Результаты поиска

Нацеливание БКМА на многочисленные миеломы: всеобъемлющий обзор иммунотерапевтических стратегий и клинических результатов.

Множественная миелома (ММ) является второй по распространенности гематологическая гелингология и остается неизлечимой, что подчеркивает настоятельную потребность в новых терапевтических стратегиях. В. Антиген созревания клеток (BCMA), выраженный преимущественно на зрелых лимфоцитах B, играет важнейшую роль в активации и созревании клеток B. Растущие данные указывают на участие BCMA в росте опухоли, метастазе и раковом стебле, что делает его многообещающей терапевтической целью. В настоящем обзоре содержится всеобъемлющий обзор ориентированных на БКМА иммунотерапевтических стратегий в ММ, включ

Feline infectious peritonitis.

The article discusses feline infectious peritonitis (FIP), an important disease frequently seen in veterinary practice. FIP causes many problems to the veterinarian as it can be difficult to definitively diagnose the disease, as there is no effective treatment, and as prophylactic interventions are not very successful. Although intense research has created a lot of new knowledge about this disease in the last years, there are still many unanswered questions. The objective of this article is to review recent knowledge and to increase understanding of the complex pathogenesis of FIP.

Clinicopathological characteristics of primary central nervous system lymphoma with low 18F-fludeoxyglucose uptake on brain positron emission tomography.

Primary central nervous system lymphoma (PCNSL) typically shows a strong uptake of F-fludeoxyglucose (FDG) imaged by positron emission tomography (PET). Uncommonly, PCNSL demonstrates a low uptake on FDG PET. We investigated the clinicopathological characteristics of the unusual cases of PCNSL with low FDG uptake.We retrospectively enrolled 104 consecutive patients with newly diagnosed PCNSL who underwent baseline brain FDG PET. The degree of FDG uptake of PCNSL was visually scored by 4 grades (0, ≤contralateral white matter; 1, >contralateral white matter and contralateral gray matter). Grade

RESEARCH COMMUNICATIONS OF THE 28th ECVIM-CA CONGRESS.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Data resource profile: Transforming Outcomes through Research in Cancer Healthcare in Victoria (TORCH-VIC).

INTRODUCTION: The Transforming Outcomes through Research in Cancer Healthcare in Victoria (TORCH-VIC) is a comprehensive population-based cohort that links cancer diagnoses recorded in the Victorian Cancer Registry with administrative health data to capture the complete cancer journey from pre-diagnosis through long-term outcomes. Established in 2022, TORCH-VIC provides real-world evidence on healthcare utilisation, patterns of care, costs, and outcomes across the cancer continuum in Victoria, Australia. METHODS: TORCH-VIC comprises adults aged 18 years and over diagnosed with colorectal, lun

LOX-1 and cancer: an indissoluble liaison.

Recently, a strong correlation between metabolic disorders, tumor onset, and progression has been demonstrated, directing new therapeutic strategies on metabolic targets. OLR1 gene encodes the LOX-1 receptor protein, responsible for the recognition, binding, and internalization of ox-LDL. In the past, several studied, aimed to clarify the role of LOX-1 receptor in atherosclerosis, shed light on its role in the stimulation of the expression of adhesion molecules, pro-inflammatory signaling pathways, and pro-angiogenic proteins, including NF-kB and VEGF, in vascular endothelial cells and macroph

Усиленная диагностика заболевания множественным склерозом на основе подхода, основанного на ансамблях

Множественный склероз (MS) — болезнь, наносящая удар по центральной нервной системе. Согласно самым последним статистическим данным MS Atlas 2.8 million люди во всем мире диагностировали MS. Недавно в рамках исследований стали изучаться методы машинного обучения для прогнозирования НР с использованием различных данных. Целью настоящего документа является разработка комплексного подхода к диагностике MS с использованием профилей выражения генов при одновременном решении проблемы классового дисбаланса, связанной с данными. Предлагается иерархический комплексный подход с использованием методов го

Critical considerations in the administration of antineoplastic therapy for patients with malignant solid tumors undergoing hemodialysis.

Patients with chronic kidney disease exhibit a higher risk of developing malignancies, and among those with end-stage renal disease (ESRD) on dialysis, approximately 7% are diagnosed with new-onset tumors within five years. Patients with ESRD who are receiving antineoplastic treatment exhibit a significantly higher incidence and greater severity of adverse effects associated with antineoplastic agents compared to individuals with normal renal function. This complexity involves multiple factors, including the therapy options and dose adjustment of antineoplastic agents, drug-related toxicities,

Выявление потенциальных нервных сигналов, вызванных наркотиками, путем проведения непропорционального анализа базы данных FAERS.

Нейроргия, вызванная наркотиками, является широко распространенной и значительной негативной реакцией. В рамках этого исследования была проанализирована база данных системы представления информации о неблагоприятных явлениях (FAERS) в Соединенных Штатах Америки (продовольствие и наркотики)2004-2024) выявления соответствующих наркотиков и потенциальных механизмов. Мы провели анализ связей между наркотиками и нейронгией с использованием базы данных FAERS. Применялись методы непропорционального анализа, включая коэффициент вероятности представления отчетности (ROR), коэффициент пропорциональной о

YTHDC1 Promotes Stemness Maintenance and Malignant Progression in Head and Neck Squamous Cell Carcinoma.

BackgroundYTH domain containing 1 (YTHDC1), an N6-methyladenosine (m6A) modification reading protein, plays a key role in regulating RNA translation and degradation. However, the role of YTHDC1 in head and neck squamous cell carcinoma (HNSCC) cancer stem cells remains largely unknown. This study is aimed at investigating the role of YTHDC1 in HNSCC and exploring its role in regulating cancer stem cells.MethodsRNA sequencing was used to detect differentially expressed genes (DEGs) between SCC9 spheres and SCC9 cells and to uncover molecular pathways and target molecules associated with CSCs. We

Роль NLRP3 испарения в нейродегенеративных и метаболических заболеваниях и в соответствующих перспективных терапевтических вмешательствах.

Инфламасомы представляют собой внутриклеточные мультипротеиновые комплексы в цитоплазме, которые регулируют воспаление во врожденной иммунной системе в ответ на патогены и на прием самопроизводственных молекул. Последние достижения значительно улучшили наше понимание активации нуклеотидно-обязательного олигомеризации домена-подобный рецептору (NLR) семейный пирин, содержащий 3 (NLRP3) воспаление на молекулярном уровне. NLRP3 принадлежит подсемейству NLRP, которая активирует Caspase 1, что приводит к производству провоспалительных цитокинов (interleukin) 1β и интерлейкин 18) и пироптоз. Это вос

Multi-omics Analysis Reveals the Correlation of Gut Microbiota and Metabolites With Thalidomide Treatment for Chemotherapy-Induced Nausea and Vomiting in Small Cell Lung Cancer.

Small cell lung cancer (SCLC) is a highly aggressive malignancy, and chemotherapy frequently causes nausea and vomiting, which can impair treatment tolerance. Because thalidomide (THD) has shown potential clinical benefit in alleviating nausea and anorexia, we investigated whether its effects might be associated with changes in gut microbial composition and metabolite profiles. Fecal samples were collected from patients with SCLC and categorized into THD-treated and control groups. Metagenomic sequencing and nontargeted metabolomic profiling were performed to characterize microbial composition

Взгляды заинтересованных сторон Соединенного Королевства на суррогатные концы рака и потенциальные возможности Соединенного Королевства в области реальных мировых данных для подтверждения их использования в процессе принятия решений.

Продолжительность общего выживаемости пациентов с раком увеличилась благодаря более раннему обнаружению и совершенствованию лечения. Однако эти улучшения породили трудности с оценкой воздействия новых методов лечения, особенно тех, которые используются на раннем этапе лечения. Поскольку общее выживание остается предпочтительным для большинства лиц, принимающих решения, для внедрения в практику клинической практики терапевтических инноваций может потребоваться много времени. Кроме того, трудно экстраполировать полученные результаты на разнородные группы населения и решить проблемы пациентов, же

Targeting CD44 and other pleiotropic co-receptors as a means for broad inhibition of tumor growth and metastasis.

Although progress has been made in the treatment of cancer, particularly for the four major types of cancers affecting the lungs, colon, breast and prostate, resistance to cancer treatment often emerges upon inhibition of major signaling pathways, which leads to the activation of additional pathways as a last-resort survival mechanism by the cancer cells. This signaling plasticity provides cancer cells with a level of operational freedom, reducing treatment efficacy. Plasticity is a characteristic of cancer cells that are not only able to switch signaling pathways but also from one cellular st

Совпадение в полном тексте источника
… Simultaneously, the completion of the Human Genome Project facilitated the recognition of diverse somatic mutations in cancer and boosted the development of molecular targeted therapies. …

EZH2 serves as a viable therapeutic target for myeloma-induced osteolytic bone destruction.

Myelomatous bone disease is a complication characterized by lytic bone lesions, reduced bone formation, bone pain, and increased fracture risk. Understanding these underlying mechanisms is crucial for developing effective therapeutic approaches. Here we show the role of enhancer of zeste homolog 2 (EZH2) in bone lesions induced by myeloma cells. Our research reveals that cytokines produced by myeloma-associated adipocytes activate the expression of EZH2 in myeloma cells. Furthermore, we find that EZH2 forms a transcriptional repression complex with transcription factor AP2α. This complex promo

YKL-40-A Protein in the Field of Translational Medicine: A Role as a Biomarker in Cancer Patients?

YKL-40 is a 40 kDa glycoprotein produced by cancer cells, inflammatory cells and stem cells. It probably has a role in cell proliferation and differentiation, inflammation, protection against apoptosis, stimulation of angiogenesis, and regulation of extracellular tissue remodelling. Plasma levels of YKL-40 are often elevated in patients with localized or advanced cancer compared to age-matched healthy subjects. Several studies have demonstrated that high plasma YKL-40 is an independent prognostic biomarker of short survival in patients with different types of cancer. However, there is not yet

Epithelial-Mesenchymal Transition in Cancer: Insights Into Therapeutic Targets and Clinical Implications.

Radiation therapy is a fundamental component of cancer treatment, benefiting 50%-70% of patients by selectively targeting malignant tissues. However, radioresistance remains a significant challenge, often driven by epithelial-mesenchymal transition (EMT). EMT increases cancer invasiveness and metastasis by upregulating mesenchymal markers, including vimentin and N-cadherin, and downregulating epithelial markers, such as E-cadherin. EMT under radiation involves principal signaling pathways, including TGF-β, Wnt/β-catenin, Notch, and ERK, which regulate EMT through transcription factors such as

A clinicopathologic study of malignancy in VCP-associated multisystem proteinopathy.

BACKGROUND: Valosin containing protein (VCP) is an important protein with many vital functions mostly related to the ubiquitin-proteasome system that provides protein quality control. VCP-associated inclusion body myopathy with Paget disease of bone and frontotemporal dementia, also termed VCP disease and multisystem proteinopathy (MSP 1), is an autosomal dominant disorder caused by monoallelic variants in the VCP gene on human chromosome 9. VCP has also been strongly involved in cancer, with over-activity of VCP found in several cancers such as prostate, pancreatic, endometrial, esophageal ca

Chimeric Antigen Receptor T-Cell Revolution Remodeling Immunity to Conquer Autoimmune Disease.

Chimeric antigen receptor T (CAR-T) cell therapy, a groundbreaking technology in tumor immunotherapy, has demonstrated unprecedented potential in the field of autoimmune diseases in recent years. This article provides a systematic review of the developmental trajectory and core concepts of CAR-T-cell therapy in autoimmune diseases, emphasizing its conceptual evolution from traditional "killing" strategies to "precision immune remodeling". Leveraging multitarget approaches (e.g., CD19 and B-cell maturation antigen) and chimeric autoantigen receptor technology, it achieves efficient elimination

Surrogate Biomarkers in Gene Therapy for Orphan Diseases: Validation, Application, and Regulatory Aspects.

The development of gene therapies for rare hereditary disorders is hindered by small patient cohorts, incomplete characterization of natural disease history, and the impracticality of conducting long-term clinical trials. Surrogate biomarkers-quantifiable indicators predictive of clinical outcomes-represent a promising strategy to accelerate the evaluation of therapeutic efficacy. This review examines the role of surrogate endpoints in gene therapy, outlining essential validation criteria, including biological plausibility, analytical reproducibility, and clinical predictive value. Regulatory