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The International Gynecologic Cancer Society Global Fellowship Program: advancing access to gynecologic oncology and surgical care worldwide.

OBJECTIVE: Gynecologic malignancies remain a leading cause of death among women in low- and middle-income countries. In 2017, the Internatio … fellows (50%) completed the survey. Nineteen respondents (95.0%) reported practicing as gynecologic oncologists, with an average of 70% of their clinical work focused on this area. However, most reported continuing to provide obstetric and benign gynecology care. Six respondents (30%) reported being the sole gynecologic oncologist at their hospital. Half of r …

Comparison between pelvic MRI, CT, and PET/CT in baseline staging and radiation planning of anal squamous cell carcinoma.

PURPOSE: To investigate the differences in baseline staging of anal squamous cell carcinoma based on CT, MRI, and PET/CT, and the resultant impact on the radiation plan. METHODS: This retrospective study included consecutive patients with anal squamous cell carcinoma who underwent baseline pelvic MRI, CT, and PET/CT (all examinations within 3 weeks of each other) from January 2010 to April 2020. CTs, MRIs, and PET/CTs were re-interpreted by three separate radiologists. Several imaging features were assessed; tumor stage was determined based on the eight edition of the American Joint Committee

Use of recommended posttreatment services for adolescent and young adult survivors of Hodgkin lymphoma.

BACKGROUND: Hodgkin lymphoma (HL) is a leading cancer diagnosis for adolescents and young adults (AYAs), with an overall 5-year survival rate of >80%. However, to the authors' knowledge, little is known regarding posttreatment patterns of care. In the current study, the authors characterized the use of guideline-recommended services in a cohort of AYA survivors of HL in Kaiser Permanente Southern California. METHODS: Patients with HL who were diagnosed between ages 15 and 39 years between 2000 and 2010 were identified. The authors calculated the number of patients who received recommended sho

Immune checkpoint blockade toxicity among patients with cancer presenting to the emergency department.

OBJECTIVES: We sought to estimate the prevalence of patients with cancer presenting to the emergency department (ED) who are undergoing treatment with immune checkpoint blockade (ICB) therapy; report their chief complaints; describe and estimate the prevalence of immune-related adverse events (IRAEs). METHODS: Four abstractors reviewed the medical records of patients with cancer treated with ICB who presented to an ED in Paris, France between January 2012 and June 2017. Chief complaints, underlying malignancy and ICB characteristics, and the final diagnoses according to the emergency physicia

Survey of Current Practice Patterns in the Treatment of Early-Stage Endometrial Cancer.

OBJECTIVES: Our aim was to assess current surgical practices and use of adjuvant therapy in the treatment of FIGO (International Federation … buted, 320 (23%) members completed the survey. Ninety-seven percent of respondents were gynecologic oncologists or fellows, and 87% treat 30 or more endometrial cancer patients yearly. Respondents were more likely to order preoperative tests such as computed tomography abdomen/pelvis and CA-125 for biopsy-proven grade 3 disease versus grade 1 (82% vs 29%). Ro …

Differential diagnosis of a pelvic mass: improved algorithms and novel biomarkers.

More than 200,000 women undergo exploratory surgery for a pelvic mass in the United States each year and 13%-21% of pelvic lesions are found to be malignant. Individual reports and meta-analysis indicate better outcomes when cancer surgery is performed by gynecologic oncologists. Despite the advantages provided by more thorough staging and cytoreductive surgery, only 30%-50% of women with ovarian cancer are referred to surgeons with specialized training in the United States. Imaging, menopausal status and biomarkers can aid in distinguishing malignant from benign pelvic masses to inform decisi…

The quality of the operative report for women with ovarian cancer in Ontario.

OBJECTIVE: To assess the quality of the operative reports from cases of ovarian cancer surgery in Ontario. METHODS: We undertook a population cohort study including all newly diagnosed ovarian cancer patients treated initially with surgery from January 1996 to December 1998 in Ontario (n = 1341). We abstracted charts from hospitals and cancer centres. All surgical and pathology notes were abstracted into an ACCESS database. RESULTS: A total of 1,341 women had surgery as the first step in management of ovarian cancer. A vertical abdominal incision was used in 87.6% of these cases. Peritoneal

Cancer patients use unconventional medical therapies far more frequently than standard history and physical examination suggest.

BACKGROUND: Studies with questionnaires have suggested that many cancer patients utilize unconventional medical therapies (UMT). There are f … entional cancer treatments and/or cause significant side effects; consequently, it is important for oncologists to detect those patients utilizing these therapies.

Hormonal therapy or chemotherapy for advanced endometrial cancer? A mixed-methods study assessing physicians' attitudes.

PURPOSE: Hormonal therapy and chemotherapy are common systemic therapy options in advanced and recurrent endometrial cancer. There is limited consensus on factors that affect therapy selection. This study aims to gain insight into those factors at the level of clinical decision-making and at the level of patient- and tumor-specific factors. METHODS: We performed an international cross-sectional study among medical oncologists and gynecologists. The survey consisted of (1) statements about barriers and facilitators that affect the process of decision-making and (2) hypothetical vignette cases …

Clinician-reported changes in octreotide prescribing for malignant bowel obstruction as a result of an adequately powered phase III study: A transnational, online survey.

BACKGROUND: Translating research evidence into clinical practice often has a long lag time. AIM: To determine the impact of a phase III randomised controlled trial on palliative care clinicians' self-reported practice change. DESIGN: Online survey about use of octreotide in managing inoperable malignant bowel obstruction due to cancer or its treatments distributed in November 2016, 2 years after the first publication of the study in a peer-reviewed journal. Demographic, self-reported practice and the reasons underpinning this were collected. Responses were aggregated to 'practice modified' o

The Impact of Education and Prescribing Guidelines on Opioid Prescribing for Breast and Melanoma Procedures.

BACKGROUND: Excessive opioid prescribing is common in surgical oncology, with 72% of prescribed opioids going unused after curative-intent surgery. In this study, we sought to reduce opioid prescribing after breast and melanoma procedures by designing and implementing an intervention focused on education and prescribing guidelines, and then evaluating the impact of this intervention. METHODS: In this single-institution study, we designed and implemented an intervention targeting key factors identified in qualitative interviews. This included mandatory education for prescribers, evidence-based

Start Making Sense: Addressing Reported Ambiguity of Final Margin Status for Oral Cavity Cancer.

BACKGROUND: The surgical pathology report contains vital information guiding postoperative care; however, it often lacks critical details regarding final resection margin status, leaving downstream providers vulnerable to misinterpretation. We sought to quantify the interpretability of our institution's oral cancer surgical pathology reports. METHODS: Head and neck surgeons, pathologists, medical and radiation oncologists retrospectively reviewed 149 pathology reports. Reviewers classified final margin status in a two-tiered process: first, as "ambiguous" or "unambiguous." Then, unambiguous m…

OSTEO: A Plan Evaluation Framework for Low-Dose Radiation Therapy in Osteoarthritis.

Low-dose radiation therapy (LDRT) for osteoarthritis (OA) is an emerging treatment modality in the United States, yet standardized methods f … idated this framework through independent evaluation of 42 LDRT plans for knee OA by four radiation oncologists at a single institution. Inter-rater reliability was high, demonstrating consistent scoring across reviewers. The OSTEO framework provides a practical method for evaluating OA LDRT plans and supports quality assurance and standardization as clinical …

Lived experiences of breast cancer survivors, family caregivers and clinicians' perspectives of service provision in Nigeria: An interpretative phenomenological analysis.

This study documented the lived experiences of breast cancer survivors, family caregivers and clinicians' perspectives of service provision from an interpretative phenomenological analytical lens. A purposive sampling technique was employed to recruit participants from the outpatient oncology clinics of Jos University Teaching Hospital (JUTH), Nigeria, using a qualitative approach. Eight breast cancer survivors participated in a focus group discussion. Four in-depth interviews were conducted among breast cancer survivors, two interviews were conducted among oncologists, and two interviews were…

Cancer therapy and the kidney.

The rapid evolution of anticancer therapies has significantly improved outcomes for patients with malignant tumor. However, these advances h … aches for evaluating kidney function and mitigating risk. A multidisciplinary collaboration between oncologists and nephrologists is essential to optimize both oncologic and kidney outcomes for this vulnerable patient population. This mini review highlights recent advances in onconephrology and updates on nephrotoxicities associated with emerging anticancer t …

Summary of Japanese clinical practice guidelines 2025 for the management of olfactory dysfunction.

The aim of the 'Summary of Japanese Clinical Practice Guidelines 2025 for the Management of Olfactory Dysfunction' is to review the latest evidence regarding olfactory dysfunction and to present the current standard approaches for diagnosis and treatment. For the present guidelines, the Clinical Practice Guideline Committee, which is composed of otorhinolaryngologists, neurologists and oncologists with extensive experience treating patients with olfactory dysfunction, was formed by the Japanese Rhinologic Society. The Committee revised and updated the 'Clinical Practice Guidelines for the Mana…

Cardiometabolic Associations of Dermatological Treatments. Part I: Systemic Therapies.

Systemic treatments for common dermatological conditions, including psoriasis, hair loss, and onychomycosis, may be associated with cardiome … Multidisciplinary efforts between dermatologists, cardiologists, endocrinologists, rheumatologists, oncologists, and primary care physicians may help reduce the risk of major adverse cardiovascular events. In Part I of this two-part continuing medical education series, we provide updates regarding the potential impact on development or worsening of cardiometa …

Multidisciplinary approach to early identification of inborn errors of immunity in patients with lymphoproliferation.

Inborn errors of immunity (IEIs) comprise a broader spectrum of manifestations than primary immunodeficiencies (PID). They often present wit … ve communication among all potentially involved specialists (clinical immunologists, hematologists, oncologists, radiologists, geneticists, and pathologists) to facilitate accurate, timely disease recognition. Early genetic diagnosis in IEIs is crucial for implementing genetic counseling, targeted therapies, and follow-up protocols, ultimately affecting patie …

Ten Наводки на биопсию почек у больных раком.

Ренальная биопсия — это важный диагностический инструмент, который следует учитывать у больных раком, население которого часто страдает почечной дисфункцией, многофакторной и клинической активностью. Точное выявление основных повреждений часто имеет решающее значение для руководства онкологической терапией, предотвращения дальнейшего упадка почечной железы и улучшения общих результатов. Однако проведение биопсии в этой уязвимой группе пациентов требует тщательной оценки процедурных рисков и клинического контекста. Это...10 Брошюра < < Советы > > обеспечивает практическую основу для

Совпадение в аннотации оригинала
Renal biopsy is an essential diagnostic tool to be considered in cancer patients, a population in whom renal dysfunction is frequent, multif … of onconephrology. Shared decision-making and multidisciplinary collaboration among nephrologists, oncologists, haematologists, and pathologists are essential.

Pleomorphic lobular carcinoma in a cat: Clinical, histopathological, and immunohistochemical characterization.

Mammary carcinomas in cats are highly aggressive neoplasms, often with the development of metastasis. Pleomorphic lobular carcinoma, on the … lar carcinoma is a neoplasm that can affect cats, and given its poor prognosis, it is important for oncologists and pathologists to be familiar with this entity.