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Exploring the Correlations between Initial Clinical and Radiological Manifestations in Takayasu's Arteritis.

BACKGROUND: Initial clinical and imaging associations in Takayasu's arteritis (TAK) are poorly defined. OBJECTIVES: To characterize initial manifestations, their associations, and long-term outcomes in a TAK cohort. METHODS: A single-center retrospective cohort study (2000 to 2024) included patients diagnosed with TAK. The significance level was set at p<0.05. RESULTS: Among 203 patients identified, 54 were excluded due to incomplete data. The final cohort comprised 149 patients (89.9% female), with a median age at diagnosis of 31 years. At diagnosis, 92.6% were symptomatic. Claudication of…

Concurrent seronegative spondyloarthropathy and Takayasu's arteritis: a case report and literature review.

Seronegative spondyloarthropathy (SpA) and Takayasu's arteritis (TA) are distinct chronic inflammatory conditions with autoimmune characteristics. While both conditions are relatively common, their concurrent occurrence is rare. This case report presents an individual diagnosed with both SpA and TA, detailing the clinical presentation, disease course, and therapeutic interventions. A review of relevant literature is also included to enhance clinical awareness of this uncommon combination. For that patients with SpA who exhibit elevated inflammatory markers, intermittent low-grade fever, fatigu…

Insight Into the Role of NLRP3 Inflammasomes in Takayasu's Arteritis: Mechanisms and Targeted Pharmacotherapies.

Takayasu's arteritis (TAK) is a rare chronic arteritis that can lead to serious consequences. Understanding of the pathogenesis of TAK remains limited, and effective therapeutic strategies for this condition are lacking. Previous studies have suggested that there may be an association between TAK and the interaction between Mycobacterium tuberculosis infection and genetic susceptibility. Emerging data indicate that the nucleotide-binding and oligomerization domain (NOD)-like receptor pyrin domain-containing protein 3 receptor (NLRP3) inflammasome may be involved in the pathogenesis of TAK, pot…

[Polymyalgia rheumatica and giant cell arteritis: two manifestations of the same disease?].

Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are associated conditions that typically affect older patients, usually over the age of 50. Their clinical presentations often overlap, and the two can even transition into one another. Increasingly, they are viewed not as distinct diseases but as manifestations of a single disease spectrum. Common symptoms include shoulder pain, headaches, and visual disturbances. Diagnosis relies on imaging and inflammatory markers. Both conditions are initially treated with glucocorticoids, increasingly complemented by IL-6 inhibitors or methotrexa…

Successful treatment with tocilizumab in a case of familial Mediterranean fever with Takayasu arteritis.

Familial Mediterranean fever (FMF) is an autoinflammatory disease associated with mutations in MEFV, which encodes pyrin. Patients with FMF present intermittent high fever with elevated inflammatory markers during periodic attacks. While some forms of vasculitis, including immunoglobulin A (IgA) vasculitis and polyarteritis nodosa have been reported in some patients with FMF, Takayasu arteritis (TAK) rarely associated with FMF. In addition, little has been known about the clinical features and pathogenesis of vasculitis with FMF. Here we report a case of FMF with TAK. Our case is remarkable on…

Incidence of pulmonary hypertension in patients with Takayasu's arteritis: A transthoracic echocardiographic evaluation.

AIM: In this study, we aim to evaluate the incidence of pulmonary hypertension (PH) using transthoracic echocardiography (TTE) in Takayasu arteritis (TA) patients. METHODS: Thirty-four outpatient Takayasu arteritis patients underwent transthoracic echocardiography (TTE) following the ESC-ERS guidelines. A tricuspid regurgitation velocity (TRV) greater than 3.4m/s indicated a high probability of pulmonary hypertension (PH). The patients were categorized based on their New York Heart Association (NYHA) functional class (FC) and symptomatic status. All patients underwent a six-minute walk test (…

Immunosuppressive Therapy in Takayasu Arteritis: A Tightrope Walk Between Inflammation and Infection.

Infectious diseases like tuberculosis (TB) are highly prevalent in developing countries. Rheumatological diseases are also not uncommon. Both are chronic illnesses with overlapping symptoms and may present a diagnostic challenge. Associations between TB and Takayasu arteritis (TA) have been reported. Immunosuppressive therapy for rheumatological disease always poses a risk of reactivation of infections like TB. Here we report a case of a 12-year-old Indian male child, a known case of TA with bilateral renal artery stenosis on methotrexate, adalimumab, and multiple antihypertensives, who presen…

Normal tension glaucoma as initial manifestation of Takayasu arteritis- an unknown entity.

ObjectiveTo report an unusual manifestation of normal tension glaucoma(NTG) in a young female as presenting feature of Takayasu arteritis (TA).MethodsWe present a case of a 24-year-old woman who was initially diagnosed with NTG, with characteristic optic disc and retinal nerve fiber layer (RNFL) changes, and corresponding visual field defects. Further evaluation with CT angiography revealed that the patient had newly diagnosed TA.ResultsNTG was likely a manifestation of the underlying vasculitis. patient was initially started on oral prednisolone by the rheumatologist which was changed to ster…

Development of a prediction model for poor prognosis in childhood-onset Takayasu's arteritis.

OBJECTIVES: Childhood-onset Takayasu's arteritis (cTAK) is a rare disease with high recurrence rates, vascular complications, and mortality. This study aimed to identify the risk factors for poor prognosis in hospitalized patients with cTAK and develop a nomogram prediction model. METHODS: This was a prospective longitudinal multicenter cohort study. Cohorts were categorized into poor and good prognosis groups according to follow-up outcomes. Poor prognosis included vascular complications, disease recurrence, persistent non-remission, and cTAK-related death. RESULTS: Of the 111 patients, 73 …

Совпадение с Такаясу Артеритом и множественным склерозом: обзор скрипта и доклад по делу.

ВВЕДЕНИЕ: Такайасу-артерит (ТА) и множественный склероз (МС) являются как иммунизированными заболеваниями, которые могут сосуществовать, при этом ТА вызывает сосудистое воспаление, а MS - обезвоживание, вызванное аберрантной активностью Т-клеток. Совпадение этих условий подчеркивает наличие общих иммунных механизмов, таких, как регулирование &quot; Т-клеток &quot; и высвобождение цитокина, что подчеркивает необходимость нюансированного понимания их взаимодействия, которое изучается в ходе описательного обзора зарегистрированных случаев. Мы рассказываем обо всех зарегистрированных случаях насил

Совпадение в аннотации оригинала
INTRODUCTION: Takayasu arteritis (TA) and multiple sclerosis (MS) are both immune-mediated diseases that can coexist, with TA causing vascular inflammation and MS involving demyelination driven by aberrant T-cell activity. The overlap of these conditions highlights shared immune mechanisms, such as T-cell dysregulation and cytokine release, underscoring the …

Ultrasonography of the superficial temporal and axillary arteries in giant cell arteritis diagnosis.

OBJECTIVES: Giant cell arteritis (GCA) is the main systemic vasculitis in individuals aged ≥ 50 years. Color Doppler ultrasound (CDS) has an established role in GCA diagnosis and management. This study aims to assess the clinical characteristics associated with a positive CDS evaluation and the impact of additional axillary artery examination on diagnostic sensitivity. MATERIAL AND METHODS: We conducted a retrospective analysis of patients undergoing CDS of the superficial temporal arteries, with or without axillary artery assessment, at our hospital, between 2009 and 2023. Patients meeting t…

Takayasu arteritis and interstitial lung disease: a case report and literature review.

INTRODUCTION AND IMPORTANCE: Although pulmonary artery involvement is well recognized, the incidence of interstitial lung disease (ILD) with Takayasu arteritis is very rare. The pathophysiology of ILD in Takayasu is still incompletely understood, in contrast to several studies establishing the relationship between ANCA-associated vasculitis and ILD. The management of this patient involved a multidisciplinary approach with long-term follow-up. CASE PRESENTATION: The authors present a case of HRCT-proven interstitial lung disease in a patient with Takayasu arteritis and heart failure. The patie…

Brachial plexopathy as a complication of axillary artery aneurysm in a case of Takayasu arteritis.

Takayasu arteritis is an inflammatory disease of unknown aetiology affecting large vessels. Medium vessel involvement is also well documented; however, neuropathy as a presenting manifestation is rare. In this case report, a young woman in her 20s presented with an 8-month history of intermittent claudication in the right upper limb progressing to rest pain with allodynia in C5-C8 distribution and painless right axillary mass. On examination, she had absent pulses in the right radial, brachial and subclavian artery with audible bruit in the right subclavian and abdominal aorta. CT angiogram sh…

Long-term Patency and Complications of Endovascular and Surgical Revascularization for Takayasu Arteritis.

PURPOSE: Takayasu arteritis (TAK) is a rare form of chronic vasculitis that is common in Asian female. As TAK predominantly affects young female with a longer life expectancy than those with atherosclerotic diseases, assessing the specific long-term outcomes of TAK treatment is important. Therefore, this study aimed to evaluate the long-term outcomes and post-procedural complications of surgical and endovascular treatment for TAK. MATERIALS AND METHODS: This single-center retrospective observational study reviewed 545 consecutive patients diagnosed with TAK between 1983 and 2020 at Seoul Nati…

Influenza A infection as a potential trigger of giant cell arteritis: A case report.

Presenting as a large vessel vasculitis, giant cell arteritis (GCA) manifests with various symptoms, including fever, myalgias, headache, and jaw claudication. Although the precise pathogenesis of GCA remains incompletely elucidated, there is speculation about the involvement of environmental factors and infectious agents like bacteria and viruses in its development. Nevertheless, data on the potential link between influenza infection and GCA are limited. In this report, we present the case of an 88-year-old patient diagnosed with GCA following a severe influenza A infection.

Baricitinib in polymyalgia rheumatica and giant cell arteritis: report of six cases.

The objective of this case series is to describe the efficacy and safety of baricitinib (BARI) in a group of patients with polymyalgia rheumatica (PMR) and/or giant cell arteritis (GCA). These patients were treated with BARI due to either a refractory disease course or the unavailability of tocilizumab because of the pandemic. A total of six patients (five females and one male, median age 64 years, range 50-83) were treated with BARI. Two of them had isolated PMR, two had PMR with associated large vessel (LV)-GCA, one had LV-GCA presenting as fever of unknown origin, and one had cranial-GCA. A…

Inflammatory back pain as an unusual manifestation of Takayasu arteritis: a case report.

Takayasu arteritis and spondyloarthritis are two rheumatological diseases whose co-existence is well-documented in the literature. Data on the presence of inflammatory back pain in Takayasu arteritis without a diagnosis of spondyloarthritis, however, is scarce. Here, we present a 33-year-old man who was admitted to the emergency department with acute-onset chest pain associated with left carotidynia, carotid bruit, and left arm claudication, normal electrocardiogram and computed tomography angiographic features suggesting Takayasu arteritis, including stenosis and occlusion of the aorta and it…

The Spectrum of Isolated Retinal Artery Occlusion Secondary to Giant Cell Arteritis.

We systematically reviewed the literature to investigate the clinical features of isolated arteritic retinal artery occlusion (A-RAO) associated with giant cell arteritis (GCA). The four primary types of A-RAO were central retinal artery occlusion (CRAO), hemi-central retinal artery occlusion (hCRAO), branch retinal artery occlusion (BRAO), and cilioretinal artery occlusion (CLRAO). The most reported presentation was unilateral CRAO, followed by bilateral CRAO, unilateral CLRAO, and bilateral BRAO. Most RAOs were accompanied by typical GCA signs and symptoms, which can help distinguish them fr…