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Immunosenescence: signaling pathways, diseases and therapeutic targets.

Immunosenescence refers to the abnormal activation or dysfunction of the immune system as people age. Inflammaging is a typical pathological inflammatory state associated with immunosenescence and is characterized by excessive expression of proinflammatory cytokines in aged immune cells. Chronic inflammation contributes to a variety of age-related diseases, such as neurodegenerative disease, cancer, infectious disease, and autoimmune diseases. Although not fully understood, recent studies contribute greatly to uncovering the underlying mechanisms of immunosenescence at the molecular and cellul

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… These cytokines also stimulate the proliferation of vascular smooth muscle cells (VSMCs) and the accumulation of oxidized low-density lipoprotein (LDL) particles, which are then captured by foam cells in vessel walls. 270 Senescent T cells, particularly cytotoxic CD8 + T cells, also contribute to the …

Артериальный тромбоэмболизм

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… Methods : THP‐1 derived foam cells were cultured within collagen hydrogels and triggered to differentiate into foam cells by treatment with lipopolysaccharide, IFN‐γ, and oxidised low‐density lipoprotein. … Foam cells density were evaluated in the treatment group compared with the control group using B‐mode ultrasonography and histopathology. …

Current advance of nanotechnology in diagnosis and treatment for malignant tumors.

Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary field that is garnering a lot of interest and investigation. Nanomedicine shows great potential for cancer diagnosis and treatment. Specifically engineered nanoparticles can be employed as contrast agents in cancer diagnostics to enable high sensitivity and high-resolution tumor detection by imaging examinations. Novel approaches for tumor labeling and detection are also made possible by the use of nanoprobes and nanobiosensors. The achievement of targeted medication delivery in cancer therapy can be acc

Respiratory and Thoracic Medicine

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Р

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Epigenetics-targeted drugs: current paradigms and future challenges.

Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA modification, histone modification, RNA modification, chromatin remodeling, and non-coding RNA regulation. These mechanisms and their associated enzymes convey genetic information independently of DNA base sequences, playing essential roles in organismal development and homeostasis. Conversely, disruptions in epigenetic landscapes critically influence the pathogenesis of various human diseases. This understanding has laid a robust theoretical groundwork for developing drugs that target epigenetics-modifyin

СРП 2013

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Электронные постеры

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RESEARCH COMMUNICATIONS OF THE 28th ECVIM-CA CONGRESS.

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62nd Annual Conference of the Indian Society of Gastroenterology, February 10th - 13th, 2022, Pune.

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Резюме АОКНМБ и СНМИКС 2025

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СНМИКОН 2024 Резюме

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Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2022.

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Neutrophil diversity and function in health and disease.

Neutrophils, the most abundant type of granulocyte, are widely recognized as one of the pivotal contributors to the acute inflammatory response. Initially, neutrophils were considered the mobile infantry of the innate immune system, tasked with the immediate response to invading pathogens. However, recent studies have demonstrated that neutrophils are versatile cells, capable of regulating various biological processes and impacting both human health and disease. Cytokines and other active mediators regulate the functional activity of neutrophils by activating multiple receptors on these cells,

Е-постеры.

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ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts

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Abstract

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Abstracts

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Резюме МКАРЕ 2023 77th Национальный конгресс " СИААРТИ "

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Proceedings of Réanimation 2020, the French Intensive Care Society International Congress.

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