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G Protein-Coupled Receptor Signaling: Implications and Therapeutic Development Advances in Cancers.

G protein-coupled receptors (GPCRs) are the largest and most diverse class of membrane proteins, mediating cellular responses to a wide range of extracellular stimuli. GPCRs initiate complex intracellular signaling networks that regulate vital physiological functions and are associated with numerous diseases, including various types of cancer. Their conserved seven-transmembrane (7TM) structure enables these signaling networks by allowing interactions with multiple ligands and intracellular effectors. In several types of tumors, abnormal GPCR signaling promotes carcinogenesis by supporting imm

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… Gαs‐targeted substances, for instance, may similarly reduce YAP/TAZ function to epinephrine, dobutamine, and glucagon [ 236 , 237 ]. …

Heyde Syndrome Unveiled: A Case Report with Current Literature Review and Molecular Insights.

Heyde syndrome, marked by aortic stenosis, gastrointestinal bleeding from angiodysplasia, and acquired von Willebrand syndrome, is often underreported. Shear stress from a narrowed aortic valve degrades von Willebrand factor multimers, leading to angiodysplasia formation and von Willebrand factor deficiency. This case report aims to raise clinician awareness of Heyde syndrome, its complexity, and the need for a multidisciplinary approach. We present a 75-year-old man with aortic stenosis, gastrointestinal bleeding from angiodysplasia, and acquired von Willebrand syndrome type 2A. The patient w

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… The multimer ratio correlated strongly with transvalvular pressure gradients and showed increased degradation during dobutamine stress echocardiography. …

ANMCO position paper 'Hypertrophic cardiomyopathy: from diagnosis to treatment'.

Hypertrophic cardiomyopathy (HCM) is a non-rare genetic cardiomyopathy, with an estimated prevalence of 1:500, characterized by an increase in the left ventricular wall thickness in the absence of increased loading conditions. The hypertrophy is mostly asymmetric and predominantly affects the basal septum and anterior wall. Left ventricular outflow tract obstruction, at rest or after provocative tests, is detected in many patients and represents the primary cause of reduced functional capacity, as well as an independent predictor of sudden cardiac death and advanced heart failure. Until ∼1 yea

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… Indeed, in patients who do not present LVOTO in basal conditions, provocative manoeuvres can be used or an echocardiogram during exercise can be performed, whereas the use of dobutamine is contraindicated. 2 , 3 Re-evaluation during exercise is recommended in all patients who do not present a gradient …

Cardiotoxicity Induced by Anticancer Therapies: A Call for Integrated Cardio-Oncology Practice.

The introduction of novel oncologic therapies, including targeted agents, immunotherapies, and antibody-drug conjugates, has transformed the therapeutic landscape of cancer care. This evolution has resulted in a dual clinical scenario; while survival outcomes have markedly improved, leading to a growing population of long-term cancer survivors, an increasing incidence of previously unrecognized treatment-related toxicities has emerged. Among these, cardiovascular adverse events represent some of the most prevalent and clinically significant complications observed in both conventional chemother

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… In cases requiring pharmacologic stress, agents like dobutamine or adenosine may be used effectively. Coronary imaging, especially coronary CT angiography (CTCA), has emerged as a valuable non-invasive technique in cancer patients with suspected obstructive coronary disease. …

Brazilian Position Statement on the Use Of Multimodality Imaging in Cardio-Oncology - 2021.

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Trial watch: beta-blockers in cancer therapy.

Compelling evidence supports the hypothesis that stress negatively impacts cancer development and prognosis. Irrespective of its physical, biological or psychological source, stress triggers a physiological response that is mediated by the hypothalamic-pituitary-adrenal axis and the sympathetic adrenal medullary axis. The resulting release of glucocorticoids and catecholamines into the systemic circulation leads to neuroendocrine and metabolic adaptations that can affect immune homeostasis and immunosurveillance, thus impairing the detection and eradication of malignant cells. Moreover, catech

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… hydroxyzine, tamsulosin α 2 | Epinephrine = norepinephrine | Clonidine, dexmedetomidine, epinephrine, norepinephrine | Smooth muscle constriction, decreased insulin and glucagon production, decreased thyroid hormone production, decrease platelet aggregation | Diverse antipsychotics β 1 | Epinephrine | Dobutamine …

Abstracts from the World Congress of Cardiology/Brazilian Congress of Cardiology 2022

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… 47.9% vs 25.6%, p < 0.001), higher rate of “cold and wet” clinical hemodynamic profile (27.2 vs 10.6%, p < 0.001); larger diastolic left ventricular (LV) diameters (65 [57–72.8] vs 59 [51–66] mm, p < 0.001), and lower LV ejection fraction (25.4 [19–36]% vs 37 [27–54]%, p < 0.001), with higher rates of dobutamine …

Резюме МКАРЕ 2023 77th Национальный конгресс &quot; СИААРТИ &quot;

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Proceedings of Reanimation 2022, the French Intensive Care Society International Congress.

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The Glycocalyx and Its Role in Vascular Physiology and Vascular Related Diseases.

PurposeIn 2007 the two senior authors wrote a review on the structure and function of the endothelial glycocalyx layer (Weinbaum in Annu Rev Biomed Eng 9:121-167, 2007). Since then there has been an explosion of interest in this hydrated gel-like structure that coats the luminal surface of endothelial cells that line our vasculature due to its important functions in (A) basic vascular physiology and (B) vascular related diseases. This review will highlight the major advances that have occurred since our 2007 paper.MethodsA literature search mainly focusing on the role of the glycocalyx in the

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… Under acutely increased flow stimulated by administration of dobutamine that elevates heart rate, there was an upregulation of NO production in the wild type mice after 30 min, but no increase in the knockout mice. …

Disorders of the Gastrointestinal System

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Hematology and Immune-Related Disorders

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ESICM LIVES 2016: part two : Milan, Italy. 1–5 October 2016

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Abstracts of the ICARE 2024 78th SIAARTI National Congress

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Proceedings of Reanimation 2023, the French Intensive Care Society International Congress.

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… Independent risk factors for ICU mortality were: mechanical ventilation (OR 2.55 [1.16–5.72], p = 0.02), vasopressor therapy (OR 3.36 [1.15–11.31], p = 0.03), home medication with renin–angiotensin–aldosterone system inhibitors (OR 2.84 [1.06–8.17], p = 0.04), and the inotropic drug (OR for dobutamine …

Abstract

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… We analyzed at rest CFV (abnormal value &gt;31 cm/s) and CFVR with exercise (n=99), dobutamine (n=100), and vasodilator stress (dipyridamole in 1,149, adenosine in 60). …

37th International Symposium on Intensive Care and Emergency Medicine (part 1 of 3) : Brussels, Belgium. 21–24 March 2017

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Proceedings of the RAMI Intern Section Meeting.

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RESEARCH COMMUNICATIONS OF THE 34th ECVIM-CA CONGRESS.

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Резюме докладов 2017 Ежегодное совещание Общества общей внутренней медицины.

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