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Differential gene expression in the human ciliary epithelium.

The generation of expression and subtractive libraries from the ocular ciliary body and cultured ciliary epithelial cells has been instrumental in the cloning, identification and characterization of many genes which, overall reflect a representative profile of transcripts expressed in ciliary nonpigmented, ciliary pigmented and ciliary muscle cells. The cell-specific expression of some of these genes (i.e. a neurotrophic factor, a gene associated with juvenile open glaucoma, and a visual component) reveal a degree of cell differentiation with a diversity of functions and properties higher than

Clinical and laboratory characteristics of paediatric patients diagnosed with angioedema: a retrospective evaluation.

INTRODUCTION: Angioedema is a heterogeneous clinical condition characterized by transient swelling of the deeper dermal and submucosal tissues and may occur either in isolation or in association with urticaria. Despite its clinical importance, data regarding clinical phenotypes, triggering factors, and inflammatory laboratory markers in paediatric angioedema remain limited. AIM: This study aimed to retrospectively evaluate the clinical characteristics and laboratory parameters of paediatric patients with angioedema. MATERIAL AND METHODS: In this single-centre retrospective study, medical rec

Tannic acid supplementation exerts biphasic effects on growth performance, immune function, and gut microbiota in Pekin duck.

Tannins, which are polyphenols present in several plant species, have been shown to exert several beneficial effects in livestock at specific levels. However, the optimal dosage for growth promotion in waterfowl like Pekin ducks remains unclear. Therefore, this study aimed to investigate the effects of dietary tannic acid (TA) supplementation on the performance of Pekin ducks. A total of 420 male Pekin ducks were assigned to to five groups and fed a basal diet supplemented with 0, 0.1, 0.2, 0.35, or 0.5% TA (control, TAS0.1, TAS0.2, TAS0.35, and TAS0.5, respectively). Growth performance, serum

miR-155-3p in Systemic Lupus Erythematosus: Association with Immune Activation and Renal-Related Parameters.

Systemic lupus erythematosus (SLE) is an autoimmune illness that affects multiple organs, causes hematological abnormalities, and alters immunological regulation. Identifying reliable biomarkers is critical for improving the diagnosis and monitoring of disease activity. This study aimed to evaluate clinical, biochemical, immunological, and molecular alterations in SLE patients compared with healthy controls, with a focus on the exploratory discrimination of whole-blood miRNA expression and conventional serological markers. A total of 100 SLE patients and 50 age-and gender-matched healthy contr

A Staged Whole-Blood Transcriptomic Framework Identifies a Compact Myeloid-Lymphoid Activity Score in Systemic Lupus Erythematosus.

BACKGROUND/OBJECTIVES: Peripheral-blood transcriptomic profiling can capture molecular heterogeneity in systemic lupus erythematosus (SLE), but discovery-stage signatures often show limited transportability across cohorts and validation layers. This study aimed to establish a staged whole-blood transcriptomic framework and to derive a compact, biologically interpretable activity score. METHODS: Public whole-blood bulk transcriptome cohorts were organised into discovery, public validation, and single-cell reference layers. Local orthogonal validation included a peripheral blood mononuclear cel

ACE inhibitor-induced isolated intestinal angioedema mimicking functional bowel disorder: a case report.

BACKGROUND: Angiotensin-converting enzyme (ACE) inhibitor-induced intestinal angioedema is a rare but clinically significant adverse drug re … omprehensive evaluation excluded infectious, inflammatory, autoimmune, and hereditary causes; serum complement C4 was normal. The clinical diagnosis of ACE inhibitor-induced isolated intestinal angioedema was made on the basis of (i) angioedema-type presentation in the absence of urticaria or pruritus, (ii) temporal association with enalapril, (iii) exclusion o …

Тематический доклад: Диагностическая неопределенность в ИК-МПГН, сосуществующая с ИгМ-ИГУС.

ОТВЕЧЕНИЕ иммунного комплекса с помощью мембранопролиферативного гломерулонефрита (ИК-МПГНН) с совпадением моноколональной гаммопатии неопределенного значения (МГУС) от моноклонной гаммопатии почечной значимости (МГРС) по-прежнему сопряжено с трудностями в тех случаях, когда выборка биопсии является недостаточной, а патологическая работа по золотому стандарту является неполной. ПРЕДСТАВЛЕНИЕ СЛУЧАИ: А 60-year-old Женщина с брюшной полностью и изжогом сердца. Обычные тесты выявили нефротическое белковое заболевание, острые повреждения почек (АКИ) и гипокомплемию. Иммунофиксация сыворотки показа

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… Complement C3 was low at 0.59 g/L (reference 0.9–1.8 g/L), and complement C4 was at the lower limit of normal at 0.10 g/L (reference 0.1–0.4 g/L). Immunoglobulin levels showed low IgG (3.96 g/L) and elevated IgM (2.63 g/L). … C4 (g/L) | 0.10 | – | Normalized | 0.1–0.4 Immunoglobulin G (g/L) | 3.96 | – | 9.3 | 7.0–16.0 Immunoglobulin M (g/L) | 2.63 | – | 2.2 | 0.4–2.3 C-reactive protein (mg/L) | 25.20 | – | 8.1 | < 10 24-h urine protein (mg/24h) | 7,930.40 | – | 1,100 | < 150 Urine protein dipstick | 4+ | – | + | Negative …

Low-dose interleukin-2 for the treatment of systemic lupus erythematosus: A systematic review and meta-analysis.

OBJECTIVES: Low-dose interleukin-2 (IL-2) is a rational therapy for a variety of autoimmune disorders as it leads to expansion and improved functionality of regulatory T (Treg) cells. In this study, we reviewed the clinical efficacy of IL-2 in patients diagnosed with systemic lupus erythematosus (SLE). METHODS: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we searched the Scopus and MEDLINE databases for clinical trials reporting standardized outcomes of clinical efficacy after treatment with low-dose IL-2 in SLE. Our primary outcome was clinical eff

Potential biomarkers for human Ascending aortic aneurysm identified through metagenomic and metabolomic analyses: A case-control study.

INTRODUCTION: Ascending aortic aneurysm (AsAA) is a high-risk cardiovascular condition; recent research indicates a possible association between gut microbiota, plasma metabolites, and the pathogenesis of AsAA. OBJECTIVE: This study aims to investigate the compositional and metabolic alterations in the gut microbiota of AsAA patients to identify potential biomarkers for AsAA. METHODS: This study enlisted 72 participants, comprising 44 individuals with AsAA and 28 healthy controls. All participants underwent examination for clinical features, and fecal and plasma samples were obtained for met

Neutrophil Z Is a Novel Marker to Differentiate Disease Flares From Bacterial Infections in Febrile SLE Patients.

AIM AND OBJECTIVES: To assess the role of newer biomarkers like neutrophil Z, myeloid-related protein 8/14 (MRP 8/14), IL-6, sCD14, and neutrophil CD64 (nCD64) to distinguish flare from infection in febrile lupus patients. METHODS: In this prospective multicentric observational study to determine the etiology of fever in febrile lupus patients, in addition to routine tests, serum procalcitonin, neutrophil X, neutrophil Y, and neutrophil Z were done. sCD14, MRP8/14, and IL-6 were done by ELISA. nCD64 expression was measured by flow cytometry. All these biomarkers were assessed individually and

Prediction of Systemic Lupus Erythematosus Exacerbation in Patients with Clinical and Subclinical Musculoskeletal Inflammation.

Background/Objectives: Systemic lupus erythematosus (SLE) is an autoimmune disease affecting multiple organ systems, characterized by remissions and relapses. Musculoskeletal involvement occurs in up to 95% of patients and may present as the initial symptom in 50%. Such involvement is often subclinical, without obvious joint or tendon inflammation. Musculoskeletal ultrasound (US) has proven valuable for detecting pathological changes in joints and periarticular structures, including in SLE patients, and early detection, particularly in subclinical stages, supports optimal therapy, monitoring,

Obesity: Friend or Foe in Sjögren's Syndrome Patients?

BACKGROUND/OBJECTIVES: In Sjögren's syndrome, exocrine glands are destructed in an autoimmune-mediated process. Obesity is known to influence a wide range of diseases. This study aimed to examine whether obesity has an impact on the disease course of our patients with Sjögren's syndrome. METHODS: Out of the regularly followed-up patients, 125 were grouped based on their body mass index (BMI). Below a BMI of 25, they were listed as "non-obese" (n = 45), whereas above a BMI of 25, they were categorized as "obese" (n = 80). Demographic, laboratory, and immunological parameters; Sjögren's syndrom

Assessment of clinical phenotypic characteristics of patients with angioedema without wheals in a turkish population.

Background: Angioedema (AE) is defined as localized, self-limited swelling of subcutaneous tissues and mucosa. Objective: The aim of this st … hout wheals may vary, depending on the underlying AE pathogenesis. C1 inhibitor level and function, complement C4 and C1q, and genetic tests contributed to the diagnosis; other laboratory tests did not contribute to the diagnosis.

[Low disease activity and remission status of systemic lupus erythematosus in a real-world study].

OBJECTIVE: To investigate the rates of low disease activity and clinical remission in patients with systemic lupus erythematosus (SLE) in a real-world setting, and to analyze the related factors of low disease activity and clinical remission. METHODS: One thousand patients with SLE were enrolled from 11 teaching hospitals. Demographic, clinical and laboratory data, as well as treatment regimes were collec-ted by self-completed questionnaire. The rates of low disease activity and remission were calculated based on the lupus low disease activity state (LLDAS) and definitions of remission in SLE

FOXP3 gene polymorphisms increase the risk of systemic lupus erythematosus in a Han Chinese population.

BACKGROUND: FOXP3 is a transcription factor that regulates the development and function of Treg, playing an essential role in preventing aut … T) was not associated with SLE. Moreover, the immunological index analysis suggested that decreased complement C4 occurred more frequently in SLE patients carrying the minor allele (A) -3279 (C > A) than those not (p = .005). CONCLUSIONS: We demonstrated that -3279 (C > A) and -924 (A > G) were associated with an increased risk of SLE and the immunological ind …

Effects of dietary supplementation with quercetagetin on nutrient digestibility, intestinal morphology, immunity, and antioxidant capacity of broilers.

Quercetagetin (QG) is gaining increased attention as a potential alternative to in-feed antioxidants due to its antioxidant activity. This experiment was conducted to investigate the effects of dietary supplementation with QG on nutrient digestibility, intestinal morphology, immunity, and antioxidant capacity of broilers. Four hundred 1-day-old Ross 308 broilers were randomly assigned into 4 groups with 10 replicates in each group and 10 broilers in each replicate. The four dietary treatments included the basal diet supplemented with 0, 3.2, 4.8, or 6.4 mg/kg QG. The results showed that dietar

Increased oxidative stress contributes to impaired peripheral CD56dimCD57+ NK cells from patients with systemic lupus erythematosus.

BACKGROUND: Systemic lupus erythematosus (SLE) is characterized by loss of immune tolerance and imbalance of immune cell subsets. Natural killer (NK) cells contribute to regulate both the innate and adaptive immune response. In this study, we aimed to detect alterations of peripheral NK cells and explore intrinsic mechanisms involving in NK cell abnormality in SLE. METHODS: Blood samples from healthy controls (HCs) and patients with SLE and rheumatoid arthritis (RA) were collected. The NK count, NK subsets (CD56bright, CD56dimCD57-, and CD56dimCD57+), phenotypes, and apoptosis were evaluated

Compartmentalization of Intrarenal Programmed Cell Death Protein 1-Ligand 1 and Its Receptor in Kidney Injury Related to Immune Checkpoint Inhibitor Nephrotoxicity.

BACKGROUND: Due to advances in cancer therapy, immune checkpoint inhibitors (ICIs) are new classes of drugs targeting programmed cell death protein 1-ligand 1 (PD-L1) or its receptor (PD-1) used in many cancer therapies. Acute interstitial nephritis (AIN) is a potential and deleterious immune-related adverse events (irAE) and the most common biopsy-proven diagnosis in ICI-related nephrotoxicity. AIN in patients receiving ICIs is was only seen in cases with tubular PD-L1 positivity, while PD-1 expression is limited to inflammatory cells and also observed in injured kidneys independent of ICI th

Coexistence of Rheumatoid Arthritis, Systemic Lupus Erythematosus, Sjogren Syndrome, Antiphospholipid Syndrome, and Ankylosing Spondylitis.

A 37-year-old Bangladeshi woman presented with low back and several joints pain and swelling for months together; there was significant morning stiffness for more than two hours. Repeated abortions, dry eye, hair fall, photosensitivity, and oral ulcer were the additional complaints. Clinical examination unveiled asymmetrical peripheral and both sacroiliac joint tenderness, positive modified Schober's test, and limited chest expansion. Schirmer's test was positive. The history of rheumatoid arthritis (RA) and ankylosing spondylitis (AS) among 1st-degree relatives was also significant. Biochemic

Association of small-fiber polyneuropathy with three previously unassociated rare missense SCN9A variants.

BACKGROUND: Small fiber polyneuropathy (SFN) involves ectopic firing and degeneration of small-diameter, somatic/autonomic peripheral axons. … kin biopsy-confirmed SFN, with blood tests revealing only high-titer antinuclear antibodies and low complement C4 consistent with B cell dysimmunity. Six years of intravenous immunoglobulin (IVIg) therapy markedly improved sensory and autonomic symptoms and normalized his neurite density. After whole exome sequencing revealed a potentially pathogenic SCN9A-A373 …