Результаты поиска

Evaluation of Serum Immune-Inflammation Index and Serum Inflammatory Response Index in Optic Neuritis.

To evaluate the associations and diagnostic performance of inflammatory markers derived from complete blood counts in patients with optic neuritis (ON) and central nervous system (CNS) demyelinating diseases. This retrospective cross-sectional study included 54 patients with ON, 43 patients with CNS demyelinating diseases without ON, and 50 age- and sex-matched healthy controls. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) were compared …

MOGAD-Associated Recurrent Optic Neuritis Unresponsive to Corticosteroids: Clinical, Visual Field, and OCT Correlation.

BACKGROUND: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a rare autoimmune demyelinating disorder. In adults, optic neuritis is the most common initial manifestation. CASE PRESENTATION: We report the case of a 23-year-old woman presenting with right eye vision loss and severe optic disc edema. The condition was unresponsive to intravenous corticosteroids. Plasmapheresis led to marked improvement. Two months later, a second episode occurred in the left eye, despite ongoing steroid therapy. INVESTIGATIONS: Initial brain and orbital MRI were normal. Optical coheren…

Six-Month Visual Outcomes in Pediatric Optic Neuritis: A Multicenter Study From South Korea.

BACKGROUND: Current knowledge regarding the causes, clinical course, treatment response, and long-term outcomes of pediatric optic neuritis remains largely derived from case reports and retrospective series. Considering the ethnic variability in its presentation and the critical role of antibody-based differential diagnoses in guiding treatment strategies, further research is necessary. The aim of this study was to provide insights into the etiology and clinical findings of pediatric optic neuritis, thereby improving our knowledge of the condition in the era of antibody-based approaches. METH…

Refractory chronic diarrhea complicated with optic neuritis in a young woman: A case report.

BACKGROUND: Collagenous sprue is a serious intestinal malabsorption disorder characterized by dull and flattened intestinal villi with subepithelial collagen deposition. At present, fewer than 100 cases have been reported in the literature. Owing to the rarity of this disease, clinicians and pathologists have insufficient understanding of it. CASE SUMMARY: The authors present a case of a 34-year-old female patient who presented with severe watery diarrhea with significant weight loss. She also experienced blurred binocular vision. The intestinal lesions were located mainly in the small intest

Optic neuritis and risk of heart failure and atrial fibrillation: A nationwide cohort study.

Autoimmune mechanisms are associated with both congestive heart failure (CHF) and atrial fibrillation (AF). Optic neuritis (ON) is known to elevate the risk of systemic autoimmune disorders. However, it remains uncertain whether ON serves as a risk factor for CHF and AF. This study aimed to investigate the association between ON and the risk of CHF and AF in a nationwide, population-based cohort. The research utilized data from Korea's National Health Insurance Service, analyzing 15,587 patients newly diagnosed with ON and 77,935 age- and sex-matched controls from 2010 to 2017. Factors of demo…

Visual Functions in Patients with Optic Neuritis Pre and Post Treatment: An Observational Study.

INTRODUCTION: Optic neuritis is an inflammatory condition affecting the optic nerve. It presents with sudden diminution of vision, also affecting colour vision, contrast sensitivity and stereoacuity. Steroids are given in optic neuritis to reduce inflammation of optic nerve. The aim of this study was to compare the visual functions in patients with optic neuritis before and after treatment with steroid therapy. METHODS: This prospective study was conducted from November 2021 to October 2022 in the Department of Ophthalmology of a tertiary-level hospital. Thirty-seven eyes affected by optic ne…

Иммунопатология оптического неурита и биомаркеров цереброспинной жидкости для острого приступа и прогнозирования рецидива.

Оптический неуриит (ON), характеризующийся воспалением и обезвоживанием зрительного нерва, является главной причиной нарушения зрения. Часто он проявляется в качестве первоначального симптома и повторяющегося синдрома у пациентов с миелином олигодендроцитом гликпротеиновым заболеванием, связанным с антителами (МОГАД), расстройством нейромиелитного спектра (NMOSD) и множественным склерозом (MS). Хотя диагноз ОН относительно прост, прогнозирование рецидивов и борьба с этим заболеванием остаются серьезными проблемами. Для эффективной и точной передачи сигналов между оптическими нейронами существе

Совпадение в аннотации оригинала
Optic neuritis (ON), characterized by inflammation and demyelination of the optic nerve, is a leading cause of vision impairment. It frequently manifests as the initial symptom and a recurrent syndrome in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosi…

Переосмысление обычного поясничного прокола в изолированном оптическом неврайте: результат большого когортного исследования.

ЦЕЛЬ: Прокол люмбара (LP) по-прежнему широко рекомендован в диагностической оценке изолированного оптического неврита (ON), когда МРТ мозга не обнаруживает повреждений, указывающих на множественный склероз (MS). Однако в эпоху современной серологической и визуальной диагностики подлинная клиническая полезность неясна. МЕТОДЫ: В этом моноцентрическом ретроспективном исследовании всех последовательных взрослых пациентов с острыми или субакуляционными повреждениями и без MS-подобных повреждений на начальном МРТ мозга мы проанализировали окончательный этиологический диагноз, конкретный вклад LP и

Совпадение в аннотации оригинала
BACKGROUND: Lumbar puncture (LP) remains widely recommended in the diagnostic evaluation of isolated optic neuritis (ON), when brain MRI does not reveal lesions suggestive of multiple sclerosis (MS). However, the true clinical utility is unclear in the era of advanced serological and imaging diagnostics. METHODS: In this monocentric retrospective study of a…

Retinal ganglion cell loss is associated with multimodal visual dysfunction following demyelinating optic neuritis.

BACKGROUND: Optic neuritis (ON) is a common manifestation of multiple sclerosis and related disorders (MSRD) characterized by retinal neurodegeneration, including thinning of ganglion cell-inner plexiform layer (GCIPL). Compared to absolute values, inter-eye differences (IED) account for variation in baseline structure and function before ON. OBJECTIVES: To determine retinal layer IED thresholds associated with multimodal visual dysfunction after unilateral demyelinating ON. METHODS: In this cross-sectional study, MSRD participants with and without a history of unilateral ON, and healthy con…

Диагностическая полезность индекса свободной цепи света в Каппе у взрослых с оптовым неритом.

Простая, быстрая и воспроизводимая процедура различения множественного склероза (MS), миелин олигодендроцита гликпротеина, связанного с антителами (MOGAD), и спектрального расстройства нейромиелита (NMOSD) при первом оптическом неуриите (ION) может быть весьма полезной для руководства ранним управлением. Мы включили всех взрослых, принятых в центр MS в Марселе для ION в период с марта 2016 и апрель 2024, с анализом CSF, включая индекс свободной цепи освещения (K-FLC). Для измерения диагностической способности индекса К-ФЛК использовались кривые эксплуатационных характеристик получателя.Результ

Совпадение в аннотации оригинала
BACKGROUND AND OBJECTIVES: A simple, quick, and reproducible procedure for distinguishing multiple sclerosis (MS), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), and neuromyelitis optica spectrum disorder (NMOSD) at inaugural optic neuritis (ION) could be highly valuable in guiding early management. METHODS: We included all adults …

Optic Neuritis After COVID-19 Vaccination: A Case Series and a Review of Literature.

BACKGROUND: The coronavirus disease (COVID-19) pandemic broke out in March 2020, causing tremendous damage to public health and more than 6 million deaths. After authorization for the emergency use of COVID-19 vaccines, various adverse events have been reported, including optic neuritis. COVID-19 vaccination was implemented in Taiwan in March 2021. METHODS: We report patients who developed optic neuritis after COVID-19 vaccination at one university-affiliated tertiary hospital, between March 2021 and December 2022. We also provided a literature review of optic neuritis cases after COVID-19 va…

Clinical outcomes and Anti-MOG antibodies in pediatric optic neuritis: A prospective observational study.

OBJECTIVES: The objective of this study was to look at the clinical outcomes, and to determine the proportion of children with visual recovery after the first demyelinating event of optic neuritis (ON). METHODOLOGY: In this observational study, children with the first clinical event of optic neuritis at an age less than 18 years were evaluated. High-contrast visual acuity, colour vision, Expanded Disability Status Scale (EDSS), Anti-MOG and AQP-4 antibodies were assessed. RESULTS: Of the 55 screened, 45 children (77 eyes), median age-98 months, 30 (67%) bilateral were enrolled. Fifty of 77 e…

Metronidazole associated optic neuritis-induced irreversible vision loss: A case report and literature review.

Optic neuritis is an inflammatory condition involving the optic nerve causing vision abnormalities ranging from decreased to complete vision loss. We present a 30 years old lady who suffered acute gradual reduced vision, which progressed to complete vision loss in her right eye the next day after receiving one dose of intravenous Metronidazole.

Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-Associated Optic Neuritis - A Case Report and Literature Review.

BACKGROUND: Myelin oligodendrocyte glycoprotein (MOG)-IgG-associated optic neuritis (ON) is a new subset of demyelinating optic neuropathy. CASE REPORT: This study presents a case of a 49-year-old woman with MOG-IgG-positive ON, who reported to the ophthalmic emergency room with decreased visual acuity, retrobulbar pain and red color desaturation in her left eye. Abnormalities in the ophthalmological examination were: decreased Snellen's distance best-corrected visual acuity (DBCVA) to 0.04 in her left eye, slightly elevated optic nerve disc in the left eye confirmed by increased peripapillar…

Correlation of Visual System Biomarkers With Motor Deficits in Experimental Autoimmune Encephalomyelitis-Optic Neuritis.

IMPORTANCE: Two recent meta-analyses reported a high prevalence of both anxiety and depression in patients with alopecia areata (AA), as well as a positive association of AA with anxiety and depression, without distinguishing between disorders and symptoms. Yet, depression and anxiety can manifest either as symptoms identified in questionnaires or as specific diagnoses defined by Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) or International Statistical Classification of Diseases and Related Health Problems, Tenth Revision criteria. OBJECTIVE: To perform a large meta-a

Двусторонний педиатрик Мьелин Олигодендроцит Гликпротеин Антибодиакулезная болезнь (МОГАД) Оптик Нерит: доклад по делу.

Оптический неуриит (ON) определяется как приобретенное расстройство зрительного нерва, которое может быть связано с демиелинизирующими заболеваниями или инфекционными или подстрекательскими процессами. У детей проявления этого заболевания отличаются от симптомов у взрослых, у которых обычно возникает двусторонний папильит после предшествовавшего вирусного заболевания. Тем не менее основная озабоченность специалистов-практиков заключается в возможности его преобразования в множественный склероз (МС). В последние годы повысился уровень информированности о проведении различия между MS и другими д

Совпадение в аннотации оригинала
Optic neuritis (ON) is defined as an acquired disorder of the optic nerve that may be associated with demyelinating diseases or infectious or inflammatory processes. In children, the manifestation of this condition differs from that in adults, where it typically presents with bilateral papillitis subsequent to a preceding viral illness. Nonetheless, the main…

Serum proteins for monitoring and predicting visual function in patients with recent optic neuritis.

It is unclear whether serum proteins can serve as biomarkers to reflect pathological changes and predict recovery in inflammation of optic nerve. We evaluated whether serum proteins could monitor and prognosticate optic neuritis (ON). We prospectively recruited consecutive patients with recent ON, classified as ON with anti-aquaporin-4 antibody (AQP4-ON), ON with anti-myelin oligodendrocyte glycoprotein antibody (MOG-ON), and double-seronegative ON (DSN-ON). Using ultrasensitive single-molecule array assays, we measured serum neurofilament light chain and glial fibrillary acidic protein (GFAP)…

Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis in a post-COVID-19 infection patient.

PURPOSE: SARS-CoV-2 viral infection affects multiple systems including the respiratory, gastrointestinal, neurological, cardiac, and ophthalmic systems. We report a case of myelin oligodendrocyte glycoprotein (MOG) related optic neuritis in a SARS-CoV-2 (COVID-19) patient. METHODS: Case report. RESULTS: A 36-year-old Malay gentleman with underlying hypertension presented with the first episode of bilateral progressively worsening blurred vision for 1 week associated with retrobulbar pain. There were no other neurological symptoms. He had fever a week before the eye symptoms and tested positi…