Результаты поиска

The Neurocognitive Impact of CAR T Cell Therapy in Hematological Cancers: A Systematic Review of Cognitive Function, Quality of Life, and Psychological Outcomes.

BackgroundChimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of hematological malignancies, offering durable remissions. However, concerns regarding its neurocognitive and psychological impact have emerged, particularly in patients experiencing immune effector cell-associated neurotoxicity syndrome (ICANS). Despite growing clinical use, the long-term effects on cognitive function, psychological well-being, and quality of life (QoL) remain unclear.ObjectiveThis systematic review evaluates the neurocognitive, psychological, and QoL outcomes associated with CAR T-cell

Совпадение в полном тексте источника
… These findings suggest that baseline cognitive reserve, neuroplasticity, and inflammatory burden influence recovery, emphasizing the need for age‐tailored rehabilitation strategies. … Geriatric population (over 65 years) often enter therapy with already‐reduced cognitive reserve and may require entirely customized rehabilitation strategies. Our age‐related findings suggest this population faces unique challenges that standard approaches don't address adequately. …

Множественные склерозы-специальные справочные кривые для объема мозга, чтобы объяснить больность.

СПРАВОЧНАЯ ИНФОРМАЦИЯ И ЦЕЛИ: Атрофия мозга важна для понимания развития заболеваний и реакции на них у людей с множественным склерозом (pwMS). Автоматические инструменты для представления данных об объеме мозга часто полагаются на исходные кривые здорового контроля (HC) для интерпретации объема мозга, в то время как потери объема мозга отличаются в PwMS. Цель этого исследования заключалась в разработке специальной эталонной модели MS для объемов мозга и в оценке ее эффективности по сравнению с кривыми, основанными на НС, в качестве доказательства концепции. МЕТОДЫ: Участники, PwMS и HC из Амс

Distress and quality of life after autologous stem cell transplantation: a randomized clinical trial to evaluate the outcome of a web-based stepped care intervention.

BackgroundPsychological distress (i.e. depression and anxiety) is a strong predictor of functional status and other aspects of quality of life in autologous stem cell transplantation following high-dose chemotherapy. Treatment of psychological distress is hypothesized to result in improvement of functional status and other aspects of quality of life. The aim is to evaluate the outcome of stepped care for psychological distress on functional status and other aspects of quality of life in patients with hematological malignancy treated with autologous stem cell transplantation.Methods/designThe s

Цифровые сигнатуры усталости и износа у пациентов с множественным склерозом во время родов.

Симптомы выпадения (WoS) во время родовспоможения (NTZ) часто интерпретируются как субклинические заболевания у пациентов с множественным склерозом (PwMS), однако их значение остается неопределенным. В перспективном исследовании " SATURATE " ( " Один центр " )NCT05701423), мы изучили, связана ли ВОС с воспалительными или нейродегенеративными повреждениями и является ли износимость мониторинга улавливанием изменений, связанных с двигателем. Thirty-four :: были зачислены лица, прошедшие лечение в НТЗ; 28 завершено 6-month Последующая деятельность и 21 :: обеспечивала доступны

Perspective recommendations on geriatric support for older adults with multiple myeloma based on challenges faced by a multidisciplinary team.

BACKGROUND: Multiple Myeloma (MM) predominantly affects older adults, with a median diagnosis age of 70 years, posing challenges in management due to frailty, comorbidities, and age-related physiological changes. As the aging population grows, the prevalence of MM in older patients is expected to rise, requiring improved clinical strategies. METHODS: This consensus report outlines a multidisciplinary framework for the identification, geriatric assessment (GA), and management of older adults with MM, emphasizing the role of frailty assessments, such as the IMWG frailty score, in tailoring trea

Neoplastic Disorders and Cardiovascular Comorbidities in Geriatric Patients: A Simple Association?

Cardiovascular disease (CVD) and cancer frequently coexist in older patients, posing significant challenges in clinical management due to overlapping risk factors and treatment-related complications. This narrative review summarizes current knowledge on the epidemiology, shared pathophysiological mechanisms and clinical impact of neoplastic comorbidities in older adults with cardiovascular diseases. It highlights the increased mortality, morbidity and diminished quality of life resulting from the coexistence of these conditions. The review also discusses personalized management strategies, emp

Редактор специального выпуска : Множественный склероз: от диагностических биомаркеров до воображаемых и клинических прогнозов

Множественный склероз (MS) представляет собой хроническое, нейро-воспалительное и нейродегенеративное заболевание центральной нервной системы (CNS), которое может вызывать множество физических и когнитивных расстройств [...]

Совпадение в полном тексте источника
… Given that the measurement of cognitive reserves and determining the extent of cognitive impairment in MS patients is emerging as one of the most prudent research problems, multiple articles in this Special Issue focus on this topic. …

'It was like taking an inner bath': A qualitative evaluation of a collaborative advance care planning-approach.

BackgroundImpaired readiness may hinder purposeful advance care planning in cancer patients. To reduce barriers to participation in end-of-life decision-making, a collaborative intervention was developed combining a psycho-oncological approach of dignity-based and cognitive-behavioural interventions, followed by a standardised advance care planning-process.AimTo evaluate the novel collaborative advance care planning-approach by synthetising cancer patient and carer perspectives on communicational and relational effects.DesignAs a sub-project of a mixed-methods evaluation study, we conducted an

Прогнозирующие детерминанты долгосрочной смертности у пожилых пациентов с новой диагностированной множественной миеломой.

Фон/цели: Множественная миелома (ММ) — опухоль плазменной клетки, диагностированная преимущественно у пожилых людей. Вместе с тем еще предстоит твердо установить значение определения слабой стороны пациента, а также определения наиболее подходящих и надежных инструментов для его оценки. Методы: Это ретроспективное исследование 36 больные в возрасте 65 - лица более старшего возраста, прошедшие комплексную гериатрическую оценку (CGA). Средний возраст пациентов 76 (СД) 6.22) с 33.3% быть женщиной. Оценка пациентов проводилась с использованием индекса упругости Международной рабочей группы по миел

Воздействие совместных мероприятий на популяризацию пожилых людей: систематический обзор и метаанализ.

Справочная информация/задачи: Сочетание учений с когнитивной подготовкой (комбинированное вмешательство) является стратегией борьбы с обусловленным возрастом когнитивным упадком; однако по-прежнему не ясно, какой из наиболее оптимальных видов упражнений необходим для максимального повышения нейрозащитного воздействия комбинированного вмешательства. Таким образом, цель этого систематического обзора и метаанализа (СРПД) состояла в том, чтобы сопоставить воздействие комбинированных мероприятий (активизация плюс когнитивная подготовка) с воздействием только физических упражнений на когнитивную фун

The challenge of chemotherapy-related cognitive impairment: assessing and managing cognitive decline after cancer treatment.

Chemotherapy-related cognitive impairment (CRCI) refers to a decline in cognitive function in patients during and after cancer treatment and is mainly associated with the use of cytotoxic chemotherapy (CT). As CT is still an essential component in the treatment of many cancers and taking into account the fact that cancer survival rates are increasing, CRCI may negatively impact the quality of life and working capacity of a growing number of individuals, especially those treated with curative intent in conditions such as breast cancer. There is still a need to address several issues related to

Совпадение в полном тексте источника
… A study that evaluated patients with breast cancer treated in an adjuvant setting ( N = 60 years and mean age 51.7 years) found that older patients with lower baseline cognitive reserve performed worse in post-CT processing speed tests than those not exposed to CT ( p < 0.003) [ 4 ]. … Thus, lower cognitive reserve is associated with potential vulnerability to a worse decline after treatment. …

Усовершенствованные методы МРТ: диагностика и последующая деятельность в связи с множественным склерозом

Снимки мозга и спинного мозга играют ключевую роль в оказании помощи врачам в диагностике и мониторинге множественных склерозов. Тем не менее значение магнитного резонансного изображения в MS выходит за рамки его клинической полезности. Усовершенствованные методы визуализации способствовали обнаружению в vivo различных компонентов MS патогенеза, и в последние годы для оценки реакции пациентов с повторной эмиссией MS на имеющиеся методы лечения использовались биомаркеры MRI. Аналогичным образом, показатели МРТ, характеризующие нейродегенерацию, демонстрируют потенциал в качестве первичных и вто

Feasibility and safety of exercise training and nutritional support prior to haematopoietic stem cell transplantation in patients with haematologic malignancies.

BackgroundPrehabilitation with regular exercise and nutritional care for patients undergoing surgeries for malignant disease was recently introduced to increase physiologic reserve prior to the procedure, accelerate recovery and improve outcomes. This study aimed to investigate the feasibility and safety of combined exercise training and nutritional support in patients with haematologic malignancies prior to haematopoietic stem cell transplantation (HSCT).MethodsIn this single-arm pilot study, 34 HSCT candidates were enrolled at least two weeks before admission for the procedure. Patients perf

Physical Activity as a Nonpharmacological Symptom Management Approach in Myeloproliferative Neoplasms: Recommendations for Future Research.

PURPOSE: Essential thrombocythemia, polycythemia vera, and myelofibrosis are rare chronic hematological malignancies known as myeloproliferative neoplasms (MPNs) and are characterized by deregulated myeloid lineage cell production, splenomegaly, and heterogeneous symptom profiles. MPN patients suffer from a significant symptom burden (eg, fatigue, depressive symptoms, early satiety) and an impaired overall quality of life (QoL). Current treatments typically include pharmacological approaches, which may come with additional side effects and may be limited by treatment-associated toxicities (ie,

Advances in microsurgery and assisted reproduction for management of male infertility.

BACKGROUND: This study examines genetic diversity among 102 registered English Bulldogs used for breeding based on maternal and paternal haplotypes, allele frequencies in 33 highly polymorphic short tandem repeat (STR) loci on 25 chromosomes, STR-linked dog leukocyte antigen (DLA) class I and II haplotypes, and the number and size of genome-wide runs of homozygosity (ROH) determined from high density SNP arrays. The objective was to assess whether the breed retains enough genetic diversity to correct the genotypic and phenotypic abnormalities associated with poor health, to allow for the elimi

Совпадение в полном тексте источника
… Although specific mechanisms underlying how individuals with normal cognition can overcome AD-associated proteotoxicity are still unclear, concepts such as “cognitive reserve” describe enhanced brain function and efficiency which may enable individuals to sustain cognitive function under pathological … Defining cognitive reserve and implications for cognitive aging. Curr Neurol Neurosci Rep. 2019;19(1):1. 15. Heberle BA, et al. Systematic review and meta-analysis of bulk RNAseq studies in human Alzheimer's disease brain tissue. bioRxiv, 2024. 16. Mathys H, et al. …

[Cost-effectiveness analysis of schizophrenic patient care settings: impact of an atypical antipsychotic under long-acting injection formulation].

UNLABELLED: Schizophrenia is a disease affecting the young adults and amounts to approximately 300,000 people in France. The French public psychiatric sector takes care of approximately 150,000 adults schizophrenics: 50% benefit from ambulatory care, 50% are in partial or full-time hospitalization care. Schizophrenia represents the first diagnosis that psychiatric sectors take in charge. The costs associated with schizophrenia, mainly hospital costs, are important and were estimated at 2% of the total medical costs in France. In the French social welfare system, the social costs (pensions, all

P905: PATIENT REPORTED OUTCOMES IN TRIPLE CLASS EXPOSED, RELAPSED/REFRACTORY MULTIPLE MYELOMA (TCE RRMM) PATIENTS IN KARMMA 3 TRIAL (PHASE 3 RCT): IDECABTAGENE VICLEUCEL (IDE-CEL) VERSUS STANDARD REGIMENS

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Prospective implementation of the HCT frailty scale in adults with lymphoproliferative syndromes candidates for autologous haematopoietic stem cell transplantation: Results from a multicentre GETH-TC study.

This prospective study evaluated the incidence and dynamics of frailty in 156 adults with lymphoproliferative syndromes undergoing autologous haematopoietic stem cell transplantation (HSCT). Frailty was assessed using the haematopoietic cell transplantation (HCT) frailty scale in patients from 15 Spanish institutions at initial consultation, transplant admission and day +100. Quality of life (QoL) was measured using the EuroQoL. At first consultation, 45 patients (28.8%) were classified as fit, 93 (59.6%) as pre-frail and 18 (11.6%) as frail. Frailty was more frequent among older patients, tho

Development of a Simplified Geriatric Score-4 (SGS-4) to Predict Outcomes After Allogeneic Hematopoietic Stem Cell Transplantation in Patients Aged over 50.

Background: The Comprehensive Geriatric Assessment (CGA) has proven to be a valuable tool for providing a more comprehensive health evaluation of allogeneic stem cell transplantation (allo-SCT) recipients. Methods: We prospectively developed and tested a new Simplified Geriatric Score-4 (SGS-4) on 135 consecutive patients aged ≥50 years who underwent allo-SCT between 2020 and 2023. Each CGA component was individually analyzed for its association with overall survival (OS), non-relapse mortality (NRM), and cumulative incidence of relapse (CIR). Then, we performed a two-factor analysis (FA) usin

Challenge of cancer in the elderly.

Despite the sustained trend of decreasing overall cancer incidence, the number of elderly patients with cancer will considerably increase in the coming years, as the incidence of cancer is elevated 11-fold after the age of 65 years compared to adults up to 65 years. This soon-to-erupt tsunami of elderly patients with cancer requires adequate treatment, for which guidelines and evidence-based data are still scarce, given the longlasting under-representation of elderly patients with cancer in cancer trials. Older adults present not only with the physiological decreases of organ functions related