity and employment status in cancer survivors. A systematic literature review.

BackgroundFinancial toxicity has traditionally been attributed to the rising costs of cancer care. As ability to work impacts one's financial situation, limited employment and reduced income may also contribute to financial toxicity. We examined evidence of the association between financial toxicity and employment status in cancer survivors.MethodsA systematic literature review was performed via PubMed, Web of Science, CINAHL, and PsycINFO with search terms including "Cancer," "Financial toxicity," and "Employment" on September 25, 2019.ResultsThirty-one papers met eligibility criteria. Thirte

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… accommodations such as flexible hours or rehabilitation services, lower length of sick leave and continuity of care [ 13 ]. … Return to work is influenced by social security systems, especially the length of paid sick leave. Furthermore, differences in legislation, incentives, and possibilities of an employer to provide employees with return to work programs differ among countries. …

Cost-effectiveness of enzyme replacement therapy for type 1 Gaucher disease.

ObjectiveTo evaluate the cost-effectiveness of enzyme replacement therapy (ERT) compared to standard medical care without ERT in the Dutch cohort of patients with type 1 Gaucher disease (GD I).DesignCost-effectiveness analysis was performed using a life-time state-transition model of the disease's natural course. Transition probabilities, effectiveness data and costs were derived from retrospective data and prospective follow-up of the Dutch study cohort.SettingThe tertiary referral center for Gaucher disease in the Netherlands.ParticipantsThe Dutch cohort of patients with GD I.InterventionERT

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… Table 6 shows the mean yearly costs of production loss resulting from sick leave and (permanent) work disability as a consequence of GD I. The costs for production loss follow the human capital costing approach and were derived in successive calculation steps. … The mean volume of sick leave in number of days per 2-week period was calculated per patient per disease state. Treated and untreated patients were taken together. …

Изучение стрессовых факторов и ресурсов труда и их предполагаемого воздействия на симптомы и трудоспособность работников с множественным склерозом: качественное исследование.

Неблагоприятные условия труда могут привести к сокращению рабочего времени, изменению карьеры или досрочному выходу из состава рабочей силы среди работников с множественным склерозом. Цель настоящего исследования состояла в том, чтобы изучить связанные с работой стрессовые факторы и ресурсы, а также их воздействие на симптомы и трудоспособность, как считают работники с множественным склерозом в Германии. МЕТОДЫ: Полуструктурные собеседования проводились по видеоконференциям и телефону. Собеседования были зарегистрированы, транскрибированы и проанализированы с использованием MAXQDA и качественн

Economic impact of immunoglobulin replacement therapy in secondary immunodeficiency to hematological cancer: a single center observational study.

This is the first report of the health economic benefits derived from preventing infections through Immunoglobulin Replacement Therapy (IgRT) in patients with secondary immunodeficiency due to hematological malignancies. We conducted a retrospective population-based cohort study using patient medical history and pharmacy data from the Hospital Clínico San Carlos for 21 patients between 2011 and 2020. The pharmacoeconomic impact of using prophylactic IgRT was assessed by comparing characteristics of the SID patients 1 year before and after initiating IgRT measured by direct medical and tangible

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… Indirect costs Sick leave was accounted for patients of working age (under 65 years). … leaves (absenteeism) (days) | 124 | 61 | 13,927.68 | 6,851.52 | 7,076.16 TOTAL | | | 405,088.18 | 295,804.42 | 109,283.76 One year after beginning IgRT, there was a notable reduction in the mean number of hospitalization days per patient to just 6.1, with this decrease proving statistically significant …

Multiple Sclerosis Nursing to Improve Care and Education (MSNICE): an observational study.

OBJECTIVE: To explore differences in patient reported outcomes, health care resources and expenditures in persons with multiple sclerosis (pwMS) with or without access to an MS-nurse. METHODOLOGY: An observational, multicenter and cross-sectional study was conducted. Seven centers with, and twelve centers without an MS-nurse participated. The multiple sclerosis impact scale-29 (MSIS-29) was the primary outcome measure. Secondary outcome measures included: hospital anxiety and depression scale, coping measures, health-economic and disease-knowledge parameters. RESULTS: Three hundred thirty-fo

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… Furthermore, no statistically significant differences were found in work change due to MS (15.8 vs. 11.7%, X²= 0.613, p  = .536), income changes (57.9% vs. 87.5, X²= 2.220, p  = .136), sick leave during the past three months (31.3% vs. 22.8%, X²= 1.736, p  = .188), permanent sick leave (68.2% vs. … 53.4% X²= 2.825, p  = .093) and permanent sick leave due to MS (73.4% vs. 56.9%, X²= 3.688, p  = .055). …

Клинические характеристики, диагноз, лечение и прогноз заболевания сывороткой ритуксимаба: ретроспективный анализ 39 Количество зарегистрированных случаев.

Заболевание сывороткой, вызванное ритуксимабом (РИСС), представляет собой необычайно запоздалую гиперчувствительность, характеризующуюся неполной клиническими характеристиками и управлением. Мы намеревались обобщить опубликованные доклады/серии с целью определения клинических моделей, терапевтических стратегий и результатов. МЕТОДЫ: PubMed, EMBASE, Web of Science, WanFang Data и China National Knowledge Infrastructure (CNKI) были найдены отчеты о болезни сыворотки, выпущенные до ноября 31, 2025, используя ключевые слова и свободные текстовые термины (например, "Rituximab", "Serum Bealth", "Ser

Профессиональная реабилитация лиц с множественным склерозом в национальной системе здравоохранения Соединенного Королевства: оценка реального положения.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Имеются ограниченные данные о том, каким образом профессиональная реабилитация лиц с множественным склерозом (МС) может осуществляться через Национальную службу здравоохранения (НСЗ) Соединенного Королевства (Соединенное Королевство) и как она работает. AIM: Уяснить механизмы и контекст осуществления VR-терапии для лиц, имеющих MS в ГСЗ, и разработать теорию пояснительных программ. МЕТОДЫ: Реалистичная оценка, включая обзор доказательств, а затем полуструктурированные собеседования. Был проведен реалистический обзор VR для лиц, имеющих MS в НСЗ six Электронные базы данны