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Study protocol for an online lifestyle modification education course for people living with multiple sclerosis: the multiple sclerosis online course (MSOC).

BACKGROUND: People living with multiple sclerosis (plwMS) seek access to information on evidence-based lifestyle-related risk factors associated with multiple sclerosis (MS). As the internet has made delivery of lifestyle information increasingly accessible and cost-effective, we designed the Multiple Sclerosis Online Course (MSOC) to deliver a multimodal lifestyle modification program for plwMS. Two MS online courses were developed: the intervention course based on lifestyle recommendations of the Overcoming Multiple Sclerosis (OMS) program and the standard-care course representing standard l…

[Features of depressive disorders and suicidal behavior in multiple sclerosis].

OBJECTIVE: The aim of the literature review was to analyze the epidemiological features, pathogenetic relationships and pathomorphological changes that determine the high incidence of depressive disorders in the population of patients with multiple sclerosis. MATERIAL AND METHODS: The analysis of the literature presented in the aggregator databases was carried out: PubMed, Google Scholar, CyberLeninka, eLIBRARY. The review includes the results of studies, meta-analyses, systematic reviews of scientific literature. For the search, queries were formed with the following keywords: «depression», …

Rehabilitation in Multiple Sclerosis (RiMS) Network Is Key to the World Health Organization's Rehabilitation 2030: A Call for Action for People With Multiple Sclerosis.

Rehabilitation is essential for improving physical, cognitive, and psychological function; independence; and quality of life for people with multiple sclerosis (MS). Rehabilitation in Multiple Sclerosis (RiMS; www.rehabinms.org) is a professional international network for clinicians and researchers dedicated to advancing MS rehabilitation through research, education, and collaboration. With a focus on knowledge exchange and professional development, RiMS supports multidisciplinary rehabilitation efforts across Europe and internationally. Recognizing the persistent challenges in delivering, acc…

Diagnosis and treatment of latent tuberculosis in patients with multiple sclerosis, expert consensus. On behalf of the Colombian Association of Neurology, Committee of Multiple Sclerosis.

BACKGROUND: Multiple sclerosis is an inflammatory and neurodegenerative demyelinating disease. Current treatment of multiple sclerosis focuses on the use of immunomodulatory, immunosuppressant, and selective immunosuppressant agents. Some of these medications may result in high risk of opportunistic infections including tuberculosis. OBJECTIVE: The purpose of this study was to obtain consensus from a panel of neurologists, pulmonologists, infectious disease specialists, and epidemiology experts regarding the diagnosis, treatment, and monitoring of latent tuberculosis in patients with multiple…

The Multiple Sclerosis Intimacy and Sexuality Questionnaire (MSISQ-15): Validation of the Dutch version in patients with multiple sclerosis and spinal cord injury.

AIMS: The Multiple Sclerosis Intimacy and Sexuality Questionnaire (MSISQ-15) evaluates symptoms of sexual dysfunction in patients with multiple sclerosis (MS). The objective of this study was to provide and validate a Dutch version of the MSISQ-15 in patients with neurological disease such as MS and spinal cord injury (SCI). METHODS: The linguistic validation process of the original English MSISQ-15 into Dutch was performed according to standardized guidelines. Sexually active patients with MS or spinal cord disorders, including SCI and cauda equine syndrome, who visited a tertiary urology ce…

Заболеваемость амиотропическим боковым склерозом на уровне муниципалитета, множественным склерозом и болезнью Паркинсона.

БАККРЫТЫЙ: Доказательства распространенности амиотропического латерального склероза (ALS), множественного склероза (MS) и болезни Паркинсона (PD) свидетельствуют о том, что у них могут быть общие патогенные факторы. ЦЕЛЬ: Изучение на муниципальном уровне в самой восточной части Финляндии динамики распространенности ALS, MS и PD. ЭТОДЫ: Ранее опубликованные ALS (годы 2010-2018 годов) и MS (годы 2012-2016 годов) были заимствованы, а данные по ПД (годы 2010-2018 годов) были получены из национального реестра прав на возмещение расходов на наркотики. Данные о населении собирались из государственног

Совпадение в аннотации оригинала
BACKGROUND: The prevalences of Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), and Parkinson's Disease (PD) have been shown to covary which suggests that they may share common pathogenetic factors. OBJECTIVE: Investigate the contemporaneous incidence patterns of ALS, MS, and PD on a municipal level in easternmost Finland. METHODS: Previously …

Correction to: The use of 7T MRI in multiple sclerosis: review and consensus statement from the North American Imaging in Multiple Sclerosis Cooperative.

[This corrects the article DOI: 10.1093/braincomms/fcae359.].

Computational Fluid Dynamic Simulation of the Cerebral Venous System in Multiple Sclerosis and Control Patients: Are Hemodynamic Variances Evident in Multiple Sclerosis?

OBJECTIVE: An investigation was performed to determine the relevant hemodynamic parameters which could help assess vascular pathology in human diseases. Using these parameters, this study aims to assess if there are any hemodynamic differences in the cerebral veins of multiple sclerosis (MS) patients and controls which could impact the etiology of MS. METHODS: 40 MS participants and 20 controls were recruited for this study. Magnetic resonance imaging (MRI) was performed to enable 3D geometries of the anatomy and the blood flow rates at the boundaries to be computed. Computational fluid dynam…

The natural history of multiple sclerosis: a geographically based study. 5. The clinical features and natural history of primary progressive multiple sclerosis.

We report a natural history study of 216 patients with primary progressive (PP)- multiple sclerosis defined by at least 1 year of exacerbation-free progression at onset. This represents 19.8% of a largely population-based patient cohort having a mean longitudinal follow-up of 23 years. This subgroup of PP-multiple sclerosis patients had a mean age of onset of 38.5 years, with females predominating by a ratio of 1.3:1.0. The rate of deterioration from disease onset was substantially more rapid than for relapsing-remitting multiple sclerosis, with a median time to disability status score (DSS) 6…

An extensive search for autoantibodies to myelin basic protein in cerebrospinal fluid of non-multiple-sclerosis patients: implications for the pathogenesis of multiple sclerosis.

Inflammation of multiple sclerosis (MS) brain and spinal cord tissue consists of macrophages, T lymphocytes and cytokines as well as B lymphocytes and immunoglobulins (IgGs). IgG can be detected in high concentrations in both central nervous system tissue and cerebrospinal fluid (CSF). Using a sensitive radioimmunoassay (RIA), autoantibodies to myelin basic protein (anti-MBP) can be detected in the CSF of 90-95% of MS patients with active disease. The purpose of the present report was to determine whether these same autoantibodies can be reliably detected in non-MS patients. Between 1978 and 1…

[Quantitative analysis of cerebrospinal fluid flow in multiple sclerosis patients].

OBJECTIVE: To study changes in the quantitative indicators of intracranial cerebrospinal fluid (CSF) flow in patients with multiple sclerosis (MS) at different stages of the disease using phase contrast magnetic resonance imaging (PC MRI). MATERIAL AND METHODS: The study included 80 patients diagnosed with MS (40 in the acute stage, 40 in remission) and 10 healthy volunteers. CSF flow parameters were assessed using a phase contrast MRI protocol. Peak velocities, stroke volume, and positive and negative flow volume through the ventricular aqueduct were analyzed. RESULTS: In the acute stage, a…

[Myoadaptive overload syndromes of lower extremities in multiple sclerosis patients].

The article addresses the actual problem of chronic pain in patients with multiple sclerosis (MS). Particular attention is paid to the nociceptive component of pain caused by the biomechanics disorders of the spine and the development of myoadaptive overload syndromes (MOSs). A pathogenetic analysis of postural and vicarious mechanisms of musculoskeletal overload occurring due to paresis, spastic hypertonicity, and spinal deformity is presented. Their importance in the pain chronification, decreased motor activity, and the quality of life of MS patients has been reported. The need for an integ…

Creatinine and C-reactive protein in amyotrophic lateral sclerosis, multiple sclerosis and Parkinson's disease.

Serum creatinine and C-reactive protein have been proposed as potential biomarkers for neurodegenerative diseases, including amyotrophic lateral sclerosis, multiple sclerosis and Parkinson's disease. However, longitudinal studies investigating temporal patterns of these biomarkers, including the phase before diagnosis, are rare. We performed a case-control study including all newly diagnosed patients with amyotrophic lateral sclerosis (N = 525), multiple sclerosis (N = 1815) or Parkinson's disease (N = 3797) during 2006-2013 in Stockholm, Sweden, who participated in the Stockholm CREAtinine Me…

Elevated IL-38 Serum Levels in Newly Diagnosed Multiple Sclerosis and Systemic Sclerosis Patients.

OBJECTIVE: Interleukin (IL)-38 is a newly discovered member of the IL-1 cytokine family with a proposed anti-inflammatory profile. We studied the probable role of this cytokine in the pathogenesis of two autoimmune diseases: multiple sclerosis (MS) and systemic sclerosis (SSc). SUBJECTS AND METHODS: A total of 87 MS patients and 86 SSc patients (40 new and recently untreated cases and 46 treated cases) were selected for this study. Eighty-seven and 80 age- and sex-matched healthy subjects were included as controls for MS and SSc, respectively. Clinical and paraclinical features of the patient…

The predictive value of CSF multiple assay in multiple sclerosis: A single center experience.

BACKGROUND: Multiple sclerosis (MS) is a chronic, immune-mediated, inflammatory, neurodegenerative disorder. Many studies are investigating the potential role of body fluid biomarkers as prognostic factors for early identification of patients presenting with clinical isolated syndrome (CIS) at high risk for conversion to MS or to recognize RRMS patients at high risk for progression. OBJECTIVES: To evaluate the correlation between levels of BAFF, chitinase 3-like 1 (CHI3L1), sCD163, Osteopontin (OPN), both on serum and cerebral spinal fluid (CSF), and the disease activity and progression. We a…

Quantitative magnetic resonance imaging reflects different levels of histologically determined myelin densities in multiple sclerosis, including remyelination in inactive multiple sclerosis lesions.

Magnetic resonance imaging (MRI) of focal or diffuse myelin damage or remyelination may provide important insights into disease progression and potential treatment efficacy in multiple sclerosis (MS). We performed post-mortem MRI and histopathological myelin measurements in seven progressive MS cases to evaluate the ability of three myelin-sensitive MRI scans to distinguish different stages of MS pathology, particularly chronic demyelinated and remyelinated lesions. At 3 Tesla, we acquired two different myelin water imaging (MWI) scans and magnetisation transfer ratio (MTR) data. Histopatholog…

Innate Immune System and Multiple Sclerosis. Granulocyte Numbers Are Reduced in Patients Affected by Relapsing-Remitting Multiple Sclerosis during the Remission Phase.

BACKGROUND: Multiple sclerosis (MS) is a neurodegenerative disease that affects the central nervous system. The cause of MS is still unknown, and the role of innate immunity is still poorly understood. OBJECTIVE: The goal of this study was to understand whether, compared to healthy controls, the elements of innate immunity are altered in the blood of MS patients in the remitting phase. METHODS: A total of 77 naïve MS patients and 50 healthy controls were included in this cohort study. Peripheral blood samples were collected and analyzed. All the calculations were performed with the statistic…

Occupational Therapy Interventions in Adults with Multiple Sclerosis or Amyotrophic Lateral Sclerosis: A Scoping Review.

This scoping review aims to describe occupational therapy interventions carried out with multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) patients in occupational therapy. A peer review of the literature was conducted in different databases: Pubmed, Scopus, Web of Science and Embase, and in some occupational therapy journals. A search of the literature published was carried out before December 2019. The inclusion criteria were as follows: (1) articles evaluating the intervention of occupational therapy in MS or ALS including experimental, randomized, nonrandomized and explorator…