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Pattern visual evoked potential luminance and multiple sclerosis.

Pattern visual evoked potentials (PVEPs) were recorded from 111 patients classified as having possible, probable or definite multiple sclerosis. Patients were stimulated with a checkerboard pattern using high and low luminances in order to test the hypothesis that an attenuated pattern luminance increases the detection rate of PVEP abnormalities. With increasing certainty of diagnosis, there was a concomitant increase in the incidence of PVEP abnormalities. However, there was no evidence that stimulating with a lower luminance pattern enhanced the sensitivity of the test. The same findings wer…

Multiple sclerosis and narcolepsy: possible similar genetic susceptibility.

We have studied 2 patients with multiple sclerosis and narcolepsy. In both patients, the DR 2 histocompatibility antigen was positive. In each of the patients, the diagnosis of narcolepsy was confirmed by polygraphic testing.

Lower extremity motor evoked potentials in multiple sclerosis.

Transcranial magnetic stimulation was performed on 25 patients with definite multiple sclerosis. Motor evoked potentials were recorded from the anterior tibial muscle. Central motor conduction time was calculated using the equation (F + M-1)/2 by stimulation of the common peroneal nerve. Motor evoked potentials were capable of detecting subclinical pyramidal tract lesions in multiple sclerosis. In patients with multiple sclerosis, the incidence of abnormality of motor and somatosensory evoked potentials was similar. Central motor conduction time was correlated with overall and pyramidal tract …

Multiple sclerosis etiology--an Epstein-Barr virus hypothesis.

The opinion has been expressed frequently in the literature that MS is caused by a combination of an environmental agent and genetic factors, possibly with an autoimmune component. However, the specific environmental agent has not as yet been identified. This paper describes cumulative circumstantial evidence which strongly points to a post-pubertal primary Epstein-Barr virus infection as this unidentified etiological event in the induction of MS disease.

Multiple sclerosis presenting as isolated oculomotor nerve palsy.

A 23-year old woman came to the emergency room with an isolated oculomotor nerve palsy (including pupillary dilatation) of rapid onset. Investigations and history revealed no cause. The subsequent course of events indicated a diagnosis of multiple sclerosis. While the third nerve has been shown to be involved during the course of multiple sclerosis, this is the first report of a case presenting as an isolated oculomotor nerve paralysis.

Arthrogryposis multiplex congenita occurring with maternal multiple sclerosis.

All children of a mother with multiple sclerosis (MS) had increasing grades of congenital joint contractures without demonstrable neuromuscular disease. Two had talipes equinovarus, one had congenital hip subluxation, and the youngest had arthrogryposis multiplex congenita. Maternal MS may be causally related to the development of congenital joint contractures.

Multiple sclerosis: plaques caused by 2-step demyelination?

Selected studies concerning events at the contour of a progressive plaque are reviewed and an explanation of the subtle changes in periplaqu … action to maintain homeostasis in the fluid surrounding neurons characterize the premorbid phase of multiple sclerosis. We suggest that the accumulation in the perivascular space of macrophages with large lysosomes digesting myelin debris (visible in electron micrographs) causes bottlenecks in the lymphatic channels serving the extracellular space near nodes of Ranv …

Bitemporal visual field defects in presumed multiple sclerosis.

Three patients with presumed multiple sclerosis had bitemporal hemianopia mimicking that caused by parasellar tumors; the visual loss was probably due to a plaque within the chiasm. The diagnosis of multiple sclerosis was made on the basis of a history of relapse and remission, signs and symptoms indicating involvement of different levels of the central nervous system, and normal neuroradiological studies. Extensive neuroradiological studies may be delayed or omitted in patients with established multiple sclerosis and nonprogressive bitemporal visual field defects if central visual acuity is n…

Multiple sclerosis and related disorders multiple sclerosis across Isfahan Province, Iran: Urban-rural disparities and no association with air quality measures.

BACKGROUND: Multiple sclerosis (MS) prevalence varies worldwide and appears to be rising in Iran. Environmental factors like air pollution have been hypothesized to contribute to MS risk. This study aimed to map MS prevalence across Isfahan Province and evaluate differences by sex and urban versus rural setting, as well as to assess any association between ambient air pollution and MS prevalence. METHODS: Data from 11,456 provincially registered MS patients in 28 counties in Isfahan, Iran, were examined in this cross-sectional ecological study. Official population estimates were used to calcu…

Advancing Nurse-Led Self-Regulation in Multiple Sclerosis Management: Developing an Interactive Web-Based Program through Action Research: Multiple Sclerosis Management.

This study aimed to develop an interactive web-based program, "I Can Manage," to support nurse-led self-regulation in the management of Multiple Sclerosis (MS). An action research approach was adopted, utilizing the Spiral Technology Action Research model, which involves the stages of listen, plan, do, study, and act. The study was conducted with 16 nurses and persons with MS (pwMS). Data were collected through in-depth individual interviews and the System Usability Scale (SUS). In the "Listen" stage, existing programs were reviewed, and a descriptive phenomenological study was conducted. In t…

Validity of Scores From the 12-Item Multiple Sclerosis Walking Scale Among Young, Middle-Aged, and Older Adults With Multiple Sclerosis.

OBJECTIVE: To examine the construct validity of inferences from scores on the 12-item multiple sclerosis walking scale (MSWS-12) as a patient-reported outcome measure of walking dysfunction among young, middle-aged, and older adults with multiple sclerosis (MS). DESIGN: Cross-sectional, comparative research design. SETTING: University research laboratory. PARTICIPANTS: The sample included 187 participants (N=187) with MS who were categorized into young (20-39y, n=50), middle-aged (40-59y, n=83), and older (60-79y, n=54) adult age groups. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURE…

Sustained clinical benefits of glatiramer acetate in relapsing multiple sclerosis patients observed for 6 years. Copolymer 1 Multiple Sclerosis Study Group.

In a randomized, placebo-controlled, double-blind study, glatiramer acetate (Copaxone) reduced the relapse rate and slowed accumulation of disability for patients with relapsing - remitting multiple sclerosis. Of the original 251 patients randomized to receive glatiramer acetate or placebo, 208 chose to continue in an open-label study with all patients receiving active drug. The majority of the original double-blind cohort continues to receive glatiramer acetate by daily subcutaneous injection and are evaluated at 6-month intervals and during suspected relapse. The data reported here are from …

Characterization of the mitochondrial genome in childhood multiple sclerosis. III. Multiple sclerosis without optic neuritis and the non-LHON-associated genes.

The higher maternal transmission of multiple sclerosis in familial cases and the coincidence of a MS-like phenotype with mitochondrial point mutations in patients with Leber's hereditary optic neuropathy has inspired a detailed assessment of the mitochondrial genome as an etiological factor in the pathogenesis of MS. To further elucidate the contribution of maternally transmitted mutations to MS susceptibility, we sequenced five protein- and all RNA-coding genes of the mtDNA from thirteen children with MS and twenty unaffected individuals. After excluding several synonymous mutations and commo…

Multiple sclerosis: abnormalities in luminance, chromatic, and temporal function at multiple retinal sites.

Visual function was assessed in a group of patients with multiple sclerosis (MS) and in a group of matched normal controls. In these patients the disease was relatively mild. For each subject, measures of a range of psychophysical visual functions were carried out at multiple sites in each eye. Previous reports have only included some of these functions. Here, luminance threshold, two-flash resolution, perceptual latency, luminance critical flicker frequency (CFF), and chromatic CFF were all measured. Variabilities of these functions and correlation between chromatic and luminance CFFs were al…

Areas of improvement for high-quality multiple sclerosis care: Insights from interviews with people with multiple sclerosis, providers, and clinical educators.

BACKGROUND: Facing lifelong medical care needs, people with multiple sclerosis (MS) experience challenges to access healthcare, particularly high-quality MS care, in many settings. Moreover, people with MS, providers, and clinical educators may have different perspectives regarding high-quality care. OBJECTIVE: This study seeks to better understand perspectives on high-quality care for multiple sclerosis and compare perspectives between people with MS, MS-specialist and non-MS specialist providers, and clinical educators to better support clinical education efforts to improve care. METHODS: …

Digital patient experience tools in multiple sclerosis: a landscape analysis of the global Patient-Reported Outcomes in Multiple Sclerosis (PROMS) initiative.

BACKGROUND: Electronic health (eHealth) applications can increase the uptake of patient-reported outcomes (PROs) in people with multiple sclerosis. We aim to present the findings of the eHealth tools landscaping exercise conducted by the global Patient-Reported Outcomes for Multiple Sclerosis (PROMS) initiative. METHODS: A structured survey was disseminated among identified eHealth tool developers. Metadata (up to 10 October 2024) were hosted on the Multiple Sclerosis Data Alliance catalogue, an open-access platform focussing on digital health tools in multiple sclerosis. eHealth tools' clini…

Can Multiple Sclerosis be Managed Over a Lifetime? A Rare 72-Year Journey of Pediatric-Onset to Secondary Progressive Multiple Sclerosis.

Multiple sclerosis (MS) is a chronic demyelinating disorder of the central nervous system characterized by cumulative neurological disability over time. Median survival from symptom onset in large cohort studies is approximately four decades, although substantially prolonged disease courses are uncommon. Pediatric-onset MS (POMS), defined by symptom onset before age 18, accounts for 3%-5% of cases and may follow a prolonged but ultimately progressive trajectory. We report the case of an 83-year-old Iranian woman with an approximately 72-year history of MS, representing an exceptionally prolong…

Характеристики и ожидания людей с множественным склерозом, использующих дополнительную терапию: перекрестное обследование на основе регистра нескольких склерозов.

Понимание особенностей и ожиданий людей с множественным склерозом (pwMS), которые используют дополнительные методы лечения, может помочь интегрировать эти методы в обычный уход. ЦЕЛИ: Описывать характеристики ПВМС, использующих дополнительные методы лечения, их общие причины и целевые симптомы, а также их ожидания в отношении воздействия этих методов. МЕТОДЫ: В период с октября 2022 года по август 2023 года было проведено перекрестное обследование ПТМС из Швейцарского регистра с множественным склерозом. Результаты: за последние шесть месяцев в работе приняли участие 888 ПМС (39,3 процента). 48

Совпадение в аннотации оригинала
BACKGROUND: Understanding the characteristics and expectations of people with multiple sclerosis (pwMS) who utilize complementary therapies can help integrate these therapies into conventional care. OBJECTIVES: To describe the characteristics of pwMS who use complementary therapies, their general reasons and targeted symptoms, and their expectations regardi…