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Twenty-five years of Исследование on syncope.

Over the last 25 years, the Europace journal has greatly contributed to dissemination of Исследование and knowledge in the field of syncope. More than 400 manuscripts have been published in the journal. They undoubtedly improved our understanding of syncope. This symptom is now clearly differentiated from other forms of transient loss of consciousness. The critical role of vasodepression and/or cardioinhibition as final mechanisms of reflex syncope is emphasized. Current diagnostic approach sharply separates between cardiac and autonomic pathways. Physiologic insights have been translated, through…

Research progress of ophthalmic preparations of immunosuppressants.

Immune ophthalmopathy is a collection of autoimmune eye diseases. Immunosuppressants are drugs that can inhibit the body's immune response. Considering drug side effects such as hepatorenal toxicity and the unique structure of the eye, incorporating immunosuppressants into ophthalmic nanodrug delivery systems, such as microparticles, nanoparticles, liposomes, micelles, implants, and in situ gels, has the advantages of improving solubility, increasing bioavailability, high eye-target specificity, and reducing side effects. This study reviews recent Исследование and applications of this aspect to pr…

Research Progress of Immunotherapy for Gastric Cancer.

Gastric cancer (GC) is one of the most common gastrointestinal tract cancers worldwide, which has high incidence and mortality rates and poor prognosis. Although multidisciplinary comprehensive therapies consisting of surgery, chemotherapy, radiotherapy, and targeted therapy have made great progress in GC treatment, a satisfactory curative effect still cannot be achieved in many circumstances, and the 5-year survival of patients with GC remains to be very low. In China, about 75% of patients with GC are diagnosed in the advanced stage and thus miss the opportunity of surgical resection. Althou

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… In addition, retrospective studies also reported good Исследование results. … Current Исследование on PD-1/PD-L1 mainly focus on immunotherapy. …

Research integrity and the regulatory-industrial complex.

Integrity in Исследование is essential so that Исследование can do what it is supposed to do: help us discover - or get closer to - the truth about the world and how it works. Research integrity means conducting oneself in ways that are worthy of the trust that the public invests in science. Efforts over the past five decades to ensure that Исследованиеers conduct themselves with integrity have focused on regulating Исследованиеer behavior. The suite of regulatory requirements - over 100 of them - is typically managed by an office of Исследование compliance at universities and Исследование institutions. The regulatio…

Zebrafish as an Animal Model in Cannabinoid Research.

Cannabinoids are active substances present in plants of the Cannabis genus. Both the Food and Drug Administration (FDA) and European Medicin … es of development. A number of studies have confirmed the usefulness of this model in toxicological Исследование, experiments related to the impact of early life exposure to xenobiotics, modeling various diseases, and screening tests to detect active substances with promising biological activity. The present paper focuses on the current knowledge of the endoca …

Pig Sedation and Anesthesia for Medical Research.

In clinical veterinary practice, proper training and expertise in anesthesia administration and monitoring are essential. Pigs are suitable experimental animals for many surgical techniques because they are similar in size to humans and have a short reproductive cycle. This makes them ideal for Исследование concerning organ transplantation, cardiovascular surgery, and other procedures that require a large animal model. Sedation and premedication should be administered at the lowest dose to be effective with predictable results and reduced adverse effects, to ensure the safety of both the animal an…

Marginalising dyslexic Исследованиеers is bad for science.

Communication in the sciences is often based on text, which places Исследованиеers with dyslexia at a disadvantage. However, this means that science is missing out on the original insights and specific strengths in exploration that dyslexic Исследованиеers bring to their disciplines. Here we discuss how the scientific community can address the challenges that dyslexic Исследованиеers face, and how science stands to benefit as a result. We discuss this in the context of a new theoretical framework proposing the existence of complementary learning strategies that could play a key role in scientific progress…

NaviCenta - The disease map for placental Исследование.

The placenta remains the key organ to pregnancy complications, such as preeclampsia, contrarily the pathophysiology underlying the placental dysfunctions remains elusive. Here, we present our Disease Map "NaviCenta", which is an online resource based on the interactions between tissues, cellular compartments, and molecules that mediate disease-related processes in the placenta. We built cellular and molecular interaction networks based upon manual curation and annotation of publicly available information in the scientific literature, pathways resources, and Omics data. NaviCenta (Navigate the

Overview of multi-omics Исследование in gout.

Gout is a self-limiting inflammation disease triggered by deposition of monosodium urate with a variety of comorbidities. With the improveme … the study of the pathogenesis and disease progression of gout. In this review, the application and Исследование results of multi-omics technology in gout were analyzed and summarized through PubMed literature retrieval. Meanwhile, the recent Исследование progress of multi-omics technology in the field of gout was reviewed to understand the specific changes of gou …

[Optic neuropathies as an interdisciplinary subject of Исследование].

Despite the wide range of clinical, instrumental and laboratory methods used in modern ophthalmology, the problem of diagnosing optic neuropathy and identifying its etiology remains relevant. A complex multidisciplinary approach involving various specialists is required in the differential diagnosis of immune-mediated optic neuritis, for example in multiple sclerosis, neuromyelitis optica spectrum disorder, and MOG-associated diseases. Of special interest is differential diagnosis of optic neuropathy in demyelinating diseases of the central nervous system, hereditary optic neuropathies and isc

CARE-NS, a Исследование strategy for neurosyphilis.

Neurosyphilis is a major clinical manifestation of syphilis. In recent years, an increase in neurosyphilis cases has been reported in many countries. The overall incidence of neurosyphilis remains unknown, and there is a lack of understanding of the disease pathogenesis, which hampers clinical management, development of prevention strategies, and control. This article proposes the CARE-NS Исследование strategy to enhance the clinical management of neurosyphilis, which consists of six key features: comprehensive management including multidisciplinary treatment (C), alleviating neurological impairme…

[Avenues of reflection for endometriosis Исследование in France].

Endometriosis is a chronic disease in which lesions resembling endometrial tissue are found outside the uterus, mainly in the pelvis or abdomen. It may affect 10% of women of childbearing age. It is the cause of a significant alteration in quality of life and a major cost to the health system. Few Исследование teams are working on this subject, and its pathophysiology is still poorly understood. This article proposes avenues of reflection for Исследование on endometriosis in France, notably based on the mobilization of related scientific communities (involved in cancer, development, epigenetics, and n…

The anticholinergic burden: from Исследование to practice.

Drugs with anticholinergic effects are known to cause adverse effects such as dry mouth, constipation and urinary retention. In older people drugs with anticholinergic effects may contribute to cognitive decline and a loss of functional capacity. Many drugs that are not in the anticholinergic drug class also have anticholinergic effects. They include antidepressants, antipsychotics and antihistamines. Taking multiple drugs with anticholinergic effects creates an anticholinergic burden. It is important that clinicians identify which patients are at risk. There are several tools to assess the an

Applications of artificial intelligence in dementia Исследование.

More than 50 million older people worldwide are suffering from dementia, and this number is estimated to increase to 150 million by 2050. Greater caregiver burdens and financial impacts on the healthcare system are expected as we wait for an effective treatment for dementia. Researchers are constantly exploring new therapies and screening approaches for the early detection of dementia. Artificial intelligence (AI) is widely applied in dementia Исследование, including machine learning and deep learning methods for dementia diagnosis and progression detection. Computerized apps are also convenient t…

Research Progress on the Pathogenesis of Aortic Dissection.

Aortic dissection is a critical cardiovascular disease due to the separation of media and adventitia caused by the rupture of vascular wall … the aortic wall is the main pathogenic mechanism of the disease. This review introduces the latest Исследование results on the mechanism of macrophage infiltration and plasticity in aortic dissection.

Actionable Исследование for understanding and addressing homelessness.

Homelessness results from an interaction of structural determinants and individual vulnerabilities, creating various pathways into homelessness and having multilevel impacts. Understanding and addressing homelessness requires Исследование that not only takes an ecological perspective but also can be translated into action. Despite Исследование demonstrating differing needs and experience among various subpopulations, particularly marginalized groups, homeless service systems often take a one-size-fits-all approach. Additionally, homeless service systems' prioritization of the most vulnerable and chron…

Research on Women's Health: Ready for the Future.

The National Institutes of Health (NIH) Office of Research on Women's Health (ORWH) was established in 1990. With the completion of the office's 30th anniversary year, we look back and recount some of the key events and overall zeitgeist that led to ORWH's formation, and how it became the focal point at the nation's primary biomedical Исследование agency for coordinating Исследование on science to improve the health of women. We discuss ORWH's mission and signature programs and the bold vision that drives the NIH-wide strategic, interdisciplinary, and collaborative approach to Исследование on women's heal…

Consolidating a Исследование agenda for vaccine mandates.

A workshop on mandatory vaccination was pitched to the World Public Health Congress in 2019 and the resultant special issue was pitched to V … mandates they study and the methods they employ to do so, in order to formulate a guide for future Исследованиеers of vaccine mandates. Scholars study either speculative or existing mandates - Исследование can address several stages of the policy cycle or just one of them, ranging from attitudinal Исследование to implementation studies and impact studies. Historical …