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Social Support in Older Adults With CKD: A Report From the CRIC (Chronic Renal Insufficiency Cohort) Study.

Rationale & objectiveSocial support in older adults with chronic kidney disease (CKD) is a potentially modifiable factor that may affect important clinical outcomes such as health-related quality of life, cognitive function, and frailty. However, limited data about the effects of social support in older patients with non-dialysis-dependent CKD exist. Our objective was to evaluate the association of social support with health-related quality of life, cognitive function, and frailty in older adults with CKD.Study designCross-sectional analysis of a prospective cohort study.Setting & population1,

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… CFAS-Wales research team Social isolation, cognitive reserve, and cognition in healthy older people PLoS One 13 8 2018 e0201008 10.1371/journal.pone.0201008 PMC6097646 30118489 20 Holtzman R.E. Rebok G.W. Saczynski J.S. Kouzis A.C. Wilcox Doyle K. Eaton W.W. …

Classification of symptom subtypes in patients with multiple myeloma during treatment: a cross-sectional survey study in China.

OBJECTIVES: To classify subgroups of cancer-related symptoms in patients with multiple myeloma (MM) during treatment and examine between-group differences in demographic and clinical characteristics in addition to functional status. DESIGN: Cross-sectional survey study. SETTING: Haematology department of two tertiary hospitals affiliated with Guilin Medical University in China. PARTICIPANTS: Using a convenience sampling method, questionnaires were distributed to patients with MM visiting two hospitals in Guilin, China. INTERVENTIONS: The patients were categorised into subgroups based on ca

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… Older patients have been more vulnerable to cognitive side effects of cancer treatments than younger patients. 25 Support for an interaction of age, cognitive reserve and exposure to chemotherapy have been identified as risk factors for cognitive decline. 26 Hsu et al reported that mild anxiety may be … Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: impact of age and cognitive reserve. J Clin Oncol 2010;28:4434–40. 10.1200/JCO.2009.27.0827 27. Hsu Y-H, Chen VC-H, Hsieh C-C, et al. …

Исследование лица, эмоциональное признание и эмоциональное укрепление памяти в релапсирующих множественных склерозах.

ПРИСУТСТВИЕ: Признание знакомых лиц и распознавание эмоций через выражение лица имеют важное значение для социального функционирования. Цель этого исследования заключалась в изучении вопроса о том, отличаются ли люди с повторно излучающимся множественным склерозом (PwMS) от здоровых контрольных лиц (HC) в выполнении различных задач, связанных с обработкой эмоций на лице. В ходе перекрестного контролируемого исследования 30 ПВМС и 35 ВК завершила базовую нейропсихологическую оценку и экспериментальные задачи по оценке визуального анализа лицевых стимулов посредством отслеживания глаз, распознав

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… This variability in performance, particularly in the early stages of the disease, has been discussed with reference to potential compensatory mechanisms underlying cognitive reserve and brain reserve [ 42 ]. …

The effect of exercise-based interventions on health-related quality of life and physical function in older patients with cancer receiving medical antineoplastic treatments: a systematic review.

Older patients with cancer are underrepresented in trials investigating the effect of exercise therapy. The aim of this systematic review was to investigate the effect of exercise therapy during medical antineoplastic treatment in older patients (≥ 65 years) with cancer. A systematic review following the Cochrane guidelines was performed. Randomized controlled trials were identified through a systematic literature search in MEDLINE, EMBASE, CENTRAL, and CINAHL up to December 2019. Study selection was performed independently by two reviewers. Four randomized controlled trials published between

The perioperative management of geriatric patients in transplantation surgery-clinical, immunological, and translational considerations.

Transplant surgery encompasses two primary branches: solid organ transplantation (SOT) and vascularized composite allotransplantation (VCA). As the global population ages, elderly transplant patients become a more pressing clinical challenge. Elderly transplant recipients require specialized care that addresses their unique needs, including increased comorbidities and frailty. Despite the growing recognition of these challenges, there is a paucity of studies that synthesize the current knowledge on this patient cohort, from immunological changes over translational challenges to tailored clinic

Exercise as a Therapeutic Strategy to Improve Cerebrovascular Function and Cognition in Breast Cancer Survivors: A Scoping Review.

Breast cancer is the most diagnosed cancer globally. While the breast cancer prevalence continues to rise, so too do patient survival rates, thus resulting in a large survivor population. Up to 75% of this population report experiencing cancer-related cognitive impairment during their cancer journey, thus reducing their quality of survivorship. This review systematically evaluates the effect of physical activity and exercise training on cerebrovascular function and cognition in breast cancer survivors. Cross-sectional, intervention or observational studies that examined the effect of acute or

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… Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: Impact of age and cognitive reserve. J. Clin. Oncol. 2010;28:4434–4440. doi: 10.1200/JCO.2009.27.0827. 43. Phillips K.M., Jim H.S., Small B.J., Laronga C., Andrykowski M.A., Jacobsen P.B. …

Supportive Care in Older Lymphoma Patients to Reduce Toxicity and Preserve Quality of Life

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Прозрачная синхронизация при прослушивании пальцев на музыке и метрономах на различных темпах в прогрессивном множественном склерозе.

Лица с повторным склерозом (MS) могут синхронизировать шаги с музыкой и метрономами при разных темпах. Однако прогресс демиэлизации, потеря нейронной связи и усиление когнитивного расстройства, вероятно, влияют на то, как люди с прогрессивным MS (PwPMS) синхронизируют движения с внешними ударами. Мы проверили, как PwPMS подключается к музыке и метрономам на высоком и низком темпе, чтобы понять способность слуха-мотора к поведению в PwPMS. Синхронизация на уровне мозга измеряется с помощью ЭЭГ. Мы целимся.1) для изучения вопроса о том, может ли PwPMS синхронизировать прослушивание различных тем

Relationship between specific microRNA expression and radioresistant conditions in HL60 acute myeloid leukemia cells.

BACKGROUND: The efficacy of cervical cancer screening programs is dependent on the participation rate. To increase participation among women not attending cervical cancer screening, self-collected samples for detection of high-risk human papillomavirus (hr-HPV) may be an option.The aims of this study were: to investigate the response rate to sending a self-collected vaginal sample for hr-HPV mRNA detection to long-term non-attendees; the compliance with follow-up among women positive for HPV in the self-sample; the prevalence of cervical dysplasia (high grade squamous intraepithelial lesion (H

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… O’Brien C , Holtzer R ( 2021 ) Cognitive Reserve Moderates Associations Between Walking Performance Under Single- and Dual-Task Conditions and Incident Mobility Impairment in Older Adults . J Gerontol A Biol Sci Med Sci 76 : 314 – 320 . 10.1093/gerona/glab178 PMC8691058 34153107 7. …

Cancer in Pregnancy: Therapeutic Decisions at the Intersection of Two Lives.

Background: Cancer during pregnancy is a rare but increasingly encountered condition due to delayed childbearing and improved survival of women with cancer. The coexistence of malignancy and pregnancy poses complex diagnostic and therapeutic challenges, requiring careful balance between maternal prognosis and fetal safety. Objective: This review aims to summarize current evidence on the diagnosis and multidisciplinary management of cancer during pregnancy, focusing on the safe use of oncologic therapies, obstetric decision-making, and maternal and fetal outcomes. Methods: A narrative review wa

Меры по согласованию и износостойкости в рамках системы многоразового склероза-системного обзора доказательств и применимости используемых систем скоринга в клинических и реальных данных.

В случае множественного склероза (MS) все большее внимание уделяется соприкосновениям и слабостям, влияющим на курс болезни, лечение и качество жизни. Цель этого обзора литературы заключается в оценке фактических данных, сильных и слабых сторон инструментов оценки соответствия и слабости у людей с НР (МСУ). МЕТОДЫ: Мы провели всеобъемлющий систематический обзор литературы, включая исследования, опубликованные между 2014 и 2024 с первоначальными данными или систематическими обзорами показателей комординации или слабости в ПТУС с использованием PRISMA 2020 методология. Были проанализированы меры

Психиатрические результаты первого two спустя годы после октября 7 - нападения: систематический обзор последствий посттравматического стресса, беспокойства, депрессии и наркомании.

ЦЕЛИ: октябрь 7 :: нападения и последовавшая за ними война создали условия для устойчивой, многоплановой травмы. В настоящем систематическом обзоре обобщаются результаты исследований, проведенных в ходе первого обзора. two годы войны, чтобы прояснить раннее распространение симптомов посттравматического стресса (ПТСС), тревоги, депрессии и связанных с наркоманией последствий среди израильского населения. МЕТОДЫ: ПОСЛЕ ПРИСМА 2020 :: были проведены обыски по ПубМеду, Психиндо, Скопусу и веб-сайту науки с целью выявления исследований, опубликованных в период с октября 7, 2023 и октябрь 7, 2025 (з

The Role of Frailty in Cardio-oncology and its Challenges.

Frailty has received increasing scientific attention as a potential explanation for adverse health outcomes among older adults. In cardio-oncology, frailty is particularly relevant due to the dual burden of cardiovascular disease and cancer, both of which accelerate the general decline in health associated with ageing. Therefore, understanding and addressing frailty in cardio-oncology has paramount importance for optimising patient outcomes, personalising treatment plans, and improving quality of life. In this review, we aim to discuss: the pathophysiology of frailty in the context of cardio-o

Дифференциальные когнитивные траектории в зависимости от степени нарушения.

Несмотря на то, что когнитивное расстройство (CI) является распространенным явлением при множественном склерозе (MS), традиционная когнитивная реабилитация часто ограничивается проблемами доступности и присоединения. Телеабилитация представляет собой доступную альтернативу, однако ее эффективность при различных уровнях жесткости CI остается неясной. Нынешнее перспективное, одноцентральное, одностороннее вмешательство с многократными мерами, направленными на выявление изменений в когнитивных и психосоциальных результатах после осуществления на дому программы познавательной телереабилитации с еж

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… These findings are in line with prior evidence suggesting that preserved cognitive reserve and neural integrity may support greater responsiveness to cognitive rehabilitation. …

Effect of physical exercise on cognitive function and brain measures after chemotherapy in patients with breast cancer (PAM study): protocol of a randomised controlled trial.

IntroductionAfter treatment with chemotherapy, many patients with breast cancer experience cognitive problems. While limited interventions are available to improve cognitive functioning, physical exercise showed positive effects in healthy older adults and people with mild cognitive impairment. The Physical Activity and Memory study aims to investigate the effect of physical exercise on cognitive functioning and brain measures in chemotherapy-exposed patients with breast cancer with cognitive problems.Methods and analyticsOne hundred and eighty patients with breast cancer with cognitive proble

Type 1 diabetes is associated with higher plasma levels of biomarkers of neurodegeneration and neuroinflammation.

IntroductionType 1 diabetes (T1D) is associated with increased risk of dementias and other neurodegenerative diseases. Plasma biomarkers of neurodegeneration and neuroinflammation hold utility in risk prediction and diagnosis of neurodegenerative disease and other neuropathology, but there remains a paucity of data in the T1D population. This study quantified plasma levels of biomarkers of neurodegeneration and neuroinflammation [phosphorylated tau-181 (pTau-181), total tau (Tau), amyloid beta 42/amyloid beta 40 (Aβ42/40), glial fibrillary acidic protein (GFAP), and neurofilament light chain (

Beta-blockers disrupt mitochondrial bioenergetics and increase radiotherapy efficacy independently of beta-adrenergic receptors in medulloblastoma.

BackgroundMedulloblastoma is the most frequent brain malignancy of childhood. The current multimodal treatment comes at the expense of serious and often long-lasting side effects. Drug repurposing is a strategy to fast-track anti-cancer therapy with low toxicity. Here, we showed the ability of β-blockers to potentiate radiotherapy in medulloblastoma with bad prognosis.MethodsMedulloblastoma cell lines, patient-derived xenograft cells, 3D spheroids and an innovative cerebellar organotypic model were used to identify synergistic interactions between β-blockers and ionising radiations. Gene expre

Clinical Practice Guidelines for Menopause: An Executive Summary and Recommendations: Indian Menopause Society 2026.

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Уровни БДФ в сыворотке и ВСБ связаны с клинорадиологическими характеристиками агрессивных заболеваний у пациентов с МЗ.

BDNF все больше привлекает к себе внимание как ключевая молекула, контролирующая ремиелионацию, играющая видную роль в нейропластике и нейрозащите. Тем не менее остается неясным, как БДФ соотносится с клинорадиологическими характеристиками, особенно на ранней стадии заболевания, когда решающее значение имеет точный прогноз для дальнейшего курса МУ. МЕТОДЫ: Концентрации БДН, NfL и GFAP в сыворотке и CSF были оценены в 106 лечение пациентов с синдромом MS (PwMS), а также 73 больные другими воспалительными/невоспалительными неврологическими или соматоформальными расстройствами с использованием ед

Effect of physical exercise on cognitive function after chemotherapy in patients with breast cancer: a randomized controlled trial (PAM study).

BACKGROUND: Up to 60% of breast cancer patients treated with chemotherapy is confronted with cognitive problems, which can have a significant impact on daily activities and quality of life (QoL). We investigated whether exercise training improves cognition in chemotherapy-exposed breast cancer patients 2-4 years after diagnosis. METHODS: Chemotherapy-exposed breast cancer patients, with both self-reported cognitive problems and lower than expected performance on neuropsychological tests, were randomized to an exercise or control group. The 6-month exercise intervention consisted of supervised